Article
Chemistry, Multidisciplinary
Sandra Ardevines, Fernando Auria-Luna, Eduardo Romanos, Vanesa Fernandez-Moreira, Andrea Benedi, M. Concepcion Gimeno, Isabel Marzo, Eugenia Marques-Lopez, Raquel P. Herrera
Summary: 1,4-Dihydropyridine is a privileged scaffold with good anticancer activity. A family of 23 new compounds based on this structure core has been synthesized, and their cytotoxicity and photo-physical properties have been evaluated.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Anabela S. Ramalho, Mieke Boon, Marijke Proesmans, Francois Vermeulen, Marianne S. Carlon, Kris De Boeck
Summary: Cystic fibrosis is a genetic disease characterized by abnormal CFTR protein function. Reliable tests are needed to measure CFTR function for diagnosis and treatment evaluation. In vitro, ex vivo, and in vivo assays are available to measure ion flux, current, and membrane potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Dahee Shim, Hwa-Jin Kim, Jungu Lee, You-Min Lee, Jae-Woong Park, Siyoung Yang, Gyeong-Hweon Lee, Myoung Ja Chung, Han-Jung Chae
Summary: With the COVID-19 pandemic, lung disorders have become a significant concern. The most common form of asthma, allergic asthma, is targeted by treatments that address inflammation. However, side effects and the heterogeneity of the condition limit the effectiveness of current treatments. This study examined the protective effects of Citrus junos Tanaka peel extract (B215) on lung inflammation and found that it reduced immune cell infiltration, plasma IgE levels, airway resistance, mucus hypersecretion, and cytokine production. These findings suggest that B215 could be a promising functional food for treating lung inflammation without adverse effects.
Article
Biochemistry & Molecular Biology
Nesren Elsayed, Hatem Sharaf El-Din, Ammar B. Altemimi, Hanaa Y. Ahmed, Anubhav Pratap-Singh, Tarek Gamal Abedelmaksoud
Summary: Egyptian beebread (EBB) was found to be a good source of protein, total free sugar, and potassium with high levels of polyunsaturated and monounsaturated fatty acids. EBB demonstrated strong antioxidant, antimicrobial, and antitumor activities, showing potential for use as natural food supplements and preservatives. The extract from EBB also showed better antiradical activity compared to the reference compound BHT.
Review
Pharmacology & Pharmacy
Marta Kus, Izabela Ibragimow, Hanna Piotrowska-Kempisty
Summary: This study aims to review the conditions for permeability studies across the Caco-2 monolayer reported in the available literature concerning validation guidelines. By summarizing the main aspects affecting the validation process, we can provide useful information for preparing the cell line and further permeability research.
Article
Nutrition & Dietetics
Ping Li, Xu Yao, Qingqing Zhou, Xia Meng, Tao Zhou, Qing Gu
Summary: This study investigated the extraction, component analysis, biological activity, and regulation of intestinal microbiota of citrus peel flavonoid extracts (CPFEs). The results showed that lemon had the highest total flavonoid content, while grapefruit, chachiensis, and lemon had the highest concentrations of naringin, hesperidin, and eriocitrin, respectively. CPFEs from grapefruit and chachiensis exhibited better antioxidant activity, alpha-glucosidase inhibitory activity, and sodium glycocholate binding ability. Furthermore, grapefruit and chachiensis CPFEs had positive effects on intestinal microecology, as they increased the relative abundance of Bifidobacterium spp. and the production of short-chain fatty acids.
FRONTIERS IN NUTRITION
(2022)
Article
Polymer Science
Imran Kazmi, Fahad A. Al-Abbasi, Syed Sarim Imam, Muhammad Afzal, Muhammad Shahid Nadeem, Hisham N. Altayb, Sultan Alshehri
Summary: LPHNPs encapsulated with PPN were developed to overcome the physicochemical limitations of PPN. The optimized PPN-LPHNPs showed small particle size, low polydispersity index, and high positive surface charge. PPN-LPHNPs exhibited excellent cytotoxicity against breast cancer cells and improved intestinal permeation and oral bioavailability compared to the conventional PPN suspension.
Review
Biochemistry & Molecular Biology
Radka Michalkova, Ladislav Mirossay, Martin Kello, Gabriela Mojzisova, Janette Baloghova, Anna Podracka, Jan Mojzis
Summary: There has been significant progress in tumor therapy in recent decades, but discovering new molecules with potential antitumor properties remains a major challenge in the field of anticancer therapy. Plants, especially nature, provide a rich source of phytochemicals with diverse biological activities. Chalcones, the bioprecursors of flavonoid and isoflavonoids synthesis in higher plants, have gained attention due to their broad spectrum of biological activities with potential clinical applications. This review summarizes the current knowledge regarding the antiproliferative and anticancer effects of natural chalcones in various types of malignancies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Xiaoyu Han, Lu Jin, Zhimin Zhao, Xinjun Xu, Shiyi Liu, Yuquan Huang, Xiaoli Liu, Yuehong Xu, Depo Yang, Wei Huang, Li Wang
Summary: The leaves of Strobilanthes cusia Kuntze exhibit antibacterial effects on penicillin-resistant Streptococcus pneumoniae. Confocal assay and Transmission Electron Microscopy revealed reduced cell wall integrity and capsule thickness in the treated bacteria. Proteomics analysis identified glycometabolism-related pathways and 23 bio-active compounds, among which Tryptanthrin showed the most promising effect.
Article
Biotechnology & Applied Microbiology
V. R. Yenuganti, R. Yadala, R. Azad, S. Singh, V. Chiluka, J. Ahire, P. Reddanna
Summary: The study identified 11 probiotic strains with anticancer effects on human colorectal carcinoma cells, affecting gene expression, some of which induced apoptosis and could be potential candidates for CRC treatment.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Biophysics
Shabi Parvez, Archana Karole, Shyam Lal Mudavath
Summary: In this study, a solid lipid nanoparticle system encapsulating a bioactive was developed and its efficacy in a human colorectal cell line was evaluated. The nerolidol loaded solid lipid nanoparticles demonstrated satisfactory properties and enhanced biological activity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biochemistry & Molecular Biology
S. Shyamalagowri, P. Charles, J. Manjunathan, M. Kamaraj, R. Anitha, A. Pugazhendhi
Summary: Every year, millions of people die from cancer, and the development of effective anticancer drugs is crucial. In this study, dragon fruit peel aqueous extract fabricated silver nanoparticles (DFPAE-AgNPs) were synthesized using a facile and green chemistry approach as a new potential anticancer agent. The DFPAE-AgNPs were spherical in shape, with a size range of 10-50 nm, and contained 73.90% silver element. The IC50 value of the DFPAE-AgNPs was found to be 37.98 +/- 0.21 μg/mL for the HepG2 cell line. The results also showed a dose-dependent increase in apoptosis in HepG2 cells treated with DFPAE-AgNPs. These findings suggest that DFPAE could be a reliable and active phytoconstituent for the fabrication of AgNPs with anticancer properties.
PROCESS BIOCHEMISTRY
(2022)
Article
Plant Sciences
Haneen Ibrahim Al Othman, Huda Hisham Alkatib, Atiqah Zaid, Sreenivasan Sasidharan, Siti Sarah Fazalul Rahiman, Tien Ping Lee, George Dimitrovski, Jalal T. Althakafy, Yong Foo Wong
Summary: This study investigated the volatile constituents and pharmacological potential of essential oils from four Citrus plant species. The results showed that these Citrus leaf oils exhibited antioxidant and antiproliferative activities, suggesting potential therapeutic effects against cancer cells.
Article
Pharmacology & Pharmacy
Haifang Chen, Guofeng Li, Ye Liu, Yifan Lang, Wuliang Yang, Wugang Zhang, Xinli Liang
Summary: The study found that a traditional Chinese medicine, Jiegeng decoction, can enhance the anticancer effect of Paclitaxel (PTX) by improving immune response and reversing drug resistance. This combination therapy shows potential in the management of lung cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Adedamola S. Arojojoye, Jong H. Kim, Chibuzor Olelewe, Sean Parkin, Samuel G. Awuah
Summary: The emerging synthetic development of chiral gold(III) complexes has shown new opportunities in catalysis and material science, and this study demonstrates the potential chemotherapeutic capability of a specific gold(III) complex.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Applied
Balaji Govindan, Anil John Johnson, Gayathri Viswanathan, Venkataraman Ramaswamy, Konnath Chacko Koshy, Sabulal Baby
NATURAL PRODUCT RESEARCH
(2019)
Article
Energy & Fuels
Vijayalekshmi Anju, Koranappallil Bahuleyan Rameshkumar, Sabulal Baby
ENERGY SOURCES PART A-RECOVERY UTILIZATION AND ENVIRONMENTAL EFFECTS
(2019)
Article
Chemistry, Applied
Reshma V. R. Nair, Devi Velayudhan Jayasree, Prabath Gopalakrishnan Biju, Sabulal Baby
NATURAL PRODUCT RESEARCH
(2020)
Review
Oncology
Vipin Mohan Dan, Thania Sara Varghese, Gayathri Viswanathan, Sabulal Baby
CURRENT CANCER DRUG TARGETS
(2020)
Article
Multidisciplinary Sciences
Ajikumaran Nair Sadasivan Nair, Reshma Vijayakumari Raveendran Nair, Aroma Prasanna Rajendran Nair, Akhila Sasikumar Nair, Sabu Thyagarajan, Anil John Johnson, Sabulal Baby
Review
Chemistry, Medicinal
Vipin Mohan Dan, Reji Saradha Raveendran, Sabulal Baby
Summary: Breast cancer is the most prevalent cancer in women globally, and Paclitaxel (PTX) is a frontline chemotherapy drug that has led to the exploration of new therapeutic targets in overcoming PTX resistance. Combining synthetic/natural therapeutics with PTX may help to combat resistance.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Applied
Nikitha Sabulal, Sabulal Baby
Summary: This article provides a comprehensive review of the chemical profiles of Amomum essential oils, focusing on the rich presence of 1,8-cineole in certain species. It also highlights the factors influencing the quality of essential oils, such as plant genotype, collection season, and isolation techniques, while emphasizing the need for further research on uninvestigated Amomum species.
JOURNAL OF ESSENTIAL OIL RESEARCH
(2021)
Article
Agricultural Engineering
Renju Kunjumon, Anil John Johnson, Rajani Kurup Sukumaryamma Remadevi, Sabulal Baby
Summary: This study screened the ASI and MAD contents of Centella asiatica accessions from a wide geographical area in south India, and identified elite lines with high saponin contents. The study also revealed the preferences of Centella asiatica for soil and ecological factors. These findings have important implications for the collection, cultivation, and conservation of Centella asiatica resources.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Multidisciplinary Sciences
Konnath Chacko Koshy, Bhaskaran Gopakumar, Antony Sebastian, Ajikumaran S. Nair, Anil John Johnson, Balaji Govindan, Sabulal Baby
Summary: This study provides insights into the flowering phenology, fruiting dynamics, and animal interactions of Melocanna baccifera, the largest fruit-producing bamboo. The study spanned over 13 years and observed eight clumps of M. baccifera, recording various aspects such as flowering duration, fruit production, and predation patterns. The findings highlight the vibrant interaction between M. baccifera flowers/fruits and visitors/predators, and provide leads towards understanding the cause of rat multiplication associated with its gregarious flowering.
Article
Chemistry, Applied
Akhil Sree Kumar, Rajani Kurup Sukumaryamma Remadevi, Anil John Johnson, Vinayak Venukumar, Farzana M. Sha, Thania Sara Varghese, Sabulal Baby
Summary: Elettaria cardamomum leaf essential oil has been poorly studied and utilized. This research analyzed the chemical composition of cardamom leaf essential oils from different locations in southern Western Ghats, India, and compared them with fresh and dry capsules. The major constituents were beta-pinene and coronarin E. Fumigant toxicity assays revealed that the essential oil from fresh capsules had the lowest LC50 against Tribolium castaneum, followed by dry capsules and leaves, and the LC50s against Sitophilus oryzae were significantly lower for fresh capsules compared to dry capsules and leaves. This study demonstrates the potential of cardamom leaves as a source of bioactive compounds for botanical pesticides.
JOURNAL OF ESSENTIAL OIL RESEARCH
(2023)
Article
Chemistry, Medicinal
Reshma Vijayakumari Raveendran Nair, Ajikumaran Nair Sadasivan Nair, Anil John Johnson, Ananthakrishnan Jayakumaran Nair, Sabulal Baby
Summary: Humboldtia unijuga Bedd., an endemic tree species in the southern region of Western Ghats in India, remains poorly explored for its chemical constituents and biological activities. This study identified twenty-nine secondary metabolites, including four new molecules, from the roots and stems of H. unijuga. Among them, oleanolic acid-3-acetate and (2S)-1-O-palmitoyl-2-O-(9Z-octadecenoyl)-3-O-(6'-sulfo-α-D-quinovopyranosyl) glycerol exhibited promising anticancer activity by inducing cell-specific apoptosis in C6 and DLA cells.
MEDICINAL CHEMISTRY RESEARCH
(2023)
Article
Plant Sciences
S. N. A. Nair, A. J. Johnson, T. Sabu, B. S. Gokul, H. M. Yeshwanth, B. Sabulal
Summary: This article reports a rare plant-insect interaction between the leafhopper Aloka depressa and the host liana, Diploclisia glaucescens. Field observations and SEM micrographs are used to provide evidence for this interaction. 20-Hydroxyecdysone, an insect moulting hormone, is detected and quantified in D. glaucescens. 20-Hydroxyecdysone is also found in the excrement of A. depressa. This association between the plant and insect is not damaging the host liana and showcases a unique plant-insect interaction.
Article
Agricultural Engineering
Renju Kunjumon, Anil John Johnson, Rajani Kurup Sukumaryamma Remadevi, Sabulal Baby
Summary: High domestic and export demands are leading to the uncontrolled collection of Bacopa monnieri herb from India. The selection and cultivation of elite genotypes is a priority for generating quality biomass. This study identified eight elite accessions of Bacopa monnieri with high levels of bioactive compounds. It also found that low altitude, wet, and marshy habitats are preferred by the herb. This study provides valuable information for the conservation and sustainable utilization of Bacopa monnieri.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Neurosciences
Vini C. Sekhar, Kamalesh K. Gulia, Ayswaria Deepti, P. S. Baby Chakrapani, Sabulal Baby, Gayathri Viswanathan
Summary: Research has found that nanoparticles of bacoside A (BM3) and bacopaside I (BM4) can alleviate seizures and protect neurons from damage.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Chemistry, Medicinal
Rajani Kurup, Ajikumaran Nair Sadasivan, Uthayakumari Kalavathy, Sabulal Baby
NATURAL PRODUCTS JOURNAL
(2020)
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.