Article
Immunology
Yunyun Zou, Aziz Ghaderpour, Bolormaa Munkhbileg, Sang-Uk Seo, Seung-Yong Seong
Summary: Taurodeoxycholate (TDCA) ameliorates DSS-induced colitis in mice by inhibiting both the activation phase and priming phase of N3I signaling.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Liang Zhao, Yibing Lv, Xiaoqi Zhou, Zilong Guo, Heli Li, Yanyan Guo, Tao Liu, Lei Tu, Liangru Zhu, Juan Tao, Guanxin Shen, Yong He, Ping Lei
Summary: The secreted form of 78-kDa glucose-regulated protein (sGRP78) has potential in the treatment of colitis. During the resolving phase, sGRP78 levels are reduced but quickly rebound, making it a potential candidate for the treatment of colitis. Administration of sGRP78 improves intestinal symptoms, restores TJ integrity, decreases immune cell infiltration, and impairs production of inflammatory cytokines.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Chunyan Peng, Chang Zheng, Fan Zhou, Ying Xie, Lei Wang, Deyan Chen, Xiaoqi Zhang
Summary: This study aimed to investigate the effectiveness of Dac51 in DSS-induced colitis and found that Dac51 could improve inflammatory bowel disease by suppressing FTO expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Lianna Zhou, Zhaoqi Yan, Wei Yang, Jessica A. Buckley, Sameer Al Diffalha, Etty N. Benveniste, Hongwei Qin
Summary: This study found that deficiency of SOCS3 in myeloid cells exacerbates colitis and is associated with increased infiltration of monocytes and neutrophils as well as enhanced expression of related genes. The findings provide new therapeutic strategies for IBD patients with hyperactivated neutrophils.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yiren Yang, Yuwei Zhang, Jiangping Song, Yaqian Li, Liuyang Zhou, Hongtao Xu, Kaizhang Wu, Jie Gao, Mouming Zhao, Yang Zheng
Summary: This study found that polysaccharides from bergamot (BP) can alleviate colitis symptoms by regulating gut microbiota and metabolism. The results showed that BP can promote the proliferation of beneficial bacteria, increase the levels of short-chain fatty acids and L-phenylalanine, and reduce inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Environmental Sciences
Nagwa Mohamed, Dalia H. El-Kashef, Ghada M. Suddek
Summary: Flavocoxid demonstrated a potential protective effect in acetic acid-induced colitis model, by attenuating oxidative stress, inflammation, and apoptosis in colonic tissues of rats.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Food Science & Technology
Haojie Zhang, Yujin Wang, Fengyuan Gao, Rucheng Liu, Wen Chen, Xue Zhao, Qian Sun, Xiaotong Sun, Jingxin Li, Chuanyong Liu, Xuelian Ma
Summary: Gamma-aminobutyric acid (GABA) is a bioactive molecule with potential health benefits, but its involvement in intestinal inflammation is debated. This study found that GABA treatment increases susceptibility to colitis in mice and induces an intestinal barrier defect by inhibiting cell proliferation and promoting apoptosis.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Zewen Mei, Xingxi Huang, Heng Zhang, Danyi Cheng, Xin Xu, Mingyue Fang, Jutuan Hu, Yangyang Liu, Yunxiang Liang, Yuxia Mei
Summary: Chitin derivatives have a therapeutic effect in ulcerative colitis mice model by relieving inflammation symptoms, protecting the colon, and increasing the abundance of gut microbiota and concentrations of short-chain fatty acids.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Immunology
Yongzhi Hua, Ruiqi Liu, Min Lu, Xueneng Guan, Suyang Zhuang, Yaozhou Tian, Zhenhai Zhang, Li Cui
Summary: Juglone has been found to have therapeutic effects on ulcerative colitis in mice, modulating gut microbiota and restoring Th17/Treg balance. The results show that juglone can alleviate UC symptoms, reduce inflammatory protein levels, and impact gut microbiota and Th17/Treg ratio.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Catherine Verhaeghe, Marja Talikka, Alain Sewer, Nicolas Sierro, Mehdi Auberson, Dariusz Peric, David Bornand, Remi Dulize, Emmanuel Guedj, Patrick Nef, Sebastien P. Tabruyn, Julia Hoeng, Manuel C. Peitsch, Giuseppe Lo Sasso
Summary: This study investigated the potential anti-inflammatory activities of tobacco alkaloids nicotine and anatabine in a fully humanized UC mouse model. The results showed that nicotine significantly reduced acute colitis symptoms and improved colitis-specific endpoints. Anatabine also demonstrated similar effectiveness, although weaker or not significant. Gene expression analysis provided insights into the possible mechanism by which nicotine attenuated DSS-induced colitis in humanized mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Anshul Sinha, Yue Li, Mohammadali Khan Mirzaei, Michael Shamash, Rana Samadfam, Irah L. King, Corinne F. Maurice
Summary: The study demonstrates that the gut virome, primarily composed of bacterial viruses, plays a crucial role in modulating intestinal inflammation and disease. Virus-like particles (VLPs) isolated from ulcerative colitis (UC) patients can alter gut bacterial diversity and enhance the severity of experimental colitis in mice. These findings suggest that the gut virome could be a potential target for therapeutic interventions in inflammatory bowel diseases.
Article
Biotechnology & Applied Microbiology
Chuan Zhang, Huiping Zhu, Hui Jie, Hengyue Ding, Hongwen Sun
Summary: Arbutin has protective effects in ulcerative colitis, potentially through the regulation of inflammatory factors and the maintenance of intestinal barrier function. Its mechanism of action may be associated with the MAPK/ELK1 pathway.
Article
Food Science & Technology
Hye-Jung Moon, Youn-Soo Cha, Kyung-Ah Kim
Summary: This study investigated the protective effects of blackcurrant (BC) on ulcerative colitis (UC) in mice. BC powder relieved symptoms of colitis, reduced the production of pro-inflammatory cytokines, regulated the NF-kappa B signaling pathway and gut barrier function related genes, and modulated the gut microbiota composition.
Article
Biochemistry & Molecular Biology
Na Wang, Weixuan Chen, Chenxu Cui, Yuru Zheng, Qiuying Yu, Hongtao Ren, Zhigang Liu, Chao Xu, Gaiping Zhang
Summary: Polyphenols from peanut skin have been found to have anti-inflammatory effects by improving the condition of colonic tissue and altering the composition of gut microbiota.
Review
Gastroenterology & Hepatology
Yakup Kilic, Shahed Kamal, Farah Jaffar, Danujan Sriranganathan, Mohammed Nabil Quraishi, Jonathan P. Segal
Summary: Inflammatory bowel disease (IBD) is a multisystem disease that affects various body systems. The extraintestinal manifestations of IBD are frequent and impact the morbidity and mortality of patients with UC and CD.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Cell Biology
Tonathiu Rodriguez, Thalia Pacheco-Fernandez, Alicia Vazquez-Mendoza, Oscar Nieto-Yanez, Imelda Juarez-Avelar, Jose L. Reyes, Luis I. Terrazas, Miriam Rodriguez-Sosa
Article
Biochemistry & Molecular Biology
Yael Delgado-Ramirez, Angel Ocana-Soriano, Yadira Ledesma-Soto, Jonadab E. Olguin, Joselin Hernandez-Ruiz, Luis I. Terrazas, Sonia Leon-Cabrera
Summary: In the context of colitis-associated colorectal cancer (CAC), the absence of STAT6 led to reduced tumor growth and increased Treg cell numbers, thus inhibiting tumorigenesis. The involvement of STAT6 in regulating Treg cells may offer potential for modulating immune responses in colitis and CAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yael Delgado-Ramirez, Itzel Baltazar-Perez, Yamileth Martinez, Blanca E. Callejas, Itzel Medina-Andrade, Jonadab E. Olguin, Norma L. Delgado-Buenrostro, Yolanda Chirino, Luis Terrazas, Sonia Leon-Cabrera
Summary: The study demonstrates that the lack of STAT1 leads to increased tumorigenicity in colitis-associated colorectal cancer and this can be suppressed by neutralizing IL-17. The findings suggest that targeting IL-17 could potentially prevent tumor formation associated with STAT1 deficiency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Aaron N. Manjarrez-Reyna, Camilo P. Martinez-Reyes, Jose A. Aguayo-Guerrero, Lucia A. Mendez-Garcia, Marcela Esquivel-Velazquez, Sonia Leon-Cabrera, Gilberto Vargas-Alarcon, Jose M. Fragoso, Elizabeth Carreon-Torres, Oscar Perez-Mendez, Jessica L. Prieto-Chavez, Galileo Escobedo
Summary: This study demonstrates that native LDL (nLDL) synergizes with LPS to alter the balance of human monocyte subsets and their ability to produce inflammatory cytokines and chemokine receptors. Patients with serum LDL-cholesterol (LDL-C) >100 mg/dL showed increased levels of NCM, IL-1 beta, LPS-binding protein (LBP), and Castelli's atherogenic risk index compared to controls with optimal LDL-C concentrations (<= 100 mg/dL).
Article
Biochemistry & Molecular Biology
Itzel Medina-Andrade, Jonadab E. Olguin, Stephanie Guerrero-Garcia, Jossael A. Espinosa, Elizabeth Garduno-Javier, Victoria Hernandez-Gomez, Felipe Vaca-Paniagua, Miriam Rodriguez-Sosa, Luis I. Terrazas
Summary: Inflammation has been closely linked to the risk of developing colon cancer, and the IL-4 receptor-mediated pathway may have a role in the development of colon tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Mireya Becerra-Diaz, Yadira Ledesma-Soto, Jonadab E. Olguin, Angel Sanchez-Barrera, Monica G. Mendoza-Rodriguez, Sandy Reyes, Abhay R. Satoskar, Luis I. Terrazas
Summary: In this study, it was found that STAT1(-/-) mice exhibited increased resistance to cestode infection, likely due to impaired recruitment of CD11b(+)CCR2(+)Ly6C(hi)Ly6G(-) cells and failure to develop M2 macrophages.
Article
Biotechnology & Applied Microbiology
Gustavo Acosta-Altamirano, Elizabeth Garduno-Javier, Victoria Hernandez-Gomez, Jossael Alonso Espinosa, Felipe Vaca-Paniagua, Miriam Rodriguez-Sosa, Imelda Juarez-Avelar, Luis Ignacio Terrazas, Juan Carlos Bravata-Alcantara, Monica Sierra-Martinez, Jonadab E. Olguin
Summary: This study explores the immune response during COVID-19 disease and identifies a potential predictive marker for protection in the Mexican population, specifically a population of monocytes expressing dual pro- and anti-inflammatory characteristics.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Antonio Andrade-Meza, Luis E. Arias-Romero, Leonel Armas-Lopez, Federico Avila-Moreno, Yolanda I. Chirino, Norma L. Delgado-Buenrostro, Veronica Garcia-Castillo, Emma B. Gutierrez-Cirlos, Imelda Juarez-Avelar, Sonia Leon-Cabrera, Monica G. Mendoza-Rodriguez, Jonadab E. Olguin, Araceli Perez-Lopez, Carlos Perez-Plasencia, Jose L. Reyes, Yesennia Sanchez-Perez, Luis I. Terrazas, Felipe Vaca-Paniagua, Olga Villamar-Cruz, Miriam Rodriguez-Sosa
Summary: In 2013, the Mexican Colorectal Cancer Research Consortium was established by researchers at UNAM to tackle the increasing problem of colorectal cancer in Mexico. The Consortium consists of a multidisciplinary team working towards understanding the pathology of this disease and achieving short- and long-term goals. The article highlights the achievements of the consortium and discusses strategies for prevention and treatment of colorectal cancer in Mexico.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Ruben D. Arroyo-Olarte, Ana Rivera-Rugeles, Eduardo Nava-Lira, Angel Sanchez-Barrera, Yadira Ledesma-Soto, Rafael Saavedra, Leonel Armas-Lopez, Luis Terrazas, Federico Avila-Moreno, Sonia Leon-Cabrera
Summary: Signal transducer and activator of transcription 6 (STAT6) promotes tumorigenesis in colitis-associated cancer (CAC) by decreasing the frequency of Foxp3+ cells and allowing for the infiltration of inflammatory cells. The study found that STAT6 plays a crucial role in the generation of inducible in vitro regulatory T cells (iTregs) and peripheral in vivo Tregs (pTregs) under inflammatory conditions. STAT6 deficiency led to stable iTregs phenotype, increased suppressive ability, and overexpression of PD-1, CTLA-4, and Foxp3, as well as decreased IFN-gamma expression. In a mouse model of CAC, STAT6-/- pTregs exhibited an activated phenotype, higher suppressive capacity, and increased expression of PD-1 and LAP, contributing to the attenuation of tumor development.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Immunology
Aldo Hugo De La Cruz-Montoya, Clara Estela Diaz Velasquez, Hector Martinez-Gregorio, Miguel Ruiz-De La Cruz, Jose Bustos-Arriaga, Tannya Karen Castro-Jimenez, Jonadab Efrain Olguin-Hernandez, Miriam Rodriguez-Sosa, Luis Ignacio Terrazas-Valdes, Luis Armando Jimenez-Alvarez, Nora Elemi Regino-Zamarripa, Gustavo Ramirez-Martinez, Alfredo Cruz-Lagunas, Irlanda Peralta-Arrieta, Leonel Armas-Lopez, Belinda Maricela Contreras-Garza, Gabriel Palma-Cortes, Carlos Cabello-Gutierrez, Renata Baez-Saldana, Joaquin Zuniga, Federico Avila-Moreno, Felipe Vaca-Paniagua
Summary: Through analyzing the viral whole genome sequences from 50 critical COVID-19 patients in Mexico City, this study reveals the genomic transition of SARS-CoV-2 and the dominance of the B.1.1.519 variant in the second wave.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jose Alfredo Aguayo-Guerrero, Lucia Angelica Mendez-Garcia, Aaron Noe Manjarrez-Reyna, Marcela Esquivel-Velazquez, Sonia Leon-Cabrera, Guillermo Melendez, Elena Zambrano, Espiridion Ramos-Martinez, Jose Manuel Fragoso, Juan Carlos Briones-Garduno, Galileo Escobedo
Summary: Robust animal data indicate that sucralose intake during pregnancy can lead to weight gain, metabolic disturbances, and low-grade systemic inflammation in offspring, but information in humans is still limited. A cross-sectional, prospective study was conducted to examine the effects of light sucralose ingestion (LSI) or heavy sucralose intake (HSI) during pregnancy on neonatal anthropometric, metabolic, and inflammatory features. Infants from HSI mothers had higher birth weight, insulin levels, and percentage of inflammatory nonclassical monocytes compared to those from LSI mothers. Furthermore, umbilical cord tissue of infants from HSI mothers showed higher levels of IL-1 beta and TNF-alpha with lower IL-10 expression. These results suggest that heavy sucralose ingestion during pregnancy can impact neonatal health.
Article
Biochemistry & Molecular Biology
Olga Villamar-Cruz, Marco Antonio Loza-Mejia, Alonso Vivar-Sierra, Hector Ivan Saldivar-Ceron, Genaro Patino-Lopez, Jonadab Efrain Olguin, Luis Ignacio Terrazas, Leonel Armas-Lopez, Federico Avila-Moreno, Sayanti Saha, Jonathan Chernoff, Ignacio Camacho-Arroyo, Luis Enrique Arias-Romero
Summary: PTP1B plays a key role in cancer development, but its molecular mechanism is unclear. This study identified Cdk3 as a novel substrate of PTP1B and demonstrated their interactions in human glioblastoma cells. Additionally, the study revealed that inhibition or depletion of PTP1B leads to cell cycle arrest and downregulation of E2F target genes through Cdk3 pathway. These findings highlight the importance of the PTP1B-Cdk3 signaling pathway in regulating cell cycle progression in human glioblastoma cells.
MOLECULAR AND CELLULAR BIOLOGY
(2023)