Article
Gastroenterology & Hepatology
Vu Q. Nguyen, Fabiano Celio, Maithili Chitnavis, Mohammad Shakhatreh, Jeffry Katz, Fabio Cominelli, Amitabh Chak, Paul Yeaton
Summary: This study examined the role of EUS in distinguishing between Crohn's disease and ulcerative colitis, finding that it can be used to diagnose active and inactive disease by measuring colon wall layer thickness and assessing transmural disease activity.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Marina Liso, Giulio Verna, Elisabetta Cavalcanti, Stefania De Santis, Raffaele Armentano, Angela Tafaro, Antonio Lippolis, Pietro Campiglia, Antonio Gasbarrini, Mauro Mastronardi, Theresa Torres Pizarro, Fabio Cominelli, Loris Riccardo Lopetuso, Marcello Chieppa
Summary: This study provides new insights and alternative approaches to treat ulcerative colitis (UC) patients. It suggests that anti-interleukin (IL)1 strategies, such as anakinra, may be a more effective therapeutic option for primary nonresponders to anti-tumor necrosis factor (TNF) therapy.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Multidisciplinary Sciences
Ryan W. Gan, Diana Sun, Amanda R. Tatro, Shirley Cohen-Mekelburg, Wyndy L. Wiitala, Ji Zhu, Akbar K. Waljee
Summary: This study replicated a machine-learning model's ability to predict acute exacerbations of inflammatory bowel disease (IBD) in a nationally representative cohort, with the random forest model outperforming the logistic regression model.
Review
Gastroenterology & Hepatology
Tommaso Lorenzo Parigi, Ferdinando D'Amico, Maria Abreu, Axel Dignass, Iris Dotan, Fernando Magro, Anne M. Griffiths, Vipul Jairath, Marietta Iacucci, Gerassimos J. Mantzaris, Colm O'Morain, Walter Reinisch, David B. Sachar, Dan Turner, Takayuki Yamamoto, David Rubin, Laurent Peyrin-Biroulet, Subrata Ghosh, Silvio Danese
Summary: Under the guidance of the International Organization for the Study of Inflammatory Bowel Disease, a consensus meeting was held to propose a common operative definition for difficult-to-treat IBD. Difficult-to-treat IBD is defined by the failure of biologics and advanced small molecules with at least two different mechanisms of action, or postoperative recurrence of Crohn's disease after two surgical resections in adults, or one in children. Chronic antibiotic-refractory pouchitis, complex perianal disease, and comorbid psychosocial complications that impair disease management also qualified as difficult-to-treat IBD.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Nutrition & Dietetics
Guangcong Ruan, Minjia Chen, Lu Chen, Fenghua Xu, Zhifeng Xiao, Ailin Yi, Yuting Tian, Yi Ping, Linling Lv, Yi Cheng, Yanling Wei
Summary: The pathogenesis of ulcerative colitis is unclear but is believed to be related to an imbalance in gut microbiota. This study found that Roseburia intestinalis may play a role in relieving colitis by upregulating Toll-like receptor 5 transcription.
Article
Biotechnology & Applied Microbiology
Lei Guo, Xiuze Chen, Haifeng Zeng, Na Tian, Weijie Lu, Jizhou Zhang, Yechen Xiao
Summary: This study presents a novel approach for expressing IL-18BP fusion protein in E. coli by fusing it with SUMO and IgG1 Fc fragments. The resulting protein showed high yield and soluble expression, and demonstrated anti-inflammatory effects in cell lines and a mouse model.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Tawnya M. Hansen, Zoann Nugent, Charles N. Bernstein, N. Jewel Samadder, Sanjay K. Murthy, Harminder Singh
Summary: The risk of death following CRC diagnosis is not affected by a diagnosis of IBD in recent years. There is a high proportion of post colonoscopy CRC among IBD-CRC patients, which has remained unchanged over the years and requires detailed root-cause analysis and interventions.
Editorial Material
Gastroenterology & Hepatology
Daniel Tassone, Siddharth Singh, Nik Sheng Ding
Summary: This article is linked to the paper by Farraye et al. Visit the provided link to view the article.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Gastroenterology & Hepatology
Manasi Agrawal, Giulia Corn, Sarita Shrestha, Nete Munk Nielsen, Morten Frisch, Jean-Frederic Colombel, Tine Jess
Summary: The study estimated the relative risk of IBD among first-generation and second-generation immigrants in Denmark, finding that the risk of IBD was lower for first-generation immigrants and increased with longer duration of stay in Denmark. The relative risk of IBD was lower only among women for second-generation immigrants.
Article
Engineering, Biomedical
Sheng Xu, Qianqian Yang, Riyuan Wang, Chi Tian, Yanting Ji, Huanhuan Tan, Ping Zhao, David L. Kaplan, Feng Wang, Qingyou Xia
Summary: This study reports the development of a silk sericin nanosphere system for the delivery of lactoferrin to treat ulcerative colitis. The system demonstrated stable morphology, specific targeting to colonic sites, and efficient cell uptake. Oral administration of the system effectively relieved symptoms of ulcerative colitis in mice and exhibited comparable therapeutic effect to high-dose lactoferrin treatment. These findings indicate the promising potential of the silk sericin nanosphere system for colitis treatment.
ACTA BIOMATERIALIA
(2022)
Article
Pharmacology & Pharmacy
Riccardo Capecchi, Paola Migliorini, Federico Zanzi, Simona Maltinti, Ilaria Puxeddu, Nicola de Bortoli, Massimo Bellini, Francesco Costa, Santino Marchi, Lorenzo Bertani
Summary: The study demonstrated a correlation between Ig glycosylation and disease activity in UC patients, suggesting a potential role for lectin-selected Ig in predicting therapeutic effectiveness. If confirmed, Ig glycosylation could serve as a biomarker in UC.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Stefania De Santis, Marina Liso, Mirco Vacca, Giulio Verna, Elisabetta Cavalcanti, Sergio Coletta, Francesco Maria Calabrese, Rajaraman Eri, Antonio Lippolis, Raffaele Armentano, Mauro Mastronardi, Maria De Angelis, Marcello Chieppa
Summary: Colorectal cancer is a non-communicable disease caused by a combination of genetic predisposition and environmental triggers, including microbiota composition. The relationship between microbiota modulation and CRC risk factors is debated, but preventive strategies targeting dysbiosis may reduce the risk. Implementing these strategies during pregnancy and lactation could be particularly effective in reducing CRC risk in offspring.
Article
Pharmacology & Pharmacy
Kehan Rao, Shumin Qin, Yuanming Yang, Kai Zhan, Haomeng Wu, Huan Zheng, Shaogang Huang
Summary: The study found that shenling baizhu powder (SBP) has therapeutic effects on TNBS-induced colitis and potential value in treating and maintaining remission of colitis. SBP effectively strengthens the epithelial barrier integrity in colitis patients by increasing the secretion of mucin and tight junction proteins while inhibiting apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Lujain Maasfeh, Anetta Hartlova, Stefan Isaksson, Johanna Sundin, Georgios Mavroudis, Otto Savolainen, Hans Strid, Lena Ohman, Maria K. Magnusson
Summary: Fecal luminal factors from healthy donors can down-regulate signaling pathways in macrophages and influence their function, while those from UC patients in remission have a weaker effect on macrophages. Metabolomic analysis revealed differential fecal metabolite composition between healthy individuals and UC patients in remission. This suggests that UC patients in remission may lack the necessary signals to condition macrophages towards a hyporesponsive and tolerogenic phenotype, making them vulnerable to relapse.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Kengo Kanayama, Jun Kato, Wataru Shiratori, Ariki Nagashima, Yuki Ohta, Takashi Taida, Keiko Saito, Chihiro Goto, Satsuki Takahashi, Ryosuke Horio, Akane Kurosugi, Tsubasa Ishikawa, Tatsuya Kaneko, Naoki Akizue, Kenichiro Okimoto, Tomoaki Matsumura, Naoya Kato
Summary: This study found that selecting subsequent treatment based on the response to initial anti-tumor necrosis factor (TNF)alpha antibody (ATA) is feasible in refractory ulcerative colitis (UC) patients. Non-ATA may be suitable as subsequent biologics for UC patients regardless of the efficacy of the first ATA.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jurij Hanzel, Peter Bossuyt, Valerie Pittet, Mark Samaan, Monika Tripathi, Wladyslawa Czuber-Dochan, Johan Burisch, Salvatore Leone, Roberto Saldana, Filip Baert, Uri Kopylov, Susanna Jaghult, Michel Adamina, Naila Arebi, Krisztina Gecse
Summary: This study aimed to develop a core outcome set for real-world studies in adult patients with inflammatory bowel disease (IBD). Candidate outcomes and outcome measures were identified through a systematic review and a modified Delphi consensus process. The international panel agreed on the final core outcome set, which will facilitate the synthesis and generation of real-world evidence.
JOURNAL OF CROHNS & COLITIS
(2023)
Letter
Allergy
Soren Helbo Skaarup, Ole Graumann, Johannes Schmid, Anne Sofie Bjerrum, Tina Skjold, Hans Juergen Hoffmann
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Johan Burisch
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Uri Kopylov, Johan Burisch, Shomron Ben-Horin, Fiona Braegger, Alonso Fernandez-Nistal, Nuria Lara, Henriette Sophie Heinrich, Stephan R. Vavricka
Summary: This study demonstrated that vedolizumab treatment resulted in improvements in extraintestinal manifestations in patients with IBD, showing its effectiveness and good safety profile.
INFLAMMATORY BOWEL DISEASES
(2023)
Letter
Dermatology
Valdemar W. Nielsen, Astrid-Helene R. Jorgensen, Yiqiu Yao, Hans C. Ring, Mohamed Attauabi, Gorm R. Madsen, Johan Burisch, Simon F. Thomsen
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Esther Clavero, Jose Manuel Sanchez-Maldonado, Angelica Macauda, Rob Ter Horst, Belem Sampaio-Marques, Artur Jurczyszyn, Alyssa Clay-Gilmour, Angelika Stein, Michelle A. T. Hildebrandt, Niels Weinhold, Gabriele Buda, Ramon Garcia-Sanz, Waldemar Tomczak, Ulla Vogel, Andres Jerez, Daria Zawirska, Marzena Watek, Jonathan N. Hofmann, Stefano Landi, John J. Spinelli, Aleksandra Butrym, Abhishek Kumar, Joaquin Martinez-Lopez, Sara Galimberti, Maria Eugenia Sarasquete, Edyta Subocz, Elzbieta Iskierka-Jazdzewska, Graham G. Giles, Malwina Rybicka-Ramos, Marcin Kruszewski, Niels Abildgaard, Francisco Garcia Verdejo, Pedro Sanchez Rovira, Miguel Inacio da Silva Filho, Katalin Kadar, Malgorzata Razny, Wendy Cozen, Matteo Pelosini, Manuel Jurado, Parveen Bhatti, Marek Dudzinski, Agnieszka Druzd-Sitek, Enrico Orciuolo, Yang Li, Aaron D. Norman, Jan Maciej Zaucha, Rui Manuel Reis, Miroslaw Markiewicz, Juan Jose Rodriguez Sevilla, Vibeke Andersen, Krzysztof Jamroziak, Kari Hemminki, Sonja I. Berndt, Vicent Rajkumar, Grzegorz Mazur, Shaji K. Kumar, Paula Ludovico, Arnon Nagler, Stephen J. Chanock, Charles Dumontet, Mitchell J. Machiela, Judit Varkonyi, Nicola J. Camp, Elad Ziv, Annette Juul Vangsted, Elizabeth E. Brown, Daniele Campa, Celine M. Vachon, Mihai G. Netea, Federico Canzian, Asta Foersti, Juan Sainz
Summary: By conducting a meta-analysis on the germline genetic data of 234 autophagy-related genes from three independent study populations, we investigated the influence of autophagy-related variants on the risk of Multiple Myeloma (MM) and examined the functional mechanisms behind the observed associations. We identified SNPs within the six CD46, IKBKE, PARK2, ULK4, ATG5, and CDKN2A loci associated with MM risk and found that their effect on disease risk was mediated by specific subsets of immune cells, as well as vitamin D3-, MCP-2-, and IL20-dependent mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Johan Burisch, Ekaterina Safroneeva, Raphael Laoun, Christopher Ma
Summary: Although UC and CD share common pathways and treatments, CD patients are more likely to undergo surgery than UC patients. Early treatment in CD can modify the disease's natural history, but there is limited evidence supporting the utility of early escalation to advanced therapies in UC. More data is needed to determine the meaningfulness of different outcomes in UC and to analyze different populations of UC patients.
JOURNAL OF CROHNS & COLITIS
(2023)
Review
Nanoscience & Nanotechnology
Niels Hadrup, Nicklas Sahlgren, Nicklas R. Jacobsen, Anne T. Saber, Karin S. Hougaard, Ulla Vogel, Keld A. Jensen
Summary: This study gathers toxicity data from inhalation studies of certain nanomaterials and their bulk and ionic counterparts in animals. The primary physicochemical and exposure data of each material are retrieved for potential grouping and interpretation. The collected materials include carbon, silver, cerium, cobalt, copper, iron, nickel, silica, titanium, and zinc. The study provides dose descriptors and carcinogenicity data for hazard assessment, as well as a discussion on the effects of particle solubility and shape. Long-term studies generally offer the lowest dose descriptors, and particle size affects the dose descriptors for near-spherical materials.
Article
Genetics & Heredity
Zhanju Liu, Ruize Liu, Han Gao, Seulgi Jung, Xiang Gao, Ruicong Sun, Xiaoming Liu, Yongjae Kim, Ho-Su Lee, Yosuke Kawai, Masao Nagasaki, Junji Umeno, Katsushi Tokunaga, Yoshitaka Kinouchi, Atsushi Masamune, Wenzhao Shi, Chengguo Shen, Zhenglin Guo, Kai Yuan, Shu Zhu, Dalin Li, Jianjun Liu, Tian Ge, Judy Cho, Mark J. Daly, Dermot P. B. McGovern, Byong Duk Ye, Kyuyoung Song, Yoichi Kakuta, Mingsong Li, Hailiang Huang, Maria Abreu, Jean-Paul Achkar, Vibeke Andersen, Charles Bernstein, Steven R. Brant, Luis Bujanda, Siew Chien Ng, Judy Cho, Mark J. Daly, Lee A. Denson, Richard H. Duerr, Lynnette R. Ferguson, Denis Franchimont, Andre Franke, Richard Gearry, Hakon Hakonarson, Jonas Halfvarson, Caren Heller, Hailiang Huang, Antonio Julia, Judith Kelsen, Hamed Khalili, Subramaniam Kugathasan, Juozas Kupcinskas, Anna Latiano, Edouard Louis, Reza Malekzadeh, Jacob L. McCauley, Dermot P. B. McGovern, Christopher Moran, David Okou, Tim Orchard, Aarno Palotie, Miles Parkes, Joel Pekow, Uros Potocnik, Graham Radford-Smith, John D. Rioux, Gerhard Rogler, Bruce Sands, Mark Silverberg, Harry Sokol, Severine Vermeire, Rinse K. Weersma, Ramnik J. Xavier, Naizhong Hu, Qian Cao, Yufang Wang, Yinglei Miao, Hongjie Zhang, Xiaoping Lv, Xiang Gao, Hu Zhang, Jingling Su, Baisui Feng, Ye Zhao, Liangru Zhu, Yan Chen, Lanxiang Zhu, Chunxiao Chen, Yali Wang, Yingde Wang, Zhi Pang, Yingxuan Chen, Xiaolan Zhang, Hui Li, Qin Yu, Mei Ye, Sumin Zhang, Wen Tang, Mei Wang, Xiaocang Cao, Ruixin Zhu, Guangxi Zhou, Zhaolian Bian, Xiaofeng Guo, Xiaoli Wu, Jinchun Liu, Wei Xu, Yuqin Li, Qin Guo, Zhiguo Guo, Mingsong Li, Zhanju Liu
Summary: This study provides the largest investigation of inflammatory bowel diseases (IBDs) in individuals of East Asian ancestries, identifying 80 IBD loci, including 81 new loci. The study also discovers new IBD genes, such as ADAP1 and GIT2, and improves the accuracy of predicting IBD risk by incorporating data from both East Asian and European ancestries.
Review
Biochemistry & Molecular Biology
Vibeke Andersen, Tue B. Bennike, Corinna Bang, John D. Rioux, Isabelle Hebert-Milette, Toshiro Sato, Axel K. Hansen, Ole H. Nielsen
Summary: Inflammatory bowel diseases (IBD) are challenging to manage due to the diversity between patients and the lack of reliable biomarkers. Diet, gut microbiota, genetics, and patient factors are all crucial for disease occurrence and progression. Recent research has identified potential biomarkers for IBD management, but further evaluation is needed. This review provides an update on cutting-edge research in IBD to improve disease management and patient quality of life.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Kristina Bertl, Georgios Tsakos, Nikolaos Pandis, Anna Bogren, Johan Burisch, Andreas Stavropoulos
Summary: This study is the first to find that oral health problems are associated with the disease-specific quality of life (QoL) of inflammatory bowel disease (IBD) patients, and vice versa. This emphasizes the potential advantages of including dental professionals in the multi-disciplinary treatment teams of IBD patients.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Letter
Oncology
Angelica Macauda, Klara Briem, Alyssa Clay-Gilmour, Wendy Cozen, Asta Foersti, Matteo Giaccherini, Chiara Corradi, Juan Sainz, Yasmeen Niazi, Rob ter Horst, Yang Li, Mihai G. Netea, Ulla Vogel, Kari Hemminki, Susan L. Slager, Judit Varkonyi, Vibeke Andersen, Elzbieta Iskierka-Jazdzewska, Joaquin Martinez-Lopez, Jan Zaucha, Nicola J. Camp, S. Vincent Rajkumar, Agnieszka Druzd-Sitek, Parveen Bhatti, Stephen J. Chanock, Shaji K. Kumar, Edyta Subocz, Grzegorz Mazur, Stefano Landi, Mitchell J. Machiela, Andres Jerez, Aaron D. Norman, Michelle A. T. Hildebrandt, Katalin Kadar, Sonja I. Berndt, Elad Ziv, Gabriele Buda, Arnon Nagler, Charles Dumontet, Malgorzata Razny, Marzena Watek, Aleksandra Butrym, Norbert Grzasko, Marek Dudzinski, Malwina Rybicka-Ramos, Eva-Laure Matera, Ramon Garcia-Sanz, Hartmut Goldschmidt, Krzysztof Jamroziak, Artur Jurczyszyn, Esther Clavero, Graham G. Giles, Matteo Pelosini, Daria Zawirska, Marcin Kruszewski, Herlander Marques, Eva Haastrup, Jose Manuel Sanchez-Maldonado, Uta Bertsch, Marcin Rymko, Marc-Steffen Raab, Elizabeth E. Brown, Jonathan N. Hofmann, Celine Vachon, Daniele Campa, Federico Canzian
Article
Toxicology
Karin Rosenkilde Laursen, Nichlas Vous Christensen, Frans A. A. Mulder, Jorg Schullehner, Hans Jurgen Hoffmann, Annie Jensen, Peter Moller, Steffen Loft, Anna-Carin B. Olin, Berit Rasmussen, Bernadette Rosati, Bo Strandberg, Marianne Glasius, Merete Bilde, Torben Sigsgaard, Climate Chamber Grp
Summary: This study investigated the effects of emissions from cooking and candle burning on inflammatory changes in individuals with mild asthma. The results showed that cooking emissions significantly increased levels of oxidatively damaged DNA and lipids in the blood, while candle emissions had a minimal impact on the respiratory system.
PARTICLE AND FIBRE TOXICOLOGY
(2023)
Article
Toxicology
Ulla Vogel, Anne T. Saber, Nicklas R. Jacobsen, Pernille H. Danielsen, Karin S. Hougaard, Niels Hadrup
ARCHIVES OF TOXICOLOGY
(2023)