Dicumarol inhibits PDK1 and targets multiple malignant behaviors of ovarian cancer cells

Cytosolic Extract of Human Adipose Stem Cells Reverses the Amyloid Beta-Induced Mitochondrial Apoptosis via P53/Foxo3a Pathway

(2017) Tian Liu et al.   PLoS One

Targeting PSG1 to enhance chemotherapeutic efficacy: new application for anti-coagulant the dicumarol

(2016) D.-x. He et al.   CLINICAL SCIENCE

Historical Hallmarks of Anticoagulation and Antiplatelet Agents

(2016) Gregory Tsoucalas et al.   CURRENT PHARMACEUTICAL DESIGN

Unexpected Discovery of Dichloroacetate Derived Adenosine Triphosphate Competitors Targeting Pyruvate Dehydrogenase Kinase To Inhibit Cancer Proliferation

(2016) Shao-Lin Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

MiR-203 promotes the growth and migration of ovarian cancer cells by enhancing glycolytic pathway

(2016) Zhao Xiaohong et al.   TUMOR BIOLOGY

Crosstalk among proteome, acetylome and succinylome in colon cancer HCT116 cell treated with sodium dichloroacetate

(2016) Danxi Zhu et al.   Scientific Reports

JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification

(2015) W. Sun et al.   CANCER RESEARCH

PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer

(2015) Fanny Dupuy et al.   Cell Metabolism

Coumarins as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studies

(2015) Anuradha Thakur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Targeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target?

(2015) Wen Zhang et al.   International Journal of Biological Sciences

Metabolic modulation of cancer: a new frontier with great translational potential

(2015) Adam Kinnaird et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers

(2015) Nam Ho Jeoung   Diabetes & Metabolism Journal

VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells

(2015) Jonathan D. Moore et al.   Oncotarget

Dichloroacetate enhances apoptotic cell death via oxidative damage and attenuates lactate production in metformin-treated breast cancer cells

(2014) Allison B. Haugrud et al.   BREAST CANCER RESEARCH AND TREATMENT

Synthesis, structure–activity relationship of iodinated-4-aryloxymethyl-coumarins as potential anti-cancer and anti-mycobacterial agents

(2014) Mahantesha Basanagouda et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dicoumarol sensitizes renal cell carcinoma Caki cells to TRAIL-induced apoptosis through down-regulation of Bcl-2, Mcl-1 and c-FLIP in a NQO1-independent manner

(2014) Eun Jung Park et al.   EXPERIMENTAL CELL RESEARCH

The Pyruvate Dehydrogenase Complexes: Structure-based Function and Regulation

(2014) Mulchand S. Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Warburg effect: molecular aspects and therapeutic possibilities

(2014) Hanh Ngo et al.   MOLECULAR BIOLOGY REPORTS

Antithrombotic Activity of a Newly Synthesized Coumarin Derivative 3-(5-Hydroxy-2,2-dimethyl-chroman-6-yl)-N-{2-[3-(5-hydroxy-2,2-dimethyl-chroman-6-yl)-propionylamino]-ethyl}-propionamide

(2013) Manish Jain et al.   Chemical Biology & Drug Design

Metabolic changes during ovarian cancer progression as targets for sphingosine treatment

(2013) Angela S. Anderson et al.   EXPERIMENTAL CELL RESEARCH

NADPH quinone oxidoreductase 1 mediates breast cancer cell resistance to thymoquinone-induced apoptosis

(2012) Kimberly M. Sutton et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protein profiles in human ovarian cancer cell lines correspond to their metabolic activity and to metabolic profiles of respective tumor xenografts

(2012) Christian Fabian et al.   FEBS Journal

Coumarin: a potential nucleus for anti-inflammatory molecules

(2012) Yogita Bansal et al.   MEDICINAL CHEMISTRY RESEARCH

Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4

(2011) Mutsuko Kukimoto-Niino et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Design, synthesis and vasorelaxant evaluation of novel coumarin–pyrimidine hybrids

(2011) Kamilia M. Amin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

DNA cleavage, antimicrobial, anti-inflammatory anthelmintic activities, and spectroscopic studies of Co(II), Ni(II), and Cu(II) complexes of biologically potential coumarin Schiff bases

(2011) M. Manjunatha et al.   JOURNAL OF COORDINATION CHEMISTRY

Developmental effects of coumarin and the anticoagulant coumarin derivative warfarin on zebrafish (Danio rerio) embryos

(2011) Stefan Weigt et al.   REPRODUCTIVE TOXICOLOGY

HIF-1 prevents the overproduction of mitochondrial ROS after cytokine stimulation through induction of PDK-1

(2010) Keita Kirito et al.   CELL CYCLE

Thirteen novel VKORC1 mutations associated with oral anticoagulant resistance: insights into improved patient diagnosis and treatment

(2010) M. WATZKA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Metabolic Modulation of Glioblastoma with Dichloroacetate

(2010) E. D. Michelakis et al.   Science Translational Medicine

Dicoumarol enhances gemcitabine-induced cytotoxicity in high NQO1-expressing cholangiocarcinoma cells

(2010) Benjaporn Buranrat   WORLD JOURNAL OF GASTROENTEROLOGY

Monitoring phosphorylation of the pyruvate dehydrogenase complex

(2009) Matthew J. Rardin et al.   ANALYTICAL BIOCHEMISTRY

Peripheral Neuropathy in Rats Exposed to Dichloroacetate

(2009) Nigel A. Calcutt et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY