Article
Pharmacology & Pharmacy
Juan Yang, Yingjuan He, Sha Nan, Juan Li, Anjuan Pi, Lele Yan, Jinshan Xu, Yuhui Hao
Summary: This study prepared propolis nanoparticles through a pH difference method and characterized their properties. The PNPs showed good stability, antioxidant capacity, and accelerated wound healing in a mouse model. These findings suggest that PNPs could be new candidates for wound healing applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Polymer Science
Harshad S. Kapare, Prabhanjan S. Giram, Sadhana S. Raut, Hemant K. Gaikwad, Ana Claudia Paiva-Santos
Summary: Flavonoids and polyphenolic compounds found in propolis, a natural bee product, play a crucial role in wound healing. This study aimed to develop and characterize a propolis-based hydrogel composition with wound healing potential. The formulation was analyzed for its phytochemical content, pH, viscosity, and in vitro release. Results from burn and excision wound healing models demonstrated the efficacy of the propolis hydrogel in promoting wound contraction and re-epithelialization, comparable to the standard povidone iodine ointment. This formulation shows promise for further clinical research on wound healing.
Review
Immunology
Samuel Knoedler, Sonja Broichhausen, Ruiji Guo, Ruoxuan Dai, Leonard Knoedler, Martin Kauke-Navarro, Fortunay Diatta, Bohdan Pomahac, Hans-Guenther Machens, Dongsheng Jiang, Yuval Rinkevich
Summary: Injuries to the skin initiate a series of synchronized healing processes. Fibroblasts play various roles in endogenous wound repair, including activating innate immune cells, depositing scar tissue, and transporting fascial connective tissue to the wounds. Understanding the diversity and versatility of fibroblasts is crucial for deciphering wound pathologies and developing new treatment approaches.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Plant Sciences
Parimah Ebadi, Mehdi Fazeli
Summary: The study found that Iranian propolis and honey had effects on HDF cell migration, proliferation, and viability in a dose-dependent manner, but no synergistic effects were observed between the two. The optimal concentrations for these effects were observed at 100 μg/ml and 200 μg/ml.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Review
Biochemistry & Molecular Biology
Thayaalini Subramaniam, Mh Busra Fauzi, Yogeswaran Lokanathan, Jia Xian Law
Summary: Skin injury healing involves complex processes with various cells, extracellular matrix, and mediators. Cell differentiation, migration, and proliferation are crucial for tissue integrity restoration. Although calcium shows promise in wound healing, challenges need to be addressed before clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Limberg Jaldin-Crespo, Nataly Silva, Jessica Martinez
Summary: This article summarizes the latest therapies for wound healing based on bionanomaterials assisted by honey and propolis, emphasizing their anti-inflammatory, antimicrobial, antioxidant, collagen synthesis stimulation, cell proliferation, and angiogenic effects. Nanomaterials enable targeted and continuous delivery at the site of the wound, avoiding systemic adverse effects.
Article
Biochemistry & Molecular Biology
Yikun Ren, Shanshan Ma, Dan Zhang, Shen Guo, Rong Chang, Yuanmeng He, Minghao Yao, Fangxia Guan
Summary: An injectable hyaluronic acid hydrogel with antioxidative and photothermal antibacterial activity has been developed as a functional dressing for infected wounds. This hydrogel demonstrates good stability, biocompatibility, and effective prevention of early infection and acceleration of wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biotechnology & Applied Microbiology
Dongqing Wang, Heying Chen, Li Lei, Jun Chen, Jimin Gao, Jiahe Liu, Qianyin Li, Yajun Xie, Yi Hu, Yilu Ni
Summary: Effective skin wound healing involves anti-inflammation, fibrosis, matrix reconstruction, and angiogenesis. This study aimed to integrate macrophage-mediated anti-inflammation and fibroblast-assisted matrix reconstruction to enhance wound healing. The results showed that M2 macrophage cytomembranes promoted wound closure, and the addition of fibroblast membranes contributed to better matrix reconstruction and angiogenesis.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Ramin Seyedian, Fatemeh Isavi, Maryam Najafiasl, Sasan Zaeri
Summary: This study developed a nanofibrous wound dressing loaded with Cordia extract, which demonstrated good biocompatibility and wound healing promotion effects.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sara Perteghella, Alice Garzoni, Alessandro Invernizzi, Milena Sorrenti, Cinzia Boselli, Antonia Icaro Cornaglia, Daniele Dondi, Simone Lazzaroni, Giorgio Marrubini, Carla Caramella, Laura Catenacci, Maria Cristina Bonferoni
Summary: Clove oil is a powerful antioxidant essential oil with various beneficial properties. Chitosan oleate was used to stabilize the clove oil nanoemulsion, which showed good stability and antioxidant effects in vitro and in a murine burn model.
