Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice

Differential Roles of the NADPH-Oxidase 1 and 2 in Platelet Activation and ThrombosisSignificance

(2016) M. Keegan Delaney et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization

(2016) Wen Yang et al.   CELL

Peptidylarginine deiminase 4 promotes age-related organ fibrosis

(2016) Kimberly Martinod et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Histone deactylase gene expression profiles are associated with outcomes in blunt trauma patients

(2016) Martin Sillesen et al.   Journal of Trauma and Acute Care Surgery

Epidemiology of venous thromboembolism in the Framingham Heart Study

(2016) Marja K. Puurunen et al.   THROMBOSIS RESEARCH

Histone deactylase gene expression profiles are associated with outcomes in blunt trauma patients

(2016) Martin Sillesen et al.   Journal of Trauma and Acute Care Surgery

Sirtuin Inhibition Induces Apoptosis-like Changes in Platelets and Thrombocytopenia

(2015) Sharda Kumari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3β

(2015) Nagalingam R. Sundaresan et al.   MOLECULAR AND CELLULAR BIOLOGY

Diabetes primes neutrophils to undergo NETosis, which impairs wound healing

(2015) Siu Ling Wong et al.   NATURE MEDICINE

SIRT3 regulates progression and development of diseases of aging

(2015) Eoin McDonnell et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Decreased SIRT3 in aged human mesenchymal stromal/stem cells increases cellular susceptibility to oxidative stress

(2014) Xue-Qing Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Age-Related Decrease in the Mitochondrial Sirtuin Deacetylase Sirt3 Expression Associated with ROS Accumulation in the Auditory Cortex of the Mimetic Aging Rat Model

(2014) Lingling Zeng et al.   PLoS One

Aging Hemostasis: Changes to Laboratory Markers of Hemostasis As We Age—A Narrative Review

(2014) Massimo Franchini et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

SIRT3 overexpression antagonizes high glucose accelerated cellular senescence in human diploid fibroblasts via the SIRT3–FOXO1 signaling pathway

(2013) Bin Zhang et al.   AGE

Molecular Mechanisms of the Crosstalk Between Mitochondria and NADPH Oxidase Through Reactive Oxygen Species—Studies in White Blood Cells and in Animal Models

(2013) Swenja Kröller-Schön et al.   ANTIOXIDANTS & REDOX SIGNALING

Thrombosis: tangled up in NETs

(2013) K. Martinod et al.   BLOOD

Hydrogen Peroxide Promotes Aging-Related Platelet Hyperactivation and Thrombosis

(2013) Sanjana Dayal et al.   CIRCULATION

ROS production in phagocytes: why, when, and where?

(2013) Sophie Dupré-Crochet et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice

(2013) K. Martinod et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of intraplatelet reactive oxygen species in the regulation of platelet glycoprotein Ibα ectodomain shedding

(2013) Pingping Zhang et al.   THROMBOSIS RESEARCH

SIRT3 regulation of mitochondrial oxidative stress

(2012) Alexandra S. Bause et al.   EXPERIMENTAL GERONTOLOGY

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus

(2012) Heather Parker et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis

(2012) M. Demers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells

(2011) Tetsuro Koyama et al.   FREE RADICAL BIOLOGY AND MEDICINE

SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production

(2011) E L Bell et al.   ONCOGENE

von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models

(2010) A. Brill et al.   BLOOD

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

(2010) Hyun-Seok Kim et al.   CANCER CELL

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction

(2008) Philip Wenzel et al.   CARDIOVASCULAR RESEARCH

Spatially distinct production of reactive oxygen species regulates platelet activation

(2008) Nadia Bakdash et al.   FREE RADICAL BIOLOGY AND MEDICINE

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The association of elevated reactive oxygen species levels from neutrophils with low-grade inflammation in the elderly

(2008) Kishiko Ogawa et al.   Immunity & Ageing