Article
Surgery
Ahmed Fawzy, M. Ashraf Balbaa, Ahmed Gaber
Summary: The study showed that using fibrin glue in inguinal lymph node dissection significantly reduced the incidence of seroma formation, total amount of serous fluid, time to remove drains, and hospital stay. However, there were no significant differences between the two groups in occurrences of hematoma, infection or superficial skin edge necrosis. Future studies need to standardize the definition of seroma and determine the optimal dosage and technique of fibrin glue in ILND.
INTERNATIONAL JOURNAL OF SURGERY
(2021)
Article
Surgery
Kengo Takimoto, Noriko Matsuura, Yoshiko Nakano, Yosuke Tsuji, Kohei Takizawa, Yoshinori Morita, Yasuaki Nagami, Kingo Hirasawa, Hiroshi Araki, Naoyuki Yamaguchi, Hiroyuki Aoyagi, Tamotsu Matsuhashi, Toshiro Iizuka, Hisanobu Saegusa, Kenji Yamazaki, Shinichiro Hori, Tomohiko Mannami, Noboru Hanaoka, Hirohito Mori, Hideki Kobara, Yoji Takeuchi, Hiroyuki Ono
Summary: In this study, endoscopic PGA sheeting showed a high success rate in closing intraoperative GI perforations, particularly for smaller perforations. All cases of delayed perforations achieved successful closure. The median time from the first application of PGA sheets to resuming diet was 6 days for intraoperative cases and 10 days for delayed cases, with no adverse events related to PGA sheeting reported.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Dermatology
Abdullah E. Kattan, Hatan Mortada, Rema Alkahtani, Reem Bin Idris, Adnan G. Gelidan, Taghreed Alhumsi
Summary: This study retrospectively analyzed skin graft surgeries using cyanoacrylate (CA) tissue glue as a fixation method. The study found a high graft uptake rate compared to other fixation methods. However, partial graft loss was observed in some cases, highlighting the need for further research on long-term outcomes and cost-effectiveness.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Surgery
Billur Sezgin, Sedat Tatar, Sercin Karahuseyinoglu, Gizem Nur Sahin, Yagmur Ergun, Gizem Meric, Kaan Ersoy
Summary: DF result in healing through a thick dermal component, while oral fibroblasts result in faster healing and less scarring through potentially privileged angiogenic and regenerative gene expression.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2021)
Article
Hematology
Atsumu Kouketsu, Yoshinaka Shimizu, Shinnosuke Nogami, Minami Yamada-Fujiwara, Hirokazu Nagai, Kensuke Yamauchi, Hitoshi Miyashita, Haruka Saito, Kenji Odashima, Yuta Yanagisawa, Tetsu Takahashi
Summary: Autologous fibrin glue shows better potential in promoting wound healing by preventing viral infection and allergic reactions, stimulating fibroblast proliferation and angiogenesis. It significantly improves safety and reduces complications compared to commercial fibrin glue.
TRANSFUSION AND APHERESIS SCIENCE
(2021)
Article
Ophthalmology
William W. Binotti, Ana Carla B. de Aguiar, Aline A. Barbosa, Sergio Burnier
Summary: This study evaluated the long-term outcomes of patients with trichiasis treated with a modified interlamellar oral mucosa graft surgery technique using fibrin glue. The results showed that the surgery had a good success rate in terms of graft adherence and reduced trichiasis recurrence, leading to high patient satisfaction.
ARQUIVOS BRASILEIROS DE OFTALMOLOGIA
(2023)
Article
Biotechnology & Applied Microbiology
He Yang, Zhiqiang Dong, Hongya Wang, Zicheng Liu, Wenbo Sun, Kun Wang, Xinfeng Xu, Wei Wen, Jun Wang, Liang Chen, Quan Zhu
Summary: This study designed a new method using oxidized regenerated cellulose and fibrin glue to cover the intersegmental plane in lung segmentectomy and prevent air leakage. The adhesive strength and effect on reducing air leakage were validated in an excised porcine lung segmentectomy model. The results showed that the combination of fibrin glue and oxidized regenerated cellulose had good sealing performance.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Ophthalmology
Christine Cioba, Samara Barbara Marafon, Barbara Gastal Borges Fortes, Mariana Thome Cavalheiro, Marcelo Fabris, Gustavo Michel, Gabriela Maria Zambon, Alexandre Marcon, Diane Ruschel Marinho
Summary: The purpose of this study was to compare the effectiveness of autologous fibrin glue and traditional sutures for conjunctival graft attachment in patients undergoing pterygium excision surgery. The results showed that autologous fibrin glue had a higher graft loss rate compared to sutures, however, it had a shorter surgical time and lower pain scores. Therefore, autologous fibrin glue can be a cost-effective alternative to sutures in certain situations.
INTERNATIONAL OPHTHALMOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jiafu Mu, Jiahe Wu, Jian Cao, Teng Ma, Liming Li, Shiqing Feng, Jianqing Gao
Summary: This study evaluates an emergency cell-free treatment using mesenchymal stem cell-derived exosomes for traumatic spinal cord injury, which has been shown to comprehensively mitigate the inhibitory lesion microenvironment, providing a promising strategy for effective emergency treatment of central nervous system trauma.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Luis Fernandez-Vega-Cueto, Mairobi Persinal-Medina, Natalia Vazquez, Manuel Chacon, Belen Alfonso-Bartolozzi, Sergio Alonso-Alonso, Teresa Sanchez, Silvia Berisa-Prado, Laura Maria Martinez-Lopez, Jesus Merayo-Lloves, Alvaro Meana
Summary: The study proposes a method to prepare autologous bio-based fibrin glue for ophthalmic surgery. The adhesive strength of FG increased with fibrinogen concentration, and FG2 and FG3 showed successful results in conjunctival autografts with equivalent properties compared to commercial FG and reduced inflammation.
Review
Biochemistry & Molecular Biology
Maaike Waasdorp, Bastiaan P. Krom, Floris J. Bikker, Paul P. M. van Zuijlen, Frank B. Niessen, Susan Gibbs
Summary: Oral mucosa heals faster, shows a more rapid immune response, and undergoes increased extracellular matrix remodeling compared to skin, leading to superior wound healing and reduced scar formation.
Article
Immunology
Luciana P. F. Abbade, Silvia Regina Catharino Sartori Barraviera, Maria Regina Cavariani Silvares, Ana Beatriz B. de C. O. Lima, Gabriela R. Haddad, Marcia A. N. Gatti, Natalia Bronzatto Medolago, Marcia Tonin Rigotto Carneiro, Lucilene Delazari dos Santos, Rui Seabra Ferreira, Benedito Barraviera
Summary: The study evaluated the safety and efficacy of HFS in treating chronic venous ulcers, showing promising results in healing ulcers. However, further multicentric phase III clinical trials are needed to confirm these findings.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Engineering, Chemical
Vijai Laxmi, Suhas S. Joshi, Amit Agrawal
Summary: The study successfully developed a microdevice using microfluidic technology to efficiently isolate platelet-poor plasma with a purity of 94.7%, without affecting the shape and size of platelets. The microdevice is compact, easy to fabricate, reliable, and suitable for rapid and convenient point-of-care applications.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2021)
Article
Chemistry, Medicinal
Stefan Ruemke, Evgenii Rubalskii, Christina Salmoukas, Kristina Hermes, Ruslan Natanov, Tim Kaufeld, Oleksandr Gryshkov, Vitalii Mutsenko, Maxim Rubalsky, Karin Burgwitz, Birgit Glasmacher, Axel Haverich, Saad Rustum, Christian Kuehn
Summary: The study evaluates the use of conventional antibiotics and bacteriophages to prevent bacterial colonization of vascular grafts. The results show that bacteriophages alone are not sufficient for protection, while antibiotics alone are effective against certain bacteria. However, the combination of antibiotics and bacteriophages can completely eradicate bacterial colonization.
Article
Biotechnology & Applied Microbiology
Yanfen Zheng, Zhiguo Li, Chuyi Liu, Xiaotong Fan, Zheng Luo, Zibiao Li, Yun-Long Wu
Summary: This study developed a multi-functional GOx-CAT nanogel (GCN) system for the treatment of diabetic oral mucosa ulcers. The results showed that the nanoscale GCN was capable of significantly eliminating intracellular ROS, increasing intracellular oxygen concentration and accelerating cell migration of human gingival fibroblasts, which could promote diabetic oral gingival ulcer healing in vivo by alleviating inflammation and promoting angiogenesis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jong-Lyel Roh
Summary: This study evaluated the effectiveness of selective deep lobe parotidectomy via Roh's incision for pleomorphic adenoma. The results showed high surgical success rate, minimal complications, well-preserved salivary secretory function, and no recurrence.
Article
Otorhinolaryngology
Manal Bin-Manie, Yeonjoo Choi, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
Summary: Dysphagia and feeding tube dependency are common in patients with advanced-stage laryngeal or hypopharyngeal cancer. Age and severe adverse events are independent factors associated with feeding tube dependency.
Review
Oncology
Jaewang Lee, Jong-Lyel Roh
Summary: Ferroptosis is a newly regulated cell death induced by iron-mediated lipid peroxidation. Altered cancer metabolism contributes to cancer proliferation, metastasis, and treatment resistance. Changes in metabolism increase the sensitivity of cancer cells to lipid peroxidation toxicity and can be targeted for cancer treatment.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jaewang Lee, Daiha Shin, Jong-Lyel Roh
Summary: Cancer disrupts lipid metabolism, leading to altered metabolism intermediates and contributing to abnormal growth and metastasis. The shift in lipid metabolism towards an increased presence of polyunsaturated fatty acids (PUFAs) in membrane phospholipids (PLs) also causes resistance to cancer therapy. The vulnerability of cancer cells to lipid peroxidation (LPO) and subsequent ferroptosis, a new form of regulated cell death, depends on adaptive lipidome remodeling, LPO patterns, and LPO scavenging ability. Understanding the molecular basis of altered lipid metabolism in cancer may offer new opportunities for overcoming cancer resistance.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Letter
Surgery
Jong-Lyel Roh
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Article
Otorhinolaryngology
Jong-Lyel Roh
Summary: This study compared the effectiveness of complete closure versus exposure of remnant parotid parenchyma in preventing postparotidectomy sialocele. The results showed that complete closure of the remnant parotid parenchyma was more effective in preventing the occurrence of sialocele.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Cell Biology
Jaewang Lee, Jong-Lyel Roh
Summary: Divalent metal transporter 1 (DMT1) inhibitors or salinomycin can induce lysosomal iron overload and selectively kill iron-addicted cancer stem cells in head and neck cancer (HNC) cells. This study revealed that DMT1 inhibition or salinomycin treatment promotes ferroptosis by increasing labile iron levels and lipid peroxidation. Silencing of DMT1 resulted in molecular changes related to iron starvation response. These findings suggest that targeting DMT1 or using salinomycin could be a novel strategy for killing iron-avid cancer cells in HNC.
Review
Oncology
Jaewang Lee, Jong-Lyel Roh
Summary: Iron dysregulation is a characteristic of cancer, characterized by increased expression of genes involved in iron metabolism and iron-sulfur cluster (ISC) biogenesis. Dysregulated iron homeostasis leads to elevated intracellular labile iron, which can result in the formation of excessive cytotoxic radicals and susceptibility to regulated cell death, including ferroptosis. Various strategies, such as redox operations, iron chelation, and replacement of iron with redox-inert metals, can destabilize or restrict ISC formation and function, providing potential therapeutic approaches for cancer treatment. Targeting ISCs to induce ferroptosis shows promise in cancer therapy. This review provides a comprehensive overview of iron metabolism, ferroptosis, and the role of ISC modulation in cancer cells, as well as the potential of targeting ISCs for ferroptosis induction in cancer treatment. Further research and clinical trials are needed to validate these strategies for various cancers, with the goal of developing novel and effective cancer treatments.
Review
Biochemistry & Molecular Biology
Jaewang Lee, Dong-Hoon Hyun
Summary: Iron is essential for life, but dysregulation of intracellular iron homeostasis can produce excessive reactive oxygen species (ROS) and cause cell death. The intracellular system regulates iron levels through various mechanisms, including hepcidin-ferroportin, DMT1-transferrin, and ferritin-NCOA4. These processes are regulated by the IRP/IRE system and Nrf2.
Review
Biochemistry & Molecular Biology
Jaewang Lee, Jong-Lyel Roh
Summary: FSP1 is a critical protein in regulating ferroptosis and resistance to ferroptosis, operating independently from the canonical pathway. This review highlights the importance of FSP1 modulation and its potential as a therapeutic target in cancer treatment. Recent advances in developing FSP1 inhibitors and their implications for cancer therapy are also discussed.
Article
Biochemistry & Molecular Biology
Jong-Lyel Roh
Summary: Ferroptosis, characterized by lipid peroxidation and iron accumulation, is inhibited by the Nrf2 pathway. In head and neck cancer cells, activating the Nrf2-antioxidant responsive element pathway leads to resistance to ferroptosis, while inhibiting this pathway reverses this resistance. Modulating the Nrf2 pathway could be a promising strategy to overcome resistance in head and neck cancer therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Surgery
Jong-Lyel Roh
Summary: This study compared the closure versus the non-closure of exposed parotid parenchyma in the occurrence of Frey syndrome (FS). The results showed that closure of the exposed parotid parenchyma and covering fascia are preferred over non-closure to prevent the development of FS.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Article
Otorhinolaryngology
Jong-Lyel Roh
Summary: Supraglottic laryngectomy has undergone advancements from open to transoral endoscopic approaches, particularly with the use of lasers, endoscopes, ultrasonic devices, and robotics. Transoral laser-assisted microsurgery has emerged as an effective alternative to partial laryngectomy or non-surgical therapies, providing faster functional recovery. A new technique called transoral laser-assisted infrahyoid supraglottic laryngectomy allows for tumor removal while preserving crucial structures, resulting in optimal preservation of laryngopharyngeal function and minimal complications.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Surgery
Jong-Lyel Roh
Summary: The retroauricular hairline incision (RAHI) approach for treating second branchial cleft cysts (2nd BCC) results in excellent cosmetic, functional, and disease control outcomes.
AESTHETIC PLASTIC SURGERY
(2023)
Article
Oncology
Vanita Noronha, Aditya Dhanawat, Vijay Maruti Patil, Nandini Menon, Ajay Kumar Singh, Pankaj Chaturvedi, Prathamesh Pai, Devendra Chaukar, Sarbani Ghosh Laskar, Kumar Prabhash
Summary: Neo-adjuvant chemotherapy has shown long term survival benefits in patients with locally advanced oral cavity squamous cell carcinomas.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Gian Marco Pace, Bianca Maria Festa, Luca Cerri, Giorgio Gregory Giordano, Michael Dale, Giuseppe Spriano, Giorgio Peretti, Armando De Virgilio
Summary: This study aimed to predict the necessity of enteral nutrition at 28 days after surgery in patients with head and neck cancers. The results showed that the machine learning models had optimistic accuracy in predicting the need for enteral nutrition, but had moderate sensitivity.
Article
Oncology
Lirui Zhang, Qiaoshi Xu, Zhien Feng
Summary: This study presents a comprehensive clinical, genomic, and transcriptomic analysis of primary ghost cell odontogenic carcinoma (GCOC). The results provide the first comprehensive molecular atlas for primary GCOC, including previously identified CTNNB1 mutation and novel alterations in MAP3K, EP300, and the 22q11.21 region. The transcriptome analysis reveals significant involvement of cytokine-cytokine receptor interaction and the PI3K-Akt signaling pathway. More GCOC cases should be compared to validate these findings for accurate clinical guidance.
Article
Oncology
Emily Capone, Vittoria Perrotti, Ilaria Cela, Rossano Lattanzio, Lucrezia Togni, Corrado Rubini, Vito Carlo Alberto Caponio, Lorenzo Lo Muzio, Martina Colasante, Francesco Giansanti, Rodolfo Ippoliti, Stefano Iacobelli, Michael J. Wick, Nicole Spardy Burr, Gianluca Sala
Summary: This study explores the potential of galectin-3 binding protein (LGALS3BP) as a novel target for antibody-drug conjugate (ADC) therapy in adenoid cystic carcinoma (ACC). The results show that LGALS3BP is highly expressed in ACC tissues and treatment with anti-LGALS3BP ADC leads to durable tumor growth inhibition in animal models.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Piero Giuseppe Meliante, Armando De Virgilio, Se-Heon Kim
Summary: This study compares the outcomes of transoral resections using the da Vinci SP and da Vinci Xi systems for oropharyngeal squamous cell carcinoma (OPSCC). The results indicate that the da Vinci SP system has advantages in terms of reduced docking and console times, as well as improved rates of wide negative resection margins. However, there were no significant differences in complication rates or postoperative functional outcomes between the two systems.