Nematodes and human therapeutic trials for inflammatory disease

Role of Inflammation and Immunity in Hypertension: Recent Epidemiological, Laboratory, and Clinical Evidence

(2016) Antoine Caillon et al.   CURRENT HYPERTENSION REPORTS

The helminth T2 RNase ω1 promotes metabolic homeostasis in an IL-33– and group 2 innate lymphoid cell–dependent mechanism

(2016) Emily Hams et al.   FASEB JOURNAL

Downregulation of the Syk Signaling Pathway in Intestinal Dendritic Cells Is Sufficient To Induce Dendritic Cells That Inhibit Colitis

(2016) Long Hang et al.   JOURNAL OF IMMUNOLOGY

Helminth infection promotes colonization resistance via type 2 immunity

(2016) Deepshika Ramanan et al.   SCIENCE

FoxP3+ T regulatory cells and immunomodulation after Schistosoma mansoni egg antigen immunization in experimental model of inflammatory bowel disease

(2015) Eiman A. Hasby et al.   CELLULAR IMMUNOLOGY

Does Strongyloides stercoralis infection protect against type 2 diabetes in humans? Evidence from Australian Aboriginal adults

(2015) Russell Hays et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Adoptive transfer of helminth antigen-pulsed dendritic cells protects against the development of experimental colitis in mice

(2015) Chelsea E. Matisz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Chronic helminth infection and helminth-derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice

(2015) Leonie Hussaarts et al.   FASEB JOURNAL

Protective effect of Lactobacillus plantarum 21, a probiotic on trinitrobenzenesulfonic acid-induced ulcerative colitis in rats

(2015) C.S.V. Satish Kumar et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The immunomodulatory parasitic worm product ES-62 reduces lupus-associated accelerated atherosclerosis in a mouse model

(2015) Tamar R. Aprahamian et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Experimental hookworm infection and gluten microchallenge promote tolerance in celiac disease

(2015) John Croese et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cohabitation in the Intestine: Interactions among Helminth Parasites, Bacterial Microbiota, and Host Immunity

(2015) Lisa A. Reynolds et al.   JOURNAL OF IMMUNOLOGY

Trichuris suis ova therapy in relapsing multiple sclerosis is safe but without signals of beneficial effect

(2015) A Voldsgaard et al.   Multiple Sclerosis Journal

Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease

(2015) Giovanni Monteleone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical trials of helminth therapy in autoimmune diseases: rationale and findings

(2015) J. O. Fleming et al.   PARASITE IMMUNOLOGY

First case report of exacerbated ulcerative colitis after anti-interleukin-6R salvage therapy

(2015) Raja Atreya   WORLD JOURNAL OF GASTROENTEROLOGY

Experimental hookworm infection and escalating gluten challenges are associated with increased microbial richness in celiac subjects

(2015) Paul Giacomin et al.   Scientific Reports

Extraintestinal Helminth Infection Limits Pathology and Proinflammatory Cytokine Expression during DSS-Induced Ulcerative Colitis: A Role for Alternatively Activated Macrophages and Prostaglandins

(2015) Yadira Ledesma-Soto et al.   Biomed Research International

Trichuris suis ova therapy in relapsing multiple sclerosis is safe but without signals of beneficial effect

(2015) A Voldsgaard et al.   Multiple Sclerosis Journal

Chronic Trichuris muris Infection in C57BL/6 Mice Causes Significant Changes in Host Microbiota and Metabolome: Effects Reversed by Pathogen Clearance

(2015) Ashley Houlden et al.   PLoS One

Chronic Trichuris muris Infection Decreases Diversity of the Intestinal Microbiota and Concomitantly Increases the Abundance of Lactobacilli

(2015) Jacob Bak Holm et al.   PLoS One

Do We Need Worms to Promote Immune Health?

(2014) Joel V. Weinstock   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Macrophages, Immunity, and Metabolic Disease

(2014) Joanne C. McNelis et al.   IMMUNITY

Colonization with Heligmosomoides polygyrus Suppresses Mucosal IL-17 Production

(2014) D. E. Elliott et al.   JOURNAL OF IMMUNOLOGY

A Helminth Immunomodulator Reduces Allergic and Inflammatory Responses by Induction of IL-10-Producing Macrophages

(2014) C. Schnoeller et al.   JOURNAL OF IMMUNOLOGY

Splenic B Cells fromHymenolepis diminuta–Infected Mice Ameliorate Colitis Independent of T Cells and via Cooperation with Macrophages

(2014) José L. Reyes et al.   JOURNAL OF IMMUNOLOGY

Loss of beta2-integrin-mediated cytoskeletal linkage reprogrammes dendritic cells to a mature migratory phenotype

(2014) Vicky Louise Morrison et al.   Nature Communications

Randomised clinical trial: the safety and tolerability ofTrichuris suisova in patients with Crohn's disease

(2013) W. J. Sandborn et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Bone marrow-derived alternatively activated macrophages reduce colitis without promoting fibrosis: participation of IL-10

(2013) Gabriella Leung et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Interleukin-4- and Interleukin-13-Mediated Alternatively Activated Macrophages: Roles in Homeostasis and Disease

(2013) Steven J. Van Dyken et al.   Annual Review of Immunology

Metabolic syndrome and chronic kidney disease

(2013) Ajay K. Singh et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

T-cell-derived, but not B-cell-derived, IL-10 suppresses antigen-specific T-cell responses inLitomosoides sigmodontis-infected mice

(2013) Irma Haben et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Reprogramming macrophages to an anti-inflammatory phenotype by helminth antigens reduces murine atherosclerosis

(2013) Ine M. J. Wolfs et al.   FASEB JOURNAL

The Th17 family: flexibility follows function

(2013) Rajatava Basu et al.   IMMUNOLOGICAL REVIEWS

SMAD regulatory networks construct a balanced immune system

(2013) Nidhi Malhotra et al.   IMMUNOLOGY

Parasitic Nematode-Induced Modulation of Body Weight and Associated Metabolic Dysfunction in Mouse Models of Obesity

(2013) Zhonghan Yang et al.   INFECTION AND IMMUNITY

Changed gluten immunity in celiac disease by Necator americanus provides new insights into autoimmunity

(2013) John Croese et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Chronic Opisthorchis felineus infection attenuates atherosclerosis – An autopsy study

(2013) Eli Magen et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Heligmosomoides polygyrus bakeri Infection Activates Colonic Foxp3+ T Cells Enhancing Their Capacity To Prevent Colitis

(2013) L. Hang et al.   JOURNAL OF IMMUNOLOGY

Possible use of Trichuris suis ova in autism spectrum disorders therapy

(2013) Dario Siniscalco et al.   MEDICAL HYPOTHESES

Relationship between Carotid Intima Media Thickness and Helminth Infections on Flores Island, Indonesia

(2013) Aprilianto Eddy Wiria et al.   PLoS One

Regulation of intestinal homeostasis and immunity with probiotic lactobacilli

(2013) Peter van Baarlen et al.   TRENDS IN IMMUNOLOGY

Trichuris suis ova in relapsing-remitting multiple sclerosis and clinically isolated syndrome (TRIOMS): study protocol for a randomized controlled trial

(2013) Berit Rosche et al.   Trials

Mo2083 A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 827 in Subjects With Moderate to Severe Crohn's Disease

(2012) Stephan R. Targan et al.   GASTROENTEROLOGY

Translatability of helminth therapy in inflammatory bowel diseases

(2012) Joel V. Weinstock et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Trichuris suis ova: Testing a helminth-based therapy as an extension of the hygiene hypothesis

(2012) Marie-Hélène Jouvin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-10 Produced by Induced Regulatory T Cells (iTregs) Controls Colitis and Pathogenic Ex-iTregs during Immunotherapy

(2012) E. G. Schmitt et al.   JOURNAL OF IMMUNOLOGY

Heligmosomoides polygyrus bakeri Induces Tolerogenic Dendritic Cells that Block Colitis and Prevent Antigen-Specific Gut T Cell Responses

(2012) A. M. Blum et al.   JOURNAL OF IMMUNOLOGY

Immunomodulatory glycan LNFPIII alleviates hepatosteatosis and insulin resistance through direct and indirect control of metabolic pathways

(2012) Prerna Bhargava et al.   NATURE MEDICINE

Regulation of Homeostasis and Inflammation in the Intestine

(2011) Thomas T. MacDonald et al.   GASTROENTEROLOGY

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

(2011) Natalie A. Molodecky et al.   GASTROENTEROLOGY

An Essential Role of the Transcription Factor GATA-3 for the Function of Regulatory T Cells

(2011) Yunqi Wang et al.   IMMUNITY

GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice

(2011) Elizabeth A. Wohlfert et al.   JOURNAL OF CLINICAL INVESTIGATION

Immune monitoring of Trichuris suis egg therapy in multiple sclerosis patients

(2011) F. Benzel et al.   JOURNAL OF HELMINTHOLOGY

Pathogenic Nematodes Suppress Humoral Responses to Third-Party Antigens In Vivo by IL-10–Mediated Interference with Th Cell Function

(2011) Wiebke Hartmann et al.   JOURNAL OF IMMUNOLOGY

The impact of parasite infections on the course of multiple sclerosis

(2011) Jorge Correale et al.   JOURNAL OF NEUROIMMUNOLOGY

Probiotic helminth administration in relapsing–remitting multiple sclerosis: a phase 1 study

(2011) JO Fleming et al.   Multiple Sclerosis Journal

Intestinal homeostasis and its breakdown in inflammatory bowel disease

(2011) Kevin J. Maloy et al.   NATURE

Identification of an innate T helper type 17 response to intestinal bacterial pathogens

(2011) Kaoru Geddes et al.   NATURE MEDICINE

Waist-to-height ratio is a better screening tool than waist circumference and BMI for adult cardiometabolic risk factors: systematic review and meta-analysis

(2011) M. Ashwell et al.   Obesity Reviews

Effect of Hookworm Infection on Wheat Challenge in Celiac Disease – A Randomised Double-Blinded Placebo Controlled Trial

(2011) A. James Daveson et al.   PLoS One

Symptoms after Ingestion of Pig Whipworm Trichuris suis Eggs in a Randomized Placebo-Controlled Double-Blind Clinical Trial

(2011) Peter Bager et al.   PLoS One

Key Concepts of Clinical Trials: A Narrative Review

(2011) Craig A. Umscheid et al.   POSTGRADUATE MEDICINE

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

(2011) D. Wu et al.   SCIENCE

Syk-coupled C-type lectins in immunity

(2011) Ann M. Kerrigan et al.   TRENDS IN IMMUNOLOGY

A Helminth Immunomodulator Exploits Host Signaling Events to Regulate Cytokine Production in Macrophages

(2011) Christian Klotz et al.   PLoS Pathogens

Experimental hookworm infection: a randomized placebo-controlled trial in asthma

(2010) J. R. Feary et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Multiple ulcers in the small and large intestines occurred during tocilizumab therapy for rheumatoid arthritis

(2010) T. Iwasa et al.   ENDOSCOPY

In Vitro-Derived Alternatively Activated Macrophages Reduce Colonic Inflammation in Mice

(2010) Meaghan M. Hunter et al.   GASTROENTEROLOGY

Alteration of the murine gut microbiota during infection with the parasitic helminth Heligmosomoides polygyrus

(2010) Seth T. Walk et al.   INFLAMMATORY BOWEL DISEASES

Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway

(2010) John R. Grainger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Heligmosomoides polygyrus Infection Can Inhibit Colitis through Direct Interaction with Innate Immunity

(2010) L. Hang et al.   JOURNAL OF IMMUNOLOGY

The Metabolic Syndrome and Cardiovascular Risk

(2010) Salvatore Mottillo et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

(2010) J. L. Round et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stability of the Regulatory T Cell Lineage in Vivo

(2010) Y. P. Rubtsov et al.   SCIENCE

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

IL-22+ CD4+ T Cells Are Associated with Therapeutic Trichuris trichiura Infection in an Ulcerative Colitis Patient

(2010) M. J. Broadhurst et al.   Science Translational Medicine

Decreased Prevalence of Lymphatic Filariasis among Diabetic Subjects Associated with a Diminished Pro-Inflammatory Cytokine Response (CURES 83)

(2010) Vivekanandhan Aravindhan et al.   PLoS Neglected Tropical Diseases

Immunologic Profiles of Persons Recruited for a Randomized, Placebo-Controlled Clinical Trial of Hookworm Infection

(2009) Daniel Blount et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Regulatory Lymphocytes and Intestinal Inflammation

(2009) Ana Izcue et al.   Annual Review of Immunology

Role of T cell TGF-β signaling in intestinal cytokine responses and helminthic immune modulation

(2009) M. Nedim Ince et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Extracts of the Rat Tapeworm, Hymenolepis diminuta, Suppress Macrophage Activation In Vitro and Alleviate Chemically Induced Colitis in Mice

(2009) M. J. G. Johnston et al.   INFECTION AND IMMUNITY

Smad7 Controls Resistance of Colitogenic T Cells to Regulatory T Cell-Mediated Suppression

(2008) Massimo C. Fantini et al.   GASTROENTEROLOGY

IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease

(2008) T Kobayashi et al.   GUT

Interleukin-6 is an important in vivo inhibitor of intestinal epithelial cell death in mice

(2008) X. Jin et al.   GUT

Differential regulation of naïve and memory CD4+ T cells by alternatively activated dendritic cells

(2008) Amy E. Anderson et al.   JOURNAL OF LEUKOCYTE BIOLOGY