Article
Multidisciplinary Sciences
J. Wagner-Skacel, D. Riedl, H. Kampling, A. Lampe
Summary: This study aimed to assess the relationship between adverse childhood experiences (ACEs), mentalization, and dissociation in adult individuals. The results showed that ACEs were associated with lower mentalization and higher dissociation. Mentalization fully mediated the relationship between ACEs and dissociation. Lower mentalization was also associated with worse depression, anxiety, somatization, and PTSD symptoms. These findings highlight the importance of early treatment for individuals affected by ACEs, with a focus on fostering the development of mentalization.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
L. K. Kuehl, K. de Punder, C. E. Deuter, D. S. Martens, C. Heim, C. Otte, K. Wingenfeld, S. Entringer
Summary: Major depressive disorder (MDD) and adverse childhood experiences (ACE) are potentially associated with accelerated cellular aging, but this study found no effects of MDD and ACE on telomere length (TL). Future research should consider the potential influence of medication intake and physical health status on the relationship between TL, MDD, and ACE.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Hunter A. Hahn, John R. Blosnich
Summary: Adverse childhood experiences are more likely to be reported by lesbian, gay, bisexual, and queer veterans compared with non-lesbian, gay, bisexual, and queer veterans. These experiences include living with someone who has mental illness, emotional abuse, and sexual abuse.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Article
Neurosciences
Brian D. Kangas, Annabel K. Short, Oanh T. Luc, Hal S. Stern, Tallie Z. Baram, Diego A. Pizzagalli
Summary: Exposure to early-life adversity leads to blunted response biases in the Probabilistic Reward Task (PRT) and decreased sucrose preference, indicating anhedonic-like phenotypes. The unpredictability of maternal care during early life is identified as a key driver of reward sensitivity deficits, highlighting the importance of maternal signals in shaping reward circuitry. The PRT is established as a powerful tool to assess the impact of early-life adversity on reward circuitry across different species.
NEUROPSYCHOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Zulfiqar A. Bhutta, Supriya Bhavnani, Theresa S. Betancourt, Mark Tomlinson, Vikram Patel
Summary: With the sustainable development goals, global child health has shifted focus from reducing mortality to improving health, nutrition, and development outcomes, which are measured as human capital. Adverse childhood experiences (ACEs), which include environmental exposures, have been found to have negative consequences on health and development. These effects can be magnified, especially during critical periods of sensitivity and developmental plasticity, and are exacerbated by global threats like climate change and conflict. This review explores the mechanisms linking ACEs to health outcomes and discusses strategies for prevention and mitigation, with a focus on low- and middle-income countries.
Article
Obstetrics & Gynecology
Emily S. Miller, Oriana Fleming, Etoroabasi E. Ekpe, William A. Grobman, Nia Heard-Garris
Summary: This study examined the association between adverse childhood experiences and adverse pregnancy outcomes, revealing that a high ACE score was associated with an increased risk of hypertensive disorders of pregnancy and preterm birth.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Psychiatry
Ole Koehler-Forsberg, Fenfen Ge, Arna Hauksdottir, Edda Bjork Thordardottir, Kristjana Asbjoernsdottir, Harpa Runarsdottir, Gunnar Tomasson, Johanna Jakobsdottir, Berglind Guomundsdottir, Andri Steinpor Bjoernsson, Engilbert Sigurosson, Thor Aspelund, Unnur A. Valdimarsdottir
Summary: Women with schizophrenia or bipolar disorder have experienced a greater number of adverse childhood experiences (ACEs), which may impact their psychological functioning. These findings suggest the importance of addressing ACEs as part of the treatment for women with these mental disorders, such as using trauma-focused psychotherapy.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
