Cytosine deamination and base excision repair cause R-loop–induced CAG repeat fragility and instability inSaccharomyces cerevisiae

The mismatch repair and meiotic recombination endonuclease Mlh1-Mlh3 is activated by polymer formation and can cleave DNA substrates in trans

(2017) Carol M. Manhart et al.   PLOS BIOLOGY

Conflict Resolution in the Genome: How Transcription and Replication Make It Work

(2016) Stephan Hamperl et al.   CELL

Roles for mismatch repair family proteins in promoting meiotic crossing over

(2016) Carol M. Manhart et al.   DNA REPAIR

Topoisomerase I‐mediated cleavage at unrepaired ribonucleotides generates DNA double‐strand breaks

(2016) Shar‐yin N Huang et al.   EMBO JOURNAL

S1-DRIP-seq identifies high expression and polyA tracts as major contributors to R-loop formation

(2016) Lamia Wahba et al.   GENES & DEVELOPMENT

Transcription–replication conflicts: how they occur and how they are resolved

(2016) Tatiana García-Muse et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Non-canonical uracil processing in DNA gives rise to double-strand breaks and deletions: relevance to class switch recombination

(2016) Stephanie Bregenhorn et al.   NUCLEIC ACIDS RESEARCH

DNA Editing by APOBECs: A Genomic Preserver and Transformer

(2016) Binyamin A. Knisbacher et al.   TRENDS IN GENETICS

The Yin and Yang of R-loop biology

(2015) Lorenzo Costantino et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of recombination at yeast nuclear pores controls repair and triplet repeat stability

(2015) Xiaofeng A. Su et al.   GENES & DEVELOPMENT

Ribonucleotides in DNA: hidden in plain sight

(2015) Sue Jinks-Robertson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Breaking bad: R-loops and genome integrity

(2015) Julie Sollier et al.   TRENDS IN CELL BIOLOGY

Ribonucleotides in DNA: hidden in plain sight

(2015) Sue Jinks-Robertson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nbs1 ChIP-Seq Identifies Off-Target DNA Double-Strand Breaks Induced by AID in Activated Splenic B Cells

(2015) Lyne Khair et al.   PLoS Genetics

The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability

(2014) Stephan Hamperl et al.   DNA REPAIR

Mlh1-Mlh3, a Meiotic Crossover and DNA Mismatch Repair Factor, Is a Msh2-Msh3-stimulated Endonuclease

(2014) Maria V. Rogacheva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TheSaccharomyces cerevisiaeMlh1-Mlh3 Heterodimer Is an Endonuclease That Preferentially Binds to Holliday Junctions

(2014) Lepakshi Ranjha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability

(2014) Julie Sollier et al.   MOLECULAR CELL

Processing of double-R-loops in (CAG)·(CTG) and C9orf72 (GGGGCC)·(GGCCCC) repeats causes instability

(2014) Kaalak Reddy et al.   NUCLEIC ACIDS RESEARCH

Genome-Wide Profiling of Yeast DNA:RNA Hybrid Prone Sites with DRIP-Chip

(2014) Yujia A. Chan et al.   PLoS Genetics

Genome-Wide Distribution of RNA-DNA Hybrids Identifies RNase H Targets in tRNA Genes, Retrotransposons and Mitochondria

(2014) Aziz El Hage et al.   PLoS Genetics

Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutL  endonuclease activation

(2013) A. Pluciennik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Different Roles of Eukaryotic MutS and MutL Complexes in Repair of Small Insertion and Deletion Loops in Yeast

(2013) Nina V. Romanova et al.   PLoS Genetics

Mismatch Repair Genes Mlh1 and Mlh3 Modify CAG Instability in Huntington's Disease Mice: Genome-Wide and Candidate Approaches

(2013) Ricardo Mouro Pinto et al.   PLoS Genetics

R-Loop Formation Is a Distinctive Characteristic of Unmethylated Human CpG Island Promoters

(2012) Paul A. Ginno et al.   MOLECULAR CELL

R Loops: From Transcription Byproducts to Threats to Genome Stability

(2012) Andrés Aguilera et al.   MOLECULAR CELL

Homologous recombination and its regulation

(2012) L. Krejci et al.   NUCLEIC ACIDS RESEARCH

Nucleotide Excision Repair, Mismatch Repair, and R-Loops Modulate Convergent Transcription-Induced Cell Death and Repeat Instability

(2012) Yunfu Lin et al.   PLoS One

Guanine repeat-containing sequences confer transcription-dependent instability in an orientation-specific manner in yeast

(2011) Nayun Kim et al.   DNA REPAIR

RNase H and Multiple RNA Biogenesis Factors Cooperate to Prevent RNA:DNA Hybrids from Generating Genome Instability

(2011) Lamia Wahba et al.   MOLECULAR CELL

Mutagenic Processing of Ribonucleotides in DNA by Yeast Topoisomerase I

(2011) N. Kim et al.   SCIENCE

AID Induces Double-Strand Breaks at Immunoglobulin Switch Regions and c-MYC Causing Chromosomal Translocations in Yeast THO Mutants

(2011) José F. Ruiz et al.   PLoS Genetics

Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX

(2011) María S. Domínguez-Sánchez et al.   PLoS Genetics

Determinants of R-loop formation at convergent bidirectionally transcribed trinucleotide repeats

(2010) Kaalak Reddy et al.   NUCLEIC ACIDS RESEARCH

Fluctuation AnaLysis CalculatOR: a web tool for the determination of mutation rate using Luria-Delbruck fluctuation analysis

(2009) B. M. Hall et al.   BIOINFORMATICS

Ribonuclease H: the enzymes in eukaryotes

(2009) Susana M. Cerritelli et al.   FEBS Journal

Double-Strand Break Repair Pathways Protect against CAG/CTG Repeat Expansions, Contractions and Repeat-Mediated Chromosomal Fragility in Saccharomyces cerevisiae

(2009) R. Sundararajan et al.   GENETICS

R loops stimulate genetic instability of CTG{middle dot}CAG repeats

(2009) Y. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of Eukaryotic Homologous Recombination

(2008) Joseph San Filippo et al.   Annual Review of Biochemistry

Mechanism and Regulation of Class Switch Recombination

(2008) Janet Stavnezer et al.   Annual Review of Immunology

A Mutation in the Putative MLH3 Endonuclease Domain Confers a Defect in Both Mismatch Repair and Meiosis in Saccharomyces cerevisiae

(2008) K. T. Nishant et al.   GENETICS

The roles of APE1, APE2, DNA polymerase   and mismatch repair in creating S region DNA breaks during antibody class switch

(2008) C. E Schrader et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES