Inferior immunogenicity and efficacy of respiratory syncytial virus fusion protein-based subunit vaccine candidates in aged versus young mice

Immunization with Low Doses of Recombinant Postfusion or Prefusion Respiratory Syncytial Virus F Primes for Vaccine-Enhanced Disease in the Cotton Rat Model Independently of the Presence of a Th1-Biasing (GLA-SE) or Th2-Biasing (Alum) Adjuvant

(2017) Kirsten Schneider-Ohrum et al.   JOURNAL OF VIROLOGY

A phase 1a, first-in-human, randomized study of a respiratory syncytial virus F protein vaccine with and without a toll-like receptor-4 agonist and stable emulsion adjuvant

(2016) Judith Falloon et al.   VACCINE

Structure-Based Design of Head-Only Fusion Glycoprotein Immunogens for Respiratory Syncytial Virus

(2016) Jeffrey C. Boyington et al.   PLoS One

Enhanced immunogenicity of a respiratory syncytial virus (RSV) F subunit vaccine formulated with the adjuvant GLA-SE in cynomolgus macaques

(2015) Kathryn Patton et al.   VACCINE

RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection

(2015) Agnieszka Jozwik et al.   Nature Communications

A Novel Respiratory Syncytial Virus (RSV) F Subunit Vaccine Adjuvanted with GLA-SE Elicits Robust Protective TH1-Type Humoral and Cellular Immunity In Rodent Models

(2015) Stacie L. Lambert et al.   PLoS One

Cutting Edge: Eosinophils Do Not Contribute to Respiratory Syncytial Virus Vaccine-Enhanced Disease

(2014) E. M. Castilow et al.   JOURNAL OF IMMUNOLOGY

Translational sciences approach to RSV vaccine development

(2013) Vanessa Kurzweil et al.   Expert Review of Vaccines

Targeting CD137 Enhances Vaccine-Elicited Anti-Respiratory Syncytial Virus CD8+ T Cell Responses in Aged Mice

(2013) S. Lee et al.   JOURNAL OF IMMUNOLOGY

Viral Shedding and Immune Responses to Respiratory Syncytial Virus Infection in Older Adults

(2013) Edward E. Walsh et al.   JOURNAL OF INFECTIOUS DISEASES

Aged Mice Exhibit a Severely Diminished CD8 T Cell Response following Respiratory Syncytial Virus Infection

(2013) Ross B. Fulton et al.   JOURNAL OF VIROLOGY

Cytomegalovirus Vaccine Strain Towne-Derived Dense Bodies Induce Broad Cellular Immune Responses and Neutralizing Antibodies That Prevent Infection of Fibroblasts and Epithelial Cells

(2013) C. Cayatte et al.   JOURNAL OF VIROLOGY

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

(2013) J. S. McLellan et al.   SCIENCE

Strategic priorities for respiratory syncytial virus (RSV) vaccine development

(2013) L.J. Anderson et al.   VACCINE

Adults 65 Years Old and Older Have Reduced Numbers of Functional Memory T Cells to Respiratory Syncytial Virus Fusion Protein

(2012) Anu Cherukuri et al.   Clinical and Vaccine Immunology

Hospitalizations Associated With Influenza and Respiratory Syncytial Virus in the United States, 1993–2008

(2012) Hong Zhou et al.   CLINICAL INFECTIOUS DISEASES

Rates of Hospitalizations for Respiratory Syncytial Virus, Human Metapneumovirus, and Influenza Virus in Older Adults

(2012) Kyle Widmer et al.   JOURNAL OF INFECTIOUS DISEASES

An adjuvanted respiratory syncytial virus fusion protein induces protection in aged BALB/c mice

(2012) Anu Cherukuri et al.   Immunity & Ageing

Development and Characterization of Synthetic Glucopyranosyl Lipid Adjuvant System as a Vaccine Adjuvant

(2011) Rhea N. Coler et al.   PLoS One

Adjuvants that stimulate TLR3 or NLPR3 pathways enhance the efficiency of influenza virus-like particle vaccines in aged mice

(2011) Kirsten Schneider-Ohrum et al.   VACCINE

Physicochemical characterization and biological activity of synthetic TLR4 agonist formulations

(2009) Ryan C. Anderson et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

The Burden of Respiratory Syncytial Virus Infection in Young Children

(2009) Caroline Breese Hall et al.   NEW ENGLAND JOURNAL OF MEDICINE