Article
Biochemistry & Molecular Biology
Nadine Nagy, Gernot Kaber, Payton L. Marshall, Aviv Hargil, Hedwich F. Kuipers, Heather D. Ishak, Marika Bogdani, Rebecca L. Hull, Maria Grandoch, Jens W. Fischer, Tracey L. Mclaughlin, Thomas N. Wight, Paul L. Bollyky, Vivekananda G. Sunkari
Summary: This study identifies a novel role for the inflammatory extracellular matrix polymer hyaluronan (HA) in the pathogenesis of type 2 diabetes. The inhibition of HA synthesis or deletion of the main HA receptor CD44 can preserve glycemic control and insulin concentrations in diabetic mice, indicating the potential of HA as a target for ameliorating beta-cell loss in type 2 diabetes.
Review
Oncology
Daiana L. Vitale, Antonella Icardi, Paolo Rosales, Fiorella M. Spinelli, Ina Sevic, Laura D. Alaniz
Summary: 4-Methylumbelliferone (4-MU), a natural product with antitumoral properties, inhibits tumor growth and progression by specifically inhibiting hyaluronan synthesis. It also impacts tumor cell functions, cancer stem cells, and the tumor microenvironment. However, more scientific evidence is needed to support its use in cancer therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tomas Koltai, Stephan Joel Reshkin, Tiago M. A. Carvalho, Rosa A. Cardone
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy with poor survival rates. Conventional treatments have limited efficacy, prompting the exploration of innovative approaches targeting the tumor microenvironment or the hyaluronan-CD44 pathway. These new strategies may offer potential benefits to improve outcomes for patients with PDAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Rafal Szatanek, Monika Baj-Krzyworzeka
Summary: Cancer metastasis involves complex interactions between various cell types and the tumor microenvironment, with tumor cells releasing proteins and nucleic acids through extracellular vesicles to facilitate dissemination. This process plays a crucial role in tumor progression and escape from immune surveillance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Evgenia Karousou, Arianna Parnigoni, Paola Moretto, Alberto Passi, Manuela Viola, Davide Vigetti
Summary: The extracellular matrix has a complex structure and the glycans within are difficult to study, but they have various effects on cells, especially the glycosaminoglycan hyaluronan. Changes in hyaluronan concentration or dimension can affect tissue stiffness and cellular response through membrane receptors. Hyaluronan plays a role in cancer progression and can be affected by growth factors and cell metabolism.
Article
Oncology
Aneta Babula, Adrianna Galuszka-Bulaga, Kazimierz Weglarczyk, Maciej Siedlar, Monika Baj-Krzyworzeka
Summary: This study investigates the interactions between monocytes and tumor-derived extracellular vesicles (TEVs) during tumor progression. The attachment and engulfment of TEVs by monocytes is influenced by the number and exposure time of TEVs. TEVs derived from different colon cancer cell lines show variations in CD44 expression and internalization efficiency. Different subsets of monocytes, characterized by CD44 expression levels, also differ in the internalization of HA-rich TEVs. The study suggests that HA carried by TEVs may enhance the interaction between monocyte subsets and TEVs, influencing the fate of TEVs and monocyte activity.
Review
Cell Biology
Theodoros Karalis, Spyros S. Skandalis
Summary: Hyaluronan plays important roles in normal physiology and cancer, and its accumulation is associated with poor prognosis in cancer patients. Targeting the hyaluronan system may be a promising therapeutic strategy.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dimitris Kokoretsis, Evangelia-Konstantina Maniaki, Konstantina Kyriakopoulou, Christos Koutsakis, Zoi Piperigkou, Nikos K. Karamanos
Summary: This article highlights the vital functions of hyaluronan (HA) in cancer cell initiation, progression, and immune response, as well as its paracrine interactions with stromal cells. Furthermore, it discusses the important role of HA in the formation of pre-metastatic niche, which may contribute to the improvement of current theranostic approaches for cancer management.
Article
Biochemistry & Molecular Biology
Jiarui Zhang, Yoshihiro Nishida, Hiroshi Koike, Lisheng Zhuo, Kan Ito, Kunihiro Ikuta, Tomohisa Sakai, Shiro Imagama
Summary: This study aimed to investigate the effects of ipriflavone on the development and progression of osteoarthritis (OA) by reducing KIAA1199 activity. The results showed that ipriflavone could suppress OA onset and progression by targeting KIAA1199 activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Alexandra N. Donlan, Tara E. Sutherland, Chelsea Marie, Saskia Preissner, Ben T. Bradley, Rebecca M. Carpenter, Jeffrey M. Sturek, Jennie Z. Ma, G. Brett Moreau, Jeffrey R. Donowitz, Gregory A. Buck, Myrna G. Serrano, Stacey L. Burgess, Mayuresh M. Abhyankar, Cameron Mura, Philip E. Bourne, Robert Preissner, Mary K. Young, Genevieve R. Lyons, Johanna J. Loomba, Sarah J. Ratcliffe, Melinda D. Poulter, Amy J. Mathers, Anthony Day, Barbara J. Mann, Judith E. Allen, William A. Petri
Summary: Research shows that elevated IL-13 levels are associated with severe COVID-19. In a mouse model, neutralizing IL-13 reduced disease severity and lung HA deposition. Administration of IL-13 induced HA in the lungs. Blocking the HA receptor CD44 prevented mortality, highlighting a potentially novel mechanism for IL-13-mediated HA synthesis in pulmonary pathology.
Article
Biochemistry & Molecular Biology
Anurag Purushothaman, Jacqueline Oliva-Ramirez, Warapen Treekitkarnmongkol, Deivendran Sankaran, Mark W. Hurd, Nagireddy Putluri, Anirban Maitra, Cara Haymaker, Subrata Sen
Summary: sEVs play an important role in PDAC development, influencing the activation state of monocyte subtypes, protein expression, and cytokine secretion. Additionally, sEV-associated HA plays a crucial role in regulating immune response and secretion of tumor-associated factors in PDAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Katerina Stepankova, Dana Marekova, Kristyna Kubasova, Radek Sedlacek, Karolina Turnovcova, Irena Vackova, Sarka Kubinova, Pavol Makovicky, Michaela Petrovicova, Jessica C. F. Kwok, Pavla Jendelova, Lucia Machova Urdzikova
Summary: This study evaluated the physiological changes and potential side effects of 4-methylumbelliferone (4MU) treatment in healthy rats. The results showed increased bile acids, blood sugars, and proteins after 4MU administration, as well as increased interleukins IL10, IL12p70, and IFN gamma. However, these effects were reversed after a 9-week wash-out period.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Hind Al Khashali, Jadziah Wareham, Ravel Ray, Ben Haddad, Kai-Ling Coleman, Robert Ranzenberger, Patrick McCombs, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans
Summary: This study investigates the roles of heparanase and IGFBP-3 in regulating the survival of non-small-cell lung cancer cells. The results suggest that inhibiting heparanase activity or expression decreases the levels of soluble HS fragments and reduces interactions between IGFBP-3 and HS. Additionally, blocking HA-CD44 signaling increases p53 activity and the levels of IGFBP-3. Silencing p53 leads to increased heparanase levels, while silencing IGFBP-3 blocks p53 activity and increases heparanase levels.
Review
Oncology
Arianna Parnigoni, Paola Moretto, Manuela Viola, Evgenia Karousou, Alberto Passi, Davide Vigetti
Summary: Breast cancer is the most common neoplasm in women, and its lethality is mainly due to the ability of tumor cells to invade and seed distant organs. Hormone receptors play a critical role in determining tumor aggressiveness and targeted therapies, but the role of the tumor microenvironment is also evident. This article focuses on the role of the extracellular matrix polysaccharide hyaluronan in relation to hormone receptor expression in breast cancer cells.
Article
Engineering, Biomedical
Ana M. Carvalho, Diana Soares da Costa, Rui L. Reis, Iva Pashkuleva
Summary: This study reveals the altered expression of hyaluronan (HA) receptors CD44 and RHAMM in the tumor microenvironment, which are associated with poor prognosis and treatment outcomes. The study also demonstrates the bi-directional communication between HA and breast cancer cell lines with different surface expression of CD44 and RHAMM. These findings are significant for the development of therapies targeting HA signaling in the tumor microenvironment.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Atsushi Uenoyama, Ikuko Kakizaki, Aki Shiomi, Naoaki Saito, Yuko Hara, Taro Saito, Hisashi Ohnuki, Hiroko Kato, Ritsuo Takagi, Takeyasu Maeda, Kenji Izumi
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2016)
Article
Biochemistry & Molecular Biology
Mihoko Sutoh Yoneyama, Yuki Tobisawa, Shingo Hatakeyama, Misaki Sato, Kiyoshi Tone, Yota Tatara, Ikuko Kakizaki, Tomihisa Funyu, Minoru Fukuda, Senji Hoshi, Chikara Ohyama, Shigeru Tsuboi
JOURNAL OF BIOCHEMISTRY
(2017)
Article
Oncology
Eri Yoshida, Daisuke Kudo, Hayato Nagase, Akiko Suto, Hiroshi Shimoda, Shinichiro Suto, Ikuko Kakizaki, Masahiko Endo, Kenichi Hakamada
ANTICANCER RESEARCH
(2018)
Article
Biochemical Research Methods
Takashi Kobayashi, Ikuko Kakizaki, Toshiya Nakamura
ANALYTICAL BIOCHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Ikuko Kakizaki, Hideyo Koizumi, Takashi Kobayashi, Toshiya Nakamura, Mitsuo Majima
CARBOHYDRATE RESEARCH
(2019)
Article
Chemistry, Applied
Shinichiro Suto, Ikuko Kakizaki, Yota Tatara, Masahiko Endo
Summary: The structure of hyaluronan is crucial for binding to HABP, with particular emphasis on the non-reducing terminal structure. Replacement of internal disaccharide units is possible for chains decasaccharide or larger.
CARBOHYDRATE POLYMERS
(2021)
Article
Oncology
Hirotake Kodama, Tohru Yoneyama, Toshikazu Tanaka, Daisuke Noro, Yuki Tobisawa, Hayato Yamamoto, Shinichiro Suto, Shingo Hatakeyama, Kazuyuki Mori, Takahiro Yoneyama, Yasuhiro Hashimoto, Ikuko Kakizaki, Shigeyuki Nakaji, Chikara Ohyama
Summary: The study evaluated the diagnostic performance of N-glycosylation signatures of immunoglobulins for detecting urothelial carcinoma, including bladder cancer and upper urinary tract UC. The results showed that N-glycosylation signatures of Igs provided significantly better clinical performance in discriminating BCa and UTUC compared to other clinical factors, and could be a promising approach for the diagnosis of UC.
Article
Biochemistry & Molecular Biology
Ikuko Kakizaki, Takayasu Kobayashi, Shinri Tamura, Hiroshi Akagi, Keiichi Takagaki
Summary: This study found that chondroitin sulfate E and heparin can upregulate neural specific markers during neural differentiation, with chondroitin sulfate E shown to play a role in spheroid formation, while a hyaluronan oligosaccharide mixture downregulated the expressions of myelin specific markers.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Hiromichi Iwamura, Kei Mizuno, Shusuke Akamatsu, Shingo Hatakeyama, Yuki Tobisawa, Shintaro Narita, Takuma Narita, Shinichi Yamashita, Sadafumi Kawamura, Toshihiko Sakurai, Naoki Fujita, Hirotake Kodama, Daisuke Noro, Ikuko Kakizaki, Shigeyuki Nakaji, Ken Itoh, Norihiko Tsuchiya, Akihiro Ito, Tomonori Habuchi, Chikara Ohyama, Tohru Yoneyama
Summary: The study aimed to establish a urological disease-specific scoring system using machine learning (ML) approach and Ig N-glycan signatures. The results showed that the scoring system was able to effectively discriminate different urological diseases and had good diagnostic ability.
Article
Biochemistry & Molecular Biology
Ikuko Kakizaki, Yoji Kato
Summary: Over the past 10 years, many products utilizing the functionality of salmon cartilage proteoglycan have come on the market, and consumer awareness of proteoglycan has increased. However, evaluating the amount and quality of proteoglycan in the products has been a major issue. In this study, the researchers propose an immunological method that can easily evaluate the amount and quality of proteoglycan in the proteoglycan-containing compositions.
JOURNAL OF APPLIED GLYCOSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Ikuko Kakizaki
Summary: Cellulase from Aspergillus niger has endo-fl-xylosidase activity and can be used for analyzing long-chain glycosaminoglycan.
TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yu Teshigahara, Ikuko Kakizaki, Wataru Hirao, Kanji Tanaka, Ryoki Takahashi
JOURNAL OF APPLIED GLYCOSCIENCE
(2020)
Article
Obstetrics & Gynecology
Seigo Tanaka, Ikuko Kakizaki, Kanji Tanaka, Tomoe Kodama, Asami Ito-Fukuyama, Shinichiro Suto, Ryoki Takahashi, Yoshihito Yokoyama
HYPERTENSION RESEARCH IN PREGNANCY
(2019)
Article
Biochemistry & Molecular Biology
Ikuko Kakizaki, Ayako Miura, Takashi Mineta, Jinseo Hong, Yoji Kato
JOURNAL OF APPLIED GLYCOSCIENCE
(2017)