The Bigger Picture: Why Oral Mucosa Heals Better Than Skin

A mixed community of skin microbiome representatives influences cutaneous processes more than individual members

(2021) Kristin H. Loomis et al.   Microbiome

Microbial signatures of health, gingivitis, and periodontitis

(2021) Loreto Abusleme et al.   PERIODONTOLOGY 2000

Exploring the role of oral microorganisms in the pathogenesis of mucositis by assessing their impact on metabolic activity and reproductive capacity of epithelial cells in vitro

(2020) Thijs M. Haverman et al.   SUPPORTIVE CARE IN CANCER

Defining the oral microbiome by whole-genome sequencing and resistome analysis: the complexity of the healthy picture

(2020) Elisabetta Caselli et al.   BMC MICROBIOLOGY

Interaction between microbiota and immunity in health and disease

(2020) Danping Zheng et al.   CELL RESEARCH

Salivary Histatin 1 and 2 Are Targeted to Mitochondria and Endoplasmic Reticulum in Human Cells

(2020) Dandan Ma et al.   Cells

Regulatory T cells in skin injury: At the crossroads of tolerance and tissue repair

(2020) Ian C. Boothby et al.   Science Immunology

Prognostic tools for hypertrophic scar formation based on fundamental differences in systemic immunity

(2020) Erik de Bakker et al.   EXPERIMENTAL DERMATOLOGY

Distinct differences in hypoxic responses between human oral mucosa and skin fibroblasts in a 3D collagen matrix

(2020) Yuko Hara-Saito et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Human Salivary Histatin-1 Is More Efficacious in Promoting Acute Skin Wound Healing Than Acellular Dermal Matrix Paste

(2020) Xiaoxuan Lei et al.   Frontiers in Bioengineering and Biotechnology

Human saliva stimulates skin and oral wound healing in vitro

(2019) Charlotte Rodrigues Neves et al.   Journal of Tissue Engineering and Regenerative Medicine

The Healing Power of Neutrophils

(2019) Mia Phillipson et al.   TRENDS IN IMMUNOLOGY

Biomimetic hydrogel for rapid and scar-free healing of skin wounds inspired by the healing process of oral mucosa

(2019) Xiaoying Kong et al.   Acta Biomaterialia

Insights into the human oral microbiome

(2018) Digvijay Verma et al.   ARCHIVES OF MICROBIOLOGY

Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair

(2018) Jonathan L. Linehan et al.   CELL

Interleukin-23 regulates interleukin-17 expression in wounds, and its inhibition accelerates diabetic wound healing through the alteration of macrophage polarization

(2018) James Lee et al.   FASEB JOURNAL

Macrophage plasticity, polarization, and function in health and disease

(2018) Abbas Shapouri-Moghaddam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Extracellular matrix contribution to skin wound re-epithelialization

(2018) Patricia Rousselle et al.   MATRIX BIOLOGY

Immune Regulation of Skin Wound Healing: Mechanisms and Novel Therapeutic Targets

(2018) Jacqueline Larouche et al.   Advances in Wound Care

Innate Lymphoid Cells: 10 Years On

(2018) Eric Vivier et al.   CELL

Transcriptional signature primes human oral mucosa for rapid wound healing

(2018) Ramiro Iglesias-Bartolome et al.   Science Translational Medicine

Multi-species oral biofilm promotes reconstructed human gingiva epithelial barrier function

(2018) Lin Shang et al.   Scientific Reports

The Role of Chemokines in Wound Healing

(2018) Anisyah Ridiandries et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The scavenging capacity of DMBT1 is impaired by germline deletions

(2017) Floris J. Bikker et al.   IMMUNOGENETICS

Saliva-Derived Commensal and Pathogenic Biofilms in a Human Gingiva Model

(2017) J.K. Buskermolen et al.   JOURNAL OF DENTAL RESEARCH

Plasticity of oral mucosal cell sheets for accelerated and scarless skin wound healing

(2017) Jong-Lyel Roh et al.   ORAL ONCOLOGY

Comparative phenotypic and functional analysis of migratory dendritic cell subsets from human oral mucosa and skin

(2017) Ilona Jennifer Kosten et al.   PLoS One

Impact of diabetes on gingival wound healing via oxidative stress

(2017) Daisuke Kido et al.   PLoS One

Treating Scars on the Oral Mucosa

(2017) Erik William Evans   Facial Plastic Surgery Clinics of North America

Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis

(2017) Kelly L. Walton et al.   Frontiers in Pharmacology

Candida and Porphyromonas gingivalis: the effect on wound closure in vitro

(2017) Thijs M. Haverman et al.   Journal of Oral Microbiology

Transition from inflammation to proliferation: a critical step during wound healing

(2016) Ning Xu Landén et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibited early immunologic response is associated with hypertrophic scarring

(2016) Liselotte Butzelaar et al.   EXPERIMENTAL DERMATOLOGY

Angiogenesis and wound repair: when enough is enough

(2016) Luisa A. DiPietro   JOURNAL OF LEUKOCYTE BIOLOGY

Hypertrophic scarring: the greatest unmet challenge after burn injury

(2016) Celeste C Finnerty et al.   LANCET

Reparative inflammation takes charge of tissue regeneration

(2016) Michael Karin et al.   NATURE

A practical guide to the oral microbiome and its relation to health and disease

(2016) K Krishnan et al.   ORAL DISEASES

Dysregulated interleukin-23 signalling contributes to the increased collagen production in scleroderma fibroblasts via balancing microRNA expression

(2016) Wakana Nakayama et al.   RHEUMATOLOGY

Neutrophil-derived chemokines on the road to immunity

(2016) Cristina Tecchio et al.   SEMINARS IN IMMUNOLOGY

Current concepts related to hypertrophic scarring in burn injuries

(2016) Ryan S. Chiang et al.   WOUND REPAIR AND REGENERATION

The Innate Immune System in Acute and Chronic Wounds

(2016) Amanda S. MacLeod et al.   Advances in Wound Care

The number of immune cells is lower in healthy oral mucosa compared to skin and does not increase after scarring

(2015) Judith E. Glim et al.   ARCHIVES OF ORAL BIOLOGY

Suppressed inflammatory gene expression during human hypertrophic scar compared to normotrophic scar formation

(2015) Lenie J. van den Broek et al.   EXPERIMENTAL DERMATOLOGY

Matrix remodeling by MMPs during wound repair

(2015) Maryam G. Rohani et al.   MATRIX BIOLOGY

Commensal–dendritic-cell interaction specifies a unique protective skin immune signature

(2015) Shruti Naik et al.   NATURE

Influence of saliva on the oral microbiota

(2015) Philip D. Marsh et al.   PERIODONTOLOGY 2000

Different wound healing properties of dermis, adipose, and gingiva mesenchymal stromal cells

(2015) Mireille A. Boink et al.   WOUND REPAIR AND REGENERATION

Gingiva Equivalents Secrete Negligible Amounts of Key Chemokines Involved in Langerhans Cell Migration Compared to Skin Equivalents

(2015) Ilona J. Kosten et al.   Journal of Immunology Research

Microbial inhibition of oral epithelial wound recovery: potential role for quorum sensing molecules?

(2015) Tine De Ryck et al.   AMB Express

Metalloproteinases and Wound Healing

(2015) Matthew P. Caley et al.   Advances in Wound Care

Extracellular Matrix Reorganization During Wound Healing and Its Impact on Abnormal Scarring

(2015) Meilang Xue et al.   Advances in Wound Care

The Roles of Growth Factors in Keratinocyte Migration

(2015) Mark A. Seeger et al.   Advances in Wound Care

Extracellular matrix components of oral mucosa differ from skin and resemble that of foetal skin

(2014) Judith E. Glim et al.   ARCHIVES OF ORAL BIOLOGY

Extracellular matrix and wound healing

(2014) F.X. Maquart et al.   PATHOLOGIE BIOLOGIE

Microbial biofilms and wound healing: an ecological hypothesis

(2014) Bastiaan P Krom et al.   PHLEBOLOGY

Human Gingival Fibroblasts Display a Non-Fibrotic Phenotype Distinct from Skin Fibroblasts in Three-Dimensional Cultures

(2014) Wesley Mah et al.   PLoS One

Intrinsic Differences between Oral and Skin Keratinocytes

(2014) Anna Turabelidze et al.   PLoS One

Dialogue between skin microbiota and immunity

(2014) Y. Belkaid et al.   SCIENCE

Epithelialization in Wound Healing: A Comprehensive Review

(2014) Irena Pastar et al.   Advances in Wound Care

MMP-7 and TIMP-1, New Targets in Predicting Poor Wound Healing in Apical Periodontitis

(2013) Ariadne Letra et al.   JOURNAL OF ENDODONTICS

The Influence of Oral Bacteria on Epithelial Cell MigrationIn Vitro

(2013) Alexa M. G. A. Laheij et al.   MEDIATORS OF INFLAMMATION

Clinical Impact Upon Wound Healing and Inflammation in Moist, Wet, and Dry Environments

(2013) Johan P.E. Junker et al.   Advances in Wound Care

Innate and Adaptive Immune Responses in Wound Epithelialization

(2013) Natasa Strbo et al.   Advances in Wound Care

Differential Expression of HIF-1α in Skin and Mucosal Wounds

(2012) L. Chen et al.   JOURNAL OF DENTAL RESEARCH

Detection and quantitation of forty eight cytokines, chemokines, growth factors and nine acute phase proteins in healthy human plasma, saliva and urine

(2012) Alamgir Khan   Journal of Proteomics

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

UVB-Induced Inflammatory Cytokine Release, DNA Damage and Apoptosis of Human Oral Compared with Skin Tissue Equivalents

(2012) Joyce Breger et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Compartmentalized Control of Skin Immunity by Resident Commensals

(2012) S. Naik et al.   SCIENCE

Oral bacteria and yeasts in relationship to oral ulcerations in hematopoietic stem cell transplant recipients

(2012) Alexa M. G. A. Laheij et al.   SUPPORTIVE CARE IN CANCER

Effects of immunosuppressive therapy on wound healing

(2012) Roshan Bootun   International Wound Journal

Cell-derived vesicles exposing coagulant tissue factor in saliva

(2011) R. J. Berckmans et al.   BLOOD

Interleukin-18 system plays an important role in keloid pathogenesis via epithelial-mesenchymal interactions

(2011) D.V. Do et al.   BRITISH JOURNAL OF DERMATOLOGY

Hyaluronan Facilitates Transforming Growth Factor-β1-dependent Proliferation via CD44 and Epidermal Growth Factor Receptor Interaction

(2011) Soma Meran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Accelerated wound healing phenotype in Interleukin 12/23 deficient mice

(2011) Marie AT Matias et al.   Journal of Inflammation-London

Whole cigarette smoke promotes human gingival epithelial cell apoptosis and inhibits cell repair processes

(2011) A. Semlali et al.   JOURNAL OF PERIODONTAL RESEARCH

Gingival Fibroblasts Display Reduced Adhesion and Spreading on Extracellular Matrix: A Possible Basis for Scarless Tissue Repair?

(2011) Fen Guo et al.   PLoS One

Time course of the angiogenic response during normotrophic and hypertrophic scar formation in humans

(2011) Willem M. van der Veer et al.   WOUND REPAIR AND REGENERATION

Positional differences in the wound transcriptome of skin and oral mucosa

(2010) Lin Chen et al.   BMC GENOMICS

IL-24 is expressed during wound repair and inhibits TGFα-induced migration and proliferation of keratinocytes

(2010) Nancy J. Poindexter et al.   EXPERIMENTAL DERMATOLOGY

The Human Oral Microbiome

(2010) F. E. Dewhirst et al.   JOURNAL OF BACTERIOLOGY

Elastin in oral connective tissue modulates the keratinization of overlying epithelium

(2010) Po-Chen Hsieh et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

‘Young’ Oral Fibroblasts Are Geno/Phenotypically Distinct

(2010) S. Enoch et al.   JOURNAL OF DENTAL RESEARCH

Factors Affecting Wound Healing

(2010) S. Guo et al.   JOURNAL OF DENTAL RESEARCH

The role of mast cells in wound healing

(2010) Michael FY Ng   International Wound Journal

Vascular regression and survival are differentially regulated by MT1-MMP and TIMPs in the aortic ring model of angiogenesis

(2009) A. C. Aplin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Structure-function relationship of the human antimicrobial peptide LL-37 and LL-37 fragments in the modulation of TLR responses

(2009) E. Margo Molhoek et al.   BIOLOGICAL CHEMISTRY

Structure-activity analysis of histatin, a potent wound healing peptide from human saliva: cyclization of histatin potentiates molar activity 1000-fold

(2009) Menno J. Oudhoff et al.   FASEB JOURNAL

Histatins Enhance Wound Closure with Oral and Non-oral Cells

(2009) M.J. Oudhoff et al.   JOURNAL OF DENTAL RESEARCH

Scarless healing of oral mucosa is characterized by faster resolution of inflammation and control of myofibroblast action compared to skin wounds in the red Duroc pig model

(2009) Karen Mak et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Expression of Integrin αvβ6 and TGF-β in Scarless vs Scar-forming Wound Healing

(2009) Ameneh Eslami et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury

(2009) Yuping Lai et al.   NATURE MEDICINE

Topographical and Temporal Diversity of the Human Skin Microbiome

(2009) E. A. Grice et al.   SCIENCE

Matrix metalloproteinase-9 delays wound healing in a murine wound model

(2009) Matthew J. Reiss et al.   SURGERY

Wound healing in oral mucosa results in reduced scar formation as compared with skin: Evidence from the red Duroc pig model and humans

(2009) Joyce W. Wong et al.   WOUND REPAIR AND REGENERATION

Tissue reactions to collagen scaffolds in the oral mucosa and skin of rats: Environmental and mechanical factors

(2008) Richard G. Jansen et al.   ARCHIVES OF ORAL BIOLOGY

Potential cellular and molecular causes of hypertrophic scar formation

(2008) Willem M. van der Veer et al.   BURNS

Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay

(2008) Menno J. Oudhoff et al.   FASEB JOURNAL

Site-specific production of TGF-β in oral mucosal and cutaneous wounds

(2008) Megan E. Schrementi et al.   WOUND REPAIR AND REGENERATION