Article
Biochemistry & Molecular Biology
Rong Yang, Wenliang Xue, Huiyun Liao, Fubin Wu, Hao Guo, Wenjie Zhang, Penghui Wang, Xiaoyan Tan, Hong Xu, Bo Chi
Summary: A multifunctional hydrogel dressing with antibacterial and antioxidative properties was fabricated to promote skin tissue regeneration and wound healing. The hydrogel possessed tunable gelation time, good tissue adhesiveness, and activity to improve collagen deposition and angiogenesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Food Science & Technology
Adem Necip, Ibrahim Demirtas, Secil Erden Tayhan, Mesut Isik, Sema Bilgin, Ismail Furkan Turan, Yasar Ipek, Suekrue Beydemir
Summary: This study presents the first findings on the effects of propolis water extract on oral mucosal wound healing and the potential antioxidant and anti-Alzheimer properties of its isolated compounds.
FOOD SCIENCE & NUTRITION
(2023)
Article
Food Science & Technology
Afraa Maiza, Tesnime Ghazouani, Franks Kamgang Nzekoue, Giovanni Caprioli, Dennis Fiorini, Sauro Vittori, Beatrice Francucci, Gabriella Marucci, Michela Buccioni, Sami Fattouch
Summary: Ayurvedic literature has proven the healing properties of ghee, which can be used for wound healing. This study compares different types of Tunisian ghee and finds that ghee with high antioxidant capacity and rich in vitamins A and E can improve fibroblast migration.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mahtab Doostan, Maryam Doostan, Parisa Mohammadi, Kamyar Khoshnevisan, Hassan Maleki
Summary: Impaired wound healing can lead to prolonged wound closure, high infection rate, and disabilities. A PVA/CS nanofibrous scaffold-loaded with flaxseed extract was developed to address this issue. The scaffold demonstrated a nano-scale cross-network structure with high water absorption and porosity. It also showed antioxidant properties and inhibition of bacterial growth, promoting accelerated wound healing in vitro.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Mubashir Hussain, Huinan Suo, Ying Xie, Ke Wang, Hua Wang, Zaiyan Hou, Yujie Gao, Lianbin Zhang, Juan Tao, Hao Jiang, Jintao Zhu
Summary: The study introduces a dopamine-substituted multidomain peptide (DAP) hydrogel with antimicrobial activity, strong adhesion, and ROS scavenging properties, showing promising results in accelerating wound closure and restoring normal tissue structure in mice wound healing experiments.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Health Care Sciences & Services
Jiarui Ou, Jianglin Zhang
Summary: This article evaluates the efficacy and safety of defubao in the treatment of psoriasis through meta-analysis. The results indicate that defubao is more effective than other commonly used drugs for psoriasis, with a lower incidence of adverse events.
JOURNAL OF HEALTHCARE ENGINEERING
(2022)
Article
Agriculture, Multidisciplinary
Sha Yan, Xuan Wang, Wenqian Wang, Wenjun Peng, Kai Wang, Jiaxing Huang, Liming Wu, Wenlin Tian, Xiaofeng Xue
Summary: This study identified the pigmented substances in Leucosceptrum canum (Lamiaceae) honey using high-resolution mass spectrometry and nuclear magnetic resonance spectroscopy. These substances, including GPBQ, GAPBQ, and DPBQ, can serve as markers to control the quality of LCH.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Dermatology
Fang Yang, Xingyuan Jiang, Yuhao Zhu, Mingyang Lee, Zhengren Xu, Jianglin Zhang, Qian Li, Mao-Ying Lin, Huijun Wang, Zhimiao Lin
Summary: This study identified LSS gene variants associated with palmoplantar keratoderma-congenital alopecia syndrome type 2, resulting in loss of enzymatic activity and abnormal cornified envelope formation. These findings highlight the importance of the cholesterol synthesis pathway in human skin cornification.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wenwen Zhang, Gomez Escalada Margarita, Di Wu, Wenqin Yuan, Sha Yan, Suzhen Qi, Xiaofeng Xue, Kai Wang, Liming Wu
Summary: This study found that Chinese red propolis has antibacterial activity, with similar effects against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA). Metabolomic analysis revealed different effects of red propolis on bacteria metabolism.
Review
Food Science & Technology
Qianer Jiang, Suvimol Charoensiddhi, Xiaofeng Xue, Biqi Sun, Yang Liu, Hesham R. El-Seedi, Kai Wang
Summary: Tropical fruits are popular for their unique flavors and nutritional value. Polyphenols, the main bioactive compounds in these fruits, have beneficial effects on gastrointestinal health. This article reviews the characteristics, polyphenol types, and effects on gut health of several representative tropical fruits, and discusses the protective mechanism of polyphenols.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Mostafa H. Baky, Mostafa B. Abouelela, Kai Wang, Mohamed A. Farag
Summary: Functional foods have gained a lot of attention in dietetics due to their nutritional value and health benefits. Consumers' increasing demands for these valuable foods require advancements in production and quality assessment tools. Bee products, such as pollen and honey, are considered important food supplements rich in various nutrients and phytonutrients.
Review
Chemistry, Multidisciplinary
Mohamed A. Farag, Abiodun O. Ajayi, Mohammed Taleb, Kai Wang, Iriny M. Ayoub
Summary: Eurycoma longifolia Jack, commonly known as Tongkat Ali, is a popular traditional herbal medicine native to southeast Asia with aphrodisiac and various other health effects. It is used for sexual dysfunction, aging, anxiety, exercise recovery, increased energy, and osteoporosis. The bioactive compounds in E. longifolia, particularly quassinoids, play a major role in its health effects. This review focuses on the production of bioactives from E. longifolia using biotechnology and extraction optimization, as well as the development of green extraction methods. Analytical approaches for quality control assessment and pharmacokinetics of E. longifolia are also discussed.
Article
Environmental Sciences
Yahya Al Naggar, Christie M. Sayes, Clancy Collom, Taiwo Ayorinde, Suzhen Qi, Hesham R. El-Seedi, Robert J. Paxton, Kai Wang
Summary: In a recent study, the potential toxicity of irregularly shaped polystyrene microplastic fragments on honey bee health was investigated. The findings revealed that chronic exposure to these fragments had no effect on honey bee survival, but did decrease feeding rate and body weight, especially at a concentration of 10μg/mL, which could have long-term consequences for honey bee health. This study's findings could be beneficial for assessing the risk of microplastics on pollinator health.
Article
Pharmacology & Pharmacy
Beibei Lu, Shunyou Hu, Chengyu Wu, Jichuan Zhang, Jianglin Zhang, Jiaheng Zhang
Summary: A multifunctional nanoplatform based on molybdenum disulfide (MoS2) was developed using ionic liquid (IL) exfoliation and surface modification to prepare IL-MoS2 nanosheets. The nanosheets showed good photothermal stability and effects, effectively inhibiting tumor cell growth under laser irradiation. The nanosheets also exhibited biocompatibility, physiological stability, and biodegradability, indicating their potential in clinical cancer treatments.
