Chromaffin cells as a model to evaluate mechanisms of cell death and neuroprotective compounds

The quantal catecholamine release from mouse chromaffin cells challenged with repeated ACh pulses is regulated by the mitochondrial Na+ /Ca2+ exchanger

(2017) Angela López-Gil et al.   JOURNAL OF PHYSIOLOGY-LONDON

ITH14001, a CGP37157-Nimodipine Hybrid Designed to Regulate Calcium Homeostasis and Oxidative Stress, Exerts Neuroprotection in Cerebral Ischemia

(2016) Izaskun Buendia et al.   ACS Chemical Neuroscience

Synthesis and Biological Evaluation of Pentacycloundecylamines and Triquinylamines as Voltage-Gated Calcium Channel Blockers

(2016) Lois-May Young et al.   ARCHIV DER PHARMAZIE

Neuroprotective profile of pyridothiazepines with blocking activity of the mitochondrial Na+/Ca2+ exchanger

(2016) Francisco J. Martínez-Sanz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Crosstalk between Ca2+ signaling and mitochondrial H2O2 is required for rotenone inhibition of mTOR signaling pathway leading to neuronal apoptosis

(2016) Chunxiao Liu et al.   Oncotarget

Benzothiazepine CGP37157 Analogues Exert Cytoprotection in Various in Vitro Models of Neurodegeneration

(2015) Francisco J. Martínez-Sanz et al.   ACS Chemical Neuroscience

Benzothiazepine CGP37157 and its 2′-isopropyl analogue modulate Ca2+ entry through CALHM1

(2015) Ana J. Moreno-Ortega et al.   NEUROPHARMACOLOGY

Minocycline inhibits ICAD degradation and the NF-κB activation induced by 6-OHDA in PC12 cells

(2014) Bao-Ping Jiang et al.   BRAIN RESEARCH

The Essential Role of p53-up-regulated Modulator of Apoptosis (Puma) and Its Regulation by FoxO3a Transcription Factor in β-Amyloid-induced Neuron Death

(2014) Rumana Akhter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Carvedilol Attenuates 6-Hydroxydopamine-Induced Cell Death in PC12 Cells: Involvement of Akt and Nrf2/ARE Pathways

(2014) Lan Wang et al.   NEUROCHEMICAL RESEARCH

FoxO3a is activated and executes neuron death via Bim in response to β-amyloid

(2013) P Sanphui et al.   Cell Death & Disease

Simvastatin Induces Neuroprotection in 6-OHDA-Lesioned PC12 via the PI3K/AKT/Caspase 3 Pathway and Anti-Inflammatory Responses

(2012) Yun-Qi Xu et al.   CNS Neuroscience & Therapeutics

NP04634 prevents cell damage caused by calcium overload and mitochondrial disruption in bovine chromaffin cells

(2009) Teresa Valero et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mitochondrial Na+/Ca2+-Exchanger Blocker CGP37157 Protects against Chromaffin Cell Death Elicited by Veratridine

(2009) S. M. Nicolau et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS