Co-ordinated activation of classical and novel PKC isoforms is required for PMA-induced mTORC1 activation

Growth factor signaling to mTORC1 by amino acid–laden macropinosomes

(2015) Sei Yoshida et al.   JOURNAL OF CELL BIOLOGY

Rapid Mitogenic Regulation of the mTORC1 Inhibitor, DEPTOR, by Phosphatidic Acid

(2015) Mee-Sup Yoon et al.   MOLECULAR CELL

Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

(2014) Suchithra Menon et al.   CELL

Ral and Rheb GTPase Activating Proteins Integrate mTOR and GTPase Signaling in Aging, Autophagy, and Tumor Cell Invasion

(2014) Timothy D. Martin et al.   MOLECULAR CELL

Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex

(2014) Anita Parmigiani et al.   Cell Reports

Sustained PKCβII activity confers oncogenic properties in a phospholipase D- and mTOR-dependent manner

(2013) Mohamad El Osta et al.   FASEB JOURNAL

Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

(2013) Christian C. Dibble et al.   NATURE CELL BIOLOGY

Sustained Activation of Protein Kinase C Induces Delayed Phosphorylation and Regulates the Fate of Epidermal Growth Factor Receptor

(2013) Mengling Liu et al.   PLoS One

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

(2012) Liron Bar-Peled et al.   CELL

Structure–Activity Studies on the Spiroketal Moiety of a Simplified Analogue of Debromoaplysiatoxin with Antiproliferative Activity

(2012) Masayuki Kikumori et al.   JOURNAL OF MEDICINAL CHEMISTRY

SH3BP4 Is a Negative Regulator of Amino Acid-Rag GTPase-mTORC1 Signaling

(2012) Young-Mi Kim et al.   MOLECULAR CELL

Delayed Phosphorylation of Classical Protein Kinase C (PKC) Substrates Requires PKC Internalization and Formation of the Pericentrion in a Phospholipase D (PLD)-dependent Manner

(2011) Mohamad A. El-Osta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidic Acid Activates Mammalian Target of Rapamycin Complex 1 (mTORC1) Kinase by Displacing FK506 Binding Protein 38 (FKBP38) and Exerting an Allosteric Effect

(2011) Mee-Sup Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological and Genetic Evaluation of Proposed Roles of Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase (MEK), Extracellular Signal-regulated Kinase (ERK), and p90RSKin the Control of mTORC1 Protein Signaling by Phorbol Esters

(2011) Bruno D. Fonseca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Class III PI-3-kinase activates phospholipase D in an amino acid–sensing mTORC1 pathway

(2011) Mee-Sup Yoon et al.   JOURNAL OF CELL BIOLOGY

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

(2009) R. J. Shaw   Acta Physiologica

Sustained Receptor Stimulation Leads to Sequestration of Recycling Endosomes in a Classical Protein Kinase C- and Phospholipase D-dependent Manner

(2009) Jolanta Idkowiak-Baldys et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression

(2008) Carolyn L. Buller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Regulation of mTORC1 and mTORC2 Complex Assembly by Phosphatidic Acid: Competition with Rapamycin

(2008) A. Toschi et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural Basis of Protein Kinase C Isoform Function

(2008) Susan F. Steinberg   PHYSIOLOGICAL REVIEWS

Phospholipase D1 is an effector of Rheb in the mTOR pathway

(2008) Y. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE