Article
Immunology
Huijeong Ahn, Hansae Lee, Gilyoung Lee, Jeongho Park, Haan-Woo Sung, Eunsong Lee, Geun-Shik Lee
Summary: The study found that parabens could disrupt Gram-negative pathogen infection through the inhibition of non-canonical inflammasome activation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Shannon N. Loftus, Jianhua Liu, Celine C. Berthier, Johann E. Gudjonsson, Mehrnaz Gharaee-Kermani, Lam C. Tsoi, J. Michelle Kahlenberg
Summary: Abnormal activation of the immune system is a known cause of lupus. Inhibiting the inflammasome and its downstream components has been shown to reduce disease severity in lupus mouse models. This study examines the effects of IL-1 beta loss on disease severity in a lupus-prone mouse model and identifies potential clinical relevance of TNF and IL-17 signaling pathways. Caution may be needed when inhibiting inflammasome or IL-1 beta signaling in SLE, especially in patients with renal involvement.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Huijeong Ahn, Gilyoung Lee, Geun-Shik Lee
Summary: Studies have shown that lower temperatures enhance the formation of MSU crystals and activation of the NLRP3 inflammasome, resulting in increased secretion of IL-1β. These findings suggest that hyperthermia therapy may reduce gout flaring.
Article
Biochemistry & Molecular Biology
Kai Wang, Cai Lu, Tong Wang, Chen Qiao, Linyu Lu, Die Wu, Ming Lu, Ruini Chen, Lu Fan, Juanjuan Tang
Summary: This study found that Hyperoside can inhibit the activation of the NLRP3 inflammasome by reducing the secretion of inflammatory factors, protecting dopaminergic neurons, and reversing motor dysfunction caused by MPTP. Hyperoside achieves this by upregulating PACAP levels.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Ji Hoon Park, Janghyun Kim, So-Young Choi, Boram Lee, Jung-Eun Lee, Heekyung Park, Ji Wook Moon, Sun-Hwa Park, Jae Min Lee, Hong Sik Lee, Junseo Oh
Summary: The study reveals that albumin/R-III inhibits the transforming growth factor-beta-Smad3 signaling by sequestering retinoic acid, leading to nuclear translocation of p65 and increased IL-1beta expression. Moreover, albumin/R-III-induced phosphorylation of Smad3 inhibits HSC activation, suggesting the potential anti-fibrotic effects of R-III.
SCIENTIFIC REPORTS
(2021)
Article
Public, Environmental & Occupational Health
Sungim Choi, Sunghee Park, Sooji Hong, Hyejoo Shin, Bong-Kwang Jung, Min Jae Kim
Summary: Fascioliasis, a food-borne helminthiasis, primarily affects cattle and sheep but can occasionally occur in humans. This study found that the aquatic herb water dropwort is the primary source of human infections in Korea. However, a cluster of patients who did not consume water dropwort but had used a green vegetable delivery service were diagnosed with fascioliasis. Further research is needed to confirm the transmission of human fascioliasis through green vegetable juice delivered by modern industrial systems.
Article
Plant Sciences
Kai Feng, Xibei Li, Yajie Yan, Ruozhenyi Liu, Zixuan Li, Nan Sun, Zhiyuan Yang, Shuping Zhao, Peng Wu, Liangjun Li
Summary: This study found that the plant height of water dropwort significantly increased after treatment with different concentrations of gibberellin (GA). Anatomical structure analysis indicated that GA treatment caused cell elongation in water dropwort. Metabolome analysis showed that flavonoids were the most abundant metabolites and their biosynthesis was regulated by GA.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Food Science & Technology
Ziyin Li, Weizuo Liao, Xinxin Yin, Lili Liu, Zhiqiang Zhao, Xiaodan Lu, Feifei Xu, Xiuqin Lin, Yingsi Chen, Jia Song, Zhini He, Qinzhi Wei, Weiliang Wu, Yongning Wu, Xingfen Yang
Summary: In this study, it was found that HYP attenuated cadmium-induced kidney injury by suppressing NLRP3 inflammasome activation. This protective effect may be achieved by reducing kidney function indexes, decreasing the release of pro-inflammatory cytokines, reducing ROS production, and suppressing NLRP3 inflammasome activation. Additionally, HYP inhibited Cd-induced MAPK/NF-kappa B pathway stimulation.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Chemistry, Medicinal
Shanshan Wei, Wanjun Ma, Chuanhao Jiang, Jiaqin Liu, Jian Liu, Bikui Zhang, Wenqun Li
Summary: The present study aimed to demonstrate the effect and mechanism of hyperoside in Doxorubicin-induced cardiotoxicity. Hyperoside attenuated the cardiac dysfunction and cardiomyocyte apoptosis induced by Doxorubicin, mainly through inhibiting the NOXs/ROS/NLRP3 inflammasome signaling pathway, which is related to oxidative stress.
PHYTOTHERAPY RESEARCH
(2023)
Article
Medicine, General & Internal
Matthias Hepprich, Jonathan M. Mudry, Claudia Gregoriano, Francois R. Jornayvaz, Sebastian Carballo, Anne Wojtusciszyn, Pierre-Alexandre Bart, Jean-Daniel Chiche, Stefan Fischli, Thomas Baumgartner, Claudia Cavelti-Weder, Dominique L. Braun, Huldrych F. Gunthard, Felix Beuschlein, Anna Conen, Emily West, Egon Isenring, Stefan Zechmann, Gabriela Bucklar, Yoann Aubry, Ludovic Dey, Beat Mueller, Patrick Hunziker, Philipp Schutz, Marco Cattaneo, Marc Y. Donath
Summary: This study examined the efficacy of canakinumab in patients with type 2 diabetes and obesity who were hospitalized with COVID-19. The results showed that canakinumab did not significantly improve the primary composite outcome of the patients. However, patients treated with canakinumab required less anti-diabetes drugs and experienced a prolonged reduction in systemic inflammation.
Article
Nutrition & Dietetics
Manal Abdulaziz Binobead, Azhar Hamad Aldakhilallah, Sahar Abdulaziz Alsedairy, Laila Naif Al-Harbi, Wahidah H. Al-Qahtani, Ghedeir M. Alshammari
Summary: This study investigated the effects of a ketogenic diet on anthropometric indices, lipid profile, and the inhibition of NLRP3 inflammasome in obese women. The results showed that the ketogenic diet led to significant weight loss, reduced waist circumference and BHB levels, and decreased BMI and appetite. Cholesterol, triglycerides, and HDL-C slightly increased, while LDL-C and 1L-1 beta decreased significantly. The questionnaire results indicated improvements in various physical symptoms.
Article
Medicine, General & Internal
Prashant Mishra, Vipin Kumar Verma, Lina Barman, Jatin Sharma, Pooja Gupta, Anant Mohan, Dharamvir Singh Arya
Summary: This study found that serum levels of SAA1 and IL-1beta may serve as potential treatment-monitoring biomarkers in adult patients with PTB and EPTB, especially during the intensive phase of therapy.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2022)
Article
Ophthalmology
Eveliina Korhonen, Maria Hytti, Niina Piippo, Kai Kaarniranta, Anu Kauppinen
Summary: This study found that damaged mitochondria induce inflammasome activation in human retinal pigment epithelial cells. Antimycin A-induced mitochondrial dysfunction leads to caspase-1-dependent inflammasome activation and production of IL-1 beta and IL-18. The study also associates AIM2 with the pathogenesis of AMD.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Judith Bockstiegel, Silas L. Wurnig, Jonas Engelhardt, Jana Enns, Finn K. Hansen, Guenther Weindl
Summary: The deficiency of HDAC6 does not affect the release of IL-1β mediated by NLRP3 in human immune cells, indicating that the inhibition of HDAC6 is not necessary for the function of the NLRP3 pathway. In addition, HDAC6 inhibitors have the potential to suppress inflammatory responses and inhibit the release of IL-1β by regulating Toll-like receptor (TLR) signaling pathway.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ines Vieira da Silva, Carlos Cardoso, Helios Martinez-Banaclocha, Angela Casini, Pablo Pelegrin, Graca Soveral
Summary: The study suggests that aquaporin AQP3 may be involved in NLRP3-inflammasome activation, affecting the production of inflammatory cytokines by regulating cell priming and cell swelling.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Immunology
Huijeong Ahn, Seung Goo Kang, Sung-il Yoon, Pyeung-Hyeun Kim, Doo Kim, Geun-Shik Lee
CELLULAR & MOLECULAR IMMUNOLOGY
(2018)
Article
Pharmacology & Pharmacy
Seong-Ryeol Kim, Jae-Hyoung Song, Jae-Hee Ahn, Geun-Shik Lee, Huijeong Ahn, Sung-il Yoon, Seung Goo Kang, Pyeung-Hyeun Kim, Sang-Min Jeon, Eun-Ji Choi, Sooyoung Shin, Younggil Cha, Sungchan Cho, Dong-eun Kim, Sun-Young Chang, Hyun-Jeong Ko
ANTIVIRAL RESEARCH
(2018)
Article
Plant Sciences
Huijeong Ahn, Byung-Cheol Han, Jeongeun Kim, Seung Goo Kang, Pyeung-Hyeun Kim, Kyoung Hwa Jang, Seung Ho So, Seung-Ho Lee, Geun-Shik Lee
JOURNAL OF GINSENG RESEARCH
(2019)
Article
Multidisciplinary Sciences
Huijeong Ahn, Jeongeun Kim, Seung Goo Kang, Sung-il Yoon, Hyun-Jeong Ko, Pyeung-Hyeun Kim, Eui-Ju Hong, Beum-Soo An, Eunsong Lee, Geun-Shik Lee
SCIENTIFIC REPORTS
(2018)
Article
Plant Sciences
Jeongeun Kim, Huijeong Ahn, Byung-Cheol Han, Hyunjung Shin, Jin-Chul Kim, Eui-Man Jung, Juyeol Kim, Heejung Yang, Jeonghyun Lee, Seung Goo Kang, Seung-Ho Lee, Geun-Shik Lee
Article
Biochemistry & Molecular Biology
Jeongeun Kim, Huijeong Ahn, Sangjung Yu, Jae-Hee Ahn, Hyun-Jeong Ko, Mi-Na Kweon, Eui-Ju Hong, Beum-Soo An, Eunsong Lee, Geun-Shik Lee
Article
Veterinary Sciences
Huijeong Ahn, Jeongeun Kim, Hansae Lee, Eunsong Lee, Geun-Shik Lee
VETERINARY RESEARCH COMMUNICATIONS
(2020)
Review
Plant Sciences
Huijeong Ahn, Byung-Cheol Han, Seung-Ho Lee, Geun-Shik Lee
JOURNAL OF GINSENG RESEARCH
(2020)
Article
Plant Sciences
Huijeong Ahn, Byung-Cheol Han, Eui-Ju Hong, Beum-Soo An, Eunsong Lee, Seung-Ho Lee, Geun-Shik Lee
Summary: The study found that RGE and its saponins can inhibit the secretion of IL-1 beta in response to UV exposure in skin keratinocytes and macrophages, with RGE primarily interrupting the priming step in keratinocytes.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Cell Biology
Huijeong Ahn, Gilyoung Lee, Jeongeun Kim, Jeongho Park, Seung Goo Kang, Sung-Il Yoon, Eunsong Lee, Geun-Shik Lee
Summary: NLRP3 inflammasome activation inhibits LCN2 secretion while inducing IL-1β in mouse macrophages. The inhibition of NLRP3 triggers on LCN2 secretion is caused by the inhibited transcription and translation of LCN2, suggesting a new linkage between inflammasome activation and LCN2 secretion in the innate immunity.
Article
Cell Biology
Huijeong Ahn, Gilyoung Lee, Geun-Shik Lee
Summary: Studies have shown that lower temperatures enhance the formation of MSU crystals and activation of the NLRP3 inflammasome, resulting in increased secretion of IL-1β. These findings suggest that hyperthermia therapy may reduce gout flaring.
Article
Immunology
Huijeong Ahn, Hansae Lee, Gilyoung Lee, Jeongho Park, Haan-Woo Sung, Eunsong Lee, Geun-Shik Lee
Summary: The study found that parabens could disrupt Gram-negative pathogen infection through the inhibition of non-canonical inflammasome activation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Huijeong Ahn, Gilyoung Lee, Byung-Cheol Han, Seung-Ho Lee, Geun-Shik Lee
Summary: This study found that maltol can inhibit the activation of inflammasomes, thus reducing inflammation. By inhibiting ROS production and Casp1 activity, maltol exerts its anti-inflammatory effects.
Article
Multidisciplinary Sciences
Huijeong Ahn, Geun-Shik Lee
SCIENTIFIC REPORTS
(2020)
Review
Medicine, Research & Experimental
Huijeong Ahn, Hyuk Moo Kwon, Eunsong Lee, Pyeung-Hyeun Kim, Eui-Bae Jeung, Geun-Shik Lee
JOURNAL OF BIOMEDICAL RESEARCH
(2018)
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.
