Article
Multidisciplinary Sciences
Lucie Pepino, Pascale Malapert, Andrew J. Saurin, Aziz Moqrich, Ana Reynders
Summary: Mounting evidence suggests that women experience more chronic pain than men, but the biological basis for these differences is still not fully understood. In this study, researchers used a mouse model to show that female mice exhibit two distinct types of pain responses to formalin, depending on their estrus cycle phase. They also found that formalin-induced pain is associated with immune modulation, particularly involving neutrophils, and this immune response is more pronounced in males than females. These findings contribute to our understanding of pain perception and immune regulation in a sex-specific manner.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Diana J. Goode, Derek C. Molliver
Summary: This study identifies a mechanism for regulating mitochondrial function by Epac2 in DRG sensory neurons, contributing to acute inflammatory hyperalgesia in male mice. Systemic administration of the cyclooxygenase 2 inhibitor celecoxib can suppress Pdha1 phosphorylation in male DRG, thereby alleviating PGE2-induced heat hyperalgesia.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Do Hyeong Gwon, Song I. Kim, Seoung Hun Lee, Chan Noh, Yeojung Kim, Sangwon Yun, Won Hyung Lee, Jun Young Oh, Dong Woon Kim, Jinpyo Hong, Sun Yeul Lee
Summary: NFAT5 deficiency may alleviate formalin-induced inflammatory pain by upregulating mTOR expression and downregulating its downstream factors in spinal dorsal neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Liam J. Peck, Ryan Patel, Paula Diaz, Yolanda M. Wintle, Anthony H. Dickenson, Andrew J. Todd, Margarita Calvo, David L. H. Bennett
Summary: The study looked at the expression of Kv1.6 in sensory neurons and its role in pain sensitivity, comparing two mouse models of constitutive Kv1.6 knock-out achieved by different methods. The results showed unexpected reductions in sensitivity to noxious heat stimuli in both mouse lines, with a more significant hyposensitivity in the gene trap model.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Genetics & Heredity
Chuan Tian, Min Zheng, Xiang Lan, Lili Liu, Zhonglv Ye, Chengyan Li
Summary: This study identified novel ferroptosis-associated hub genes, including lipocalin 2 (LCN2), in T-cell acute lymphoblastic leukemia (T-ALL). Further experiments demonstrated that high expression of LCN2 in T-ALL promotes ferroptotic cell death, suggesting LCN2 as a potential therapeutic target for T-ALL.
Article
Oncology
Yanfei Li, Dafa Shi, Haoran Zhang, Xiang Yao, Ke Ren
Summary: This study confirms that MRI can detect early CI-AKI and investigates the involvement of immune-related responses, pyroptosis, and mitophagy in contrast-induced acute renal injury. The findings suggest that NLRP3 inflammasomes and mitophagy may play a role in mitigating kidney injury in CI-AKI.
ANALYTICAL CELLULAR PATHOLOGY
(2022)
Article
Medical Laboratory Technology
Ze-Liang Qiu, Bi-Qing Yan, Rui Zhao, Dong-Wei Xu, Kan Shen, Xing-Qi Deng, Shi-Qi Lu
Summary: This study aimed to assess the early predictive values of hepcidin, NGAL, and their combination for secondary AKI in patients with sepsis. Results indicated that higher serum hepcidin and urine NGAL levels at admission were independent predictors of AKI development in critically septic patients. Serum hepcidin and urine NGAL were comparable predictive indicators of AKI occurrence, with their combination showing improved accuracy in prediction.
CLINICA CHIMICA ACTA
(2021)
Article
Medicine, Research & Experimental
Marcos Lisboa Neves, Jhenifer Karvat, Roli Rodrigues Simoes, Guilherme Fleury Fina Speretta, Renata Maria Lataro, Morgana Duarte da Silva, Adair Roberto Soares Santos
Summary: The study investigated the effects of ABVN stimulation on pain models in rats and found that stimulation on the left side could inhibit pain signaling, dependent on the activation of the vagus nerve and cholinergic receptors.
Article
Cell Biology
Moritz Moeller, Christine Moser, Ulrike Weiss, Ellen Niederberger
Summary: Alpha Synuclein is a synaptic protein associated with neurodegenerative diseases, particularly Parkinson's disease. Research suggests that inhibiting Alpha Synuclein may be beneficial in alleviating pain symptoms following nerve injury.
Article
Pharmacology & Pharmacy
Rodrigo Maia-Marques, Igor M. R. Nascimento, Pedro S. S. Lauria, Ellen C. P. da Silva, Darizy F. Silva, Luciana L. Casais-e-Silva
Summary: Venom from Bothrops leucurus induces severe pain and mechanical hyperalgesia, involving neurotransmitters, nitric oxide, and prostaglandins. Inhibiting specific inflammatory mediators pathways may be an effective therapeutic strategy for pain management during envenoming.
Article
Behavioral Sciences
Guadalupe Garcia, Vladimir A. Martinez-Rojas, Janet Murbartian
Summary: TREK-1 channels play a crucial role in acute and persistent nociceptive hypersensitivity, with selective blockade or activation affecting pain behaviors. The activity of TREK-1 at peripheral and spinal sites can reduce neuronal excitability in a formalin-induced nociception model.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Chemistry, Medicinal
Qianqian Liang, Zhen Qiao, Qiqi Zhou, Dengqi Xue, KeWei Wang, Liming Shao
Summary: This study reports the synthesis of N-indazole-4-aryl piperazine carboxamide analogues as TRPV1 modulators. Compound 28 is identified as a potent and selective TRPV1 agonist, relieving inflammatory and thermal pain by desensitizing the native TRPV1 current in mice. The study also reveals an important hydrogen interaction between Arg557 and the indazole of compound 28.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Andrea Bortolin, Estrela Neto, Meriem Lamghari
Summary: Calcium plays a crucial role in various physiological processes as a signalling mediator. It is involved in pathways that control fast responses like neuronal action potential firing and slow processes like gene transcriptional regulation. In pathological conditions, these mechanisms are also implicated in tumor cell reprogramming and pain regulation. Understanding the interactions between these mechanisms can lead to the identification of new therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zixuan Wang, Stefano Martellucci, Alicia Van Enoo, Dana Austin, Cohava Gelber, Wendy M. Campana
Summary: SP16, derived from AAT, is a bioactive peptide that can increase neurite length and regenerative gene expression in sensory neurons. It activates the Akt and ERK1/2 cell-signaling pathways in an LRP1-dependent manner. SP16 shows efficacy in attenuating nociceptive, inflammatory, and neuropathic pain in three different pain models, and also inhibits inflammatory cell recruitment and satellite cell activation.
Review
Biochemistry & Molecular Biology
Shota Yamamoto, Nobuaki Egashira
Summary: Bortezomib, a common chemotherapy drug for hematologic malignancy, can lead to severe peripheral neuropathy as a side effect. There is a lack of understanding regarding the pathological mechanisms of Bortezomib-induced peripheral neuropathy (BIPN), highlighting the importance of research in this area to develop effective prevention and treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
