Mismatch Repair Genes Mlh1 and Mlh3 Modify CAG Instability in Huntington's Disease Mice: Genome-Wide and Candidate Approaches

Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activities

(2013) Michael A. Edelbrock et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutL  endonuclease activation

(2013) A. Pluciennik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MSH3 Polymorphisms and Protein Levels Affect CAG Repeat Instability in Huntington's Disease Mice

(2013) Stéphanie Tomé et al.   PLoS Genetics

The Nucleotide Sequence, DNA Damage Location, and Protein Stoichiometry Influence the Base Excision Repair Outcome at CAG/CTG Repeats

(2012) Agathi-Vasiliki Goula et al.   BIOCHEMISTRY

Tissue-specific mismatch repair protein expression: MSH3 is higher than MSH6 in multiple mouse tissues

(2012) Stéphanie Tomé et al.   DNA REPAIR

Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice

(2012) L. Mollersen et al.   HUMAN MOLECULAR GENETICS

Aberrant protein expression and frequent allelic loss of MSH3 in colorectal cancer with low-level microsatellite instability

(2012) Jens Plaschke et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Human Mismatch Repair Protein hMutLα Is Required to Repair Short Slipped-DNAs of Trinucleotide Repeats

(2012) Gagan B. Panigrahi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic background modulates behavioral impairments in R6/2 mice and suggests a role for dominant genetic modifiers in Huntington’s disease pathogenesis

(2012) Randi-Michelle Cowin et al.   MAMMALIAN GENOME

Noncanonical Mismatch Repair as a Source of Genomic Instability in Human Cells

(2012) Javier Peña-Diaz et al.   MOLECULAR CELL

The mismatch repair system protects against intergenerational GAA repeat instability in a Friedreich ataxia mouse model

(2012) Vahid Ezzatizadeh et al.   NEUROBIOLOGY OF DISEASE

CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion

(2012) J.- M. Lee et al.   NEUROLOGY

Msh2 Acts in Medium-Spiny Striatal Neurons as an Enhancer of CAG Instability and Mutant Huntingtin Phenotypes in Huntington’s Disease Knock-In Mice

(2012) Marina Kovalenko et al.   PLoS One

Pms2 Suppresses Large Expansions of the (GAA·TTC)n Sequence in Neuronal Tissues

(2012) Rebecka L. Bourn et al.   PLoS One

Mammalian mismatch repair: error-free or error-prone?

(2012) Javier Peña-Diaz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1

(2011) Leroy Hubert et al.   HUMAN MOLECULAR GENETICS

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Sequence-based characterization of structural variation in the mouse genome

(2011) Binnaz Yalcin et al.   NATURE

Mouse genomic variation and its effect on phenotypes and gene regulation

(2011) Thomas M. Keane et al.   NATURE

Reorganizing the protein space at the Universal Protein Resource (UniProt)

(2011)   NUCLEIC ACIDS RESEARCH

Quantification of Age-Dependent Somatic CAG Repeat Instability in Hdh CAG Knock-In Mice Reveals Different Expansion Dynamics in Striatum and Liver

(2011) Jong-Min Lee et al.   PLoS One

Conformational trapping of Mismatch Recognition Complex MSH2/MSH3 on repair-resistant DNA loops

(2011) W. H. Lang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel approach to investigate tissue-specific trinucleotide repeat instability

(2010) Jong-Min Lee et al.   BMC Systems Biology

Evidence that hMLH3 functions primarily in meiosis and in hMSH2-hMSH3 mismatch repair

(2010) Nicole Charbonneau et al.   CANCER BIOLOGY & THERAPY

Fine Mapping in 94 Inbred Mouse Strains Using a High-Density Haplotype Resource

(2010) A. Kirby et al.   GENETICS

Wot the ‘L—Does MutL do?

(2010) Yaroslava Y. Polosina et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSβ, but clustered slip-outs are poorly repaired

(2010) Gagan B. Panigrahi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MutL: conducting the cell's response to mismatched and misaligned DNA

(2009) Yaroslava Y. Polosina et al.   BIOESSAYS

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

Diverse effects of individual mismatch repair components on transcription-induced CAG repeat instability in human cells

(2009) Yunfu Lin et al.   DNA REPAIR

Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset

(2009) Meera Swami et al.   HUMAN MOLECULAR GENETICS

Huntingtin facilitates polycomb repressive complex 2

(2009) Ihn Sik Seong et al.   HUMAN MOLECULAR GENETICS

Coordination between Polymerase β and FEN1 Can Modulate CAG Repeat Expansion

(2009) Yuan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CTG/CAG Repeat Instability Is Modulated by the Levels of Human DNA Ligase I and Its Interaction with Proliferating Cell Nuclear Antigen

(2009) Arturo López Castel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Huntington's disease: the case for genetic modifiers

(2009) James F Gusella et al.   Genome Medicine

MSH2 ATPase Domain Mutation Affects CTG•CAG Repeat Instability in Transgenic Mice

(2009) Stéphanie Tomé et al.   PLoS Genetics

Stoichiometry of Base Excision Repair Proteins Correlates with Increased Somatic CAG Instability in Striatum over Cerebellum in Huntington's Disease Transgenic Mice

(2009) Agathi-Vassiliki Goula et al.   PLoS Genetics

Mutagenic roles of DNA “repair” proteins in antibody diversity and disease-associated trinucleotide repeat instability

(2008) Meghan M. Slean et al.   DNA REPAIR

Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes

(2008) Ella Dragileva et al.   NEUROBIOLOGY OF DISEASE

DNA instability in postmitotic neurons

(2008) R. Gonitel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA