Conformational dynamics and self-association of intrinsically disordered Huntingtin exon 1 in cells

Molecular mechanisms of protein aggregation from global fitting of kinetic models

(2016) Georg Meisl et al.   Nature Protocols

Misfolded Polyglutamine, Polyalanine, and Superoxide Dismutase 1 Aggregate via Distinct Pathways in the Cell

(2014) Saskia Polling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Temperature-dependent solvation modulates the dimensions of disordered proteins

(2014) R. Wuttke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CAPITO—a web server-based analysis and plotting tool for circular dichroism data

(2013) Christoph Wiedemann et al.   BIOINFORMATICS

DJ-1 modulates aggregation and pathogenesis in models of Huntington's disease

(2013) Muhammad U. Sajjad et al.   HUMAN MOLECULAR GENETICS

Live cell imaging and biophotonic methods reveal two types of mutant huntingtin inclusions

(2013) Nicholas S. Caron et al.   HUMAN MOLECULAR GENETICS

A Platform to View Huntingtin Exon 1 Aggregation Flux in the Cell Reveals Divergent Influences from Chaperones hsp40 and hsp70

(2013) Angelique R. Ormsby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-Molecule Spectroscopy of Cold Denaturation and the Temperature-Induced Collapse of Unfolded Proteins

(2013) Mikayel Aznauryan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tyrosine 416 Is Phosphorylated in the Closed, Repressed Conformation of c-Src

(2013) Sevgi Irtegun et al.   PLoS One

Beta conformation of polyglutamine track revealed by a crystal structure of Huntingtin N-terminal region with insertion of three histidine residues

(2013) Meewhi Kim   Prion

Unmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation

(2013) S. L. Crick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin

(2013) Nicholas Stephane Caron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temperature dependence of protein folding kinetics in living cells

(2012) M. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Inclusion Bodies of Mutant Huntingtin Exon 1 Obscure Small Fibrillar Aggregate Species

(2012) Steffen J. Sahl et al.   Scientific Reports

Assessing the contribution of heterogeneous distributions of oligomers to aggregation mechanisms of polyglutamine peptides

(2011) Andreas Vitalis et al.   BIOPHYSICAL CHEMISTRY

Protein Stability and Folding Kinetics in the Nucleus and Endoplasmic Reticulum of Eucaryotic Cells

(2011) A. Dhar et al.   BIOPHYSICAL JOURNAL

Aggregation Kinetics of Interrupted Polyglutamine Peptides

(2011) Robert H. Walters et al.   JOURNAL OF MOLECULAR BIOLOGY

A new micropatterning method of soft substrates reveals that different tumorigenic signals can promote or reduce cell contraction levels

(2011) Qingzong Tseng et al.   LAB ON A CHIP

A Two-Step Path to Inclusion Formation of Huntingtin Peptides Revealed by Number and Brightness Analysis

(2010) Giulia Ossato et al.   BIOPHYSICAL JOURNAL

Tracking Mutant Huntingtin Aggregation Kinetics in Cells Reveals Three Major Populations That Include an Invariant Oligomer Pool

(2010) Maya A. Olshina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein folding stability and dynamics imaged in a living cell

(2010) Simon Ebbinghaus et al.   NATURE METHODS

Estimation of the number of α-helical and β-strand segments in proteins using circular dichroism spectroscopy

(2010) Narasimha Sreerama et al.   PROTEIN SCIENCE

An accurate model of polyglutamine

(2010) Jyothi L. Digambaranath et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Application of a temperature-dependent fluorescent dye (Rhodamine B) to the measurement of radiofrequency radiation-induced temperature changes in biological samples

(2009) Yuen Y. Chen et al.   BIOELECTROMAGNETICS

The Predicted Structure of the Headpiece of the Huntingtin Protein and Its Implications on Huntingtin Aggregation

(2009) Nicholas W. Kelley et al.   JOURNAL OF MOLECULAR BIOLOGY

Examining Polyglutamine Peptide Length: A Connection between Collapsed Conformations and Increased Aggregation

(2009) Robert H. Walters et al.   JOURNAL OF MOLECULAR BIOLOGY

The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation

(2009) Stephen Tam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism

(2009) Ashwani K Thakur et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Single-molecule spectroscopy of the temperature-induced collapse of unfolded proteins

(2009) D. Nettels et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Towards a transgenic model of Huntington’s disease in a non-human primate

(2008) Shang-Hsun Yang et al.   NATURE

PCR-amplification of GC-rich regions: 'slowdown PCR'

(2008) Ulrich H Frey et al.   Nature Protocols