Review
Oncology
Morena Fasano, Ida D'Onofrio, Maria Paola Belfiore, Antonio Angrisani, Valentina Caliendo, Carminia Maria Della Corte, Mario Pirozzi, Sergio Facchini, Marianna Caterino, Cesare Guida, Valerio Nardone, Alfonso Reginelli, Salvatore Cappabianca
Summary: This review discusses the role of clinical management, geriatric evaluation, and therapeutic approaches in elderly patients with head and neck squamous cell carcinoma (HNSCC). Elderly HNSCC patients are often frail with multiple comorbidities and may receive suboptimal treatment. The review summarizes different strategies for the clinical management of elderly HNSCC patients.
Review
Biochemistry & Molecular Biology
David C. Marcu, Cristian Grava, Loredana G. Marcu
Summary: The latest developments in the management of head and neck cancer involve the use of artificial intelligence and radiomics, particularly delta radiomics, for patient stratification and treatment evaluation. Radiomics enables the extraction of data from imaging modalities to evaluate tumor features and guide treatment decisions. Delta radiomics, which assesses feature variations over time, is shown to have superior value for predicting treatment outcomes and stratifying patients into risk categories. This work aims to review and evaluate the role of delta radiomics in head and neck cancer for tumor response and normal-tissue toxicity predictions, as well as highlight the significance of holomics for comprehensive patient characterization and treatment optimization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Maria Gebre-Medhin, Eva Brun, Per Engstrom, Hedda Haugen Cange, Lalle Hammarstedt-Nordenvall, Johan Reizenstein, Jan Nyman, Edvard Abel, Signe Friesland, Helena Sjodin, Henrik Carlsson, Karin Soderkvist, Marcus Thomasson, Bjorn Zackrisson, Per Nilsson
Summary: The study demonstrates that for patients with locoregionally advanced HNSCC, cisplatin is superior to cetuximab in terms of locoregional control when used in combination with radiotherapy.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Camil Ciprian Mirestean, Cristiana Eugenia Simionescu, Roxana Irina Iancu, Mihai Cosmin Stan, Dragos Petru Teodor Iancu, Florinel Badulescu
Summary: Chondrosarcoma is a rare disease with a relatively good prognosis. In this case, a 30-year-old patient was treated with surgery, chemotherapy, and radiotherapy. Despite the early loss from the oncological record, there was no recurrence of the disease. Treatment decisions should consider tumor size, resection margins, and potential adverse reactions to adjuvant therapy.
Article
Oncology
Yannan Wang, Mengxue Wang, Yan Tang, Bincan Sun, Kai Wang, Feiya Zhu
Summary: The perioperative mortality rate of head and neck cancer was approximately 1%, with causes of death including acute heart failure, rupture of large blood vessels in the neck, and respiratory failure. Risk factors for perioperative mortality included preoperative radiotherapy, previous chemotherapy, hypertension, diabetes, advanced clinical stage, and postoperative infection.
Article
Oncology
Sachin R. Jhawar, Marcelo Bonomi, Paul M. Harari
Summary: The Oncology Grand Rounds series aims to help readers apply the results of key studies in clinical practice, using case presentations, literature reviews, and treatment recommendations to enhance understanding of the latest developments in oncology.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Cell Biology
Yuanyuan Liu, Xing Wang, Yuying Liu, Jianqiang Yang, Wei Mao, Chen Feng, Xiaoliang Wu, Xinwei Chen, Lixiao Chen, Pin Dong
Summary: NAT10 promotes lymph node metastasis in HNSCC by stabilizing the GLMP transcript through ac4C modification. Inhibition of NAT10 may serve as a therapeutic strategy for HNSCC.
CELL DEATH & DISEASE
(2023)
Review
Oncology
Miguel Reis Ferreira, Anna Pasto, Tony Ng, Vinod Patel, Teresa Guerrero Urbano, Cynthia Sears, William G. Wade
Summary: This article focuses on how microbiota research can contribute to the improvement of radiotherapy for head and neck squamous cell carcinoma (HN-SCC), specifically discussing its relevance to human physiology, its interactions with HN-SCC, and the potential use of microbiota as predictive and prognostic biomarkers. The article also discusses the potential of leveraging the microbiota and its interactions with immunity to improve treatment results, drawing parallels with other cancers where research is more advanced. The authors map out future directions of research and explain clinical implications in detail.
CANCER TREATMENT REVIEWS
(2022)
Article
Oncology
Wenli Liu, Aiham Qdaisat, Renata Ferrarotto, Clifton D. Fuller, Ming Guo, Larissa A. Meyer, Santhosshi Narayanan, Gabriel Lopez, Lorenzo Cohen, Eduardo Bruera, Ehab Y. Hanna, Sai-Ching J. Yeung
Summary: This study examined the association between hypomagnesemia and survival in patients with head and neck cancer receiving concurrent chemoradiation with cisplatin and/or carboplatin. It was found that higher frequency and severity of hypomagnesemia during treatment were significantly associated with shorter survival, independent of other known prognostic factors. Further prospective studies are necessary to investigate the impact of preventing hypomagnesemia on survival in this patient population.
Article
Medicine, Research & Experimental
Jing Wei, Hui Deng, Lihua Wu, Jianbo Song, Junping Zhang, Wenhui Yang, Mengxian Zhang, Hongtao Zhen
Summary: This study aimed to explore the epidemiological characteristics and prognostic factors of head and neck lymphoepithelial carcinoma (LEC). A retrospective cohort study was conducted using data from the Surveillance, Epidemiology and End Results database. Kaplan-Meier survival analysis and Cox regression models were used to assess overall survival (OS) and cancer-specific survival (CSS). Nomograms were established to predict OS and CSS in patients with nasopharyngeal LEC, and the effects of treatment were compared using the restricted mean survival time (RMST). The results showed that head and neck LEC had a favorable prognosis, and radiotherapy played a significant role in managing nasopharyngeal LEC patients influenced by multiple prognostic factors.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Shinsuke Suzuki, Satoshi Toyoma, Yohei Kawasaki, Takechiyo Yamada
Summary: Fibroblasts, which survive irradiation and increase the secretion of IL-6, play a role in inducing the migration ability of head and neck cancer cells.
Review
Oncology
Francesca De Felice, Liliana Belgioia, Daniela Alterio, Pierluigi Bonomo, Marta Maddalo, Fabiola Paiar, Nerina Denaro, Renzo Corvo, Anna Merlotti, Paolo Bossi, Giovanni L. Pappagallo, Rolando M. D'Angelillo, Stefano M. Magrini, Stefano Arcangeli
Summary: Comparing weekly cisplatin with three-weekly cisplatin chemoradiotherapy for locally advanced head and neck cancer, the study found that there were no significant differences in clinical outcomes and toxicity, but the compliance to treatment was higher in the three-weekly regimen.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Review
Oncology
Biao Ning, Yixin Liu, Tianhe Huang, Yongchang Wei
Summary: Osteosarcoma is the most common bone malignancy in children and adolescents. Despite advancements in surgery and chemotherapy, overall survival rates have reached a bottleneck. Extensive research is urgently needed to develop new therapeutic targets. Autophagy, a process of recycling cellular components, plays a critical role in osteosarcoma. This article summarizes the association between autophagy and proliferation, metastasis, chemotherapy, radiotherapy, and immunotherapy of osteosarcoma, identifying potential targets for therapy.
Article
Oncology
Vijay Maruti Patil, Vanita Noronha, Nandini Menon, Rahul Rai, Atanu Bhattacharjee, Ajay Singh, Kavita Nawale, Shweta Jogdhankar, Rupali Tambe, Sachin Dhumal, Riddhi Sawant, Mitali Alone, Devanshi Karla, Zoya Peelay, Shruti Pathak, Arun Balaji, Suman Kumar, Nilendu Purandare, Archi Agarwal, Ameya Puranik, Abhishek Mahajan, Amit Janu, Gunjesh Kumar Singh, Neha Mittal, Subhash Yadav, Shripad Banavali, Kumar Prabhash
Summary: This study found that only 1%-3% of patients in low- and middle-income countries have access to the approved regimens for treating advanced head and neck squamous cell carcinoma due to cost issues. Previous research has shown that metronomic chemotherapy can improve survival. The study aimed to assess whether the addition of low-dose nivolumab to triple metronomic chemotherapy improved overall survival.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
John A. Vargo, Vitali Moiseenko, Jimm Grimm, Jimmy Caudell, David A. Clump, Ellen Yorke, Jinyu Xue, Yevgeniy Vinogradskiy, Eduardo G. Moros, Panayiotis Mavroidis, Sheena Jain, Issam El Naqa, Lawrence B. Marks, Dwight E. Heron
Summary: This study systematically reviewed the available literature on tumor control probability with SBRT in head and neck cancer patients, finding a dose-response relationship suggesting better local control and possibly improved overall survival with doses of 35 to 45 Gy (in 5 fractions) compared with <30 Gy. It is suggested that SBRT doses equivalent to 5-fraction doses of 40 to 50 Gy are used for retreatment.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Genetics & Heredity
Yingying Jiang, Kun Wu, Wei Cao, Qin Xu, Xu Wang, Xing Qin, Xiaoning Wang, Yan Li, Jianjun Zhang, Wantao Chen
Article
Dentistry, Oral Surgery & Medicine
Yu Zhang, Canbang Peng, Zhen Tian, Wei Cao, Xi Yang, Tong Ji
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2020)
Review
Oncology
Yu Zhang, Chengzhong Lin, Xu Wang, Tong Ji
Article
Otorhinolaryngology
Wenkai Zhou, Canbang Peng, Zheqi Liu, Wei Cao
Summary: This study analyzed the risk factors for survival in elderly patients with oral squamous cell carcinoma and developed a novel clinical signature for prognosis. Results indicated that high N stage, low hemoglobin level, low BMI, and high NLR were associated with poor survival outcomes. The constructed nomogram showed a good predictive ability.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Oncology
Xuejie Li, Zheqi Liu, Wenkai Zhou, Xiaofang Liu, Wei Cao
Summary: The study revealed that high expression of CCL22 in T/MF SCC may promote the recruitment of Th2 cells and help predict a better survival. Additionally, mutations in NOTCH1 inhibit the differentiation of Th2 cells, facilitating tumor progression.
Article
Oncology
Yu Zhang, Mingtao Chen, Zheqi Liu, Xu Wang, Tong Ji
Summary: A study found that the neuropeptide CGRP links PNI and LNM in oral squamous cell carcinoma, and preoperative plasma CGRP levels can predict LNM in OSCC.
Editorial Material
Oncology
Wei Cao, Qiang Shen, Ming Yann Lim
FRONTIERS IN ONCOLOGY
(2021)
Article
Otorhinolaryngology
Cangbang Peng, Ming Tao Chen, Zheqi Liu, Yibo Guo, Yu Zhang, Tong Ji
Summary: Inflammatory myofibroblastic tumors in the head and neck (HNIMTs) sometimes exhibit aggressive clinical features and can undergo malignant transformation. This study found that tumor size, location, and preoperative neutrophil-to-lymphocyte ratio may be associated with the risk of malignant transformation in HNIMTs. Postoperative radiotherapy can benefit HNIMT patients at high risk of malignant transformation.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2022)
Article
Oncology
Lei Wang, Wenjing Pang, Kun Zhou, Lei Li, Feng Wang, Wei Cao, Xiangjun Meng
Summary: This study provides further insights into the risk factors for esophageal squamous cell carcinoma (ESCC) in patients with a history of head and neck squamous cell carcinoma (HNSCC). The study found that HNSCC patients, especially drinkers with an alcohol flushing response and those with high Ki67 labeling index (Ki67 LI) in HNSCC tissue, were more likely to develop ESCC.
JOURNAL OF ONCOLOGY
(2022)
Article
Cell Biology
Yu Zhang, Chengzhong Lin, Zheqi Liu, Yiting Sun, Mingtao Chen, Yibo Guo, Wei Liu, Chenping Zhang, Wantao Chen, Jian Sun, Ronghui Xia, Yuhua Hu, Xi Yang, Jiang Li, Zhiyuan Zhang, Wei Cao, Shuyang Sun, Xu Wang, Tong Ji
Summary: This study reveals that cancer cells can utilize nociceptive nerves to survive in nutrient-poor environments. Cancer cells secrete NGF through ROS-triggered activation of c-Jun, which stimulates nerves to produce CGRP. The neurogenic CGRP induces cytoprotective autophagy in cancer cells through Rap1-mediated disruption of the mTOR-Raptor interaction. Blocking CGRP can inhibit the vicious cycle between cancer cells and nerves and therapeutically benefit nutrient-starvation therapies.
Article
Biochemistry & Molecular Biology
Zhenlin Dai, Zheqi Liu, Rong Yang, Wei Cao, Tong Ji
Summary: Osteosarcoma (OS), the most common malignant bone tumor, lacks updated treatment strategies. This study identified EVI2B as a significantly upregulated gene in OS tumor samples and demonstrated its association with chemokine signaling, cytokine-cytokine receptor interaction, and Human T-cell leukemia virus 1 infection. The prognostic prediction model including EVI2B, DOCK2, and CD33 indicated EVI2B as an independent protective prognostic marker in OS. The study also revealed the close relationship between EVI2B expression, monocyte and macrophage infiltration in OS, providing clear evidence for its prognostic value.
