Incorporating an allosteric regulatory site in an antibody through backbone design

Design of Allosterically Regulated Protein Catalysts

(2015) Olga V. Makhlynets et al.   BIOCHEMISTRY

New Tricks for Old Proteins: Single Mutations in a Nonenzymatic Protein Give Rise to Various Enzymatic Activities

(2015) Yurii S. Moroz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineering an allosteric transcription factor to respond to new ligands

(2015) Noah D Taylor et al.   NATURE METHODS

Design of an allosterically regulated retroaldolase

(2015) Elizabeth A. Raymond et al.   PROTEIN SCIENCE

AbDesign: An algorithm for combinatorial backbone design guided by natural conformations and sequences

(2015) Gideon D. Lapidoth et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

A “Fuzzy”-Logic Language for Encoding Multiple Physical Traits in Biomolecules

(2014) Shira Warszawski et al.   JOURNAL OF MOLECULAR BIOLOGY

The ensemble nature of allostery

(2014) Hesam N. Motlagh et al.   NATURE

De novo design of a transmembrane Zn2+-transporting four-helix bundle

(2014) Nathan H. Joh et al.   SCIENCE

A Unified View of “How Allostery Works”

(2014) Chung-Jung Tsai et al.   PLoS Computational Biology

An Inhibitory Antibody Blocks the First Step in the Dithiol/Disulfide Relay Mechanism of the Enzyme QSOX1

(2013) Iris Grossman et al.   JOURNAL OF MOLECULAR BIOLOGY

The Designability of Protein Switches by Chemical Rescue of Structure: Mechanisms of Inactivation and Reactivation

(2013) Yan Xia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reprogramming an ATP-driven protein machine into a light-gated nanocage

(2013) Daniel Hoersch et al.   Nature Nanotechnology

Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution

(2012) Sarel J. Fleishman et al.   CELL

Hot Spots for Allosteric Regulation on Protein Surfaces

(2011) Kimberly A. Reynolds et al.   CELL

Metal-Mediated Affinity and Orientation Specificity in a Computationally Designed Protein Homodimer

(2011) Bryan S. Der et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

RosettaScripts: A Scripting Language Interface to the Rosetta Macromolecular Modeling Suite

(2011) Sarel J. Fleishman et al.   PLoS One

De Novo Enzyme Design Using Rosetta3

(2011) Florian Richter et al.   PLoS One

Design of a switchable eliminase

(2011) I. V. Korendovych et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin

(2011) S. J. Fleishman et al.   SCIENCE

Surface Sites for Engineering Allosteric Control in Proteins

(2008) J. Lee et al.   SCIENCE