DNA Repair by the Radical SAM Enzyme Spore Photoproduct Lyase: From Biochemistry to Structural Investigations

Mechanisms of DNA Repair by Photolyase and Excision Nuclease (Nobel Lecture)

(2016) Aziz Sancar   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sulfatases and radical SAM enzymes: emerging themes in glycosaminoglycan metabolism and the human microbiota

(2016) A. Benjdia et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Rhodobacter sphaeroidesCryB is a bacterial cryptochrome with (6-4) photolyase activity

(2016) Andrea von Zadow et al.   FEBS Journal

The B12-Radical SAM Enzyme PoyC Catalyzes Valine Cβ-Methylation during Polytheonamide Biosynthesis

(2016) Aubérie Parent et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Carbon extension in peptidylnucleoside biosynthesis by radical SAM enzymes

(2016) Edward A Lilla et al.   Nature Chemical Biology

Why Nature Uses Radical SAM Enzymes so Widely: Electron Nuclear Double Resonance Studies of Lysine 2,3-Aminomutase Show the 5′-dAdo• “Free Radical” Is Never Free

(2015) Masaki Horitani et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photochemistry and Photobiology of the Spore Photoproduct: A 50-Year Journey

(2015) Peter Setlow et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

The thiostrepton A tryptophan methyltransferase TsrM catalyses a cob(II)alamin-dependent methyl transfer reaction

(2015) Alhosna Benjdia et al.   Nature Communications

Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase

(2014) Alhosna Benjdia et al.   CHEMICAL COMMUNICATIONS

Radical S-Adenosylmethionine Enzymes

(2014) Joan B. Broderick et al.   CHEMICAL REVIEWS

Solution phase dynamics of the DNA repair enzyme spore photoproduct lyase as probed by H/D exchange

(2014) Shourjo Ghose et al.   FEBS LETTERS

Spore Photoproduct Lyase: The Known, the Controversial, and the Unknown

(2014) Linlin Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combined Mössbauer spectroscopic, multi-edge X-ray absorption spectroscopic, and density functional theoretical study of the radical SAM enzyme spore photoproduct lyase

(2014) Sunshine C. Silver et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

The structure of an authentic spore photoproduct lesion in DNA suggests a basis for recognition

(2014) Isha Singh et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A Radical Transfer Pathway in Spore Photoproduct Lyase

(2013) Linlin Yang et al.   BIOCHEMISTRY

Chemical Syntheses of Oligodeoxyribonucleotides Containing Spore Photoproduct

(2013) Yajun Jian et al.   JOURNAL OF ORGANIC CHEMISTRY

The catalytic mechanism for aerobic formation of methane by bacteria

(2013) Siddhesh S. Kamat et al.   NATURE

Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism

(2013) Daniel P Dowling et al.   Nature Chemical Biology

Crystal structure of a prokaryotic (6-4) photolyase with an Fe-S cluster and a 6,7-dimethyl-8-ribityllumazine antenna chromophore

(2013) F. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

X-ray structure of an AdoMet radical activase reveals an anaerobic solution for formylglycine posttranslational modification

(2013) P. J. Goldman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Radical SAM enzymes and radical enzymology

(2012) Squire J. Booker   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

DNA photolyases and SP lyase: structure and mechanism of light-dependent and independent DNA lyases

(2012) Alhosna Benjdia   CURRENT OPINION IN STRUCTURAL BIOLOGY

CryB from Rhodobacter sphaeroides: a unique class of cryptochromes with new cofactors

(2012) Yann Geisselbrecht et al.   EMBO REPORTS

Electron Tunneling Pathways and Role of Adenine in Repair of Cyclobutane Pyrimidine Dimer by DNA Photolyase

(2012) Zheyun Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thiostrepton tryptophan methyltransferase expands the chemistry of radical SAM enzymes

(2012) Stéphane Pierre et al.   Nature Chemical Biology

Structural insights into recognition and repair of UV-DNA damage by Spore Photoproduct Lyase, a radical SAM enzyme

(2012) Alhosna Benjdia et al.   NUCLEIC ACIDS RESEARCH

Structural Insights into Radical Generation by the Radical SAM Superfamily

(2011) Jessica L. Vey et al.   CHEMICAL REVIEWS

Crystal Structures and Repair Studies Reveal the Identity and the Base-Pairing Properties of the UV-Induced Spore Photoproduct DNA Lesion

(2011) Korbinian Heil et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chemical Synthesis, Crystal Structure and Enzymatic Evaluation of a Dinucleotide Spore Photoproduct Analogue Containing a Formacetal Linker

(2011) Gengjie Lin et al.   CHEMISTRY-A EUROPEAN JOURNAL

Probing the Reaction Mechanism of Spore Photoproduct Lyase (SPL) via Diastereoselectively Labeled Dinucleotide SP TpT Substrates

(2011) Linlin Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dynamics and mechanism of cyclobutane pyrimidine dimer repair by DNA photolyase

(2011) Z. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Radically Different Mechanism for S-Adenosylmethionine-Dependent Methyltransferases

(2011) T. L. Grove et al.   SCIENCE

Structural Basis for Methyl Transfer by a Radical SAM Enzyme

(2011) A. K. Boal et al.   SCIENCE

Elucidation of Spore-Photoproduct Formation by Isotope Labeling

(2010) Gengjie Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Complete stereospecific repair of a synthetic dinucleotide spore photoproduct by spore photoproduct lyase

(2010) Sunshine C. Silver et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Diphthamide biosynthesis requires an organic radical generated by an iron–sulphur enzyme

(2010) Yang Zhang et al.   NATURE

Dynamics and mechanism of repair of ultraviolet-induced (6–4) photoproduct by photolyase

(2010) Jiang Li et al.   NATURE

A role for the elongator complex in zygotic paternal genome demethylation

(2010) Yuki Okada et al.   NATURE

Spore Photoproduct: A Key to Bacterial Eternal Life

(2009) Céline Desnous et al.   CHEMICAL REVIEWS

Identification and Characterization of a Novel Member of the Radical AdoMet Enzyme Superfamily and Implications for the Biosynthesis of the Hmd Hydrogenase Active Site Cofactor

(2009) S. E. McGlynn et al.   JOURNAL OF BACTERIOLOGY

Spore Photoproduct Lyase Catalyzes Specific Repair of the 5Rbut Not the 5SSpore Photoproduct

(2009) Tilak Chandra et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of the human RECQ1 helicase reveals a putative strand-separation pin

(2009) A. C. W. Pike et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure and Mechanism of a DNA (6-4) Photolyase

(2008) Melanie J. Maul et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and properties of DNA containing a spore photoproduct analog

(2008) Eva Bürckstümmer et al.   CHEMICAL COMMUNICATIONS

The Radical SAM Superfamily

(2008) Perry A. Frey et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

DNA Repair and Free Radicals, New Insights into the Mechanism of Spore Photoproduct Lyase Revealed by Single Amino Acid Substitution

(2008) Alexia Chandor-Proust et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Function of Photolyase andin VivoEnzymology: 50th Anniversary

(2008) Aziz Sancar   JOURNAL OF BIOLOGICAL CHEMISTRY

Combined NMR and DFT Studies for the Absolute Configuration Elucidation of the Spore Photoproduct, a UV-Induced DNA Lesion

(2008) Claire Mantel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily

(2008) Abhishek Chatterjee et al.   Nature Chemical Biology

Structure of a protein-DNA complex essential for DNA protection in spores of Bacillus species

(2008) K. S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for glycyl radical formation by pyruvate formate-lyase activating enzyme

(2008) J. L. Vey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA