Mogroside IIIE Attenuates LPS-Induced Acute Lung Injury in Mice Partly Through Regulation of the TLR4/MAPK/NF-κB Axis via AMPK Activation

HMGB1 induces human non-small cell lung cancer cell motility by activating integrin αvβ3/FAK through TLR4/NF-κB signaling pathway

(2016) Jianhua Zhu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IinQ attenuates systemic inflammatory responses via selectively impairing the Myddosome complex formation upon TLR4 ligation

(2016) Kidong Kang et al.   BIOCHEMICAL PHARMACOLOGY

Oleanolic acid induces autophagic death in human gastric cancer cells in vitro and in vivo

(2016) Hao Nie et al.   CELL BIOLOGY INTERNATIONAL

Cardioprotective effect of metformin in lipopolysaccharide-induced sepsis via suppression of toll-like receptor 4 (TLR4) in heart

(2016) Haleh Vaez et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Asiatic Acid Inhibits Lipopolysaccharide-Induced Acute Lung Injury in Mice

(2016) Zhiling Li et al.   INFLAMMATION

13-Methylberberine reduces HMGB1 release in LPS-activated RAW264.7 cells and increases the survival of septic mice through AMPK/P38 MAPK activation

(2016) Ki Churl Chang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

AMPK activation by metformin inhibits local innate immune responses in the isolated rat heart by suppression of TLR 4-related pathway

(2016) Haleh Vaez et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Phloretin attenuates LPS-induced acute lung injury in mice via modulation of the NF-κB and MAPK pathways

(2016) Wen-Chung Huang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ethyl pyruvate inhibits the acetylation and release of HMGB1 via effects on SIRT1/STAT signaling in LPS-activated RAW264.7 cells and peritoneal macrophages

(2016) Young Min Kim et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Kegan Liyan oral liquid ameliorates lipopolysaccharide-induced acute lung injury through inhibition of TLR4-mediated NF-κB signaling pathway and MMP-9 expression

(2016) Xie Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Permissive role of AMPK and autophagy in adiponectin deficiency-accentuated myocardial injury and inflammation in endotoxemia

(2016) Jun Ren et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Protective effects of Ginsenoside Rg1 against carbon tetrachloride-induced liver injury in mice through suppression of inflammation

(2016) Yao Xin et al.   PHYTOMEDICINE

Mogrol Derived from Siraitia grosvenorii Mogrosides Suppresses 3T3-L1 Adipocyte Differentiation by Reducing cAMP-Response Element-Binding Protein Phosphorylation and Increasing AMP-Activated Protein Kinase Phosphorylation

(2016) Naoki Harada et al.   PLoS One

In vitro AMPK activating effect and in vivo pharmacokinetics of mogroside V, a cucurbitane-type triterpenoid from Siraitia grosvenorii fruits

(2016) Zuliang Luo et al.   RSC Advances

RP105 Protects Against Apoptosis in Ischemia/Reperfusion-Induced Myocardial Damage in Rats by Suppressing TLR4-Mediated Signaling Pathways

(2015) Jun Yang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Dachengqi Decoction Attenuates Inflammatory Response via Inhibiting HMGB1 Mediated NF-κB and P38 MAPK Signaling Pathways in Severe Acute Pancreatitis

(2015) Zhuoan Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Daidzein attenuates lipopolysaccharide-induced acute lung injury via toll-like receptor 4/NF-kappaB pathway

(2015) Guang Feng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Exploring in vitro, in vivo metabolism of mogroside V and distribution of its metabolites in rats by HPLC-ESI-IT-TOF-MSn

(2015) Feng Xu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Fucosterol attenuates lipopolysaccharide-induced acute lung injury in mice

(2015) Yuexia Li et al.   JOURNAL OF SURGICAL RESEARCH

Role of Sphingolipids in the Pathobiology of Lung Inflammation

(2015) Riccardo Ghidoni et al.   MEDIATORS OF INFLAMMATION

Advances in Understanding of the Pathogenesis of Acute Respiratory Distress Syndrome

(2015) Charles Sharp et al.   RESPIRATION

Ursolic acid protects hepatocytes against lipotoxicity through activating autophagy via an AMPK pathway

(2015) Fanyu Meng et al.   Journal of Functional Foods

Chronic treatment with metformin suppresses toll-like receptor 4 signaling and attenuates left ventricular dysfunction following myocardial infarction

(2014) Hamid Soraya et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Endogenous expression pattern of resolvin D1 in a rat model of self-resolution of lipopolysaccharide-induced acute respiratory distress syndrome and inflammation

(2014) Wei Sun et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease

(2014) D. Grahame Hardie   JOURNAL OF INTERNAL MEDICINE

Rapid identification and quantification of five major mogrosides in Siraitia grosvenorii (Luo-Han-Guo) by high performance liquid chromatography–triple quadrupole linear ion trap tandem mass spectrometry combined with microwave-assisted extraction

(2014) Yan Shen et al.   MICROCHEMICAL JOURNAL

Protective effects and mechanisms of mogroside V on LPS-induced acute lung injury in mice

(2014) Dongfang Shi et al.   PHARMACEUTICAL BIOLOGY

Anti-inflammatory Activities ofGouania leptostachyaMethanol Extract and its Constituent Resveratrol

(2014) To Thi Mai Dung et al.   PHYTOTHERAPY RESEARCH

The acute respiratory distress syndrome

(2013) Jesús Villar et al.   Current Opinion in Critical Care

Regulation of wound healing and organ fibrosis by toll-like receptors

(2012) Peter Huebener et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

TLR agonists are highly effective at eliciting functional memory CTLs of effector memory phenotype in peptide immunization

(2012) Kendra Smyth et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Acute Respiratory Distress Syndrome: Pathogenesis and Treatment

(2011) Michael A. Matthay et al.   Annual Review of Pathology-Mechanisms of Disease

Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle

(2011) Xu-bing Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Anti-inflammatory Activities of Mogrosides from Momordica grosvenori in Murine Macrophages and a Murine Ear Edema Model

(2011) Rong Di et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Beyond Mortality

(2010) Roger G. Spragg et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Metformin inhibits HMGB1 release in LPS-treated RAW 264.7 cells and increases survival rate of endotoxaemic mice

(2010) Konstantin Tsoyi et al.   BRITISH JOURNAL OF PHARMACOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

(2010) H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-inflammatory effect of Momordica grosvenori Swingle extract through suppressed LPS-induced upregulation of iNOS and COX-2 in murine macrophages

(2009) Min-Hsiung Pan et al.   Journal of Functional Foods

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

(2008) Yumiko Imai et al.   CELL