Computationally guided discovery of a reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling

Micro-flow photosynthesis of new dienophiles for inverse-electron-demand Diels–Alder reactions. Potential applications for pretargeted in vivo PET imaging

(2017) Emilie M. F. Billaud et al.   Chemical Science

Click Chemistry and Radiochemistry: The First 10 Years

(2016) Jan-Philip Meyer et al.   BIOCONJUGATE CHEMISTRY

Hydrophilictrans-Cyclooctenylated Noncanonical Amino Acids for Fast Intracellular Protein Labeling

(2016) Eszter Kozma et al.   CHEMBIOCHEM

New Red-Emitting Tetrazine-Phenoxazine Fluorogenic Labels for Live-Cell Intracellular Bioorthogonal Labeling Schemes

(2016) Gergely Knorr et al.   CHEMISTRY-A EUROPEAN JOURNAL

[4+2] Cycloadditions of Seven-Membered-Ring trans-Alkenes: Decreasing Reactivity with Increasing Substitution of the Seven-Membered Ring

(2016) John Santucci et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Meter-Long Multiblock Copolymer Microfibers Via Interfacial Bioorthogonal Polymerization

(2015) Shuang Liu et al.   ADVANCED MATERIALS

Improved Metabolic Stability for 18F PET Probes Rapidly Constructed via Tetrazine trans-Cyclooctene Ligation

(2015) Ramajeyam Selvaraj et al.   BIOCONJUGATE CHEMISTRY

Genetic code expansion enabled site-specific dual-color protein labeling: superresolution microscopy and beyond

(2015) Ivana Nikić et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Genetic Code Expansion Enables Live-Cell and Super-Resolution Imaging of Site-Specifically Labeled Cellular Proteins

(2015) Chayasith Uttamapinant et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Systematic Evaluation of Bioorthogonal Reactions in Live Cells with Clickable HaloTag Ligands: Implications for Intracellular Imaging

(2015) Heather E. Murrey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ideal Bioorthogonal Reactions Using A Site-Specifically Encoded Tetrazine Amino Acid

(2015) Robert J. Blizzard et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective, rapid and optically switchable regulation of protein function in live mammalian cells

(2015) Yu-Hsuan Tsai et al.   Nature Chemistry

Biosynthesis of the C15-acetogenin laurepoxide may involve bromine-induced skeletal rearrangement of a Δ4-oxocene precursor

(2015) Michael T. Taylor et al.   TETRAHEDRON LETTERS

Inverse Electron-Demand Diels–Alder Bioorthogonal Reactions

(2015) Haoxing Wu et al.   Topics in Current Chemistry

Bioorthogonal Reactions for Labeling Proteins

(2014) Kathrin Lang et al.   ACS Chemical Biology

Finding the Right (Bioorthogonal) Chemistry

(2014) David M. Patterson et al.   ACS Chemical Biology

Genetically encoded unstrained olefins for live cell labeling with tetrazine dyes

(2014) Yan-Jiun Lee et al.   CHEMICAL COMMUNICATIONS

Cellular Incorporation of Unnatural Amino Acids and Bioorthogonal Labeling of Proteins

(2014) Kathrin Lang et al.   CHEMICAL REVIEWS

Click Chemistry in Complex Mixtures: Bioorthogonal Bioconjugation

(2014) Craig S. McKay et al.   CHEMISTRY & BIOLOGY

Planar Chiral Dialkoxysilane: Introduction of Inherent Chirality and High Reactivity in Conventional Achiral Alkene

(2014) Katsuhiko Tomooka et al.   CHEMISTRY-A EUROPEAN JOURNAL

Pretargeted imaging using bioorthogonal chemistry in mice

(2014) Raffaella Rossin et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double-labelling and FRET

(2014) Kaihang Wang et al.   Nature Chemistry

Conformationally strained trans-cyclooctene with improved stability and excellent reactivity in tetrazine ligation

(2014) Ampofo Darko et al.   Chemical Science

Two-Color Glycan Labeling of Live Cells by a Combination of Diels-Alder and Click Chemistry

(2013) Andrea Niederwieser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Reactive trans-Cyclooctene Tags with Improved Stability for Diels–Alder Chemistry in Living Systems

(2013) Raffaella Rossin et al.   BIOCONJUGATE CHEMISTRY

Bioorthogonal chemistry: strategies and recent developments

(2013) Carlo P. Ramil et al.   CHEMICAL COMMUNICATIONS

Inverse electron demand Diels–Alder (iEDDA)-initiated conjugation: a (high) potential click chemistry scheme

(2013) Astrid-Caroline Knall et al.   CHEMICAL SOCIETY REVIEWS

trans-Cyclooctene—a stable, voracious dienophile for bioorthogonal labeling

(2013) Ramajeyam Selvaraj et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Live-Cell Imaging of Cyclopropene Tags with Fluorogenic Tetrazine Cycloadditions

(2012) Jun Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genetic Encoding of Bicyclononynes and trans-Cyclooctenes for Site-Specific Protein Labeling in Vitro and in Live Mammalian Cells via Rapid Fluorogenic Diels–Alder Reactions

(2012) Kathrin Lang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Functionalized Cyclopropenes As Bioorthogonal Chemical Reporters

(2012) David M. Patterson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Moderating Strain without Sacrificing Reactivity: Design of Fast and Tunable Noncatalyzed Alkyne–Azide Cycloadditions via Stereoelectronically Controlled Transition State Stabilization

(2012) Brian Gold et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biomedical Applications of Tetrazine Cycloadditions

(2011) Neal K. Devaraj et al.   ACCOUNTS OF CHEMICAL RESEARCH

Clicking 1,2,4,5-tetrazine and cyclooctynes with tunable reaction rates

(2011) Weixuan Chen et al.   CHEMICAL COMMUNICATIONS

Design and Synthesis of Highly Reactive Dienophiles for the Tetrazine–trans-Cyclooctene Ligation

(2011) Michael T. Taylor et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total synthesis of hyacinthacine A2: stereocontrolled 5-aza-cyclooctene photoisomerization and transannular hydroamination with planar-to-point chirality transfer

(2011) Maksim Royzen et al.   Chemical Science

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

(2009) Ellen M. Sletten et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tetrazine-Based Cycloadditions: Application to Pretargeted Live Cell Imaging

(2008) Neal K. Devaraj et al.   BIOCONJUGATE CHEMISTRY

A Photochemical Synthesis of Functionalizedtrans-Cyclooctenes Driven by Metal Complexation

(2008) Maksim Royzen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels−Alder Reactivity

(2008) Melissa L. Blackman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY