Article
Oncology
Ifra Mushtaq, Gh Rasool Bhat, Bilal Rah, Syed Besina, Sheikh Zahoor, Muneer A. Wani, Mubashir A. Shah, Sadaf Bashir, Muzamil Farooq, Rafiq A. Rather, Dil Afroze
Summary: Genetic instabilities and telomere dysfunction play a crucial role in cancer development, especially gastric cancer. This study evaluates the clinical implications of c-Myc, hTERT expression, and telomere length, shedding light on their significance in gastric cancer progression.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Ruozhu Yang, Yi Han, Xinyu Guan, Yue Hong, Jiahao Meng, Shirong Ding, Qian Long, Wenjun Yi
Summary: TERT is an essential enzyme responsible for telomere maintenance and genome stability. In breast cancer, the overactivation of hTERT plays a critical role in tumor initiation and progression. Understanding the mechanisms of hTERT activation in cancer could lead to improved understanding of the disease and the development of more effective treatment strategies.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Biochemistry & Molecular Biology
Anna A. Plyasova, Dmitry D. Zhdanov
Summary: Alternative splicing of hTERT pre-mRNA regulates telomerase activity and determines cell functions. In addition to telomerase activity regulation, alternative splicing provides cells with splice variants that may have alternative biological activities.
Article
Biochemistry & Molecular Biology
Li Tao, Wei Zhang, Yaxin Zhang, Mei Zhang, Yueying Zhang, Xing Niu, Qing Zhao, Zhenxing Liu, Yuyin Li, Aipo Diao
Summary: The study showed that caffeine can promote the expression of TERT to extend telomere length and prevent cellular senescence. In animal studies, caffeine also reversed the decline in organ index and improved tissue structure in aging mice. These results suggest that caffeine-containing foods can delay cellular senescence and aging through the expression of TERT.
Article
Medicine, Research & Experimental
Bo Wang, Jianping Jiang, Yun Zhang, Yingying Shen, Liqiang Wu, Siqi Tang, Shengyun Lin
Summary: The study investigated the use of plant extracts as potential therapeutic strategies for cancer treatment, particularly in high-risk MDS patients. The newly extracted coumarin HDE from Oldenlandia diffusa Willd efficiently inhibited MDS cell proliferation and induced apoptosis, with the combination of HDE and BIIB021 showing synergistic antitumor effects on SKM-1 cells, providing a novel therapeutic combination for higher-risk MDS.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biology
Hueng-Chuen Fan, Fung-Wei Chang, Jeng-Dau Tsai, Kao-Min Lin, Chuan-Mu Chen, Shinn-Zong Lin, Ching-Ann Liu, Horng-Jyh Harn
Summary: Telomeres cap the ends of eukaryotic chromosomes and are essential for genome protection and replication. The maintenance of telomere length is regulated by various factors and dysfunctions in telomere maintenance and telomerase activation are associated with diseases, particularly cancer. Understanding the molecular mechanisms behind telomere length regulation and protection is crucial for future therapeutic opportunities.
Article
Environmental Sciences
Boru Li, Shuangjian Qin, Ying Cai, Kai Zheng, Bingyu Wang, Runbing Li, Haiyan Huang, Ming Zeng, Fang Xiao, Xinyun Xu
Summary: The study used proteomics and bioinformatics to screen the differentially expressed proteins (DEPs) in HK-2 cells exposed to PM2.5 from Shenzhen and Taiyuan. Significant changes in DEPs expression were observed after exposure to PM2.5 from both cities, indicating a potential correlation between DEPs differences and PM2.5 components in Shenzhen and Taiyuan.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Oncology
Olivier Adotevi, Dewi Vernerey, Pascale Jacoulet, Aurelia Meurisse, Caroline Laheurte, Hamadi Almotlak, Marion Jacquin, Vincent Kaulek, Laura Boullerot, Marine Malfroy, Emeline Orillard, Guillaume Eberst, Aurelie Lagrange, Laure Favier, Marie Gainet-Brun, Ludovic Doucet, Luis Teixeira, Zineb Ghrieb, Anne-Laure Clairet, Yves Guillaume, Marie Kroemer, Didier Hocquet, Melanie Moltenis, Samuel Limat, Elisabeth Quoix, Celine Mascaux, Didier Debieuvre, Christine Fagnoni-Legat, Christophe Borg, Virginie Westeel
Summary: The purpose of this study was to test the safety, immunogenicity, and efficacy of UCPVax vaccine in patients with metastatic non-small-cell lung cancer. The results showed that UCPVax vaccine was highly immunogenic and safe, and achieved interesting 1-year survival rate in advanced NSCLC patients.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Oncology
Miguel Angel Gonzalez-Moles, Eloisa Moya-Gonzalez, Alberto Garcia-Ferrera, Paola Nieto-Casado, Pablo Ramos-Garcia
Summary: TERT protein overexpression in oral cancer is significantly associated with poor survival and has prognostic value. This systematic review and meta-analysis, based on 21 studies and 1698 patients, support the immunohistochemical assessment of TERT overexpression as a new indicator for prognostic evaluation of oral squamous cell carcinoma.
