Article
Gastroenterology & Hepatology
Kaline Arnauts, Padhmanand Sudhakar, Sare Verstockt, Cynthia Lapierre, Selina Potche, Clara Caenepeel, Bram Verstockt, Jeroen Raes, Severine Vermeire, Joao Sabino, Catherine Verfaillie, Marc Ferrante
Summary: Microbial dysbiosis is a known phenomenon in patients with inflammatory bowel disease, but the exact mechanism behind host-microbial interactions remains unclear. This study found that the transcriptional response of epithelial cells was not different between patients with ulcerative colitis (UC) and non-IBD controls following exposure to microbiota. However, UC microbiota exposure led to a significant decrease in epithelial barrier integrity, regardless of the origin of the epithelial cells. Furthermore, UC microbiota induced stress responses in all epithelial cells, while responses to healthy volunteer (HV) microbiota were milder.
Article
Oncology
Lauren C. Chartier, Gordon S. Howarth, Debbie Trinder, Suzanne Mashtoub
Summary: The study investigated the combination of Emu oil and grape seed extract in a model of colitis-associated colorectal cancer, showing that the combination improved clinical indicators and reduced colonic tumors, suggesting potential in managing ulcerative colitis and colorectal cancer.
Review
Medicine, General & Internal
Dianbo Yao, Wanlin Dai, Ming Dong, Chaoliu Dai, Shuodong Wu
Summary: The MUC2 mucus barrier plays a crucial role in ulcerative colitis (UC). Interventions such as dietary adjustment, repair of the mucus barrier, microbiota transplantation, and targeted elimination of pathogenic bacteria can reduce the occurrence and recurrence of UC, maintaining a long-term remission period.
Review
Pharmacology & Pharmacy
Miguel Silva, Valentina Brunner, Markus Tschurtschenthaler
Summary: Colorectal cancer is a complex condition caused by a combination of environmental, genetic, and epigenetic factors, with disruptions in gut microbiota structure associated with various intestinal diseases, including cancer. Bacteria can induce cellular transformation and promote tumor progression through mechanisms such as biofilm formation and genotoxin secretion. The gut microbiota is also involved in drug metabolism, radiotherapy responses, and targeted immunotherapy, with therapy efficacy varying based on the composition of the host's gut microbiota.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Wei Yu, Zizheng Jiang, Zhiqiang Zhang, Lu Jiang, Chen Liu, Chang Lu, Zhenghao Liang, Guoliang Wang, Jing Yan
Summary: This study used network pharmacology and gene co-expression network analysis to predict the mechanisms of the WSC formula in treating ulcerative colitis. The results showed that the formula can suppress inflammation, regulate gut microbiota balance, and improve the progression of colitis.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Samantha Gonzalez Delgado, Idalia Garza-Veloz, Fabiola Trejo-Vazquez, Margarita L. Martinez-Fierro
Summary: This study aims to integrate scientific data on the role of the intestinal microbiota in regulating gut serotonin signaling and reuptake and its involvement in the pathogenesis of IBD. It is found that the use of selective serotonin reuptake inhibitors as an adjuvant therapy can improve disease activity and extraintestinal manifestations in IBD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Gastroenterology & Hepatology
Ana Elisa Valencise Quaglio, Thais Gagno Grillo, Ellen Cristina Souza De Oliveira, Luiz Claudio Di Stasi, Ligia Yukie Sassaki
Summary: Dysbiosis in the gut microbiota is closely associated with various gastrointestinal disorders such as IBS, IBD, and CRC, potentially leading to mucosal barrier disruption, chronic inflammation, and cancer progression. Specific harmful bacteria, like E. coli and ETBF, are linked to an increased risk of developing CRC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Ruiqiao He, Pan Li, Jinfeng Wang, Bota Cui, Faming Zhang, Fangqing Zhao
Summary: Fecal microbiota transplantation is a promising treatment for microbiota dysbiosis associated diseases. This study investigated the effect of different types of donor-derived microbiota on FMT efficacy. The research found two dominant types of microbiota in CDI and IBD patients, and observed the interaction between recipient and donor-derived microbiota during FMT.
Review
Biochemistry & Molecular Biology
Ellen Cristina Souza de Oliveira, Ana Elisa Valencise Quaglio, Daniela Oliveira Magro, Luiz Claudio Di Stasi, Ligia Yukie Sassaki
Summary: Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder characterized by an overactive immune response to environmental factors, including gut microbiota and dietary components. MicroRNAs (miRNAs) have been associated with various physiological processes and play a role in the regulation of inflammatory pathways. Differences in miRNA profiles can be used as a diagnostic and prognostic marker in IBD. The interaction between miRNAs and intestinal microbiota is still not fully understood, but recent studies have shown their role in modulating intestinal homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Sergii Tkach, Andrii Dorofeyev, Iurii Kuzenko, Tetyana Falalyeyeva, Olena Tsyryuk, Oleksandr Kovalchuk, Nazarii Kobyliak, Ludovico Abenavoli, Luigi Boccuto
Summary: This study aimed to evaluate the clinical and microbiological efficacy, tolerability, and safety of fecal microbiota transplantation (FMT) in patients with mild-to-moderate ulcerative colitis (UC). The results showed that FMT as an add-on therapy performed better in improving symptoms and disease activity levels compared to standard-care treatment. Additionally, FMT was found to significantly improve gut microbiota composition.
FRONTIERS IN MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Aonghus Lavelle, Stephane Nancey, Jean-Marie Reimund, David Laharie, Philippe Marteau, Xavier Treton, Matthieu Allez, Xavier Roblin, Georgia Malamut, Cyriane Oeuvray, Nathalie Rolhion, Xavier Dray, Dominique Rainteau, Antonin Lamaziere, Emilie Gauliard, Julien Kirchgesner, Laurent Beaugerie, Philippe Seksik, Laurent Peyrin-Biroulet, Harry Sokol
Summary: This study investigated the association between gut microbiota, bile acids, and colorectal cancer in IBD patients. The results found that specific bacterial taxa were associated with cancer, while bile acids were not. Additionally, clustering analysis identified microbiota clusters associated with clinical features.
Article
Biochemistry & Molecular Biology
Marco Gentili, Laura Hidalgo-Garcia, Teresa Vezza, Erika Ricci, Graziella Migliorati, Alba Rodriguez-Nogales, Carlo Riccardi, Julio Galvez, Simona Ronchetti
Summary: TAT-GILZ treatment has been shown to be effective in models of inflammatory bowel diseases, improving gut permeability and gut microbiota. It has therapeutic effects and contributes to the repair of intestinal damage.
Review
Biochemistry & Molecular Biology
Povilas Miknevicius, Ruta Zulpaite, Bettina Leber, Kestutis Strupas, Philipp Stiegler, Peter Schemmer
Summary: Probiotics can help prevent or reduce the side effects induced by chemotherapy, including gastrointestinal toxicity, weight loss, and diarrhea. However, further clinical studies are needed to determine the most effective dosage and combination of probiotics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Integrative & Complementary Medicine
Sarah S. Mohamed, Nourtan F. Abdeltawab, Walaa Wadie, Lamiaa A. Ahmed, Ramy M. Ammar, Sabine Rabini, Heba Abdel-Aziz, Mohamed T. Khayyal
Summary: The study found that dysbiosis in the gut microbiota is associated with the development of DSS-induced UC, and STW 5 effectively prevents microbial dysbiosis and reduces inflammation processes, providing evidence for its beneficial effects in this condition.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Article
Gastroenterology & Hepatology
Aralia Leon-Coria, Manish Kumar, Matthew Workentine, France Moreau, Michael Surette, Kris Chadee
Summary: The study reveals a significant role of Muc2 mucin in maintaining a healthy microbiota, critical in shaping innate host defenses to promote intestinal homeostasis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Chemistry, Applied
Vita D'Amico, Ilaria Arduino, Mirco Vacca, Rosa Maria Iacobazzi, Davide Altamura, Antonio Lopalco, Rosanna Rizzi, Annalisa Cutrignelli, Valentino Laquintana, Franco Massimo, Maria De Angelis, Nunzio Denora, Angela Assunta Lopedota
Summary: The purpose of this study was to develop an innovative drug delivery system for the oral treatment of inflammatory bowel disease in children using budesonide. Microspheres loaded with budesonide or an inclusion complex were formulated using different ratios of alginate, Eudragit & REG; FS 30D, with or without inulin. The microspheres showed high yields and encapsulation efficiencies, and demonstrated colonic release triggered by pH, transit time, and microbiota.
