Structural review of PPARγ in complex with ligands: Cartesian- and dihedral angle principal component analyses of X-ray crystallographic data

Different structures of the two peroxisome proliferator-activated receptor gamma (PPARγ) ligand-binding domains in homodimeric complex with partial agonist, but not full agonist

(2015) Masao Ohashi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Conformational Diversity of the Helix 12 of the Ligand Binding Domain of PPARγ and Functional Implications

(2015) Mariana R. B. Batista et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Conformational selection in protein binding and function

(2014) Thomas R. Weikl et al.   PROTEIN SCIENCE

Role of PPARγin the Differentiation and Function of Neurons

(2014) Rodrigo A. Quintanilla et al.   PPAR Research

An alternate binding site for PPARγ ligands

(2014) Travis S. Hughes et al.   Nature Communications

Structural basis of the transactivation deficiency of the human PPARγ F360L mutant associated with familial partial lipodystrophy

(2014) Clorinda Lori et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

ThePDB_REDOserver for macromolecular structure model optimization

(2014) Robbie P. Joosten et al.   IUCrJ

Grcarma: A fully automated task-oriented interface for the analysis of molecular dynamics trajectories

(2013) Panagiotis I. Koukos et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Structural Characterization of Amorfrutins Bound to the Peroxisome Proliferator-Activated Receptor γ

(2013) Jens C. de Groot et al.   JOURNAL OF MEDICINAL CHEMISTRY

PPARγ signaling and metabolism: the good, the bad and the future

(2013) Maryam Ahmadian et al.   NATURE MEDICINE

Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ1 and χ2 Dihedral Angles

(2012) Robert B. Best et al.   Journal of Chemical Theory and Computation

New 2-(Aryloxy)-3-phenylpropanoic Acids as Peroxisome Proliferator-Activated Receptor α/γ Dual Agonists Able To Upregulate Mitochondrial Carnitine Shuttle System Gene Expression

(2012) A. Laghezza et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ligand and Receptor Dynamics Contribute to the Mechanism of Graded PPARγ Agonism

(2012) Travis S. Hughes et al.   STRUCTURE

ProDy: Protein Dynamics Inferred from Theory and Experiments

(2011) A. Bakan et al.   BIOINFORMATICS

GeoPCA: a new tool for multivariate analysis of dihedral angles based on principal component geodesics

(2011) Karen Sargsyan et al.   NUCLEIC ACIDS RESEARCH

Pre-existing soft modes of motion uniquely defined by native contact topology facilitate ligand binding to proteins

(2011) Lidio Meireles et al.   PROTEIN SCIENCE

Rosiglitazone and pioglitazone increase fracture risk in women and men with type 2 diabetes

(2010) R. E. Aubert et al.   DIABETES OBESITY & METABOLISM

The nuclear receptor PPARγ individually responds to serotonin- and fatty acid-metabolites

(2010) Tsuyoshi Waku et al.   EMBO JOURNAL

The rise and fall of rosiglitazone

(2010) S. E. Nissen   EUROPEAN HEART JOURNAL

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

(2010) Jang Hyun Choi et al.   NATURE

PDB_REDO: automated re-refinement of X-ray structure models in the PDB

(2009) Robbie P. Joosten et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

New 2-Aryloxy-3-phenyl-propanoic Acids As Peroxisome Proliferator-Activated Receptors α/γ Dual Agonists with Improved Potency and Reduced Adverse Effects on Skeletal Muscle Function

(2009) Giuseppe Fracchiolla et al.   JOURNAL OF MEDICINAL CHEMISTRY

Conformational Analysis in a Multidimensional Energy Landscape: Study of an Arginylglutamate Repeat

(2009) Sara R. R. Campos et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The intrinsic dynamics of enzymes plays a dominant role in determining the structural changes induced upon inhibitor binding

(2009) A. Bakan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Limitations and lessons in the use of X-ray structural information in drug design

(2008) A DAVIS et al.   DRUG DISCOVERY TODAY

The giant protein AHNAK involved in morphogenesis and laminin substrate adhesion of myelinating Schwann cells

(2008) Claudio Salim et al.   GLIA

A Functional Peroxisome Proliferator-activated Receptor-γ Ligand-binding Domain Is Not Required for Adipogenesis

(2008) Christopher J. Walkey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Construction of the free energy landscape of biomolecules via dihedral angle principal component analysis

(2008) Alexandros Altis et al.   JOURNAL OF CHEMICAL PHYSICS

Crystal Structure of the Peroxisome Proliferator-Activated Receptor γ (PPARγ) Ligand Binding Domain Complexed with a Novel Partial Agonist: A New Region of the Hydrophobic Pocket Could Be Exploited for Drug Design

(2008) Roberta Montanari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Insight into PPARγ Activation Through Covalent Modification with Endogenous Fatty Acids

(2008) Tsuyoshi Waku et al.   JOURNAL OF MOLECULAR BIOLOGY

Close Correspondence between the Motions from Principal Component Analysis of Multiple HIV-1 Protease Structures and Elastic Network Modes

(2008) Lei Yang et al.   STRUCTURE

HOLLOW: Generating Accurate Representations of Channel and Interior Surfaces in Molecular Structures

(2008) Bosco K Ho et al.   BMC STRUCTURAL BIOLOGY