Article
Biochemistry & Molecular Biology
Shuang Li, Qian Xin, Guangyao Fang, Yi Deng, Fengyuan Yang, Chenming Qiu, Yongjian Yang, Cong Lan
Summary: Physical exercise can prevent cardiac hypertrophy by upregulating mitochondrial TERT expression. Overexpression of mitochondrial-targeted TERT improves mitochondrial dysfunction and reduces oxidative stress, leading to the attenuation of cardiac hypertrophy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Chemistry, Medicinal
Lin Zhu, Zhenchao Liu, Yuqian Ren, Xiaolin Wu, Yingjuan Liu, Tingting Wang, Yizhao Li, Yusheng Cong, Yunliang Guo
Summary: Salidroside isolated from Rhodiola rosea L has been found to have potential therapeutic effects on hippocampal neuron senescence and injury. It can increase cell viability, reduce beta-galactosidase levels, improve cognition dysfunction in ageing mice, and alleviate neuronal degeneration in the CA1 region of ageing mice. Additionally, salidroside may exert its protective effects through reducing oxidative stress levels, inhibiting p21 and p16 protein expressions, and promoting telomerase reverse transcriptase protein expression.
PHYTOTHERAPY RESEARCH
(2021)
Article
Cell Biology
Lingyi Wu, Sumin Wang, Bo Tang, Li Tang, Yuanyuan Lei, Yaojiang Liu, Min Yang, Guodong Yang, Dan Zhang, En Liu
Summary: This study revealed that the abnormal expression of hTERT and Gli1 in gastric cancer tissues is associated with invasion depth, lymph node metastasis, TNM stage, and distant metastasis. By regulating Gli1 expression, hTERT promotes invasion and metastasis of gastric cancer cells. Targeting the hTERT/Sp1/Gli1 axis may offer a new therapeutic strategy for gastric cancer.
JOURNAL OF MOLECULAR HISTOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jeff Sherman, Grant Verstandig, Yisroel Brumer
Summary: Advancements in biotechnology and machine learning have created a conducive environment for exploring relationships between genomic and epigenetic data with potential therapeutic implications. The study found that CRISPR knockout has strong efficacy in inhibiting growth of tumor cells with varying levels of TERT expression, providing key biomarkers for therapeutic efficacy and potential pathways for drug development. These findings further support the potential of artificial intelligence in oncology.
Article
Medicine, General & Internal
Piotr Macek, Mieszko Wieckiewicz, Rafal Poreba, Pawel Gac, Katarzyna Bogunia-Kubik, Marta Dratwa, Anna Wojakowska, Grzegorz Mazur, Helena Martynowicz
Summary: This study investigated the relationship between SNP of the TERT gene and the severity of sleep bruxism, and identified the independent risk factors for sleep bruxism. The results showed that one SNP of TERT was associated with the episode index of phasic bruxism, and the lack of this SNP, male sex, and arterial hypertension were independent risk factors for phasic bruxism.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Alexander Ries, Astrid Slany, Christine Pirker, Johanna C. C. Mader, Doris Mejri, Thomas Mohr, Karin Schelch, Daniela Flehberger, Nadine Maach, Muhammad Hashim, Mir Alireza Hoda, Balazs Dome, Georg Krupitza, Walter Berger, Christopher Gerner, Klaus Holzmann, Michael Grusch
Summary: In this study, novel hTERT-transduced mesothelial cell and Meso-CAF models were generated and characterized, and their impact on PM cell growth was investigated.
