Article
Biotechnology & Applied Microbiology
Ying Li, Yujie Zhang, Dongqing Ye, Yuyang Song, Junling Shi, Yi Qin, Yanlin Liu
Summary: Increasing intracellular serine levels can reduce H2S release, while increasing extracellular serine levels is ineffective. In addition, specific gene expression regulates H2S release. These findings contribute to the understanding of the H2S regulation mechanism in yeast during fermentation.
Review
Chemistry, Medicinal
Jia-Ying Zhao, Kai-Rui Feng, Feng Wang, Jian-Wei Zhang, Jay Fei Cheng, Guo-Qiang Lin, Dingding Gao, Ping Tian
Summary: Phosphoglycerate dehydrogenase (PHGDH), as a rate-limiting enzyme in the serine biosynthesis pathway, is overexpressed in various diseases, especially in cancer, making it a promising drug target for cancer therapy. Inhibitors of PHGDH have been identified as significant and emerging options for anticancer treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Environmental Sciences
Maha Aljabri, Saif Alharbi, Rahmah N. Al-Qthanin, Fekry M. Ismaeil, Jiana Chen, Salah Fatouh Abou-Elwafa
Summary: Under saline soil conditions, applying treated beet sugar filter cake and molasses can enhance the root length, diameter, and leaf area of sugar beet, increase sugar content and root yield, leading to the highest recoverable sugar yield. Increasing the availability of Ca2+ or K content in the soil by applying soil amendments and molasses improves root yield, quality index, and recoverable sugar yield of sugar beet.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ruben Casatejada-Anchel, Jesus Munoz-Bertomeu, Sara Rosa-Tellez, Armand D. Anoman, Sergio G. Nebauer, Alejandro Torres-Moncho, Alisdair R. Fernie, Roc Ros
Summary: The Phosphorylated Pathway of Serine Biosynthesis (PPSB) plays a crucial role in plant growth and metabolism, with PGDH2 and PGDH3 impacting plant development. PGDH2 has a stronger effect on plant growth compared to PGDH3, while the latter may have additional functions in photosynthetic cells.
Review
Oncology
Mingxue Li, Canrong Wu, Yueying Yang, Mengzhu Zheng, Silin Yu, Jinhui Wang, Lixia Chen, Hua Li
Summary: The dysregulation of serine metabolism, particularly through the upregulation of PHGDH, is a common feature in various types of cancer cells. Inhibition of PHGDH has been shown to be effective in inhibiting the proliferation of cancer cells, making it a potential target for cancer treatment. Further research and development of PHGDH inhibitors may have significant implications for precision medicine and personalized cancer treatment strategies.
Article
Biochemistry & Molecular Biology
Xia Zhou, Yuping Tan, Kun Gou, Lei Tao, Yuan Luo, Yue Zhou, Zeping Zuo, Qingxiang Sun, Youfu Luo, Yinglan Zhao
Summary: In this study, a novel PHGDH inhibitor, compound b36, was identified as an effective agent in inhibiting the proliferation of breast cancer and ovarian cancer cells, disrupting DNA synthesis, and inducing cell cycle arrest. This new compound could potentially serve as a promising candidate for anticancer drug development.
BIOORGANIC CHEMISTRY
(2021)
Review
Neurosciences
Marianne Maugard, Pierre-Antoine Vigneron, Juan P. Bolanos, Gilles Bonvento
Summary: Brain energy metabolism involves the intricate relationship between neurons and glial cells, with a specific metabolic pathway connecting glial metabolism to synaptic activity and plasticity through L-serine biosynthesis. Modulating astrocyte-mediated L-serine homeostasis may offer novel therapeutic approaches for brain disorders.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kohji Yamamoto, Shinya Mohri, Shigeki Furuya
Summary: The newly identified enzyme bmPHGDH plays a crucial role in synthesizing L-serine in the larva of silkworm Bombyx mori, especially in the synthesis of silk proteins. The expression of bmPHGDH in different parts of silkworms has been studied, showing its importance in serine biosynthesis.
ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Plant Sciences
Lei Liu, Pengfei Zhang, Guozhong Feng, Wenfeng Hou, Tianhao Liu, Zhijia Gai, Yanhui Shen, Xin Qiu, Xiangnan Li
Summary: The physiological mechanisms involved in xanthine metabolism during salt priming for improving low-temperature tolerance were studied. Salt priming promoted the growth of sugar beet leaves and increased the maximum quantum efficiency of PS II. However, the treatment with either xanthine dehydrogenase inhibitor (XOI) or exogenous allantoin (EA) alone increased the content of reactive oxygen species (ROS) in the leaves under low-temperature stress. Xanthine metabolism modulated ROS metabolism, photosynthetic carbon assimilation, and carbohydrate metabolism, thus enhancing low-temperature tolerance in sugar beet.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Hanyu Xu, Xiaoyu Qing, Qian Wang, Chunmei Li, Luhua Lai
Summary: Human D-3-phosphoglycerate dehydrogenase (PHGDH), a key enzyme in de novo serine biosynthesis, shows potential as a target for anticancer drug development due to its amplification in various cancers. Understanding the enzyme's oligomeric states and the impact on enzymatic activity is crucial for drug design. Hotspot residues identified computationally can guide the design process by disrupting the oligomeric structure of PHGDH.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jinna Li, Bing Yu, Chunquan Ma, Hongli Li, Desheng Jiang, Jingdong Nan, Meng Xu, He Liu, Sixue Chen, Huizi Duanmu, Haiying Li
Summary: Salt stress induces cellular dehydration and oxidative stress in plants through the production of reactive oxygen species (ROS). The plant ROS scavenging system, including antioxidant enzymes, is crucial for maintaining cellular redox homeostasis. A study on the salt-tolerant sugar beet apomictic monosomic additional M14 line (BvM14) revealed that six antioxidant enzymes were responsive to salt stress. Cloning and overexpression of these genes in transgenic plants improved salt stress tolerance by regulating the levels of H2O2, MDA, AsA, and GSH. This research provides insights into the roles of antioxidant enzymes in the response to salt stress and offers genetic resources for crop engineering and breeding.
Article
Biochemistry & Molecular Biology
Yuguang Wang, Shuang Wang, Ye Tian, Qiuhong Wang, Sixue Chen, Hongli Li, Chunquan Ma, Haiying Li
Summary: The study identified BvbHLH93 as a key bHLH transcription factor in response to salt stress in plants. The up-regulation of BvbHLH93 in roots and leaves by salt stress and its overexpression in Arabidopsis enhanced salt tolerance by regulating antioxidant enzymes and ROS generation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Kui Wang, Li Luo, Shuyue Fu, Mao Wang, Zihao Wang, Lixia Dong, Xingyun Wu, Lunzhi Dai, Yong Peng, Guobo Shen, Hai-Ning Chen, Edouard Collins Nice, Xiawei Wei, Canhua Huang
Summary: Using integrative metabolomics and transcriptomics analyses, the study reveals that hepatocellular carcinoma (HCC) tissues have increased serine levels but decreased expression of phosphoglycerate dehydrogenase (PHGDH), a key enzyme in serine biosynthesis. The increased serine levels are obtained through enhanced PHGDH catalytic activity mediated by protein arginine methyltransferase 1 (PRMT1)-mediated methylation of PHGDH at arginine 236. Furthermore, PRMT1-mediated PHGDH methylation correlates with poor prognosis for HCC patients and blocking PHGDH methylation inhibits serine synthesis and restrains HCC growth.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Eiji Okamura, Kinuka Ohtaka, Ryuichi Nishihama, Kai Uchida, Ayuko Kuwahara, Keiichi Mochida, Masami Yokota Hirai
Summary: The phosphorylated pathway of serine biosynthesis is initiated with 3-phosphoglycerate dehydrogenase (PGDH). The study analyzed PGDH isozymes of representative land plants and found diversification in sensitivity to effector amino acids among isozymes. Mutagenesis analysis revealed specific residues involved in allosteric regulation of PGDH.
BIOCHEMICAL JOURNAL
(2021)
Review
Chemistry, Medicinal
Quentin Spillier, Raphael Frederick
Summary: PHGDH, a metabolic enzyme in the serine synthetic pathway, is crucial for cancer growth and proliferation. Research on PHGDH inhibitors has not yet yielded clinically usable compounds due to their weak potency or limited selectivity, highlighting the importance of continuing to develop new chemical series for potential therapeutic use in cancer and other diseases.
EXPERT OPINION ON THERAPEUTIC PATENTS
(2021)