The pentameric complex drives immunologically covert cell–cell transmission of wild-type human cytomegalovirus

Impact of Antibodies and Strain Polymorphisms on Cytomegalovirus Entry and Spread in Fibroblasts and Epithelial Cells

(2017) Xiaohong Cui et al.   JOURNAL OF VIROLOGY

Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial of RG7667, a Combination Monoclonal Antibody, for Prevention of Cytomegalovirus Infection in High-Risk Kidney Transplant Recipients

(2016) Julie H. Ishida et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phenotypic characterization of human cytomegalovirus strains in cell cultures based on their transmission kinetics

(2016) Narmadha Subramanian et al.   JOURNAL OF GENERAL VIROLOGY

Monoclonal Antibodies to Different Components of the Human Cytomegalovirus (HCMV) Pentamer gH/gL/pUL128L and Trimer gH/gL/gO as well as Antibodies Elicited during Primary HCMV Infection Prevent Epithelial Cell Syncytium Formation

(2016) Giuseppe Gerna et al.   JOURNAL OF VIROLOGY

Genetic Stability of Bacterial Artificial Chromosome-Derived Human Cytomegalovirus during CultureIn Vitro

(2016) Isa Murrell et al.   JOURNAL OF VIROLOGY

Maternal immune correlates of protection from human cytomegalovirus transmission to the fetus after primary infection in pregnancy

(2016) Daniele Lilleri et al.   REVIEWS IN MEDICAL VIROLOGY

Complex Interplay of the UL136 Isoforms Balances Cytomegalovirus Replication and Latency

(2016) Katie Caviness et al.   mBio

Primary human cytomegalovirus infections: Kinetics of ELISA-IgG and neutralizing antibody in pauci/asymptomatic pregnant women vs symptomatic non-pregnant subjects

(2015) Chiara Fornara et al.   JOURNAL OF CLINICAL VIROLOGY

Human cytomegalovirus: taking the strain

(2015) Gavin W. G. Wilkinson et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

A viral regulator of glycoprotein complexes contributes to human cytomegalovirus cell tropism

(2015) Gang Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and biochemical studies of HCMV gH/gL/gO and Pentamer reveal mutually exclusive cell entry complexes

(2015) Claudio Ciferri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-redundant and Redundant Roles of Cytomegalovirus gH/gL Complexes in Host Organ Entry and Intra-tissue Spread

(2015) Niels A. W. Lemmermann et al.   PLoS Pathogens

Capacity of Broadly Neutralizing Antibodies to Inhibit HIV-1 Cell-Cell Transmission Is Strain- and Epitope-Dependent

(2015) Lucia Reh et al.   PLoS Pathogens

Cellular defense against latent colonization foiled by human cytomegalovirus UL138 protein

(2015) S. H. Lee et al.   Science Advances

A High-Affinity Native Human Antibody Neutralizes Human Cytomegalovirus Infection of Diverse Cell Types

(2014) Lawrence M. Kauvar et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

HCMV pUL135 Remodels the Actin Cytoskeleton to Impair Immune Recognition of Infected Cells

(2014) Richard J. Stanton et al.   Cell Host & Microbe

An Epistatic Relationship between the Viral Protein Kinase UL97 and the UL133-UL138 Latency Locus during the Human Cytomegalovirus Lytic Cycle

(2014) G. Li et al.   JOURNAL OF VIROLOGY

Antagonistic Determinants Controlling Replicative and Latent States of Human Cytomegalovirus Infection

(2014) M. Umashankar et al.   JOURNAL OF VIROLOGY

A Randomized Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus

(2014) Maria Grazia Revello et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antibody-driven design of a human cytomegalovirus gHgLpUL128L subunit vaccine that selectively elicits potent neutralizing antibodies

(2014) Anna Kabanova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutralisation of HIV-1 cell-cell spread by human and llama antibodies

(2014) Laura E McCoy et al.   Retrovirology

Human cytomegalovirus tropism for mucosal myeloid dendritic cells

(2014) Laura Hertel   REVIEWS IN MEDICAL VIROLOGY

Prevention of Transfusion-Transmitted Cytomegalovirus Infections: Which is the Optimal Strategy?

(2014) Malte Ziemann et al.   TRANSFUSION MEDICINE AND HEMOTHERAPY

Human cytomegalovirus gH/gL/UL128/UL130/UL131A complex elicits potently neutralizing antibodies in mice

(2014) Yingxia Wen et al.   VACCINE

A Neutralizing Anti-gH/gL Monoclonal Antibody Is Protective in the Guinea Pig Model of Congenital CMV Infection

(2014) Marcy R. Auerbach et al.   PLoS Pathogens

Human Cytomegalovirus Vaccine Based on the Envelope gH/gL Pentamer Complex

(2014) Felix Wussow et al.   PLoS Pathogens

Human Cytomegalovirus Glycoprotein UL141 Targets the TRAIL Death Receptors to Thwart Host Innate Antiviral Defenses

(2013) Wendell Smith et al.   Cell Host & Microbe

Broadly neutralizing antibodies that inhibit HIV-1 cell to cell transmission

(2013) Marine Malbec et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antibody inhibition of human cytomegalovirus spread in epithelial cell cultures

(2013) Xiaohong Cui et al.   JOURNAL OF VIROLOGICAL METHODS

Impact of Sequence Variation in the UL128 Locus on Production of Human Cytomegalovirus in Fibroblast and Epithelial Cells

(2013) I. Murrell et al.   JOURNAL OF VIROLOGY

Comparative Analysis of gO Isoforms Reveals that Strains of Human Cytomegalovirus Differ in the Ratio of gH/gL/gO and gH/gL/UL128-131 in the Virion Envelope

(2013) M. Zhou et al.   JOURNAL OF VIROLOGY

Human Cytomegalovirus Infection of Langerhans-Type Dendritic Cells Does Not Require the Presence of the gH/gL/UL128-131A Complex and Is Blocked after Nuclear Deposition of Viral Genomes in Immature Cells

(2013) E. J. Lauron et al.   JOURNAL OF VIROLOGY

High-Multiplicity HIV-1 Infection and Neutralizing Antibody Evasion Mediated by the Macrophage-T Cell Virological Synapse

(2013) C. J. A. Duncan et al.   JOURNAL OF VIROLOGY

Fetal Human Cytomegalovirus Transmission Correlates with Delayed Maternal Antibodies to gH/gL/pUL128-130-131 Complex during Primary Infection

(2013) Daniele Lilleri et al.   PLoS One

Pentameric complex of viral glycoprotein H is the primary target for potent neutralization by a human cytomegalovirus vaccine

(2013) D. C. Freed et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-to-cell spread of HIV-1 and evasion of neutralizing antibodies

(2013) Torben Schiffner et al.   VACCINE

Neutralizing antibodies are unable to inhibit direct viral cell-to-cell spread of human cytomegalovirus

(2013) Christian L. Jacob et al.   VIROLOGY

Antibodies Against Neutralization Epitopes of Human Cytomegalovirus gH/gL/pUL128-130-131 Complex and Virus Spreading May Correlate with Virus Control In Vivo

(2012) Daniele Lilleri et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Efficient Human Cytomegalovirus Reactivation Is Maturation Dependent in the Langerhans Dendritic Cell Lineage and Can Be Studied using a CD14+Experimental Latency Model

(2012) Margaret M. Huang et al.   JOURNAL OF VIROLOGY

A Vaccine Based on the Rhesus Cytomegalovirus UL128 Complex Induces Broadly Neutralizing Antibodies in Rhesus Macaques

(2012) Felix Wussow et al.   JOURNAL OF VIROLOGY

Neutralization Resistance of Virological Synapse-Mediated HIV-1 Infection Is Regulated by the gp41 Cytoplasmic Tail

(2012) N. D. Durham et al.   JOURNAL OF VIROLOGY

Antiviral function and efficacy of polyvalent immunoglobulin products against CMV isolates in different human cell lines

(2012) K. Frenzel et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Restoration of viral epithelial tropism improves immunogenicity in rabbits and rhesus macaques for a whole virion vaccine of human cytomegalovirus

(2012) Tong-Ming Fu et al.   VACCINE

Cell-Cell Transmission Enables HIV-1 to Evade Inhibition by Potent CD4bs Directed Antibodies

(2012) Irene A. Abela et al.   PLoS Pathogens

UL74 of human cytomegalovirus reduces the inhibitory effect of gH-specific and gB-specific antibodies

(2011) Xiao Jing Jiang et al.   ARCHIVES OF VIROLOGY

Multiploid Inheritance of HIV-1 during Cell-to-Cell Infection

(2011) A. Del Portillo et al.   JOURNAL OF VIROLOGY

Cytomegalovirus glycoprotein-B vaccine with MF59 adjuvant in transplant recipients: a phase 2 randomised placebo-controlled trial

(2011) Paul D Griffiths et al.   LANCET

Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy

(2011) Alex Sigal et al.   NATURE

HCMV Spread and Cell Tropism are Determined by Distinct Virus Populations

(2011) Laura Scrivano et al.   PLoS Pathogens

Reconstruction of the complete human cytomegalovirus genome in a BAC reveals RL13 to be a potent inhibitor of replication

(2010) Richard J. Stanton et al.   JOURNAL OF CLINICAL INVESTIGATION

Sequential mutations associated with adaptation of human cytomegalovirus to growth in cell culture

(2010) D. J. Dargan et al.   JOURNAL OF GENERAL VIROLOGY

Human cytomegalovirus UL141 promotes efficient downregulation of the natural killer cell activating ligand CD112

(2010) V. Prod'homme et al.   JOURNAL OF GENERAL VIROLOGY

Virological Synapse-Mediated Spread of Human Immunodeficiency Virus Type 1 between T Cells Is Sensitive to Entry Inhibition

(2010) N. Martin et al.   JOURNAL OF VIROLOGY

Cell-Cell Spread of Human Immunodeficiency Virus Type 1 Overcomes Tetherin/BST-2-Mediated Restriction in T cells

(2010) C. Jolly et al.   JOURNAL OF VIROLOGY

Virus Cell-to-Cell Transmission

(2010) W. Mothes et al.   JOURNAL OF VIROLOGY

Human cytomegalovirus tropism for endothelial/epithelial cells: scientific background and clinical implications

(2010) M. Grazia Revello et al.   REVIEWS IN MEDICAL VIROLOGY

Isolation of Human Monoclonal Antibodies That Potently Neutralize Human Cytomegalovirus Infection by Targeting Different Epitopes on the gH/gL/UL128-131A Complex

(2009) A. Macagno et al.   JOURNAL OF VIROLOGY

Partial Inhibition of Human Immunodeficiency Virus Replication by Type I Interferons: Impact of Cell-to-Cell Viral Transfer

(2009) D. Vendrame et al.   JOURNAL OF VIROLOGY

Mode of Transmission Affects the Sensitivity of Human Immunodeficiency Virus Type 1 to Restriction by Rhesus TRIM5 

(2008) M. W. Richardson et al.   JOURNAL OF VIROLOGY

UL74 of Human Cytomegalovirus Contributes to Virus Release by Promoting Secondary Envelopment of Virions

(2008) X. J. Jiang et al.   JOURNAL OF VIROLOGY

Polyclonal cytomegalovirus-specific antibodies not only prevent virus dissemination from the portal of entry but also inhibit focal virus spread within target tissues

(2008) Nikolaus Wirtz et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Avoiding the void: cell-to-cell spread of human viruses

(2008) Quentin Sattentau   NATURE REVIEWS MICROBIOLOGY