Conformational dynamics of human protein kinase CK2α and its effect on function and inhibition

Structure–activity relationship study of 4-(thiazol-5-yl)benzoic acid derivatives as potent protein kinase CK2 inhibitors

(2016) Hiroaki Ohno et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Microsecond Molecular Dynamics Simulations of Influenza Neuraminidase Suggest a Mechanism for the Increased Virulence of Stalk-Deletion Mutants

(2016) Jacob D. Durrant et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The role of protein dynamics in the evolution of new enzyme function

(2016) Eleanor Campbell et al.   Nature Chemical Biology

Specific inhibition of CK2α from an anchor outside the active site

(2016) Paul Brear et al.   Chemical Science

Biomolecular interactions modulate macromolecular structure and dynamics in atomistic model of a bacterial cytoplasm

(2016) Isseki Yu et al.   eLife

A Note of Caution on the Role of Halogen Bonds for Protein Kinase/Inhibitor Recognition Suggested by High- And Low-Salt CK2α Complex Structures

(2015) Barbara Guerra et al.   ACS Chemical Biology

Conformational Flexibility of Human Casein Kinase Catalytic Subunit Explored by Metadynamics

(2014) Aurélie Gouron et al.   BIOPHYSICAL JOURNAL

The Protein Kinase CK2Andante Holoenzyme Structure Supports Proposed Models of Autoregulation and Trans-Autophosphorylation

(2014) Alexander Schnitzler et al.   JOURNAL OF MOLECULAR BIOLOGY

First Structure of Protein Kinase CK2 Catalytic Subunit with an Effective CK2β-Competitive Ligand

(2013) Jennifer Raaf et al.   ACS Chemical Biology

Protein structural ensembles are revealed by redefining X-ray electron density noise

(2013) P. T. Lang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low-density crystal packing of human protein kinase CK2 catalytic subunit in complex with resorufin or other ligands: a tool to study the unique hinge-region plasticity of the enzyme without packing bias

(2012) Karsten Klopffleisch et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Computational studies of molecular machines: the ribosome

(2012) Karissa Y Sanbonmatsu   CURRENT OPINION IN STRUCTURAL BIOLOGY

Unprecedented Selectivity and Structural Determinants of a New Class of Protein Kinase CK2 Inhibitors in Clinical Trials for the Treatment of Cancer

(2011) Roberto Battistutta et al.   BIOCHEMISTRY

Allosteric Suppression of HIV-1 Reverse Transcriptase Structural Dynamics upon Inhibitor Binding

(2011) James M. Seckler et al.   BIOPHYSICAL JOURNAL

Enzymatic activity with an incomplete catalytic spine: insights from a comparative structural analysis of human CK2α and its paralogous isoform CK2α′

(2011) Nils Bischoff et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Structural and functional determinants of protein kinase CK2α: facts and open questions

(2011) Roberto Battistutta et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

A detailed thermodynamic profile of cyclopentyl and isopropyl derivatives binding to CK2 kinase

(2011) Takayoshi Kinoshita et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy

(2011) L. R. Masterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emergence of protein kinase CK2 as a key target in cancer therapy

(2010) Janeen H. Trembley et al.   BIOFACTORS

Discovery and SAR of 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic Acid (CX-4945), the First Clinical Stage Inhibitor of Protein Kinase CK2 for the Treatment of Cancer

(2010) Fabrice Pierre et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protein kinases: evolution of dynamic regulatory proteins

(2010) Susan S. Taylor et al.   TRENDS IN BIOCHEMICAL SCIENCES

Conformational plasticity of the catalytic subunit of protein kinase CK2 and its consequences for regulation and drug design

(2009) Karsten Niefind et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Protein Kinase CK2 in Health and Disease

(2009) K. Niefind et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Protein Kinase CK2 in Health and Disease

(2009) R. Battistutta   CELLULAR AND MOLECULAR LIFE SCIENCES

New Protein Kinase CK2 Inhibitors: Jumping out of the Catalytic Box

(2009) Renaud Prudent et al.   CHEMISTRY & BIOLOGY

The Catalytic Subunit of Human Protein Kinase CK2 Structurally Deviates from Its Maize Homologue in Complex with the Nucleotide Competitive Inhibitor Emodin

(2008) Jennifer Raaf et al.   JOURNAL OF MOLECULAR BIOLOGY