CARBOHYDRATE POLYMERS
(2023)
Correction
Nutrition & Dietetics
Mirco Vacca, Benedetta Raspini, Francesco Maria Calabrese, Debora Porri, Rachele De Giuseppe, Marcello Chieppa, Marina Liso, Rosa Maria Cerbo, Elisa Civardi, Francesca Garofoli, Hellas Cena, Maria De Angelis
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Pasqua Letizia Pesole, Marina Liso, Rossella Donghia, Vito Guerra, Antonio Lippolis, Mauro Mastronardi, Palma Aurelia Iacovazzi
Summary: This study aimed to analyze the relationship between serum levels of 90K/Mac-2 BP and the response to infliximab in IBD patients. The results of this observational study showed that high levels of 90K were associated with poor response to infliximab. Additionally, a positive correlation was found between 90K and C-reactive protein (CRP). Circulating 90K may serve as a new non-invasive biomarker for monitoring the response to infliximab.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Maria Calasso, Marinella Marzano, Giusy Rita Caponio, Giuseppe Celano, Bruno Fosso, Francesco Maria Calabrese, Domenico De Palma, Mirco Vacca, Elisabetta Notario, Graziano Pesole, Maria De Angelis, Francesca De Leo
Summary: To extend the shelf-life of bakery products, a type-III sourdough combined with a mixture of probiotics was used, which resulted in improved physicochemical and microbiological attributes. The addition of bioprotective-cultures and the sourdough had positive effects on microbial and metabolite improvements in the products, leading to a longer shelf-life. These findings suggest a potential alternative to chemical preservatives for extending the shelf-life of processed foods.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Nutrition & Dietetics
Francesco Maria Calabrese, Giuseppe Celano, Caterina Bonfiglio, Angelo Campanella, Isabella Franco, Alessandro Annunziato, Gianluigi Giannelli, Alberto Ruben Osella, Maria De Angelis
Summary: Calorie-restrictive dietary interventions and physical activity regimens can reduce the progression of NAFLD, and there is a close relationship between liver function and gut microbiota.
Review
Green & Sustainable Science & Technology
Giusy Rita Caponio, Fabio Minervini, Grazia Tamma, Giuseppe Gambacorta, Maria De Angelis
Summary: Grapes, especially Vitis vinifera L., are widely cultivated and winemaking produces a large amount of waste. These residues are causing environmental and economic sustainability issues. To combat this, researchers are exploring ways to create high-value products from these waste materials. Grape pomace, a byproduct of winemaking, contains compounds like polyphenols, phenolic acids, resveratrol, and fiber that have antioxidant properties. Traditional uses of grape pomace include producing distillates and extracting tartaric acid and coloring substances, but newer applications include extracting antioxidants, using it as fermentation substrates and biomass for energy production, and extracting fiber for high-value bioactive product development. This article discusses the involvement of bioactive molecules from grape pomace in human biological functions and their applications in the agri-food sector.
Article
Biochemistry & Molecular Biology
Mirco Vacca, Daniela Pinto, Alessandro Annunziato, Arianna Ressa, Maria Calasso, Erica Pontonio, Giuseppe Celano, Maria De Angelis
Summary: This study aimed to investigate the characteristics of a laboratory-made gluten-free bread supplemented with powdered extract from artichoke leaves. The results showed that the bread with artichoke extract had a lower glycemic index and higher antioxidant properties. Fecal fermentation experiments revealed that the bread with artichoke extract had higher levels of volatile organic compounds and could reduce the expression of inflammatory cytokines in cells. Overall, this preliminary study suggests that combining artichoke extract with sourdough technology could enhance the nutritional and healthy features of gluten-free bread.
Review
Biochemistry & Molecular Biology
Mohamad Khalil, Hala Abdallah, Danute Razuka-Ebela, Maria Calasso, Maria De Angelis, Piero Portincasa
Summary: Given the important role of gut microbiota in host homeostasis and energy balance, changes in its composition can lead to immune-mediated inflammatory disorders and increased intestinal permeability. Za'atar, a popular plant-based food in the Eastern Mediterranean region, contains antioxidant compounds and fiber that have shown health benefits in cardiovascular and metabolic diseases. Studies have also explored the effects of Za'atar on gut microbiota and gastrointestinal diseases, especially its polyphenols. However, more research is needed on the potential clinical applications of Za'atar as a nutraceutical in gastrointestinal disorders.
Review
Biochemistry & Molecular Biology
Aurelia Scarano, Barbara Laddomada, Federica Blando, Stefania De Santis, Giulio Verna, Marcello Chieppa, Angelo Santino
Summary: This article examines the effects of dietary polyphenols on human health, focusing on their antioxidant properties and chelating abilities. It explores the importance of polyphenols and their iron-binding abilities in inflammatory/immunomodulatory responses, with specific attention to macrophages and dendritic cells, as well as their impact on gut microbiota. The article also highlights the need for further investigation into the polyphenol-iron metabolism-inflammatory responses axis and the polyphenol-iron availability-gut microbiota relationship to prevent or counteract pathological conditions.
Article
Biochemistry & Molecular Biology
Giulia Vandoni, Federica D'Amico, Marco Fabbrini, Luigi Mariani, Sabina Sieri, Amanda Casirati, Lorenza Di Guardo, Michele Del Vecchio, Andrea Anichini, Roberta Mortarini, Francesco Sgambelluri, Giuseppe Celano, Nadia Serale, Maria De Angelis, Patrizia Brigidi, Cecilia Gavazzi, Silvia Turroni
Summary: Despite recent breakthroughs in melanoma treatment, overall survival rate remains low. This study characterizes a cohort of melanoma patients and identifies potential biomarkers for treatment response, such as obesity and specific gut microbiota and metabolites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Giuseppe Celano, Francesco Maria Calabrese, Giuseppe Riezzo, Benedetta D'Attoma, Antonia Ignazzi, Martina Di Chito, Annamaria Sila, Sara De Nucci, Roberta Rinaldi, Michele Linsalata, Mirco Vacca, Carmen Aurora Apa, Maria De Angelis, Gianluigi Giannelli, Giovanni De Pergola, Francesco Russo
Summary: Recent studies have further deepened the strong connection between gut microbiota and obesity. The effectiveness of the very-low-calorie ketogenic diet (VLCKD) in positively impacting host homeostasis has been measured, but little is known about its modification on the intestinal metabolome. This pilot study analyzed fecal and urinary metabolome in 25 obese patients undergoing VLCKD for eight weeks, revealing specific urinary and fecal metabolites that could be considered as a signature of partial restore toward host eubiosis.
Article
Endocrinology & Metabolism
Dario Domenico Lofrumento, Alessandro Miraglia, Velia La Pesa, Antonella Sonia Treglia, Marcello Chieppa, Francesco De Nuccio, Giuseppe Nicolardi, Claudia Miele, Francesco Beguinot, Corrado Garbi, Bruno Di Jeso
Summary: In type 2 Diabetes, beta-cell failure is caused by loss of cell mass, mostly by apoptosis, but also by simple dysfunction. The study found that increased flux of glucose in the hexosamine biosynthetic pathway affects beta-cell-beta-cell homotypic interactions.