Cellular and Molecular Mechanisms of Diabetic Atherosclerosis: Herbal Medicines as a Potential Therapeutic Approach

Regulation of Vascular Smooth Muscle Cell Dysfunction Under Diabetic Conditions by miR-504Significance

(2016) Marpadga A. Reddy et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pioglitazone, a PPARγ agonist, attenuates PDGF-induced vascular smooth muscle cell proliferation through AMPK-dependent and AMPK-independent inhibition of mTOR/p70S6K and ERK signaling

(2016) Islam Osman et al.   BIOCHEMICAL PHARMACOLOGY

Reduction of CTRP9, a novel anti-platelet adipokine, contributes to abnormal platelet activity in diabetic animals

(2016) Wenqing Wang et al.   Cardiovascular Diabetology

Salvianolic acid B improves vascular endothelial function in diabetic rats with blood glucose fluctuations via suppression of endothelial cell apoptosis

(2016) Younan Ren et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Curcumin analog L3 alleviates diabetic atherosclerosis by multiple effects

(2016) Bin Zheng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

NOX4-derived reactive oxygen species limit fibrosis and inhibit proliferation of vascular smooth muscle cells in diabetic atherosclerosis

(2016) Elyse Di Marco et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chinese Herbal Medicine on Cardiovascular Diseases and the Mechanisms of Action

(2016) Cuiqing Liu et al.   Frontiers in Pharmacology

MiR-138 promotes smooth muscle cells proliferation and migration in db/db mice through down-regulation of SIRT1

(2015) Juan Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases

(2015) Beshay N.M. Zordoky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

PKC-β activation inhibits IL-18-binding protein causing endothelial dysfunction and diabetic atherosclerosis

(2015) Marie-Claude Durpès et al.   CARDIOVASCULAR RESEARCH

Ginkgolide A reduces inflammatory response in high-glucose-stimulated human umbilical vein endothelial cells through STAT3-mediated pathway

(2015) Qiuping Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Attenuation of atherosclerotic lesions in diabetic apolipoprotein E-deficient mice using gene silencing of macrophage migration inhibitory factor

(2015) Hui Sun et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Antidiabetic potential of salvianolic acid B in multiple low-dose streptozotocin-induced diabetes

(2015) Safoura Raoufi et al.   PHARMACEUTICAL BIOLOGY

Amelioration by Catalpol of Atherosclerotic Lesions in Hypercholesterolemic Rabbits

(2015) Jiang-yue Liu et al.   PLANTA MEDICA

Alteration of Mevalonate Pathway in Proliferated Vascular Smooth Muscle from Diabetic Mice: Possible Role in High-Glucose-Induced Atherogenic Process

(2015) Guo-Ping Chen et al.   Journal of Diabetes Research

Ligustrazine attenuates the platelet-derived growth factor-BB-induced proliferation and migration of vascular smooth muscle cells by interrupting extracellular signal-regulated kinase and P38 mitogen-activated protein kinase pathways

(2015) LIFEI YU et al.   Molecular Medicine Reports

Suppressor of Cytokine Signaling 1–Derived Peptide Inhibits Janus Kinase/Signal Transducers and Activators of Transcription Pathway and Improves Inflammation and Atherosclerosis in Diabetic Mice

(2014) Carlota Recio et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Gal-geun-dang-gwi-tang improves diabetic vascular complication in apolipoprotein E KO mice fed a western diet

(2014) So Min Lee et al.   BMC Complementary and Alternative Medicine

The interleukin-1 receptor antagonist anakinra improves endothelial dysfunction in streptozotocin-induced diabetic rats

(2014) Susana Vallejo et al.   Cardiovascular Diabetology

Immunization with advanced glycation end products modified low density lipoprotein inhibits atherosclerosis progression in diabetic apoE and LDLR null mice

(2014) Lin Zhu et al.   Cardiovascular Diabetology

miR33 Inhibition Overcomes Deleterious Effects of Diabetes Mellitus on Atherosclerosis Plaque Regression in Mice

(2014) Emilie Distel et al.   CIRCULATION RESEARCH

Salvianolic Acid B Inhibits Atherogenesis of Vascular Cells through Induction of Nrf2-dependent Heme Oxygenase-1

(2014) Hyun Jung Lee et al.   CURRENT MEDICINAL CHEMISTRY

Role of AGEs-RAGE System in Cardiovascular Disease

(2014) Kei Fukami et al.   CURRENT PHARMACEUTICAL DESIGN

Protection from diabetes-induced atherosclerosis and renal disease by d-carnosine-octylester: effects of early vs late inhibition of advanced glycation end-products in Apoe-null mice

(2014) Stefano Menini et al.   DIABETOLOGIA

Paeonol Inhibits Proliferation of Vascular Smooth Muscle Cells Stimulated by High Glucose via Ras-Raf-ERK1/2 Signaling Pathway in Coculture Model

(2014) Junjun Chen et al.   Evidence-based Complementary and Alternative Medicine

Effects of the ginkgo biloba extract on the superoxide dismutase activity and apoptosis of endothelial progenitor cells from diabetic peripheral blood

(2014) M. Zhao et al.   GENETICS AND MOLECULAR RESEARCH

mTOR mediates the cross-talk of macrophage polarization and autophagy in atherosclerosis

(2014) Feng Tian et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Pioglitazone inhibits high glucose-induced expression of receptor for advanced glycation end products in coronary artery smooth muscle cells

(2014) BEI-BING DI et al.   Molecular Medicine Reports

Evidence for the Involvement of JAK/STAT/SOCS Pathway in the Mechanism of Tangshen Formula-Treated Diabetic Nephropathy

(2014) Jingjing Hu et al.   PLANTA MEDICA

Tetramethylpyrazine Ameliorates High Glucose-Induced Endothelial Dysfunction by Increasing Mitochondrial Biogenesis

(2014) Qiong Xu et al.   PLoS One

Combating oxidative stress in diabetic complications with Nrf2 activators: How much is too much?

(2014) Sih Min Tan et al.   REDOX REPORT

Vitamin B6 Supplementation Improves Oxidative Stress and Enhances Serum Paraoxonase/Arylesterase Activities in Streptozotocin-Induced Diabetic Rats

(2014) Sibel Taş et al.   TheScientificWorldJOURNAL

PKCβ Promotes Vascular Inflammation and Acceleration of Atherosclerosis in Diabetic ApoE Null Mice

(2013) Linghua Kong et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Autophagy in obesity and atherosclerosis: Interrelationships between cholesterol homeostasis, lipoprotein metabolism and autophagy in macrophages and other systems

(2013) Mireille Ouimet   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Molecular mechanisms of hypolipidemic effects of curcumin

(2013) Jean-Marc Zingg et al.   BIOFACTORS

High glucose condition increases NADPH oxidase activity in endothelial microparticles that promote vascular inflammation

(2013) Felix Jansen et al.   CARDIOVASCULAR RESEARCH

SOCS and diabetes-ups and downs of a turbulent relationship

(2013) Dariusz Suchy et al.   CELL BIOCHEMISTRY AND FUNCTION

Ginkgo biloba extract reduces high-glucose-induced endothelial reactive oxygen species generation and cell adhesion molecule expression by enhancing HO-1 expression via Akt/eNOS and p38 MAP kinase pathways

(2013) Hsiao-Ya Tsai et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Acyl-CoA Synthetase 1 Is Induced by Gram-negative Bacteria and Lipopolysaccharide and Is Required for Phospholipid Turnover in Stimulated Macrophages

(2013) Katya B. Rubinow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic modulators of STAT signalling for human diseases

(2013) Gabriella Miklossy et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibition of Nuclear Factor of Activated T-Cells (NFAT) Suppresses Accelerated Atherosclerosis in Diabetic Mice

(2013) Anna V. Zetterqvist et al.   PLoS One

Traditional Chinese medicine formula Qing Huo Yi Hao as superoxide anion scavenger in high glucose-treated endothelial cells

(2012) Qiong Xu et al.   ACTA PHARMACOLOGICA SINICA

Pro-Inflammatory Role of MicroRNA-200 in Vascular Smooth Muscle Cells From Diabetic Mice

(2012) Marpadga A. Reddy et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of STAT3 signaling prevents vascular smooth muscle cell proliferation and neointima formation

(2012) Jan-Marcus Daniel et al.   BASIC RESEARCH IN CARDIOLOGY

An update on advanced glycation endproducts and atherosclerosis

(2012) Serena Del Turco et al.   BIOFACTORS

D-carnosine octylester attenuates atherosclerosis and renal disease in ApoE null mice fed a Western diet through reduction of carbonyl stress and inflammation

(2012) Stefano Menini et al.   BRITISH JOURNAL OF PHARMACOLOGY

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Role of TRIB3 in Diabetic and Overnutrition-Induced Atherosclerosis

(2012) J. R. Sowers   DIABETES

Silence of TRIB3 Suppresses Atherosclerosis and Stabilizes Plaques in Diabetic ApoE-/-/LDL Receptor-/- Mice

(2012) Z.-h. Wang et al.   DIABETES

Biology and significance of the JAK/STAT signalling pathways

(2012) Hiu Kiu et al.   GROWTH FACTORS

Diabetic atherosclerosis in APOE*4 mice: synergy between lipoprotein metabolism and vascular inflammation

(2012) Lance A. Johnson et al.   JOURNAL OF LIPID RESEARCH

Glucose-Dependent Insulinotropic Polypeptide Prevents the Progression of Macrophage-Driven Atherosclerosis in Diabetic Apolipoprotein E-Null Mice

(2012) Yukinori Nogi et al.   PLoS One

Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1

(2012) J. E. Kanter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antihyperglycemic Effect ofGinkgo bilobaExtract in Streptozotocin-Induced Diabetes in Rats

(2012) Daye Cheng et al.   Biomed Research International

Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia

(2011) Zoltan Ungvari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Roles of SIRT1 in High Glucose-induced Endothelial Impairment: Association with Diabetic Atherosclerosis

(2011) Juhong Yang et al.   ARCHIVES OF MEDICAL RESEARCH

Suppressors of Cytokine Signaling (SOCS) Proteins and JAK/STAT Pathways

(2011) Taiga Tamiya et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Acyl-CoA synthetase 1 is required for oleate and linoleate mediated inhibition of cholesterol efflux through ATP-binding cassette transporter A1 in macrophages

(2011) Jenny E. Kanter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Protective effect of ligustrazine against myocardial ischaemia reperfusion in rats: The role of endothelial nitric oxide synthase

(2011) Lei Lv et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Indices of Obesity and Cardiometabolic Risk

(2011) Adam Whaley-Connell et al.   HYPERTENSION

Plasma Glucose Lowering Mechanisms of Catalpol, an Active Principle from Roots of Rehmannia glutinosa, in Streptozotocin-Induced Diabetic Rats

(2011) Ja-Ping Shieh et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inhibition of glucose-induced vascular endothelial growth factor expression by Salvia miltiorrhiza hydrophilic extract in human microvascular endothelial cells: Evidence for mitochondrial oxidative stress

(2011) Shuhong Qian et al.   JOURNAL OF ETHNOPHARMACOLOGY

Extract of Salvia miltiorrhiza (Danshen) induces Nrf2-mediated heme oxygenase-1 expression as a cytoprotective action in RAW 264.7 macrophages

(2011) Seung Eun Lee et al.   JOURNAL OF ETHNOPHARMACOLOGY

EGb761, a Ginkgo Biloba Extract, Is Effective Against Atherosclerosis In Vitro, and in a Rat Model of Type 2 Diabetes

(2011) Soo Lim et al.   PLoS One

How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?

(2010) Yohannes Mebratu et al.   CELL CYCLE

Activation of Protein Kinase C Isoforms and Its Impact on Diabetic Complications

(2010) Pedro Geraldes et al.   CIRCULATION RESEARCH

Enhanced Levels of microRNA-125b in Vascular Smooth Muscle Cells of Diabetic db/db Mice Lead to Increased Inflammatory Gene Expression by Targeting the Histone Methyltransferase Suv39h1

(2010) L. M. Villeneuve et al.   DIABETES

Aberrant hepatic TRIB3 gene expression in insulin-resistant obese humans

(2010) H. Oberkofler et al.   DIABETOLOGIA

Ginkgo biloba extract enhances glucose tolerance in hyperinsulinism-induced hepatic cells

(2010) Lei Zhou et al.   Journal of Natural Medicines

Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus

(2010) Inge A. M. van den Oever et al.   MEDIATORS OF INFLAMMATION

Mammalian Tribbles homolog 3 impairs insulin action in skeletal muscle: role in glucose-induced insulin resistance

(2009) Jiarong Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Nuclear Factor of Activated T Cells Regulates Osteopontin Expression in Arterial Smooth Muscle in Response to Diabetes-Induced Hyperglycemia

(2009) Lisa M. Nilsson-Berglund et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Long-term high glucose concentration influences Akt, ERK1/2, and PTP1B protein expression in human aortic smooth muscle cells

(2009) Doina Popov et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tetramethylpyrazine suppresses interleukin-8 expression in LPS-stimulated human umbilical vein endothelial cell by blocking ERK, p38 and nulear factor-κB signaling pathways

(2009) Xiu-Ying Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Monocytes from Patients with Type 1 Diabetes Spontaneously Secrete Proinflammatory Cytokines Inducing Th17 Cells

(2009) E. M. Bradshaw et al.   JOURNAL OF IMMUNOLOGY

The Pathologic Continuum of Diabetic Vascular Disease

(2009) Gabriela Orasanu et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Antioxidative effect of the herbal remedy Qin Huo Yi Hao and its active component tetramethylpyrazine on high glucose-treated endothelial cells

(2009) Yingxiu Kang et al.   LIFE SCIENCES

Signal Transducer and Activator of Transcription-1 Is Critical for Apoptosis in Macrophages Subjected to Endoplasmic Reticulum Stress In Vitro and in Advanced Atherosclerotic Lesions In Vivo

(2008) Wah-Seng Lim et al.   CIRCULATION

Glycation as an atherogenic modification of LDL

(2008) Nahla Younis et al.   CURRENT OPINION IN LIPIDOLOGY

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

(2008) Xiuyun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of NCB-02, Atorvastatin and Placebo on Endothelial Function, Oxidative Stress and Inflammatory Markers in Patients with Type 2 Diabetes Mellitus

(2008) P Usharani et al.   Drugs in research & development

The use of interleukin-1-receptor antagonists in the treatment of diabetes mellitus

(2008) Marc Y Donath et al.   Nature clinical practice. Endocrinology & metabolism