Identification of small molecule inhibitors for influenza a virus using in silico and in vitro approaches

Binding of RNA by the Nucleoproteins of Influenza Viruses A and B

(2016) Alice Labaronne et al.   Viruses-Basel

Structure-Based Drug Discovery for Prion Disease Using a Novel Binding Simulation

(2016) Daisuke Ishibashi et al.   EBioMedicine

Time-Resolved Visualisation of Nearly-Native Influenza A Virus Progeny Ribonucleoproteins and Their Individual Components in Live Infected Cells

(2016) Sergiy Avilov et al.   PLoS One

Characterization of a Large Cluster of Influenza A(H1N1)pdm09 Viruses Cross-Resistant to Oseltamivir and Peramivir during the 2013-2014 Influenza Season in Japan

(2015) Emi Takashita et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2013–2014

(2015) Emi Takashita et al.   ANTIVIRAL RESEARCH

In Vitro Evaluation of Synergistic Inhibitory Effects of Neuraminidase Inhibitors and Methylglyoxal Against Influenza Virus Infection

(2015) Siriwan Charyasriwong et al.   ARCHIVES OF MEDICAL RESEARCH

Protein sequence conservation and stable molecular evolution reveals influenza virus nucleoprotein as a universal druggable target

(2015) Mustafeez Mujtaba Babar et al.   INFECTION GENETICS AND EVOLUTION

A Novel Antiviral Target Structure Involved in the RNA Binding, Dimerization, and Nuclear Export Functions of the Influenza A Virus Nucleoprotein

(2015) Michinori Kakisaka et al.   PLoS Pathogens

Phosphorylation at the Homotypic Interface Regulates Nucleoprotein Oligomerization and Assembly of the Influenza Virus Replication Machinery

(2015) Arindam Mondal et al.   PLoS Pathogens

Anti-influenza Viral Effects of Honey In Vitro: Potent High Activity of Manuka Honey

(2014) Ken Watanabe et al.   ARCHIVES OF MEDICAL RESEARCH

Large-scale analysis of influenza A virus nucleoprotein sequence conservation reveals potential drug-target sites

(2014) Andreas Kukol et al.   VIROLOGY

Estimating the Fitness Advantage Conferred by Permissive Neuraminidase Mutations in Recent Oseltamivir-Resistant A(H1N1)pdm09 Influenza Viruses

(2014) Jeff Butler et al.   PLoS Pathogens

Structure-Based Discovery of the Novel Antiviral Properties of Naproxen against the Nucleoprotein of Influenza A Virus

(2013) Nathalie Lejal et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Long-term Survival and Biomarker Correlates of Tasquinimod Efficacy in a Multicenter Randomized Study of Men with Minimally Symptomatic Metastatic Castration-Resistant Prostate Cancer

(2013) A. J. Armstrong et al.   CLINICAL CANCER RESEARCH

Design, Synthesis, and in Vitro Biological Evaluation of 1H-1,2,3-Triazole-4-carboxamide Derivatives as New Anti-influenza A Agents Targeting Virus Nucleoprotein

(2012) Huimin Cheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-influenza virus activity of Ginkgo biloba leaf extracts

(2012) Takahiro Haruyama et al.   Journal of Natural Medicines

Structural Basis for RNA Binding and Homo-Oligomer Formation by Influenza B Virus Nucleoprotein

(2012) A. K.-L. Ng et al.   JOURNAL OF VIROLOGY

Estimated global mortality associated with the first 12 months of 2009 pandemic influenza A H1N1 virus circulation: a modelling study

(2012) Fatimah S Dawood et al.   LANCET INFECTIOUS DISEASES

Quinoline: A versatile heterocyclic

(2012) Akranth Marella et al.   SAUDI PHARMACEUTICAL JOURNAL

Pharmacokinetics, tolerability, and preliminary efficacy of paquinimod (ABR-215757), a new quinoline-3-carboxamide derivative: Studies in lupus-prone mice and a multicenter, randomized, double-blind, placebo-controlled, repeat-dose, dose-ranging study in

(2011) Anders A. Bengtsson et al.   ARTHRITIS AND RHEUMATISM

Structure-based discovery of anti-influenza virus A compounds among medicines

(2011) Mayuko Fukuoka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Community Transmission of Oseltamivir-Resistant A(H1N1)pdm09 Influenza

(2011) Aeron C. Hurt et al.   NEW ENGLAND JOURNAL OF MEDICINE

E339...R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors

(2011) Y.-F. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers

(2011) S. W. Gerritz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of novel antiviral agents directed against the influenza A virus nucleoprotein using photo-cross-linked chemical arrays

(2010) Kyoji Hagiwara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Successful Applications of Computer Aided Drug Discovery: Moving Drugs from Concept to the Clinic

(2010) Tanaji Talele et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Strand-specific real-time RT-PCR for distinguishing influenza vRNA, cRNA, and mRNA

(2010) Eiryo Kawakami et al.   JOURNAL OF VIROLOGICAL METHODS

Functional Analysis of the Influenza Virus H5N1 Nucleoprotein Tail Loop Reveals Amino Acids That Are Crucial for Oligomerization and Ribonucleoprotein Activities

(2010) W.-H. Chan et al.   JOURNAL OF VIROLOGY

Oseltamivir-Resistant Variants of the 2009 Pandemic H1N1 Influenza A Virus Are Not Attenuated in the Guinea Pig and Ferret Transmission Models

(2010) C. W. Seibert et al.   JOURNAL OF VIROLOGY

Identification of influenza A nucleoprotein as an antiviral target

(2010) Richard Y Kao et al.   NATURE BIOTECHNOLOGY

Emergence and spread of oseltamivir-resistant A(H1N1) influenza viruses in Oceania, South East Asia and South Africa

(2009) Aeron C. Hurt et al.   ANTIVIRAL RESEARCH

Fragment molecular orbital calculation using the RI-MP2 method

(2009) Takeshi Ishikawa et al.   CHEMICAL PHYSICS LETTERS

Antiviral resistance in influenza viruses circulating in Central and South America based on the detection of established genetic markers

(2009) Josefina García et al.   Influenza and Other Respiratory Viruses

Infections With Oseltamivir-Resistant Influenza A(H1N1) Virus in the United States

(2009) Nila J. Dharan   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Theoretical study of the prion protein based on the fragment molecular orbital method

(2009) Takeshi Ishikawa et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

NS2/NEP protein regulates transcription and replication of the influenza virus RNA genome

(2009) Nicole C. Robb et al.   JOURNAL OF GENERAL VIROLOGY

Mutational Analysis of Conserved Amino Acids in the Influenza A Virus Nucleoprotein

(2009) Z. Li et al.   JOURNAL OF VIROLOGY

Zanamivir-Resistant Influenza Viruses with a Novel Neuraminidase Mutation

(2009) A. C. Hurt et al.   JOURNAL OF VIROLOGY

Structure-based design of molecular cancer therapeutics

(2009) Rob L.M. van Montfort et al.   TRENDS IN BIOTECHNOLOGY

Structural basis for oseltamivir resistance of influenza viruses

(2009) P.J. Collins et al.   VACCINE

Challenges in Modern Drug Discovery: A Case Study of Boceprevir, an HCV Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

(2008) F. George Njoroge et al.   ACCOUNTS OF CHEMICAL RESEARCH

Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design

(2008) Andy Ka-Leung Ng et al.   FASEB JOURNAL