Structural similarities of human and mammalian lipocalins, and their function in innate immunity and allergy

The Menagerie of Human Lipocalins: A Natural Protein Scaffold for Molecular Recognition of Physiological Compounds

(2015) André Schiefner et al.   ACCOUNTS OF CHEMICAL RESEARCH

An Integrated In Silico Approach for the Structural and Functional Exploration of Lipocalin 2 and its Functional Insights with Metalloproteinase 9 and Lipoprotein Receptor-Related Protein 2

(2015) Mrinmoy Ghosh et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

The role of neutrophil gelatinase associated lipocalin (NGAL) as biological constituent linking depression and cardiovascular disease

(2015) L. Gouweleeuw et al.   BRAIN BEHAVIOR AND IMMUNITY

Liver is the major source of elevated serum lipocalin-2 levels after bacterial infection or partial hepatectomy: A critical role for IL-6/STAT3

(2015) Ming-Jiang Xu et al.   HEPATOLOGY

Macrophage iron homeostasis and polarization in the context of cancer

(2015) Michaela Jung et al.   IMMUNOBIOLOGY

Allergy to furry animals: New insights, diagnostic approaches, and challenges

(2015) Jon R. Konradsen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Characterization of human memory CD4+ T-cell responses to the dog allergen Can f 4

(2015) Aino L. Rönkä et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Thymic stromal lymphopoietin activation of basophils in patients with allergic asthma is IL-3 dependent

(2015) Brittany M. Salter et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human Urinary Composition Controls Antibacterial Activity of Siderocalin

(2015) Robin R. Shields-Cutler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Papain Degrades Tight Junction Proteins of Human Keratinocytes In Vitro and Sensitizes C57BL/6 Mice via the Skin Independent of its Enzymatic Activity or TLR4 Activation

(2015) Caroline Stremnitzer et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Expression and localisation of brain-type organic cation transporter (BOCT/24p3R/LCN2R) in the normal rat hippocampus and after kainate-induced excitotoxicity

(2015) Wan-Jie Chia et al.   NEUROCHEMISTRY INTERNATIONAL

A population-based study of animal component sensitization, asthma, and rhinitis in schoolchildren

(2015) Anders Bjerg et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Interplay between enterobactin, myeloperoxidase and lipocalin 2 regulates E. coli survival in the inflamed gut

(2015) Vishal Singh et al.   Nature Communications

IgE Reactivity of the Dog Lipocalin Allergen Can f 4 and the Development of a Sandwich ELISA for Its Quantification

(2015) Marja Rytkönen-Nissinen et al.   Allergy Asthma & Immunology Research

Pollen Allergies in Humans and their Dogs, Cats and Horses: Differences and Similarities

(2015) Erika Jensen-Jarolim et al.   Clinical and Translational Allergy

Caution: Reptile pets shuttle grasshopper allergy and asthma into homes

(2015) Erika Jensen-Jarolim et al.   World Allergy Organization Journal

Plasma Neutrophil Gelatinase-Associated Lipocalin Is Primarily Related to Inflammation during Sepsis: A Translational Approach

(2015) Gordon P. Otto et al.   PLoS One

Roles of neutrophil gelatinase-associated lipocalin (NGAL) in human cancer

(2015) Saverio Candido et al.   Oncotarget

Changes in cat specific IgE and IgG antibodies with decreased cat exposure

(2014) Elizabeth A. Erwin et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Complementary roles of mouse lipocalins in chemical communication and immunity

(2014) Romana Stopková et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Bacterial Siderophores That Evade or Overwhelm Lipocalin 2 Induce Hypoxia Inducible Factor 1α and Proinflammatory Cytokine Secretion in Cultured Respiratory Epithelial Cells

(2014) Victoria I. Holden et al.   INFECTION AND IMMUNITY

Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children

(2014) Susan V. Lynch et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Molecular and Immunological Characterization of the First Allergenic Lipocalin in Hamster

(2014) José Alberto Torres et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bet v 1 from Birch Pollen Is a Lipocalin-like Protein Acting as Allergen Only When Devoid of Iron by Promoting Th2 Lymphocytes

(2014) Franziska Roth-Walter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo

(2014) Derek K. Chu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil Gelatinase-Associated Lipocalin in Dogs with Naturally Occurring Renal Diseases

(2014) W.-L. Hsu et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Structural aspects of dog allergies: The crystal structure of a dog dander allergen Can f 4

(2014) Merja H. Niemi et al.   MOLECULAR IMMUNOLOGY

Antihistamine response: a dynamically refined function at the host-tick interface

(2014) James J Valdés   Parasites & Vectors

Neutrophil Gelatinase-Associated Lipocalin Increases HLA-G+/FoxP3+ T-Regulatory Cell Population in an In Vitro Model of PBMC

(2014) Gaetano La Manna et al.   PLoS One

Human CD4+ T Cell Responses to the Dog Major Allergen Can f 1 and Its Human Homologue Tear Lipocalin Resemble Each Other

(2014) Aino L. K. Liukko et al.   PLoS One

The Major Cow Milk Allergen Bos d 5 Manipulates T-Helper Cells Depending on Its Load with Siderophore-Bound Iron

(2014) Franziska Roth-Walter et al.   PLoS One

Designing a Multimer Allergen for Diagnosis and Immunotherapy of Dog Allergic Patients

(2014) Ola B. Nilsson et al.   PLoS One

Dialogue between skin microbiota and immunity

(2014) Y. Belkaid et al.   SCIENCE

Neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinase-9 (MMP-9) prognostic value in lung adenocarcinoma

(2014) José Manuel Ruiz-Morales et al.   TUMOR BIOLOGY

Network based analyses of gene expression profile of LCN2 overexpression in esophageal squamous cell carcinoma

(2014) Bingli Wu et al.   Scientific Reports

Dog saliva - an important source of dog allergens

(2013) N. Polovic et al.   ALLERGY

A cross-sectional analysis of pet-specific immunoglobulin E sensitization and allergic symptomatology and household pet keeping in a birth cohort population

(2013) Jerel M. Ezell et al.   ALLERGY AND ASTHMA PROCEEDINGS

Secret of the major birch pollen allergen Bet v 1: identification of the physiological ligand

(2013) Christian Seutter von Loetzen et al.   BIOCHEMICAL JOURNAL

Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes

(2013) Joanna M. Warszawska et al.   JOURNAL OF CLINICAL INVESTIGATION

Modeling iron-catecholates binding to NGAL protein

(2013) Cristina Gómez-Casado et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Association between pet-keeping and asthma in school children

(2013) Biljana Medjo et al.   PEDIATRICS INTERNATIONAL

Expression and Function of the Lipocalin-2 (24p3/NGAL) Receptor in Rodent and Human Intestinal Epithelia

(2013) Christian Langelueddecke et al.   PLoS One

Elevation of neutrophil gelatinase-associated lipocalin (NGAL) in non-azotemic dogs with urinary tract infection

(2013) Evence Daure et al.   RESEARCH IN VETERINARY SCIENCE

Cohabiting family members share microbiota with one another and with their dogs

(2013) Se Jin Song et al.   eLife

Acute Phase Protein Lipocalin-2 Is Associated with Formalin-induced Nociception and Pathological Pain

(2013) Mithilesh Kumar Jha et al.   Immune Network

Characterization of the dog lipocalin allergen Can f 6: the role in cross-reactivity with cat and horse

(2012) O. B. Nilsson et al.   ALLERGY

CCL2 is critical for immunosuppression to promote cancer metastasis

(2012) Chie Kudo-Saito et al.   CLINICAL & EXPERIMENTAL METASTASIS

Exposure to Dog Allergens and Subsequent Allergic Sensitization: An Updated Review

(2012) Jordan Smallwood et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Animal Lipocalin Allergens

(2012) Christiane Hilger et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Involvement of Can f 5 in a Case of Human Seminal Plasma Allergy

(2012) Maria Basagaña et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Can f 1 levels in hair and homes of different dog breeds: Lack of evidence to describe any dog breed as hypoallergenic

(2012) Doris W. Vredegoor et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Blocking IL-25 signalling protects against gut inflammation in a type-2 model of colitis by suppressing nuocyte and NKT derived IL-13

(2012) Ana Camelo et al.   JOURNAL OF GASTROENTEROLOGY

Interleukin-10-Induced Neutrophil Gelatinase-Associated Lipocalin Production in Macrophages with Consequences for Tumor Growth

(2012) M. Jung et al.   MOLECULAR AND CELLULAR BIOLOGY

Alternatively Activated Macrophages and Airway Disease

(2011) Derek E. Byers et al.   CHEST

Evaluation of two new recombinant guinea-pig lipocalins, Cav p 2 and Cav p 3, in the diagnosis of guinea-pig allergy

(2011) C. Hilger et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Sphingosine-1-phosphate signalling induces the production of Lcn-2 by macrophages to promote kidney regeneration

(2011) Anna Sola et al.   JOURNAL OF PATHOLOGY

Molecular and immunological characterization of Can f 4: a dog dander allergen cross-reactive with a 23 kDa odorant-binding protein in cow dander

(2010) L. Mattsson et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Non-Proteolytic Aeroallergens from Mites, Cat and Dog Exert Adjuvant-Like Activation of Bronchial Epithelial Cells

(2010) Camilla Österlund et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Crystal Structure of the Dog Lipocalin Allergen Can f 2: Implications for Cross-reactivity to the Cat Allergen Fel d 4

(2010) Chaithanya Madhurantakam et al.   JOURNAL OF MOLECULAR BIOLOGY

Two modes of fatty acid binding to bovine β-lactoglobulin-crystallographic and spectroscopic studies

(2010) Joanna Loch et al.   JOURNAL OF MOLECULAR RECOGNITION

Iron traffics in circulation bound to a siderocalin (Ngal)–catechol complex

(2010) Guanhu Bao et al.   Nature Chemical Biology

Human allergy to environmental pet danders: a public health perspective

(2010) Daniel O. Morris   VETERINARY DERMATOLOGY

A new crystal form of human tear lipocalin reveals high flexibility in the loop region and induced fit in the ligand cavity

(2009) Daniel A. Breustedt et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Prostatic kallikrein: A new major dog allergen

(2009) Lars Mattsson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Suboptimal recognition of a T cell epitope of the major dog allergen Can f 1 by human T cells

(2009) Riikka Juntunen et al.   MOLECULAR IMMUNOLOGY

Neutrophil gelatinase-associated lipocalin (NGAL/Lcn2) is upregulated in gastric mucosa infected with Helicobacter pylori

(2009) Warner Alpízar-Alpízar et al.   VIRCHOWS ARCHIV

AllergoOncology: the role of IgE-mediated allergy in cancer

(2008) E. Jensen-Jarolim et al.   ALLERGY

The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands

(2008) Christian Radauer et al.   BMC EVOLUTIONARY BIOLOGY