Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model

(2015) A. R. R. Maia et al.   ANNALS OF ONCOLOGY

Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis

(2015) Xiaolong Zhuo et al.   JOURNAL OF CELL BIOLOGY

Targeting MPS1 Enhances Radiosensitization of Human Glioblastoma by Modulating DNA Repair Proteins

(2015) U. B. Maachani et al.   MOLECULAR CANCER RESEARCH

Plk1 and Mps1 Cooperatively Regulate the Spindle Assembly Checkpoint in Human Cells

(2015) Conrad von Schubert et al.   Cell Reports

Pancreatic Adenocarcinoma

(2015) David P. Ryan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Key role of dual specificity kinase TTK in proliferation and survival of pancreatic cancer cells

(2014) B P Kaistha et al.   BRITISH JOURNAL OF CANCER

Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer

(2014) F Al-Ejeh et al.   Oncogenesis

A TPR domain–containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora B

(2013) Wilco Nijenhuis et al.   JOURNAL OF CELL BIOLOGY

Universal Quantitative Kinase Assay Based on Diagonal SCX Chromatography and Stable Isotope Dimethyl Labeling Provides High-definition Kinase Consensus Motifs for PKA and Human Mps1

(2013) Marco L. Hennrich et al.   JOURNAL OF PROTEOME RESEARCH

Selective Inhibition of Pancreatic Ductal Adenocarcinoma Cell Growth by the Mitotic MPS1 Kinase Inhibitor NMS-P715

(2013) R. B. Slee et al.   MOLECULAR CANCER THERAPEUTICS

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

(2013) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

The cancer biology of whole-chromosome instability

(2013) P H G Duijf et al.   ONCOGENE

TTK/hMPS1 Is an Attractive Therapeutic Target for Triple-Negative Breast Cancer

(2013) Virginie Maire et al.   PLoS One

Clinical and molecular characterization of HER2 amplified-pancreatic cancer

(2013) Angela Chou et al.   Genome Medicine

The MPS1 Family of Protein Kinases

(2012) Xuedong Liu et al.   Annual Review of Biochemistry

Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint)

(2012) Philippe Thebault et al.   BIOCHEMICAL JOURNAL

Impact of FOLFIRINOX Compared With Gemcitabine on Quality of Life in Patients With Metastatic Pancreatic Cancer: Results From the PRODIGE 4/ACCORD 11 Randomized Trial

(2012) Sophie Gourgou-Bourgade et al.   JOURNAL OF CLINICAL ONCOLOGY

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

(2012) Andrew V. Biankin et al.   NATURE

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Paradoxical Relationship between Chromosomal Instability and Survival Outcome in Cancer

(2011) N. J. Birkbak et al.   CANCER RESEARCH

Identification of Aneuploidy-Selective Antiproliferation Compounds

(2011) Yun-Chi Tang et al.   CELL

Characterization of Spindle Checkpoint Kinase Mps1 Reveals Domain with Functional and Structural Similarities to Tetratricopeptide Repeat Motifs of Bub1 and BubR1 Checkpoint Kinases

(2011) Semin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of the Cellular and Antitumor Effects of MPI-0479605, a Small-Molecule Inhibitor of the Mitotic Kinase Mps1

(2011) K. D. Tardif et al.   MOLECULAR CANCER THERAPEUTICS

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

(2011) Thierry Conroy et al.   NEW ENGLAND JOURNAL OF MEDICINE

High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells

(2011) J. Daniel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the Mitotic Checkpoint for Cancer Therapy with NMS-P715, an Inhibitor of MPS1 Kinase

(2010) R. Colombo et al.   CANCER RESEARCH

Cellular Abundance of Mps1 and the Role of Its Carboxyl Terminal Tail in Substrate Recruitment

(2010) Tingting Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diagnosis and Prognostication of Ductal Adenocarcinomas of the Pancreas Based on Genome-Wide DNA Methylation Profiling by Bacterial Artificial Chromosome Array-Based Methylated CpG Island Amplification

(2010) Masahiro Gotoh et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Proliferation of aneuploid human cells is limited by a p53-dependent mechanism

(2010) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

(2010) Nicholas Kwiatkowski et al.   Nature Chemical Biology

Phenotype and Genotype of Pancreatic Cancer Cell Lines

(2010) Emily L. Deer et al.   PANCREAS

Chemical Genetic Inhibition of Mps1 in Stable Human Cell Lines Reveals Novel Aspects of Mps1 Function in Mitosis

(2010) Tale Sliedrecht et al.   PLoS One

The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis

(2010) M. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Six-Gene Signature Predicts Survival of Patients with Localized Pancreatic Ductal Adenocarcinoma

(2010) Jeran K. Stratford et al.   PLOS MEDICINE

Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: a perspective from genetic studies in mice

(2009) C. V. Rao et al.   CARCINOGENESIS

Defining the Human Deubiquitinating Enzyme Interaction Landscape

(2009) Mathew E. Sowa et al.   CELL

TTK/hMps1 Mediates the p53-Dependent Postmitotic Checkpoint by Phosphorylating p53 at Thr18

(2009) Y.-F. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells

(2009) Eric Campeau et al.   PLoS One

Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells

(2009) Aniek Janssen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detection of novel cancer-testis antigen-specific T-cell responses in TIL, regional lymph nodes, and PBL in patients with esophageal squamous cell carcinoma

(2008) Yoshiki Mizukami et al.   CANCER SCIENCE

Mps1 Phosphorylates Borealin to Control Aurora B Activity and Chromosome Alignment

(2008) Nannette Jelluma et al.   CELL

Death through a tragedy: mitotic catastrophe

(2008) H Vakifahmetoglu et al.   CELL DEATH AND DIFFERENTIATION

Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores

(2008) Anthony Tighe et al.   JOURNAL OF CELL BIOLOGY

Examining the link between chromosomal instability and aneuploidy in human cells

(2008) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

Extra centrosomes and/or chromosomes prolong mitosis in human cells

(2008) Zhenye Yang et al.   NATURE CELL BIOLOGY

Gene Expression Signature of Cigarette Smoking and Its Role in Lung Adenocarcinoma Development and Survival

(2008) Maria Teresa Landi et al.   PLoS One

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE