Controlling miRNA-like off-target effects of an siRNA with nucleobase modifications

Design and Synthesis of 2,5-Disubstituted-1,3,4-Oxadiazole Hybrids Bearing Pyridine and 1,2,3-Triazole Pharmacophores

(2016) Reena Kaushik et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Structure-Guided Control of siRNA Off-Target Effects

(2016) Scott R. Suter et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Abasic pivot substitution harnesses target specificity of RNA interference

(2015) Hye-Sook Lee et al.   Nature Communications

Click Modification of RNA at Adenosine: Structure and Reactivity of 7-Ethynyl- and 7-Triazolyl-8-aza-7-deazaadenosine in RNA

(2014) Kelly J. Phelps et al.   ACS Chemical Biology

Structural basis for microRNA targeting

(2014) N. T. Schirle et al.   SCIENCE

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Short Interfering RNA Guide Strand Modifiers from Computational Screening

(2013) Kazumitsu Onizuka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

7-Substituted 8-aza-7-deazaadenosines for modification of the siRNA major groove

(2012) José M. Ibarra-Soza et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The Crystal Structure of Human Argonaute2

(2012) N. T. Schirle et al.   SCIENCE

Modified siRNA Structure With a Single Nucleotide Bulge Overcomes Conventional siRNA-mediated Off-target Silencing

(2011) Pooja Dua et al.   MOLECULAR THERAPY

Silencing or Stimulation? siRNA Delivery and the Immune System

(2011) Kathryn A. Whitehead et al.   Annual Review of Chemical and Biomolecular Engineering

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Staying on message: design principles for controlling nonspecific responses to siRNA

(2010) Shirley Samuel-Abraham et al.   FEBS Journal

Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs

(2010) Narendra Vaish et al.   NUCLEIC ACIDS RESEARCH

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

(2010) Jesper B. Bramsen et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-like off-target transcript regulation by siRNAs is species specific

(2009) J. Burchard et al.   RNA

Chemically modified siRNA: tools and applications

(2008) J WATTS et al.   DRUG DISCOVERY TODAY

Probing the Active Site of a Diels−Alderase Ribozyme by Photoaffinity Cross-Linking

(2008) Richard Wombacher et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect

(2008) Kumiko Ui-Tei et al.   NUCLEIC ACIDS RESEARCH