Article
Infectious Diseases
Kazuhiro Kamata, Khin Nyo Thein, Lasham Di Ja, Nay Chi Win, Su Mon Kyaw Win, Yuko Suzuki, Ai Ito, Hidekazu Osada, Irina Chon, Wint Wint Phyu, Yuta Aizawa, Tatsuki Ikuse, Tomomi Ota, Yadanar Kyaw, Htay Htay Tin, Yugo Shobugawa, Hisami Watanabe, Reiko Saito, Akihiko Saitoh
Summary: Acute lower respiratory infection (ALRI) caused by viruses poses a significant threat to the health and lives of hospitalized children in Myanmar. This study provides detailed information on viral etiologies, clinical manifestations, and outcomes of ALRI in Myanmar. RSV and rhinovirus were the most commonly detected viruses, and influenza virus and RSV were frequently associated with fatal cases.
BMC INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
L. M. Vos, R. Bruyndonckx, N. P. A. Zuithoff, P. Little, J. J. Oosterheert, B. D. L. Broekhuizen, C. Lammens, K. Loens, M. Viveen, C. C. Butler, D. Crook, K. Zlateva, H. Goossens, E. C. J. Claas, M. Ieven, A. M. Van Loon, T. J. M. Verheij, F. E. J. Coenjaerts
Summary: This study found that respiratory virus infections lead to more severe symptoms and longer duration, and are positively correlated with viral load.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Public, Environmental & Occupational Health
Rodrigo C. Menezes, Isabella B. B. Ferreira, Luciana Sobral, Stefania L. Garcia, Hugo N. Pustilnik, Mariana Araujo-Pereira, Bruno B. Andrade
Summary: This study aimed to identify the clinical features associated with viral pathogens responsible for severe lower respiratory tract infections (LRTI) in children. The study found that different viral agents have distinct associations with clinical features in children.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2024)
Article
Pediatrics
Phanthila Sitthikarnkha, Rattapon Uppala, Sirapoom Niamsanit, Sumitr Sutra, Kaewjai Thepsuthammarat, Leelawadee Techasatian, Watit Niyomkarn, Jamaree Teeratakulpisarn
Summary: Among hospitalized children in Thailand, RSV LRTI was the leading cause of hospitalization, with the highest incidence occurring during the rainy season. The mortality rate of RSV LRTI was higher in infants under 1 year old and children with underlying illnesses; future preventive interventions should target these patient groups.
Article
Infectious Diseases
Zhilei Zhang, Li Tan, Miao Tan, Xiaolin Zhang, Wenji He, Ming Li, Juan He, Yue Pan, Bin Xu, Songtao Bin, Zhengyan Gan, Lingmei Yan, Yuxing Sun, Hongchao Jiang, Qiangming Sun, Zhen Zhang
Summary: This article reports the first case of HRV-A11-associated lower respiratory tract infection in China. The nucleotide and amino acid mutations in these clinical strains were analyzed, and mutations in the capsid protein region and specific epitopes were found. The study results may provide references for virological surveillance and vaccine development.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Eric A. F. Simoes, Marc Botteman, Viktor Chirikov
Summary: This study reports on the epidemiology and healthcare resource utilization of respiratory syncytial virus (RSV) among Japanese children stratified by gestational and chronological age. The study found that the incidence and hospitalization rates of RSV medically attended lower respiratory tract infection (MALRI) were 14.3/100 child-years and 6.0/100 child-years, respectively, in the first 5 months. Additionally, the majority of children experienced RSV MALRI events by 24 months of chronological age, though there were differences observed between preterm and full-term infants.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Biotechnology & Applied Microbiology
Ming Li, Cuilian Li, Xiaoli Jian, Dingrui Han, Jinglin Zhao, Li Jiang
Summary: This study aimed to investigate the viral combinations and associations with respiratory infections in children. The detection of RSV and PIV-3 viruses in oropharyngeal swab samples was found to be associated with both ALRTI and AURTI cases. These results provide initial evidence for the potential use of microbiota-based diagnostics in severe acute respiratory infections.
JOURNAL OF APPLIED MICROBIOLOGY
(2023)
Article
Virology
Sai-Zhen Zeng, Le-Yun Xie, Tian Yu, Li-li Zhong, Jin-song Li, Zhao-Jun Duan, Bing Zhang, Qi-yi Zeng
Summary: For children with severe HAdV pneumonia, the duration of viral shedding is longer, with slower decrease in viral load and longer persistence for HAdV-7 infection.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Microbiology
Ivo Hoefnagels, Josephine van de Maat, Jeroen J. A. van Kampen, Annemarie van Rossum, Charlie Obihara, Gerdien A. Tramper-Stranders, Astrid P. Heikema, Willem de Koning, Anne-Marie van Wermerskerken, Deborah Horst-Kreft, Gertjan J. A. Driessen, Janine Punt, Frank J. Smit, Andrew Stubbs, Jeroen G. Noordzij, John P. Hays, Rianne Oostenbrink
Summary: This study found high rates of viral detection and co-infection in children with lower respiratory tract infections (LRTIs), but no significant associations between respiratory microbiome profiles and hospitalization.
Article
Virology
Alicia A. Annamalay, Salome Abbott, Siew-Kim Khoo, Julie Hibbert, Joelene Bizzintino, Guicheng Zhang, Ingrid Laing, Andrew Currie, Peter N. Le Souef, Robin J. Green
Summary: The study found that certain cytokines had higher concentrations in ALRI cases compared to non-respiratory controls, and that levels of certain cytokines were higher in ALRI cases with viruses. Additionally, HIV-infected cases had significantly lower levels of certain cytokines compared to HIV-uninfected cases, while levels of other cytokines were significantly higher in HIV-infected cases.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Virology
Guohong Zhu, Dan Xu, Yuanyuan Zhang, Tianlin Wang, Lingyan Zhang, Weizhong Gu, Meiping Shen
Summary: The study found that the rates of viral infection in children vary by different ages and seasons, with the highest positivity rate of adenovirus appearing in the preschool period, respiratory syncytial virus being highest in infants, and influenza virus increasing with age. The total positive rate of viral infection in different seasons is highest in winter, with influenza positivity rate also being highest in winter.
Article
Virology
Yan Yan, Jinhan Sun, Kai Ji, Jianhui Guo, Lei Han, Fang Li, Yuning Sun
Summary: Lower respiratory tract infection is a major cause of childhood mortality and viral infection is the main pathogen. Human rhinovirus, respiratory syncytial virus, and parainfluenza virus type 3 are the most frequently identified pathogens. Coinfection of virus and bacteria can lead to more severe pneumonia.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Environmental Sciences
Alejandro Alvaro-Meca, Daniel Sepulveda-Crespo, Rosa Resino, Pablo Ryan, Isidoro Martinez, Salvador Resino
Summary: This study analyzes the association between hospital admissions for viral lower respiratory tract infections (LRTI) in older adults and short-term exposure to environmental factors. The study found that low temperatures, high humidity, and high concentrations of NO2, O3, PM10, and CO are associated with an increased odds of hospital admissions for viral LRTI in older people.
ENVIRONMENTAL HEALTH
(2022)
Article
Environmental Sciences
Alejandro Alvaro-Meca, Maria del Carmen Goez, Rosa Resino, Vanesa Matias, Daniel Sepulveda-Crespo, Isidoro Martinez, Salvador Resino
Summary: This study evaluated the association between short-term exposure to environmental factors and hospital admissions for acute viral lower respiratory infections in children under two years old. The results showed that lower temperature, higher relative humidity, and higher concentrations of NO2, SO2, O-3, and PM10 were associated with increased odds of hospital admissions for viral ALRI.
ENVIRONMENTAL RESEARCH
(2022)
Article
Medicine, General & Internal
Yifei Duan, Jinlan He, Yali Cui, Wensheng Li, Yongmei Jiang
Summary: In west China, respiratory viruses influenza A and respiratory syncytial virus (RSV) were found to be the most common among young children with acute respiratory tract infection, showing pronounced seasonality. During the SARS-CoV-2 pandemic, isolation measures led to a decline in the number of ARTI cases.