A Platform to View Huntingtin Exon 1 Aggregation Flux in the Cell Reveals Divergent Influences from Chaperones hsp40 and hsp70

PolyQ Proteins Interfere with Nuclear Degradation of Cytosolic Proteins by Sequestering the Sis1p Chaperone

(2013) Sae-Hun Park et al.   CELL

Putting Huntingtin “Aggregation” in View with Windows into the Cellular Milieu

(2013) Danny M. Hatters   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Disease-Associated Polyglutamine Stretches in Monomeric Huntingtin Adopt a Compact Structure

(2012) Clare Peters-Libeu et al.   JOURNAL OF MOLECULAR BIOLOGY

Physical Chemistry of Polyglutamine: Intriguing Tales of a Monotonous Sequence

(2012) Ronald Wetzel   JOURNAL OF MOLECULAR BIOLOGY

Tracking protein aggregation and mislocalization in cells with flow cytometry

(2012) Yasmin M Ramdzan et al.   NATURE METHODS

The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities

(2011) Jurre Hageman et al.   BIOCHEMICAL JOURNAL

A Compact β Model of huntingtin Toxicity

(2011) Qi Charles Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Amyloid-β forms fibrils by nucleated conformational conversion of oligomers

(2011) Jiyong Lee et al.   Nature Chemical Biology

Identifying polyglutamine protein species in situ that best predict neurodegeneration

(2011) Jason Miller et al.   Nature Chemical Biology

Amyloid fibril protein nomenclature: 2010 recommendations from the nomenclature committee of the International Society of Amyloidosis

(2010) Jean D. Sipe et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Conformation Sensors that Distinguish Monomeric Proteins from Oligomers in Live Cells

(2010) Yasmin M. Ramdzan et al.   CHEMISTRY & BIOLOGY

Tracking Mutant Huntingtin Aggregation Kinetics in Cells Reveals Three Major Populations That Include an Invariant Oligomer Pool

(2010) Maya A. Olshina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp70 and Hsp40 Functionally Interact with Soluble Mutant Huntingtin Oligomers in a Classic ATP-dependent Reaction Cycle

(2010) Gregor P. Lotz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A causative link between the structure of aberrant protein oligomers and their toxicity

(2010) Silvia Campioni et al.   Nature Chemical Biology

Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

(2010) Della C. David et al.   PLOS BIOLOGY

Conformational detection of prion protein with biarsenical labeling and FlAsH fluorescence

(2009) Bradley M. Coleman et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Far-red fluorescent tags for protein imaging in living tissues

(2009) Dmitry Shcherbo et al.   BIOCHEMICAL JOURNAL

Thermodynamics of β-Sheet Formation in Polyglutamine

(2009) Andreas Vitalis et al.   BIOPHYSICAL JOURNAL

Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice

(2009) Ehud Cohen et al.   CELL

Examining Polyglutamine Peptide Length: A Connection between Collapsed Conformations and Increased Aggregation

(2009) Robert H. Walters et al.   JOURNAL OF MOLECULAR BIOLOGY

Loss of Hsp70 Exacerbates Pathogenesis But Not Levels of Fibrillar Aggregates in a Mouse Model of Huntington's Disease

(2009) J. L. Wacker et al.   JOURNAL OF NEUROSCIENCE

Single homopolypeptide chains collapse into mechanically rigid conformations

(2009) L. Dougan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secondary Structure of Huntingtin Amino-Terminal Region

(2009) Mee Whi Kim et al.   STRUCTURE

The Intrinsic Stiffness of Polyglutamine Peptides

(2008) Vijay R. Singh et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Misfolded proteins partition between two distinct quality control compartments

(2008) Daniel Kaganovich et al.   NATURE

A polymer physics perspective on driving forces and mechanisms for protein aggregation

(2007) Rohit V. Pappu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Time-lapse analysis of aggregate formation in an inducible PC12 cell model of Huntington's disease reveals time-dependent aggregate formation that transiently delays cell death

(2007) B. Gong et al.   BRAIN RESEARCH BULLETIN