Article
Biochemistry & Molecular Biology
Deepak Kumar Mishra, Pratibha Srivastava, Amod Sharma, Ramraj Prasad, Soubhagya Kumar Bhuyan, Rahuldev Malage, Pramod Kumar, Pramod Kumar Yadava
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Rishi K. Jaiswal, Pramod Kumar, Manoj Kumar, Pramod K. Yadava
MOLECULAR CARCINOGENESIS
(2018)
Article
Medicine, Research & Experimental
Suresh Singh Yadav, Manoj Kumar, Akhil Varshney, Pramod Kumar Yadava
Article
Infectious Diseases
Pramod Kumar, Priti Yadav, Kishor Ingole, Rishi K. Jaiswal, Nasira S. Khalid, Durgesh G. Deshmukh, Ajay K. Goel, Pramod K. Yadava
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2020)
Article
Multidisciplinary Sciences
Anshika Srivastava, Rudra Kumar Pandey, Prajjval Pratap Singh, Pramod Kumar, Avinash Arvind Rasalkar, Rakesh Tamang, George van Driem, Pankaj Shrivastava, Gyaneshwer Chaubey
Review
Microbiology
Shruti Ahlawat, Pramod Kumar, Hari Mohan, Sandeep Goyal, Krishna Kant Sharma
Summary: The human gut microbiota plays a crucial role in host health, with alterations in composition leading to the development of gastrointestinal disorders. Modulating gut microbiota composition and utilizing advanced treatment methods are key approaches for managing gut disorders in the future.
CRITICAL REVIEWS IN MICROBIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Pramod Kumar, Alka Rani, Shalini Singh, Anuj Kumar
Summary: The authentication of food is a pressing issue due to the growing population and direct impact of food on public health. DNA and omics-based methods, such as genomics, metabolomics, and proteomics, are increasingly used in food industry for authentication purposes, detecting adulteration, determining food quality, and identifying allergens, toxins, and carcinogens. Novel methods like CRISPR-Cas have shown potential in enhancing production of beneficial microorganisms and controlling damaging pathogens relevant to food. These methods enable the detection of source, adulteration, mislabeling, and allergens in food products.
JOURNAL OF FOOD SAFETY
(2022)
Review
Endocrinology & Metabolism
Aditi Dhingra, Divyani Sharma, Anuj Kumar, Shalini Singh, Pramod Kumar
Summary: Cancer of the female reproductive system, particularly ovarian cancer, is a deadly disease that is often undiagnosed until its later stages. Environmental, genetic, and microbial factors play a significant role in the development of this cancer. The microbial diversity and richness in the reproductive tract and gut are important factors that contribute to the risk of developing ovarian carcinoma.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2022)
Article
Microbiology
Prerna Mandhan, Mansi Sharma, Sushmita Pandey, Neha Chandel, Nidhi Chourasia, Amit Moun, Divyani Sharma, Rubee Sukar, Niyati Singh, Shubhangi Mathur, Aarti Kotnala, Neetu Negi, Ashish Gupta, Anuj Kumar, R. Suresh Kumar, Pramod Kumar, Shalini Singh
Summary: An effective and rapid diagnosis is crucial in controlling the COVID-19 pandemic by isolating infected individuals and providing specialized treatment. Enhanced testing capacity has been proven to effectively curb the transmission of SARS-CoV-2 during the initial phases of outbreaks. However, the cost of molecular diagnosis limits diagnostic capacity in resource-limited countries. This study introduces two pooling strategies, P-5 and P-10, to improve throughput and save resources and time in a high-throughput COVID-19 diagnostic laboratory.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pratiksha Jadaun, Chandrabhan Seniya, Sudhir Kumar Pal, Sanjit Kumar, Pramod Kumar, Vijay Nema, Smita S. Kulkarni, Anupam Mukherjee
Summary: The study found that C-Phycocyanin (C-PC) can inhibit HIV-1 replication and reduce the generation of mitochondrial ROS. The results showed a strong interaction between C-PC and HIV-1 proteins, and its mechanism of action was through the inhibition of reverse transcriptase and protease enzymes. Additionally, C-PC treatment reduced the production of ROS and the activation of caspase-3/7 in HIV-1-infected cells.
Article
Public, Environmental & Occupational Health
Sanchita Roy Pradhan, M. H. Yashavarddhan, Ashish Gupta, Pramod Kumar, Anuj Kumar, Nazneen Arif, Usha Agrawal, R. Suresh Kumar, Shalini Singh
Summary: The Indian Council of Medical Research (ICMR) established a high-throughput viral diagnostic laboratory (HTVDL) during the COVID-19 pandemic to expand testing capacity and adopt rapid testing procedures. The HTVDL provided testing support in two regions of India with a capacity of 6000 tests per day. This article shares the experience of establishing a high-throughput laboratory in developing countries like India and is helpful globally for setting up HTVDLs.
FRONTIERS IN PUBLIC HEALTH
(2023)
Letter
Infectious Diseases
P. Kumar, P. Yadav, D. G. Deshmukh, P. A. Bulle, D. Singh, N. Singh, K. K. Sharma, M. Jain, K. V. Ingole, A. K. Goel, P. K. Yadava
CLINICAL MICROBIOLOGY AND INFECTION
(2017)