Article
Chemistry, Multidisciplinary
Wenkai Zhou, Yisheng Feng, Chengzhong Lin, Chi Kuan Chao, Ziqi He, Shiyao Zhao, Jieyuan Xue, Xu-Yun Zhao, Wei Cao
Summary: A highly expressed lncRNA DUXAP9, found in oral squamous cell carcinoma (OSCC), is positively associated with poor prognosis. DUXAP9 promotes OSCC cell proliferation, migration, invasion, and tumor growth through the upregulation of N-cadherin, Vimentin, Ki67, PCNA, and EZH2 and downregulation of E-cadherin. Yin Yang 1 (YY1) activates the transcription of DUXAP9 in OSCC. Moreover, DUXAP9 interacts with EZH2 and inhibits its degradation, thereby blocking its translocation from the nucleus to the cytoplasm. DUXAP9 may serve as a promising therapeutic target for OSCC.
Article
Cell Biology
Zheqi Liu, Wenkai Zhou, Chengzhong Lin, Xiaoning Wang, Xu Zhang, Yu Zhang, Rong Yang, Wantao Chen, Wei Cao
Summary: FOXD2-AS1 is closely associated with clinical characteristics in oral squamous cell carcinoma, and its high expression predicts poor prognosis in patients. It functions by promoting cell proliferation and migration, suppressing adaptive immunity, and participating in the development of oral squamous cell carcinoma.
Article
Oncology
Lei Wang, Wenjing Pang, Kun Zhou, Lei Li, Feng Wang, Wei Cao, Xiangjun Meng
Summary: This study investigated the clinicopathological features of esophageal cancer in patients with a history of head and neck squamous cell carcinoma (HNSCC). Most cases were male patients aged 50-69 years, with higher proportion of early esophageal cancer and successful surgical treatment in the synchronous carcinoma group compared to the metachronous carcinoma group. Detection of esophageal cancer should be prioritized in HNSCC patients.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Oncology
Vanita Noronha, Aditya Dhanawat, Vijay Maruti Patil, Nandini Menon, Ajay Kumar Singh, Pankaj Chaturvedi, Prathamesh Pai, Devendra Chaukar, Sarbani Ghosh Laskar, Kumar Prabhash
Summary: Neo-adjuvant chemotherapy has shown long term survival benefits in patients with locally advanced oral cavity squamous cell carcinomas.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Gian Marco Pace, Bianca Maria Festa, Luca Cerri, Giorgio Gregory Giordano, Michael Dale, Giuseppe Spriano, Giorgio Peretti, Armando De Virgilio
Summary: This study aimed to predict the necessity of enteral nutrition at 28 days after surgery in patients with head and neck cancers. The results showed that the machine learning models had optimistic accuracy in predicting the need for enteral nutrition, but had moderate sensitivity.
Article
Oncology
Lirui Zhang, Qiaoshi Xu, Zhien Feng
Summary: This study presents a comprehensive clinical, genomic, and transcriptomic analysis of primary ghost cell odontogenic carcinoma (GCOC). The results provide the first comprehensive molecular atlas for primary GCOC, including previously identified CTNNB1 mutation and novel alterations in MAP3K, EP300, and the 22q11.21 region. The transcriptome analysis reveals significant involvement of cytokine-cytokine receptor interaction and the PI3K-Akt signaling pathway. More GCOC cases should be compared to validate these findings for accurate clinical guidance.
Article
Oncology
Emily Capone, Vittoria Perrotti, Ilaria Cela, Rossano Lattanzio, Lucrezia Togni, Corrado Rubini, Vito Carlo Alberto Caponio, Lorenzo Lo Muzio, Martina Colasante, Francesco Giansanti, Rodolfo Ippoliti, Stefano Iacobelli, Michael J. Wick, Nicole Spardy Burr, Gianluca Sala
Summary: This study explores the potential of galectin-3 binding protein (LGALS3BP) as a novel target for antibody-drug conjugate (ADC) therapy in adenoid cystic carcinoma (ACC). The results show that LGALS3BP is highly expressed in ACC tissues and treatment with anti-LGALS3BP ADC leads to durable tumor growth inhibition in animal models.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Piero Giuseppe Meliante, Armando De Virgilio, Se-Heon Kim
Summary: This study compares the outcomes of transoral resections using the da Vinci SP and da Vinci Xi systems for oropharyngeal squamous cell carcinoma (OPSCC). The results indicate that the da Vinci SP system has advantages in terms of reduced docking and console times, as well as improved rates of wide negative resection margins. However, there were no significant differences in complication rates or postoperative functional outcomes between the two systems.
