Immunohistochemical analysis of PDK1, PHD3 and HIF-1α expression defines the hypoxic status of neuroblastoma tumors

Artificial neural network classifier predicts neuroblastoma patients’ outcome

(2016) Davide Cangelosi et al.   BMC BIOINFORMATICS

PDK1 promotes tumor cell proliferation and migration by enhancing the Warburg effect in non-small cell lung cancer

(2016) Tao Liu et al.   ONCOLOGY REPORTS

Glycolytic inhibitor 2-deoxyglucose simultaneously targets cancer and endothelial cells to suppress neuroblastoma growth in mice

(2015) Chao-Cheng Huang et al.   Disease Models & Mechanisms

Targeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target?

(2015) Wen Zhang et al.   International Journal of Biological Sciences

Individual patient risk stratification of high-risk neuroblastomas using a two-gene score suited for clinical use

(2015) Kristoffer von Stedingk et al.   INTERNATIONAL JOURNAL OF CANCER

Genetic abnormalities in adolescents and young adults with neuroblastoma: A report from the Italian Neuroblastoma Group

(2015) Katia Mazzocco et al.   PEDIATRIC BLOOD & CANCER

Cellular memory of hypoxia elicits neuroblastoma metastasis and enables invasion by non-aggressive neighbouring cells

(2015) A Herrmann et al.   Oncogenesis

Fructose-2,6-Bisphosphate synthesis by 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth

(2015) Jason Chesney et al.   Oncotarget

Use of Attribute Driven Incremental Discretization and Logic Learning Machine to build a prognostic classifier for neuroblastoma patients

(2014) Davide Cangelosi et al.   BMC BIOINFORMATICS

Revised Risk Estimation and Treatment Stratification of Low- and Intermediate-Risk Neuroblastoma Patients by Integrating Clinical and Molecular Prognostic Markers

(2014) A. Oberthuer et al.   CLINICAL CANCER RESEARCH

Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR

(2014) Anne-Theres Henze et al.   Nature Communications

Logic Learning Machine creates explicit and stable rules stratifying neuroblastoma patients

(2013) Davide Cangelosi et al.   BMC BIOINFORMATICS

Expression of pyruvate dehydrogenase kinase-1 in gastric cancer as a potential therapeutic target

(2012) HOON HUR et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification

(2012) L. J. Valentijn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expressions of individual PHDs associate with good prognostic factors and increased proliferation in breast cancer patients

(2011) Emmi Peurala et al.   BREAST CANCER RESEARCH AND TREATMENT

Impact of the hypoxic tumor microenvironment on the regulation of cancer stem cell characteristics

(2010) Qun Lin et al.   CANCER BIOLOGY & THERAPY

Accurate Outcome Prediction in Neuroblastoma across Independent Data Sets Using a Multigene Signature

(2010) K. De Preter et al.   CLINICAL CANCER RESEARCH

Hypoxia and Hypoxia-Inducible Factors: Master Regulators of Metastasis

(2010) X. Lu et al.   CLINICAL CANCER RESEARCH

Selecting Systemic Cancer Therapy One Patient at a Time: Is There a Role for Molecular Profiling of Individual Patients With Advanced Solid Tumors?

(2010) James H. Doroshow   JOURNAL OF CLINICAL ONCOLOGY

A biology-driven approach identifies the hypoxia gene signature as a predictor of the outcome of neuroblastoma patients

(2010) Paolo Fardin et al.   Molecular Cancer

The l1-l2 regularization framework unmasks the hypoxia signature hidden in the transcriptome of a set of heterogeneous neuroblastoma cell lines

(2009) Paolo Fardin et al.   BMC GENOMICS

Tumor Vasculature Is Regulated by PHD2-Mediated Angiogenesis and Bone Marrow-Derived Cell Recruitment

(2009) Denise A. Chan et al.   CANCER CELL

Activation of a prometastatic gene expression program in hypoxic neuroblastoma cells

(2009) Preamrudee Poomthavorn et al.   ENDOCRINE-RELATED CANCER

The prolyl-hydroxylase EGLN3 and not EGLN1 is inactivated by methylation in plasma cell neoplasia

(2009) Eleftheria Hatzimichael et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Predicting outcomes for children with neuroblastoma using a multigene-expression signature: a retrospective SIOPEN/COG/GPOH study

(2009) Joëlle Vermeulen et al.   LANCET ONCOLOGY

The kinesin KIF1B  acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor

(2008) S. Schlisio et al.   GENES & DEVELOPMENT

Regulation of cancer cell metabolism by hypoxia-inducible factor 1

(2008) Gregg L. Semenza   SEMINARS IN CANCER BIOLOGY