Article
Chemistry, Physical
Aditi Prabhune, Ranjan Dey
Summary: Deep Eutectic Solvents (DESs) have emerged as potential alternatives to conventional solvents in many industrial applications due to their safety, greenness, ease of preparation and wide range of applications.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Multidisciplinary
Alberto Rubin Pedrazzo, Claudio Cecone, Francesco Trotta, Marco Zanetti
Summary: Beta-cydodextrin (beta CD)-based polymers have versatile applications but traditional syntheses using organic solvents or toxic reactants are environmentally harmful. A sustainable approach using mechanochemistry and NaDESs for synthesizing beta CD polymers shows promise for green and efficient production.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Review
Immunology
Miranda D. Chavez, Hubert M. Tse
Summary: Mitochondrial dysfunction and oxidative stress are associated with T cell-mediated autoimmune diseases, and targeting metabolic pathways can inhibit autoreactive T cell activation. Increasing the requirements of Tregs for ROS and oxidative phosphorylation can promote self-tolerance and inhibit the activity of autoreactive T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Maninder Meenu, Vasudha Bansal, Sudha Rana, Nitya Sharma, Vinod Kumar, Vaishali Arora, Monika Garg
Summary: Anthocyanins are extracted using alternative solvents such as ionic liquids, deep eutectic solvents, and natural deep eutectic solvents, which are more environmentally friendly and efficient compared to conventional solvents. Acid-based deep eutectic solvents with 20-30% water content showed the highest anthocyanin extraction yield. Ultrasonic-assisted extraction was the most common and efficient method, and DES-based extracts exhibited the highest stability and antioxidant activity. Fruits and their by-products are the most commonly used samples, while cereal and legumes are less explored.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2023)
Review
Engineering, Environmental
Amirah Azzouz, Maan Hayyan
Summary: Deep eutectic solvents (DESs) have attracted significant interest in fields such as nanotechnology due to their beneficial characteristics and potential to replace conventional agents with higher environmental impacts. Research studies have demonstrated the promise of DESs in improving efficiency and sustainability in nano-scale applications. Therefore, a comprehensive review of the recent advances in these fields is crucial.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Fabian Thomas, Oliver Kayser
Summary: This study demonstrates the advantages of performing cannabinoid biotransformations in natural deep eutectic solvents (NADES), which significantly increase cannabinoid production. The research also suggests flexible manipulation of solvent compositions to enhance total cannabinoid content or alter cannabinoid specificity.
BIOCHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Chemical
Francesca Russo, Matteo Tiecco, Francesco Galiano, Raffaella Mancuso, Bartolo Gabriele, Alberto Figoli
Summary: In this study, porous polymeric membranes were prepared using DESs and NADESs for the first time, and the performance of the membranes was optimized by adding co-solvents and adjusting the composition of the coagulation bath. The results demonstrated the potential of DESs and NADESs as solvents for the preparation of sustainable polymeric membranes for water treatment applications.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Engineering, Environmental
Maria F. Nava-Ocampo, Lamya Al Fuhaid, Robert Verpoorte, Young Hae Choi, Mark C. M. van Loosdrecht, Johannes S. Vrouwenvelder, Geert J. Witkamp, Andreia S. F. Farinha, Szilard S. Bucs
Summary: The study demonstrates that NADES can act as a biofilm structural breaker, solubilizing the main components of biofilms and weakening their structure, potentially serving as an environmentally-friendly green solvent for biofilm treatment.
Article
Chemistry, Physical
Helene Liepelt Nystedt, Krister Gjestvang Gronlien, Hanne Hjorth Tonnesen
Summary: Natural deep eutectic solvents (NADES) show promise as drug carriers in new drug delivery systems for topical applications, although further investigation into their effects in biological systems is needed.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
Jose L. Trenzado, Cristina Benito, Mert Atilhan, Santiago Aparicio
Summary: This study investigated the hydrophobic Natural Deep Eutectic Solvent formed by cineole and decanoic acid through both experimental and computational approaches. The experimental study measured physicochemical properties and Raman spectra, confirming the formation of hydrogen bonding. The computational analysis using Density Functional Theory and Molecular Dynamics simulation provided nanoscopic characterization and predicted phase equilibria. Moreover, the interaction of the solvent with POPC lipid was studied, revealing its disruptive effects on cell membranes.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Biochemistry & Molecular Biology
Gaetana Napolitano, Gianluca Fasciolo, Paola Venditti
Summary: Mitochondria in aerobic eukaryotic cells not only produce energy but also harmful substances such as ROS, and possess an efficient antioxidant system to detoxify these substances. As ROS production increases, mitochondria are damaged and release more harmful substances, but their antioxidant system can detoxify exogenous ROS at the expense of reducing the equivalents generated in mitochondria.
Article
Engineering, Chemical
Yunchang Fan, Hui Luo, Chunyan Zhu, Wenjin Li, Di Wu, Hongwei Wu
Summary: The hydrophobic natural alcohols based deep eutectic solvents (NADESs) synthesized in this work showed high extraction ability for quinine, with NADESs of lower viscosity and stronger hydrogen bond accepting ability exhibiting stronger extraction ability. Quinine acted as a hydrogen bond acceptor in the hydrogen bonding with NADESs, and the extraction efficiency of NADESs for quinine was higher than other solvents such as ionic liquids, trichloromethane, and ethyl acetate. The NADES phase could be reused for extraction, and quinine could be recovered from NADES phase via back extraction with 1.0% acetic acid aqueous solution, showing potential as promising solvents for extraction of bioactive compounds.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Review
Chemistry, Analytical
Susanna Della Posta, Valeria Gallo, Alessandra Gentili, Chiara Fanali
Summary: The need to reduce the ecological impact of waste in the extraction and analysis processes has led to the use of alternative green solvents. Deep eutectic solvents (DESs) have shown superior extraction capabilities for bioactive molecules, but have difficulties in removal from extracted mixtures. This review provides an overview and critical evaluation of methods for recovering bioactive molecules from extracts obtained using DESs and natural deep eutectic solvents (NADESs).
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Neurosciences
Vaibhav Walia, Deepak Kaushik, Vineet Mittal, Kuldeep Kumar, Ravinder Verma, Jatin Parashar, Rokeya Akter, Md Habibur Rahman, Saurabh Bhatia, Ahmed Al-Harrasi, Chenmala Karthika, Tanima Bhattacharya, Hitesh Chopra, Ghulam Md Ashraf
Summary: Alzheimer's disease is the sixth leading cause of death in elderly patients, characterized by progressive neuronal degeneration and cognitive impairment. Oxidative stress plays a key role in the pathogenesis of AD.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Chemistry, Physical
Jinhao Yao, Chunlu Li, Lei Xiao, Yingying Wu, Qianwen Wu, Zhifang Cui, Bo Wang
Summary: By studying the thermal stability and conformational changes of cellulase in different natural deep eutectic solvents (NADESs), green and suitable solvents were found to enhance the stability of cellulase, which is important for the utilization of lignocellulosic biomass.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Review
Food Science & Technology
Nathalie Barouh, Claire Bourlieu-Lacanal, Maria Cruz Figueroa-Espinoza, Erwann Durand, Pierre Villeneuve
Summary: Lipid oxidation is a major concern in the food, cosmetic, and pharmaceutical sectors, and different antioxidant additives are used to prevent or slow down this process. Tocopherols, specifically natural extracts or pure synthetic molecules, are widely used as antioxidants, but research on their efficiency has yielded contradictory results. In addition to chemical reactivity, the physical properties and interactions with other compounds play a crucial role in determining the efficacy of antioxidants like tocopherols.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2022)
Review
Food Science & Technology
Jeanne Kergomard, Frederic Carriere, Nathalie Barouh, Pierre Villeneuve, Veronique Vie, Claire Bourlieu
Summary: This review summarizes the knowledge about the physico-chemical composition, digestive behavior, and oxidative stability of plant polar lipid assemblies, and emphasizes their potential as functional ingredients in human diet and their potentialities to substitute artificial surfactants/antioxidants.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Pierre Villeneuve, Claire Bourlieu-Lacanal, Erwann Durand, Jerome Lecomte, David Julian McClements, Eric A. Decker
Summary: Lipid oxidation is a major cause of quality deterioration in food products, and the presence of colloidal structures and interfaces play a crucial role in this process. Micelles in emulsions and reverse micelles in bulk oils are reservoirs for antioxidants and pro-oxidants, and serve as nanoreactors where lipid oxidation reactions occur.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Chemistry, Physical
Adejanildo da S. Pereira, Aline Habibe de Souza, Jully L. Fraga, Pierre Villeneuve, Alexandre G. Torres, Priscilla F. F. Amaral
Summary: Lipases are versatile enzymes with high potential for industrial use in the pharmaceutical, cosmetic, and food industries. They have been widely used in the synthesis of various industrial molecules, including phytosterol esters, which have beneficial effects on health. This review highlights the important role of lipases in the synthesis of phytosterol esters and identifies Candida rugosa lipases as the most relevant biocatalysts for this process. The optimal conditions for enzymatic synthesis of phytosterol esters are also discussed, along with the need for further research in this field.
Article
Biochemistry & Molecular Biology
Ngai Ying Denise Li, David J. Moore, Michael A. Thompson, Eloise Welfare, Michael Rappolt
Summary: Humectants are widely used in topical formulations to provide cosmetic and health benefits to the skin. This study investigated the effects of three humectants on a phospholipid-based skincare formulation. The results show that while the humectants affected the structure of the bilayers in a similar manner, there were differences in their effects on the thermal behavior of the bilayers. Betaine and sarcosine stabilized the gel phase and increased membrane rigidity, while acetic monoethanolamide decreased both transition temperatures. The humectants had no significant structural changes on the bilayers in the fluid phase.
CHEMISTRY AND PHYSICS OF LIPIDS
(2022)
Article
Pharmacology & Pharmacy
Joanna Hummer, Thomas Birngruber, Frank Sinner, Leanne Page, Frank Toner, Clive S. Roper, David J. Moore, Mark B. Baker, Mila Boncheva Bettex
Summary: This paper presents a new approach to optimize topical products and select lead formulation candidates. The study compares the diffusion of diclofenac through all skin layers using open flow microperfusion and the Franz diffusion cell. The results demonstrate that the diffusion of diclofenac through the dermis and subcutis does not correlate with its diffusion through the skin barrier, and the Franz diffusion cell data alone cannot predict it. This approach provides a convenient tool for product development and selection.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Food Science & Technology
Rim Nassar, Barbara Vernus, Gilles Carnac, Gilles Fouret, Benedicte Goustard, Francois Casas, Lionel Tintignac, Isabelle Cassar-Malek, Brigitte Picard, Iban Seiliez, Thomas Brioche, Christelle Koechlin-Ramonatxo, Christelle Bertrand-Gaday, Aline Hamade, Fadia Najjar, Beatrice Chabi, Anne Bonnieu
Summary: Myostatin deficiency leads to increased protein degradation in post-mortem muscle, primarily through enhanced calpain activity. Autophagy, ubiquitin-proteasome, and caspase systems are not upregulated in this process.
Article
Pharmacology & Pharmacy
Mihaela Gorcea, Majella E. Lane, David J. Moore
Summary: The purpose of this in vivo exploratory study was to investigate the conformational order and chain packing of human stratum corneum lipids in healthy face skin as a function of depth. The study found that the lipid order of the stratum corneum increases with depth in face skin, but shows significant differences compared to arm skin.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Nutrition & Dietetics
Mathilde Cancalon, Nathalie Barouh, Youna Hemery, Erwann Durand, Philippe Guesnet, Pierre Villeneuve, Claire Bourlieu-Lacanal
Summary: The postnatal period is characterized by rapid growth and development, with lipids, especially LC-PUFA such as DHA and ARA, playing a crucial role. The objective of infant formulas is to mimic the composition and structure of breast milk as the gold standard, providing the best alternative to breastfeeding. European regulations now require DHA supplementation in formulas, and ARA is also fortified although there is no minimum requirement. This review aims to provide an update on key parameters for better control of LC-PUFA supplementation in infant formulas.
CAHIERS DE NUTRITION ET DE DIETETIQUE
(2022)
Review
Chemistry, Multidisciplinary
Bowen Hou, Rabia Durrani, Andre Delavault, Erwann Durand, Chenyu Jiang, Yiyang Long, Lili Song, Jian Song, Weiwei Huan, Fei Gao
Summary: This review focuses on the application of deep eutectic solvents (DESs) for protein extraction and purification, as well as their effects and principles on renewable biomasses. The study finds that DESs have the ability to maintain the activity and stability of extracted proteins, compared to traditional solvents. They show potential for reproducible and scalable protein extraction and purification, while enabling waste valorization in certain cases.
FRONTIERS IN CHEMISTRY
(2022)
Article
Food Science & Technology
Nastassia Kaugarenia, Sophie Beaubier, Erwann Durand, Arnaud Aymes, Pierre Villeneuve, Francois Lesage, Romain Kapel
Summary: This study aimed to generate mineral-chelating peptides from total rapeseed meal proteins while preserving antimicrobial properties. Enzymatic proteolysis of total rapeseed protein isolate selectively hydrolyzed the cruciferins. Design of Experiments method and multicriteria optimization were used to predict kinetics and maximize yield and purity. The resulting peptide fraction showed high metal-chelating activity and antioxidant properties.
Review
Food Science & Technology
Eric A. Decker, Pierre Villeneuve
Summary: This article introduces the characteristics of oil bodies, which are stored as emulsified lipid droplets in plant lipids, and their advantages in food formulations. The impact of extraction processes and other factors on the oxidative stability of oil bodies is discussed, and the role of constituent components of oil bodies membranes in antioxidant effects is explored.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Agronomy
Celia Mousties, Claire Bourlieu-Lacanal, Youna M. Hemery, Bruno Barea, Pierre Villeneuve, Adrien Servent, Pascaline Alter, Marc Lebrun, Arnaud Laillou, Frank T. Wieringa, Sylvie Avallone
Summary: The study showed that all RUTF products displayed good lipid stability, with only the European-manufactured one complying with international recommendations on vitamin A and E contents. One of the products made in Asia exceeded the regulatory limit of mycotoxins.
OCL-OILSEEDS AND FATS CROPS AND LIPIDS
(2022)
Article
Food Science & Technology
Erwann Durand, Sophie Beaubier, Isidora Ilic, Frederic Fine, Romain Kapel, Pierre Villeneuve
Summary: Preventing lipid oxidation is a major concern in agri-food and cosmetic sectors, leading to a growing interest in isolating novel naturally occurring antioxidants from plant biomass. Bioactive peptides, which are biologically active sequence of amino acid residues, have shown great potential as antioxidants from plant biomass.
CURRENT RESEARCH IN FOOD SCIENCE
(2021)