Article
Biotechnology & Applied Microbiology
Yong Fang, Cailing E, Shixing Wu, Zudong Meng, Guifang Qin, Rongying Wang
Summary: Psoriasis, an autoimmune skin disorder, involves dysregulation of circRNAs and microRNAs, which can affect cell proliferation, migration, invasion, apoptosis, and gene expression related to the disease pathology.
Article
Immunology
Hong Wang, Yangchun Xu, Meishan Jin, Hongxia Li, Shanshan Li
Summary: The study revealed the inhibitory effect of miR-383 in a rat psoriasis model, suppressing the pathological process by regulating LCN2 and the JAK/STAT signaling pathway to alleviate inflammation and promote keratinocyte apoptosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Ling Zhang, Shenglan Zhang, Jianbin Wang, Xiaojing Li
Summary: The study explored the expression of miR-146b in psoriatic tissue and its correlation with disease activity and inflammation. It was found that miR-146b overexpression promoted keratinocyte proliferation and inhibited apoptosis, as well as TRAIL-induced apoptosis.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Immunology
Masahiro Kamata, Yayoi Tada
Summary: Psoriasis is an immune-mediated disease in which immune cells and skin cells interact, leading to aberrant differentiation and proliferation of keratinocytes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Shuiqi Li, Xiaohua Zhu, Na Zhang, Ruixiang Cao, Lei Zhao, Xin Li, Jiang'an Zhang, Jianbin Yu
Summary: The research discovered that in psoriasis models, NORAD is involved in regulating keratinocyte proliferation by negatively regulating miR-26a and affecting the expression of CDC6, subsequently impacting the proliferation of keratinocytes.
Article
Biochemistry & Molecular Biology
Pa-Fan Hsiao, Yi-Ting Huang, Po-Hsuan Lu, Ling-Ya Chiu, Tzu-Han Weng, Chi-Feng Hung, Nan-Lin Wu
Summary: This study investigates the expression and regulation of TXNIP in psoriasis, as well as its role in skin keratinocyte differentiation and EGFR signaling.
Article
Biochemistry & Molecular Biology
Qi He, Nian Liu, Feng Hu, Quan Shi, Xianming Pi, Hongxiang Chen, Jiawen Li, Bo Zhang
Summary: The study showed that the expression of circ_0061012 was significantly increased in psoriasis patients' skin, and IL-22 treatment could enhance circ_0061012 expression. Circ_0061012 promoted proliferation and metastasis of HaCaT cells by interacting with miR-194-5p, while miR-194-5p counteracted these effects by targeting GAB1.
BIOSCIENCE REPORTS
(2021)
Article
Immunology
You-Wang Lu, Yong-Jun Chen, Nian Shi, Lu-Hui Yang, Hong-Mei Wang, Rong-Jing Dong, Yi-Qun Kuang, Yu-Ye Li
Summary: In this study, genes and cytokines related to the pathogenesis of psoriasis were identified through gene expression analysis. These findings may contribute to the diagnosis and treatment of psoriasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Renchao Dong, Xiaohui Wang, Lu Wang, Changyuan Wang, Kai Huang, Ting Fu, Kexin Liu, Jingjing Wu, Huijun Sun, Qiang Meng
Summary: The study showed that Yan could alleviate chronic ethanol-induced liver injury by inhibiting cellular senescence through regulating miR-194/FXR axis, which resulted in reduced expression of cell senescence markers and inhibition of cell cycle arrest.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biology
Tongfei Wang, Wei Li, Haitao Li, Weina Li
Summary: The study revealed significant differences in the expression levels of miR-194 and miR-192 in serum samples and bronchial wash samples of NSCLC participants, which were associated with tumor staging, metastasis, and pathological grade.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Andreas Orsmond, Lara Bereza-Malcolm, Tom Lynch, Lyn March, Meilang Xue
Summary: The skin barrier consists of a physical barrier in the epidermis and an immune barrier in both dermis and epidermis, which cooperate to maintain skin homeostasis and human health. Dysregulation can lead to various skin diseases, with psoriasis being one of the most prevalent due to disrupted barrier function. Recent research has focused on understanding disease pathogenesis involving keratinocytes, immune cells, genetic and environmental factors, and advancements in current and future treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yujun Sheng, Leilei Wen, Xiaodong Zheng, Mengqing Li, Dan Wang, Sixian Chen, Ran Li, Lili Tang, Fusheng Zhou
Summary: Psoriasis is an autoimmune skin disorder influenced by genetic, epigenetic, and environmental factors. The study found that specific methylation sites in the CYP2S1 gene region may participate in the development of psoriasis by affecting keratinocyte proliferation and immune response.
Article
Pharmacology & Pharmacy
Yun-zi Liu, Ming-yuan Xu, Xiao-yu Dai, Lang Yan, Lei Li, Rui-zhen Zhu, Li-jun Ren, Ji-qian-zhu Zhang, Xiao-fang Zhang, Jin-feng Li, Yi-jun Tian, Wen-jing Shi, Ye-qiang Liu, Chun-lei Jiang, Jiang-bo Zhu, Ji-kuai Chen
Summary: PKM2, highly expressed in psoriatic epidermis, plays a crucial role in promoting glycolytic metabolism and cell proliferation in psoriatic keratinocytes. Inhibition of PKM2 or glycolysis effectively suppresses keratinocyte proliferation, suggesting PKM2 as a potential therapeutic target for psoriasis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Yi Kong, Jian Jiang, Yuqiong Huang, Xin Liu, Zilin Jin, Li Li, Fen Wei, Xinxin Liu, Jie Yin, Yonghui Zhang, Qingyi Tong, Hongxiang Chen
Summary: Psoriasis is a chronic, noninfectious, painful, disfiguring and disabling skin disease. Narciclasine shows potential as a novel anti-psoriasis drug by inhibiting inflammatory mediators and improving lipid metabolism.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Le Liu, Xiao-xiao Kang
Summary: An increasing number of studies have revealed a close relationship between ferroptosis and the progression of various diseases. However, the significance of ferroptosis in psoriasis remains largely unexplored. This study found that ferroptosis is significantly activated during the progression of psoriasis and promotes inflammatory responses by upregulating ACSL4 expression. This discovery offers new targets for the clinical detection, prevention, and treatment of psoriasis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Pathology
Xiaobo Zhang, Chen Wang, Danhua Shen
Summary: This study investigated the Clinicopathological features and FH mutation in FH-dUL. FH-dUL is rare and the combination of predictive Clinicopathological evaluation, FH and 2SC IHC test, and molecular test were helpful for the screening of FH-dUL or even HLRCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Gaurav Dubey, Mithilesh Singh, Himmat Singh, Mohit Agarwal, Shailendra Singh Chandel, Anurag Mishra, Ravindra Pal Singh, Neelima Kukreti
Summary: SnoRNAs play a crucial role in autoimmune diseases, influencing gene expression, immune cell development, and immune regulation. They have the potential to be biomarkers or therapeutic targets for disease management. However, further research is needed to elucidate their precise molecular mechanisms.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
P. Suhaj, D. Do, T. Olejar, R. Pichova, O. Lang, R. Matej
Summary: Pancreatic polypeptide cell hyperplasia (PPY-H) is a multiplication of neuroendocrine cells producing pancreatic polypeptide (PPY). The development and role of PPY-H still need to be further elucidated. This study analyzed 12 cases of PPY-H accompanying pancreatic neuroendocrine neoplasias (NEN) and found that gastrointestinal symptoms may be more related to PPY-H rather than NEN hormonal production. Strong SSTR2 expression in PPY-H suggests the potential utility of radiotracers in clinical diagnostics, but further studies are needed.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Ruyun Zhang, Xiaofei Liao, Bin Zhang, Xiaohong Huang, Guanjie Qin, Xiangyun Kong, Yuan Xie, Yunyan Mo, Jinxuan Dai, Chunqiao Gan, Zan Luo, Jingyan Lu, Wei Jiang
Summary: This study found that patients with high COV+TIL score had worse prognosis in nasopharyngeal carcinoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Waleed Hassan Almalki
Summary: Understanding the molecular pathways behind cardiovascular illnesses is crucial. Recent studies have revealed the role of Xist RNA in cardiovascular diseases, including epigenetic changes, gene expression, cellular identity, and sex chromosomal inactivation. Dysregulation of Xist RNA expression is associated with conditions such as atherosclerosis, hypertrophy, and cardiac fibrosis.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Yanxin Dong, Boshi Fan, Mingyang Li, Jiale Zhang, Shun Xie, Shouyin Dia, Qingge Jia, Taiqian Gong
Summary: Tescalcin (TESC) is upregulated in esophageal squamous carcinoma (ESCC) and is associated with poor prognosis, tumor infiltration, staging, and lymph node metastasis. TESC promotes proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) progression in ESCC, as well as activates the AKT pathway. TESC may serve as a prognostic factor and provide a new therapeutic strategy for ESCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Ozge Sukruoglu Erdogan, Demet Akdeniz Odemis, Zubeyde Yalniz Kayim, Orkun Gurbuz, Seref Bugra Tuncer, Seda Kilic, Betul Celik, Samuray Tuncer, Sema Buyukkapu Bay, Rejin Kebudi, Hulya Yazici
Summary: This study found that methylation of the RB1 gene promoter does not influence the hereditary transmission of familial retinoblastoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Syam Mohan, Mohammed Ageeli Hakami, Hamad Ghaleb Dailah, Asaad Khalid, Asim Najmi, Khalid Zoghebi, Maryam A. Halawi, Thaifallah Munahi Alotaibi
Summary: Cancer is a complex disease caused by multiple factors, and miR-155 plays a significant role as a regulator of the NF-kappa B signaling pathway, contributing to cancer development and progression.
PATHOLOGY RESEARCH AND PRACTICE
(2024)