Article
Medicine, General & Internal
Christopher C. Butler, F. D. Richard Hobbs, Oghenekome A. Gbinigie, Najib M. Rahman, Gail Hayward, Duncan B. Richards, Jienchi Dorward, David M. Lowe, Joseph F. Standing, Judith Breuer, Saye Khoo, Stavros Petrou, Kerenza Hood, Jonathan S. Nguyen-Van-Tam, Mahendra G. Patel, Benjamin R. Saville, Joe Marion, Emma Ogburn, Julie Allen, Heather Rutter, Nick Francis, Nicholas P. B. Thomas, Philip Evans, Melissa Dobson, Tracie-Ann Madden, Jane Holmes, Victoria Harris, May Ee Png, Mark Lown, Oliver van Hecke, Michelle A. Detry, Christina T. Saunders, Mark Fitzgerald, Nicholas S. Berry, Lazaro Mwandigha, Ushma Galal, Sam Mort, Bhautesh D. Jani, Nigel D. Hart, Haroon Ahmed, Daniel Butler, Micheal McKenna, Jem Chalk, Layla Lavallee, Elizabeth Hadley, Lucy Cureton, Magdalena Benysek, Monique Andersson, Maria Coates, Sarah Barrett, Clare Bateman, Jennifer C. Davies, Ivy Raymundo-Wood, Andrew Ustianowski, Andrew Carson-Stevens, Ly-Mee Yu, Paul Little
Summary: This study aimed to determine the safety, effectiveness, and cost-effectiveness of molnupiravir in vaccinated high-risk patients in the community. The results showed that molnupiravir did not reduce hospital admissions or deaths associated with COVID-19 compared to usual care in this population.
Article
Virology
Kenichiro Takahashi, Tsuguto Fujimoto, Nozomu Hanaoka, Mariko Tamura, Yoko Suzuki, Shigetaka Sugihara
Summary: This study aims to investigate the usefulness of clinical manifestations in deciding the use of adenovirus IC kits for children with upper respiratory infections (URI). The study found that when patients lack the clinical manifestations of fever, rhinorrhea, and tonsillar exudate, the results of adenovirus IC kits are often negative.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Virology
Yiman Huang, Chao Wang, Fenlian Ma, Qiong Guo, Lihong Yao, Aijun Chen, Xiaoyi Luo, Lishu Zheng
Summary: The study described the epidemiology and genotypic diversity of HAdV in hospitalized children with RTIs in Beijing, China. The main epidemic strains were found to be HAdV-B3 and HAdV-B7, with a recombinant HAdV-C strain CBJ113 forming an epidemic trend.
Article
Virology
Chuanyu Yang, Chunmei Zhu, Yuan Qian, Jie Deng, Baoyuan Zhang, Runan Zhu, Fang Wang, Yu Sun, Dongmei Chen, Qi Guo, Yutong Zhou, Lei Yu, Ling Cao, Linqing Zhao
Summary: Nosocomial infections of human adenovirus (HAdV) were investigated in a pediatric hospital in Beijing. Genotyping based on phylogenetic analysis combined with clinical data showed that most cases were community acquired infections rather than nosocomial infections, with only a minority potentially being transmitted within the hospital.
Article
Pediatrics
Li Wang, Xiaoting Hu, Zhenzhen Huang, Yangjie Zhang, Xiaoyuan Zhao, Xiaohua Liu, Hua Mao, Huixiang Hao, Wanli Xue
Summary: The typing and clinical characteristics of adenovirus (AdV) infection in children hospitalized with acute respiratory tract infection (ARTI) were investigated in this study. Among the hospitalized children with ARTIs, 4.48% (328/7832) tested positive for AdV. AdV type 3 and 7 were frequently found, with type 7 being associated with more severe outcomes. Clinical symptoms included cough, sputum not easily coughable, wheezing or shortness of breath, and fever.
Review
Virology
Veridiane Maria Pscheidt, Tatiana Schaffer Gregianini, Leticia Garay Martins, Ana Beatriz Gorini da Veiga
Summary: The study found that the infection rate of HAdV in respiratory infection patients in Rio Grande do Sul, Brazil was 2.8%, with a mortality rate of 3%. HAdV cases were mainly concentrated in winter and early spring, more common in male patients, and mostly in children. Patients with heart diseases and immunocompromised conditions were at higher risk of mortality.
REVIEWS IN MEDICAL VIROLOGY
(2021)
Article
Medicine, General & Internal
Wen Xu, Juan Du, Ting-Ting Wei, Lin-Yi Chen, Xin-Xin Yang, Tu Bo, Han-Yu Liu, Ming-Zhu Xie, Tian-Shuo Zhao, Jun-Lian Yang, Fuqiang Cui, Wei-Wei Chen, Qing-Bin Lu
Summary: This study found that there were changes in bile acids in patients with HAdV-7 infection, which may be metabolic signatures of HAdV-7 infection. Bile acids may play a protective role against HAdV-7 infection by inhibiting its replication.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Mark Legacy, Dugald Seely, Ellen Conte, Athanasios Psihogios, Tim Ramsay, Dean A. Fergusson, Salmaan Kanji, John-Graydon Simmons, Kumanan Wilson
Summary: COVID-19 has caused worldwide morbidity and mortality, and effective treatments are still needed, especially for people in the community. This study aims to explore if nutrients such as vitamin C, vitamin D, vitamin, and zinc are effective treatment options for outpatients diagnosed with COVID-19.
Article
Infectious Diseases
Ildiko Gagyor, Alastair D. Hay
Summary: Clinical and antimicrobial stewardship outcomes are crucial in pragmatic primary care trials, but currently lack agreed standards for design. Recommendations for future research designs include specifying interpretation of conflicting results, ensuring prescriptions from external sources are included in AMS effectiveness measures, prioritizing antimicrobial resistance in outcomes, considering antibiotics used in interventions as part of the outcome, and involving patients in establishing principles for prioritizing AMS or clinical outcomes.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Pediatrics
Huifeng Fan, Ying Cui, Xuehua Xu, Dongwei Zhang, Diyuan Yang, Li Huang, Tao Ding, Gen Lu
Summary: A classification model using complete blood count was developed to predict severity in pediatric patients with HAdV lower respiratory tract infections. The monocyte ratio was found to be the most obvious difference between mild and severe cases at onset and could be used as an early marker for accurate prediction of severity. A model using four risk factors (monocyte ratio, hematocrit, red blood cell count, and platelet count) was constructed to accurately assess the risk of severe cases in the early stages of HAdV lower respiratory tract infections.
FRONTIERS IN PEDIATRICS
(2022)
Article
Virology
Yan Yan, Jinhan Sun, Kai Ji, Jianhui Guo, Lei Han, Fang Li, Yuning Sun
Summary: Lower respiratory tract infection is a major cause of childhood mortality and viral infection is the main pathogen. Human rhinovirus, respiratory syncytial virus, and parainfluenza virus type 3 are the most frequently identified pathogens. Coinfection of virus and bacteria can lead to more severe pneumonia.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Ricardo Sant'Anna da Costa, Maria Isabel N. Di Azevedo, Ana Luiza dos Santos Baptista Borges, Filipe Anibal Carvalho-Costa, Gabriel Martins, Walter Lilenbaum
Summary: Dogs, known hosts of Leptospira interrogans, were found to shed the pathogen in their urine with unexpectedly prevalent Icterohaemorrhagiae serogroup, despite remaining clinically asymptomatic. Asymptomatic shedding of leptospires in dogs, particularly virulent strains, represents a significant public health risk that cannot be ignored.
Article
Virology
Ana B. Gorini da Veiga, Leticia G. Martins, Irina Riediger, Alix Mazetto, Maria do Carmo Debur, Tatiana S. Gregianini
Summary: Respiratory viral infections can be severe, especially for children, elderly, and patients with comorbidities. In Brazil, the official surveillance system investigates various viruses, but some cases with no identified pathogens remain. This study analyzed viruses in patients without underlying diseases, revealing the potential for coronaviruses to cause severe disease in healthy adults.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Pediatrics
Yi Chen, Tao Lin, Chang-Bing Wang, Wan-Li Liang, Guang-Wan Lian, Mark Zanin, Sook-San Wong, Xin-Gui Tian, Jia-Yu Zhong, Ying-Ying Zhang, Jia-Hui Xie, Ling-Ling Zheng, Fei-Yan Chen, Run Dang, Ming-Qi Zhao, Yi-Yu Yang, Rong Zhou, Bing Zhu
Summary: This study describes the epidemiology and subtype shifting of human adenovirus (HAdV) infection among children with acute respiratory illness in Guangzhou, China. The results showed a clear seasonal distribution of HAdV, with increased cases and a shift in dominant subtype from HAdV-3 to HAdV-7 in 2018 and 2019. The study also found an increase in mortality rate among children with severe HAdV cases.
WORLD JOURNAL OF PEDIATRICS
(2022)
Article
Virology
Sydney Snaider, Yueting Zheng, Patrick Hearing
Summary: This study uncovers the critical role of pRb and class I HDACs in the IFN-induced formation of a repressor complex that promotes persistent HAdV infections. The mechanism underlying HAdV persistence has not been fully explored. Here, we provide insight into the contributions of the host cell to IFN-mediated persistent HAdV infection.
JOURNAL OF VIROLOGY
(2022)
Article
Immunology
Xiao-Lan Chen, Yang Wang, Wan-Wan Peng, Yi-Jun Zheng, Tian-Nan Zhang, Ping-Jun Wang, Jin-Da Huang, Qi-Yi Zeng
INTERNATIONAL IMMUNOPHARMACOLOGY
(2018)
Article
Cell Biology
Jinda Huang, Wanwan Peng, Yijun Zheng, Hu Hao, Sitao Li, Yu Yao, Yue Ding, Junliang Zhang, Juanjuan Lyu, Qiyi Zeng
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Immunology
Yue Ding, Yijun Zheng, Jinda Huang, Wanwan Peng, Xinxin Chen, Xiangjin Kang, Qiyi Zeng
INTERNATIONAL IMMUNOPHARMACOLOGY
(2019)
Review
Biochemistry & Molecular Biology
John Sieh Dumbuya, Siqi Li, Lili Liang, Qiyi Zeng
Summary: Sepsis-associated encephalopathy (SAE) is a common organ dysfunction in sepsis patients without central nervous system infection. Its pathophysiology involves oxidative stress, cytokine and proinflammatory factors, cerebral circulation disturbances, blood-brain barrier permeability changes, neurotransmitter and amino acid level alterations, and dysfunction of cerebral microvascular cells, mitochondria, microglia, and astrocytes. Diagnosis of SAE is challenging due to the need to exclude CNS infection, and diagnostic tools such as EEG, neuroimaging, and biomarkers are commonly used. Treatment focuses on managing underlying conditions, using antibiotics, supportive therapy, and judicious use of sedative medication like dexmedetomidine. Other potential neuroprotective agents like dexamethasone, melatonin, and magnesium are being explored. Managing modifiable factors is crucial for improving neurological outcomes. However, there are limited experimentation models and treatment strategies for pediatric SAE, and extrapolation from adult models is challenging.
MOLECULAR MEDICINE
(2023)