Enoch Ng, Emily H. Y. Wong, Nir Lipsman, Sean M. Nestor, Peter Giacobbe
Summary: This study aimed to investigate the impact of adverse childhood experiences (ACEs) on outcomes of depression patients receiving repetitive transcranial magnetic stimulation (rTMS). The results showed that ACEs did not significantly affect depression outcomes, but may lead to a steeper initial decline.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Stephan Goerigk, Matthias A. Reinhard, Barbara B. Barton, Gerrit Burkhardt, Thomas Ehring, Katja Bertsch, Benedikt L. Amann, Nina Sarubin, Elias Seidl, Peter Falkai, Richard Musil, Andrea Jobst, Frank Padberg
Summary: This study demonstrates the promising potential of adverse childhood experiences (ACE) as a transdiagnostic construct. By identifying seven ACE subcategories, the study shows the strong predictive power of these subcategories in relation to psychopathology. The study highlights the importance of integrating co-occurring ACE information to inform diagnostics and treatment.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Jing Shi, Hua Guo, Sijia Liu, Wei Xue, Fengmei Fan, Hui Li, Hongzhen Fan, Huimei An, Zhiren Wang, Shuping Tan, Fude Yang, Yunlong Tan
Summary: This study aimed to explore the differences and similarities in subcortical structure volumes and neurocognition among individuals with first-episode schizophrenia (FES), bipolar disorder (BD), major depression disorder (MDD), and healthy controls (HCs). The findings revealed that FES and BD patients had larger left lateral ventricle volumes, while FES had reduced bilateral hippocampus and amygdala volumes compared to HCs. Both BD and MDD showed lower bilateral amygdala volumes than HCs. Additionally, FES, BD, and MDD displayed varying degrees of cognitive impairments across different cognitive dimensions. Significant relationships were found between subcortical volumes and neurocognition in FES and BD, but not in MDD and HCs. Furthermore, some subcortical volumes, along with age and years of education, were found to predict variations in neurocognitive performance.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Anesthesiology
Georgia Antoniou, Emilie Lambourg, J. Douglas Steele, Lesley A. Colvin
Summary: Adverse childhood experiences have been linked to increased multimorbidity, with physical and mental health consequences throughout life. This study aimed to assess evidence for central neural changes associated with adverse childhood experiences in subjects with chronic pain, major depressive disorder (MDD), or both using systematic review and meta-analysis.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Psychology, Clinical
Justyna Kasznia, Aleksandra Pytel, Bartlonniej Stanczykiewicz, Jerzy Samochowiec, Katarzyna Waszczuk, Malgorzata Kulik, Agnieszka Cyran, Blazej Misiak
Summary: This study found that individuals with schizophrenia-spectrum disorders (SSD) tend to use avoidance coping styles, which may be associated with a history of adverse childhood experiences.
PSYCHOLOGY RESEARCH AND BEHAVIOR MANAGEMENT
(2021)
Article
Clinical Neurology
Mark A. Bond, Amy L. Stone, Robert Salcido, Phillip W. Schnarrs
Summary: This study found that using a Likert scale to measure ACEs in SGMs can better predict anxiety and post-traumatic stress disorder compared to the traditional ACEs index. Half of the SGMs in the sample experienced 3 or more ACEs, a much higher rate than in a nationally representative sample.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Public, Environmental & Occupational Health
Katherine LeMasters, Lisa M. Bates, Esther O. Chung, John A. Gallis, Ashley Hagaman, Elissa Scherer, Siham Sikander, Brooke S. Staley, Lauren C. Zalla, Paul N. Zivich, Joanna Maselko
Summary: The study found a significant association between Adverse Childhood Experiences (ACEs) and women's depression, especially during the perinatal period. The most common ACE domains were home violence and neglect. Women with four or more ACEs showed the most pronounced elevation in depression symptoms.
Article
Public, Environmental & Occupational Health
Sakurako S. Okuzono, Natalie Slopen, Koichiro Shiba, Aki Yazawa, Katsunori Kondo, Ichiro Kawachi
Summary: This study aimed to identify subpopulations that are particularly vulnerable to long-term adverse health consequences of disaster-related trauma. The findings suggested that adverse childhood experiences (ACEs) may potentiate the association between disaster-related trauma and subsequent cognitive disability among older adult disaster survivors.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Review
Neurosciences
Odile A. van den Heuvel, Premika S. W. Boedhoe, Sara Bertolin, Willem B. Bruin, Clyde Francks, Iliyan Ivanov, Neda Jahanshad, Xiang-Zhen Kong, Jun S. Kwon, Joseph O'Neill, Tomas Paus, Yash Patel, Fabrizio Piras, Lianne Schmaal, Carles Soriano-Mas, Gianfranco Spalletta, Guido A. van Wingen, Je-Yeon Yun, Chris Vriend, H. Blair Simpson, Daan van Rooij, Marcelo Q. Hoexter, Martine Hoogman, Jan K. Buitelaar, Paul Arnold, Jan C. Beucke, Francesco Benedetti, Irene Bollettini, Anushree Bose, Brian P. Brennan, Alessander S. De Nadai, Kate Fitzgerald, Patricia Gruner, Edna Gruenblatt, Yoshiyuki Hirano, Chaim Huyser, Anthony James, Kathrin Koch, Gerd Kvale, Luisa Lazaro, Christine Lochner, Rachel Marsh, David Mataix-Cols, Pedro Morgado, Takashi Nakamae, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Erika Nurmi, Christopher Pittenger, Y. C. Janardhan Reddy, Joao R. Sato, Noam Soreni, S. Evelyn Stewart, Stephan F. Taylor, David Tolin, Sophia I. Thomopoulos, Dick J. Veltman, Ganesan Venkatasubramanian, Susanne Walitza, Zhen Wang, Paul M. Thompson, Dan J. Stein
Summary: Neuroimaging has significantly advanced our understanding of OCD's neurobiology, with ENIGMA consortium's collaborative efforts enhancing statistical power. Their work involves samples from multiple countries and regions, utilizing machine learning techniques for research, contributing to the development of neurobiological models of OCD and global scientific collaboration.
HUMAN BRAIN MAPPING
(2022)
Review
Neurosciences
Christopher R. K. Ching, Derrek P. Hibar, Tiril P. Gurholt, Abraham Nunes, Sophia I. Thomopoulos, Christoph Abe, Ingrid Agartz, Rachel M. Brouwer, Dara M. Cannon, Sonja M. C. de Zwarte, Lisa T. Eyler, Pauline Favre, Tomas Hajek, Unn K. Haukvik, Josselin Houenou, Mikael Landen, Tristram A. Lett, Colm McDonald, Leila Nabulsi, Yash Patel, Melissa E. Pauling, Tomas Paus, Joaquim Radua, Marcio G. Soeiro-de-Souza, Giulia Tronchin, Neeltje E. M. van Haren, Eduard Vieta, Henrik Walter, Ling-Li Zeng, Martin Alda, Jorge Almeida, Dag Alnaes, Silvia Alonso-Lana, Cara Altimus, Michael Bauer, Bernhard T. Baune, Carrie E. Bearden, Marcella Bellani, Francesco Benedetti, Michael Berk, Amy C. Bilderbeck, Hilary P. Blumberg, Erlend Boen, Irene Bollettini, Caterina del Mar Bonnin, Paolo Brambilla, Erick J. Canales-Rodriguez, Xavier Caseras, Orwa Dandash, Udo Dannlowski, Giuseppe Delvecchio, Ana M. Diaz-Zuluaga, Danai Dima, Edouard Duchesnay, Torbjorn Elvsashagen, Scott C. Fears, Sophia Frangou, Janice M. Fullerton, David C. Glahn, Jose M. Goikolea, Melissa J. Green, Dominik Grotegerd, Oliver Gruber, Bartholomeus C. M. Haarman, Chantal Henry, Fleur M. Howells, Victoria Ives-Deliperi, Andreas Jansen, Tilo T. J. Kircher, Christian Knoechel, Bernd Kramer, Beny Lafer, Carlos Lopez-Jaramillo, Rodrigo Machado-Vieira, Bradley J. MacIntosh, Elisa M. T. Melloni, Philip B. Mitchell, Igor Nenadic, Fabiano Nery, Allison C. Nugent, Viola Oertel, Roel A. Ophoff, Miho Ota, Bronwyn J. Overs, Daniel L. Pham, Mary L. Phillips, Julian A. Pineda-Zapata, Sara Poletti, Mircea Polosan, Edith Pomarol-Clotet, Arnaud Pouchon, Yann Quide, Maria M. Rive, Gloria Roberts, Henricus G. Ruhe, Raymond Salvador, Salvador Sarro, Theodore D. Satterthwaite, Aart H. Schene, Kang Sim, Jair C. Soares, Michael Staeblein, Dan J. Stein, Christian K. Tamnes, Georgios V. Thomaidis, Cristian Vargas Upegui, Dick J. Veltman, Michele Wessa, Lars T. Westlye, Heather C. Whalley, Daniel H. Wolf, Mon-Ju Wu, Lakshmi N. Yatham, Carlos A. Zarate, Paul M. Thompson, Ole A. Andreassen
Summary: MRI-derived brain measures have been widely studied in bipolar disorder (BD) and provide insights into the connections between genes, the environment, and behavior. The ENIGMA Bipolar Disorder Working Group is a collaborative effort that aims to generate consensus findings and improve the replicability of studies on BD. Through large-scale neuroimaging studies, the working group has discovered patterns of brain alterations associated with BD, as well as the effects of medications and clinical risk profiles.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Christoph Abe, Christopher R. K. Ching, Benny Liberg, Alexander V. Lebedev, Ingrid Agartz, Theophilus N. Akudjedu, Martin Alda, Dag Alnaes, Silvia Alonso-Lana, Francesco Benedetti, Michael Berk, Erlend Boen, Caterina del Mar Bonnin, Fabian Breuer, Katharina Brosch, Rachel M. Brouwer, Erick J. Canales-Rodriguez, Dara M. Cannon, Yann Chye, Andreas Dahl, Orwa Dandash, Udo Dannlowski, Katharina Dohm, Torbjorn Elvsashagen, Lukas Fisch, Janice M. Fullerton, Jose M. Goikolea, Dominik Grotegerd, Beathe Haatveit, Tim Hahn, Tomas Hajek, Walter Heindel, Martin Ingvar, Kang Sim, Tilo T. J. Kircher, Rhoshel K. Lenroot, Ulrik F. Malt, Colm McDonald, Sean R. McWhinney, Ingrid Melle, Tina Meller, Elisa M. T. Melloni, Philip B. Mitchell, Leila Nabulsi, Igor Nenadic, Nils Opel, Bronwyn J. Overs, Francesco Panicalli, Julia-Katharina Pfarr, Sara Poletti, Edith Pomarol-Clotet, Joaquim Radua, Jonathan Repple, Kai G. Ringwald, Gloria Roberts, Elena Rodriguez-Cano, Raymond Salvador, Kelvin Sarink, Salvador Sarro, Simon Schmitt, Frederike Stein, Chao Suo, Sophia I. Thomopoulos, Giulia Tronchin, Eduard Vieta, Lars T. Westlye, Adam G. White, Lakshmi N. Yatham, Nathalia Zak, Paul M. Thompson, Ole A. Andreassen, Mikael Landen
Summary: This study revealed that patients with BD showed faster ventricular enlargements and slower thinning of specific brain regions. More manic episodes were associated with faster cortical thinning, primarily in the prefrontal cortex.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Psychiatry
Serena Borroni, Linda Franchini, Silvia Brioschi, Giulia Vassena, Elisabetta Masci, Chiara Franzoni, Giulia Ruotolo, Cristina Colombo, Andrea Fossati
Summary: This study examines the role of sociodemographic and clinical variables as well as personality pathological features in predicting high lethality suicide attempts. The results indicate that previous suicide attempts and current suicide ideation play a role in predicting serious suicide attempts. Specifically, the Detachment domain is associated with high lethality suicide attempts and remains a significant predictor even when considering the effects of previous attempts and ideation.
PERSONALITY AND MENTAL HEALTH
(2023)
Article
Clinical Neurology
Elena Mazza, Federico Calesella, Marco Paolini, Camilla di Pasquasio, Sara Poletti, Cristina Lorenzi, Andrea Falini, Raffaella Zanardi, Cristina Colombo, Francesco Benedetti
Summary: Our study investigated the effects of insulin and its derived measures on white matter microstructure and neural functional connectivity in patients with bipolar disorder (BD). The results showed that insulin was negatively associated with fractional anisotropy and positively influenced radial diffusivity and mean diffusivity. Additionally, insulin resistance had a significant effect on radial diffusivity, while insulin sensitivity was positively associated with fractional anisotropy and negatively associated with radial diffusivity and mean diffusivity. These findings suggest that insulin may play a role in the pathophysiology of BD by affecting white matter microstructure and functional connectivity.
Article
Clinical Neurology
Marco Paolini, Mariagrazia Palladini, Mario Gennaro Mazza, Federica Colombo, Benedetta Vai, Patrizia Rovere-Querini, Andrea Falini, Sara Poletti, Francesco Benedetti
Summary: Cognitive impairment is a common residual symptom in COVID-19 survivors and is associated with various brain changes. This study investigated the neural correlates of subjective cognitive decline using multimodal imaging in a sample of 58 COVID-19 survivors. The findings revealed widespread white matter disruption and abnormal functional connectivity in the brains of individuals with cognitive complaints. These results suggest a potential brain signature of cognitive decline in COVID-19 survivors and may aid in the identification of therapeutic targets for mitigating long-term cognitive dysfunction.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Sigrid Breit, Elena Mazza, Sara Poletti, Francesco Benedetti
Summary: Major depressive disorder (MDD) is a complex and serious mental disorder that can result in chronic recurrent symptoms, treatment resistance, and suicidal behavior. Immune dysregulation and brain volume changes, particularly in white matter (WM), are associated with MDD. Neuroimaging markers and blood markers, such as inflammation-related cytokines, may serve as predictors of treatment response in MDD, but the relationship between peripheral inflammation, WM integrity, and antidepressant response is still not clearly understood. This review aims to explore the association between inflammation and WM integrity, and their impact on MDD pathophysiology and progression, as well as the potential role of novel biomarkers in improving MDD prevention and treatment strategies.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Clinical Neurology
Benedetta Vai, Federico Calesella, Claudia Lenti, Lidia Fortaner-Uya, Elisa Caselani, Paola Fiore, Sigrid Breit, Sara Poletti, Cristina Colombo, Raffaella Zanardi, Francesco Benedetti
Summary: Suicide attempts in Bipolar Disorder are characterized by high levels of lethality and impulsivity. Reduced rates of amygdala and cortico-limbic habituation can identify a fMRI phenotype of suicidality in the disorder related to internal over-arousing states. This study found that bipolar suicide attempters have lower habituation levels in several cortico-limbic areas, suggesting that reduced habituation in the cortico-limbic system may serve as a biomarker for suicidality. Machine learning techniques achieved high accuracy in differentiating suicide attempters from non-attempters.
PSYCHIATRY RESEARCH-NEUROIMAGING
(2023)
Article
Medicine, General & Internal
Mariagrazia Palladini, Mario Gennaro Mazza, Andrea Scalabrini, Patrizia Rovere Querini, Sara Poletti, Francesco Benedetti
Summary: COVID-19 survivors experience intense depressive and post-traumatic symptoms in the sub-acute stages. Survivor guilt may contribute to the development of post-COVID psychiatric implications. This study aims to uncover the affective mechanism behind these implications by examining the association between survivor guilt, psychopathology, and maladaptive attributional style. The study evaluated symptoms of depression, post-traumatic distress, and sleep disturbances in 195 COVID-19 survivors one month after discharge.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Marco Paolini, Yasmin Harrington, Laura Raffaelli, Sara Poletti, Raffaella Zanardi, Cristina Colombo, Francesco Benedetti
Summary: This study investigated the impact of Neutrophil-to-lymphocyte ratio (NLR) on treatment response in Major Depressive Disorder (MDD) patients, and the influence of sex and hippocampal volume on this relationship. The results showed that NLR had a different effect on treatment response in females compared to males. Additionally, NLR negatively affected hippocampal volume in females, and hippocampal volume partially mediated the effect of NLR on treatment response in females.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Marco Paolini, Yasmin Harrington, Federica Colombo, Valentina Bettonagli, Sara Poletti, Matteo Carminati, Cristina Colombo, Francesco Benedetti, Raffaella Zanardi
Summary: A study found that there is a correlation between MRI imaging and treatment response in patients with major depressive disorder (MDD). The study analyzed MRI scans of 100 patients and found that lower grey matter volumes, particularly in the hippocampus and temporal lobe-related areas, were associated with worse treatment outcomes. Functional connectivity patterns were also found to be related to treatment response.
JOURNAL OF PSYCHOPHARMACOLOGY
(2023)
Letter
Criminology & Penology
Lorenzo Fregna, Francesco Attanasio, Guido Travaini, Cristina Colombo
VIOLENCE AND GENDER
(2023)
