Boosting CNS axon regeneration by harnessing antagonistic effects of GSK3 activity

Inhibition of CRMP2 phosphorylation repairs CNS by regulating neurotrophic and inhibitory responses

(2016) Jun Nagai et al.   EXPERIMENTAL NEUROLOGY

Promotion of Functional Nerve Regeneration by Inhibition of Microtubule Detyrosination

(2016) P. Gobrecht et al.   JOURNAL OF NEUROSCIENCE

The GSK3–MAP1B pathway controls neurite branching and microtubule dynamics

(2016) Monia Barnat et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Boosting Central Nervous System Axon Regeneration by Circumventing Limitations of Natural Cytokine Signaling

(2016) Marco Leibinger et al.   MOLECULAR THERAPY

GSK3β regulates AKT-induced central nervous system axon regeneration via an eIF2Bε-dependent, mTORC1-independent pathway

(2016) Xinzheng Guo et al.   eLife

mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system

(2016) Linqing Miao et al.   eLife

Role of GSK3 in peripheral nerve regeneration

(2015) Dietmar Fischer et al.   Neural Regeneration Research

Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2

(2014) Márcia A Liz et al.   BMC BIOLOGY

Signaling regulations of neuronal regenerative ability

(2014) Yi Lu et al.   CURRENT OPINION IN NEUROBIOLOGY

Sustained GSK3 activity markedly facilitates nerve regeneration

(2014) Philipp Gobrecht et al.   Nature Communications

Glaucoma and optic nerve repair

(2013) Heike Diekmann et al.   CELL AND TISSUE RESEARCH

Glycogen Synthase Kinase 3 Beta (GSK3β) at the Tip of Neuronal Development and Regeneration

(2013) Oscar Seira et al.   MOLECULAR NEUROBIOLOGY

CXCL12/SDF-1 facilitates optic nerve regeneration

(2013) Annemarie Heskamp et al.   NEUROBIOLOGY OF DISEASE

Interleukin-6 contributes to CNS axon regeneration upon inflammatory stimulation

(2013) M Leibinger et al.   Cell Death & Disease

Neuronal STAT3 activation is essential for CNTF- and inflammatory stimulation-induced CNS axon regeneration

(2013) M Leibinger et al.   Cell Death & Disease

PI3K–GSK3 signalling regulates mammalian axon regeneration by inducing the expression of Smad1

(2013) Saijilafu et al.   Nature Communications

Role of mTOR in neuroprotection and axon regeneration after inflammatory stimulation

(2012) Marco Leibinger et al.   NEUROBIOLOGY OF DISEASE

Prevention of posttraumatic axon sprouting by blocking collapsin response mediator protein 2-mediated neurite outgrowth and tubulin polymerization

(2012) S.M. Wilson et al.   NEUROSCIENCE

Promoting optic nerve regeneration

(2012) Dietmar Fischer et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Taxol Facilitates Axon Regeneration in the Mature CNS

(2011) V. Sengottuvel et al.   JOURNAL OF NEUROSCIENCE

Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain

(2010) Marc P. M. Soutar et al.   JOURNAL OF NEUROCHEMISTRY

GSK3  Regulates Myelin-Dependent Axon Outgrowth Inhibition through CRMP4

(2010) Y. Z. Alabed et al.   JOURNAL OF NEUROSCIENCE

GSK3 signalling in neural development

(2010) Eun-Mi Hur et al.   NATURE REVIEWS NEUROSCIENCE

Increased CRMP2 Phosphorylation is Observed in Alzheimers Disease; Does this Tell us Anything About Disease Development?

(2009) M. Soutar et al.   Current Alzheimer Research

Nonprimed and DYRK1A-primed GSK3 -phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons

(2009) T. M. E. Scales et al.   JOURNAL OF CELL SCIENCE

Lacosamide Isothiocyanate-Based Agents: Novel Agents To Target and Identify Lacosamide Receptors

(2009) Ki Duk Park et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neuroprotective and Axon Growth-Promoting Effects following Inflammatory Stimulation on Mature Retinal Ganglion Cells in Mice Depend on Ciliary Neurotrophic Factor and Leukemia Inhibitory Factor

(2009) M. Leibinger et al.   JOURNAL OF NEUROSCIENCE

Relative Resistance of Cdk5-phosphorylated CRMP2 to Dephosphorylation

(2008) Adam R. Cole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inactivation of Glycogen Synthase Kinase 3 Promotes Axonal Growth and Recovery in the CNS

(2008) J. Dill et al.   JOURNAL OF NEUROSCIENCE

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

(2008) K. K. Park et al.   SCIENCE