ADVANCED THERAPEUTICS
(2023)
Article
Materials Science, Biomaterials
Beibei Lu, Chengyu Wu, Jichuan Zhang, Jianglin Zhang, Jiaheng Zhang
Summary: Currently, more than 70% of adults suffer from obesity, including chronic and long-term obesity cases. As diabetes patients continue to rise worldwide, there is an urgent need for effective oral drugs to replace insulin. However, the gastrointestinal tract poses a major obstacle for oral drug preparations. In this study, a highly effective oral drug in the form of an ionic liquid (IL) was developed using L-(-)-carnitine and geranic acid. The IL was found to significantly enhance transdermal drug transport and exhibited good biocompatibility and stability. Therefore, IL holds potential as a valuable carrier for oral drug delivery, providing an effective treatment for diabetes and a potential solution to the obesity epidemic.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Xueqin Huang, Lingzhi Chen, Tianjian Sha, Yongjian Lin, Runmin Zeng, Jun Xu, Shanze Chen, Huai-Hong Cai, Jianglin Zhang, Haibo Zhou, Ping-Hua Sun, Xingyu Jiang
Summary: This study presents a sensing platform for melanoma screening that combines a wearable microneedle patch and nanoparticles. The platform can detect real-time changes of tyrosinase in human skin and distinguish melanoma patients from normal individuals, providing potential clinical significance for early diagnosis and monitoring of cutaneous melanoma.
Article
Computer Science, Artificial Intelligence
Zheng Wang, Ying Xiao, Li Peng, Zhuolin Zhang, Xiaojun Li, Yang Xue, Jie Zhang, Jianglin Zhang
Summary: An AI-based approach is developed to automatically quantify ascites from CT scans, which is more efficient than manual segmentation. The proposed model demonstrates good performance and can aid radiologists in rapidly grading ascites on CT volume images.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Article
Chemistry, Applied
Hazel Corrigan, Aoife Dunne, Niamh Purcell, Yuyang Guo, Kai Wang, Hongzhuan Xuan, Daniel Granato
Summary: Designing functional foods as delivery systems is a customized strategy to reduce noncommunicable diseases risk. The study optimized a combination of t-resveratrol (RES), chlorogenic acid (CHA), and quercetin (QUE) and developed a functional tea formulation enriched with the optimal polyphenol combination (OPM). Experimental results showed that the antioxidant capacity of these compounds varied depending on the assays and compounds. Adding OPM (100 mg/L) to chamomile tea showed increased antioxidant activity and protection against oxidation.
Article
Nanoscience & Nanotechnology
Beibei Lu, Jianglin Zhang, Jiaheng Zhang
Summary: In this study, curcumin-based ionic liquid liposome (Cur-Bet-IL-Lip) was prepared using a combination of theoretical calculation and experimental research. The Cur-Bet-IL-Lip showed good stability and biocompatibility, and it could penetrate the skin's stratum corneum and deliver curcumin to the epidermis and dermis. Compared to other forms of curcumin, Cur-Bet-IL-Lip had better uptake ability and could reduce the expression of inflammatory factors and increase collagen expression in human immortalized keratinocyte cells.
ACS APPLIED BIO MATERIALS
(2023)
Review
Veterinary Sciences
Hesham R. El-Seedi, Hanan R. Ahmed, Aida A. Abd El-Wahed, Aamer Saeed, Ahmed F. Algethami, Nour F. Attia, Zhiming Guo, Syed G. Musharraf, Alfi Khatib, Sultan M. Alsharif, Yahya Al Naggar, Shaden A. M. Khalifa, Kai Wang
Summary: This review focuses on the composition of the honeybee immune system and the effects of exposure to stressors on immune competence. Nutrition and phytochemicals play a crucial role in honeybee immunity.
VETERINARY SCIENCES
(2022)
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.
