Pharmacogenetic meta-analysis of baseline risk factors, pharmacodynamic, efficacy and tolerability endpoints from two large global cardiovascular outcomes trials for darapladib

Lipoprotein-Associated Phospholipase A 2 Loss-of-Function Variant and Risk of Vascular Diseases in 90,000 Chinese Adults

(2016) Iona Y. Millwood et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The genetics of drug efficacy: opportunities and challenges

(2016) Matthew R. Nelson et al.   NATURE REVIEWS GENETICS

Lipoprotein‐Associated Phospholipase A2Activity Is a Marker of Risk But Not a Useful Target for Treatment in Patients With Stable Coronary Heart Disease

(2016) Lars Wallentin et al.   Journal of the American Heart Association

A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

(2015) Majid Nikpay et al.   NATURE GENETICS

Effect of Darapladib on Major Coronary Events After an Acute Coronary Syndrome

(2014) Michelle L. O’Donoghue et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Phasing of Many Thousands of Genotyped Samples

(2012) Amy L. Williams et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A high-performance computing toolset for relatedness and principal component analysis of SNP data

(2012) X. Zheng et al.   BIOINFORMATICS

Genome-Wide Association Study Evaluating Lipoprotein-Associated Phospholipase A 2 Mass and Activity at Baseline and After Rosuvastatin Therapy

(2012) Audrey Y. Chu et al.   Circulation-Cardiovascular Genetics

The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes

(2012) Darren A. Cusanovich et al.   HUMAN MOLECULAR GENETICS

Study design and rationale for the Stabilization of pLaques usIng Darapladib—Thrombolysis in Myocardial Infarction (SOLID-TIMI 52) trial in patients after an acute coronary syndrome

(2011) Michelle L. O'Donoghue et al.   AMERICAN HEART JOURNAL

Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies

(2011) H. Grallert et al.   EUROPEAN HEART JOURNAL

Carriage of the V279F Null Allele within the Gene Encoding Lp-PLA2 Is Protective from Coronary Artery Disease in South Korean Males

(2011) Yangsoo Jang et al.   PLoS One

Study design and rationale for the clinical outcomes of the STABILITY Trial (STabilization of Atherosclerotic plaque By Initiation of darapLadIb TherapY) comparing darapladib versus placebo in patients with coronary heart disease

(2010) Harvey White et al.   AMERICAN HEART JOURNAL

Robust relationship inference in genome-wide association studies

(2010) Ani Manichaikul et al.   BIOINFORMATICS

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Lipoprotein-associated phospholipase A2 gene V279F polymorphisms and coronary heart disease: a meta-analysis

(2010) Guo-Hua Zheng et al.   MOLECULAR BIOLOGY REPORTS

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

Genotype imputation for genome-wide association studies

(2010) Jonathan Marchini et al.   NATURE REVIEWS GENETICS

PLA2G7 gene polymorphisms and coronary heart disease risk: A meta-analysis

(2010) Qianqian Wang et al.   THROMBOSIS RESEARCH

Genome-Wide Association Study of Lp-PLA2 Activity and Mass in the Framingham Heart Study

(2010) Sunil Suchindran et al.   PLoS Genetics

Effects of G994T in the Lp-PLA2 Gene on the Plasma Oxidized LDL Level and Carotid Intima-Media Thickness in Japanese: The Shimane Study

(2009) T. Wang et al.   AMERICAN JOURNAL OF HYPERTENSION

Genotype Imputation

(2009) Yun Li et al.   Annual Review of Genomics and Human Genetics

Effects of the Direct Lipoprotein-Associated Phospholipase A 2 Inhibitor Darapladib on Human Coronary Atherosclerotic Plaque

(2008) Patrick W. Serruys et al.   CIRCULATION

Common variants at 30 loci contribute to polygenic dyslipidemia

(2008) Sekar Kathiresan et al.   NATURE GENETICS

Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development

(2008) Robert L Wilensky et al.   NATURE MEDICINE