Development of cell-penetrating bispecific antibodies targeting the N-terminal domain of androgen receptor for prostate cancer therapy†

Preclinical Study using Malat1 Small Interfering RNA or Androgen Receptor Splicing Variant 7 Degradation Enhancer ASC-J9 ® to Suppress Enzalutamide-resistant Prostate Cancer Progression

(2017) Ronghao Wang et al.   EUROPEAN UROLOGY

Emerging antibody-drug conjugates for treating lymphoid malignancies

(2017) Anna Wolska-Washer et al.   EXPERT OPINION ON EMERGING DRUGS

Phase I/II Trial of Labetuzumab Govitecan (Anti-CEACAM5/SN-38 Antibody-Drug Conjugate) in Patients With Refractory or Relapsing Metastatic Colorectal Cancer

(2017) Efrat Dotan et al.   JOURNAL OF CLINICAL ONCOLOGY

RasIns: Genetically Encoded Intrabodies of Activated Ras Proteins

(2017) Mehmet Cetin et al.   JOURNAL OF MOLECULAR BIOLOGY

Red Marrow–Absorbed Dose for Non-Hodgkin Lymphoma Patients Treated with 177 Lu-Lilotomab Satetraxetan, a Novel Anti-CD37 Antibody–Radionuclide Conjugate

(2016) Johan Blakkisrud et al.   JOURNAL OF NUCLEAR MEDICINE

Nanotechnological carriers for cancer chemotherapy: The state of the art

(2015) Marilene Estanqueiro et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Trastuzumab guided nanotheranostics: A lipid based multifunctional nanoformulation for targeted drug delivery and imaging in breast cancer therapy

(2015) Priyambada Parhi et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Cetuximab-oxaliplatin-liposomes for epidermal growth factor receptor targeted chemotherapy of colorectal cancer

(2015) Sara Zalba et al.   JOURNAL OF CONTROLLED RELEASE

EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer

(2015) Lucas J. Brand et al.   Oncotarget

DNA-dependent targeting of cell nuclei by a lupus autoantibody

(2015) Richard H. Weisbart et al.   Scientific Reports

Androgen receptor: structure, role in prostate cancer and drug discovery

(2014) MH Eileen Tan et al.   ACTA PHARMACOLOGICA SINICA

Characterization of Niphatenones that Inhibit Androgen Receptor N-Terminal Domain

(2014) Carmen A. Banuelos et al.   PLoS One

A nucleolytic lupus autoantibody is toxic to BRCA2-deficient cancer cells

(2014) Philip W. Noble et al.   Scientific Reports

Identification of Androgen Receptor Splice Variant Transcripts in Breast Cancer Cell Lines and Human Tissues

(2014) Dong Gui Hu et al.   Hormones & Cancer

The use of fluorescent intrabodies to detect endogenous gankyrin in living cancer cells

(2013) Anne-Sophie Rinaldi et al.   EXPERIMENTAL CELL RESEARCH

An androgen receptor N-terminal domain antagonist for treating prostate cancer

(2013) Jae-Kyung Myung et al.   JOURNAL OF CLINICAL INVESTIGATION

Metastatic castration-resistant prostate cancer: new therapies, novel combination strategies and implications for immunotherapy

(2013) C G Drake et al.   ONCOGENE

Prostate cancer progression after androgen deprivation therapy: mechanisms of castrate resistance and novel therapeutic approaches

(2013) T Karantanos et al.   ONCOGENE

A Cancer Specific Cell-Penetrating Peptide, BR2, for the Efficient Delivery of an scFv into Cancer Cells

(2013) Ki Jung Lim et al.   PLoS One

Purification of clinical-grade disulfide stabilized antibody fragment variable—Pseudomonas exotoxin conjugate (dsFv-PE38) expressed in Escherichia coli

(2012) Hua Jiang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Cell-penetrating anti-GFAP VHH and corresponding fluorescent fusion protein VHH-GFP spontaneously cross the blood-brain barrier and specifically recognize astrocytes: application to brain imaging

(2012) Tengfei Li et al.   FASEB JOURNAL

Androgen Receptor Splice Variants Activate Androgen Receptor Target Genes and Support Aberrant Prostate Cancer Cell Growth Independent of Canonical Androgen Receptor Nuclear Localization Signal

(2012) Siu Chiu Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Cell-Penetrating Bispecific Antibody for Therapeutic Regulation of Intracellular Targets

(2012) R. H. Weisbart et al.   MOLECULAR CANCER THERAPEUTICS

Targeting Cancer with a Lupus Autoantibody

(2012) J. E. Hansen et al.   Science Translational Medicine

Small Molecule Inhibitors Targeting the “Achilles' Heel” of Androgen Receptor Activity: Figure 1.

(2011) Marianne D. Sadar   CANCER RESEARCH

Recombinant Fv-Hsp70 Protein Mediates Neuroprotection After Focal Cerebral Ischemia in Rats

(2010) Xinhua Zhan et al.   STROKE

Conformational mAb as a Tool for Integrin Ligand Discovery

(2009) Ben H. Njus et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

A Novel Androgen Receptor Splice Variant Is Up-regulated during Prostate Cancer Progression and Promotes Androgen Depletion-Resistant Growth

(2009) Z. Guo et al.   CANCER RESEARCH

Adeno-associated virus–delivered short hairpin-structured RNA for androgen receptor gene silencing induces tumor eradication of prostate cancer xenografts in nude mice: A preclinical study

(2009) Aijing Sun et al.   INTERNATIONAL JOURNAL OF CANCER

Gene silencing by cell-penetrating, sequence-selective and nucleic-acid hydrolyzing antibodies

(2009) Woo-Ram Lee et al.   NUCLEIC ACIDS RESEARCH