Article
Chemistry, Multidisciplinary
Zhi Liu, Gregory A. Simchick, Jing Qiao, Morgan M. Ashcraft, Shuolin Cui, Tamas Nagy, Qun Zhao, May P. Xiong
Summary: A nanochelator system utilizing the physiological environment of iron overload was developed to improve iron elimination and pharmacokinetic properties in mice, showing promising results for iron chelation therapy with no adverse effects observed in toxicity studies. This ROS-responsive nanochelator design could be a safe alternative for effectively removing iron chelates from the body in iron chelation therapy regimens requiring repeated dosing.
Article
Pharmacology & Pharmacy
Qiongtao Song, Ying Zhao, Yanrong Yang, Xue Han, Junguo Duan
Summary: The study demonstrates that AS-IV has significant protective effects against retinal iron overload toxicity in vivo and in vitro, possibly through regulating iron-handling proteins and inhibiting MAPKs and NF-kappa B activation.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Cell Biology
Eddie Tam, Hye K. Sung, Gary Sweeney
Summary: Iron overload leads to insulin resistance in H9c2 cardiomyoblast cells. Overexpression of MitoNEET can protect against iron accumulation in the mitochondria and subsequent insulin resistance. Iron overload increases mitochondrial iron content, ROS production, mitochondrial fission, and decreases insulin-stimulated Akt and ERK1/2 phosphorylation. MitoNEET overexpression attenuates these effects and upregulates levels of PGC1 alpha protein.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Cell Biology
Jiancheng Yang, Qinghua Tang, Yuhong Zeng
Summary: Iron overload is a common problem in chronic and common diseases, and melatonin has been found to have iron chelating and antioxidant properties, making it a potential therapy for iron overload-related disorders.
AGEING RESEARCH REVIEWS
(2022)
Article
Engineering, Biomedical
Bijun Zhu, Jiangjiexing Wu, Tong Li, Songtao Liu, Junheng Guo, Yijun Yu, Xinyi Qiu, Yue Zhao, Haoran Peng, Jinli Zhang, Leiying Miao, Hui Wei
Summary: In this study, the use of MVF nanozyme as a precise regulator of ROS in periodontitis is proposed. By selectively eliminating H2O2, the most prominent ROS, MVF contributes to limiting inflammation, regulating immune microenvironment, promoting periodontal regeneration, and stimulating osteogenic differentiation of periodontal stem cells. MVF regulates ROS through the Nrf2/HO-1 pathway and promotes osteogenic differentiation through the PI3K/Akt pathway. Nanozymes have the potential to be an important precision medicine tool in periodontitis therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Cell Biology
Eddie Tam, Hye Kyoung Sung, Nhat Hung Lam, Sally You, Sungji Cho, Saher M. M. Ahmed, Ali A. A. Abdul-Sater, Gary Sweeney
Summary: Iron overload leads to cardiovascular diseases, including heart failure. This study showed that iron overload triggers cell death in H9c2 cells by promoting intracellular and mitochondrial iron accumulation and ROS production. The use of iron-binding fluorescent reporters and antioxidants reduced these effects, and decreased apoptosis and lytic cell death. Overexpression of the mitochondrial membrane protein MitoNEET lowered iron and ROS accumulation in the mitochondria, leading to reduced cell death in response to iron overload.
Article
Anatomy & Morphology
Ming Yan, Yun Zhang, Wanting Niu, Kezhou Liu, Lingyun Xue, Kexin Zhou
Summary: During orthodontic tooth movement, the most mechanosensitive cells in alveolar bone, osteocytes, suffer from compressive force and lead to alveolar bone resorption on the compression side. The mechanisms of compressive force-induced osteocyte death remain unclear. This study establishes an OTM model and examines the involvement of reactive oxygen species (ROS)-mediated endoplasmic reticulum stress (ERS) pathway in compressive force-induced osteocyte death.
MICROSCOPY RESEARCH AND TECHNIQUE
(2023)
Review
Immunology
Sarah Weber, Anastasia Parmon, Nina Kurrle, Frank Schnuetgen, Hubert Serve
Summary: MDS and AML patients often experience systemic iron overload issues, iron is closely associated with the pathogenesis and potential treatment strategies of the diseases, imbalances in iron homeostasis may lead to various cell death.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Tulika Basak, Rupinder Kaur Kanwar
Summary: Iron plays a complex role in tumour biology, acting both as a cancer clearance agent and a cancer promoter. Iron-induced oxidative stress has a significant impact on pro-tumorigenesis and anti-tumorigenesis processes, making it challenging to determine the iron thresholds that favor tumor clearance. Additionally, iron deficiency and overload are associated with chronic diseases such as cancer and chronic infections. Therefore, diagnosing patients' iron status before opting for subsequent therapies is critical.
Article
Cell Biology
Yukitaka Shizukuda, Douglas R. Rosing
Summary: Hereditary hemochromatosis with the homozygous C282Y HFE mutation (HH-282H) is a genetic condition that leads to iron overload and elevated reactive oxygen species (ROS) levels. Even after successful iron removal therapy, patients with HH-282H still have chronically elevated ROS levels. This review proposes using HH-282H patients as a clinical model to assess the impact of elevated ROS on the development of cardiovascular diseases and to identify effective anti-ROS interventions.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Miao Li, Zhaofeng Pan, Qi He, Jiacong Xiao, Baihao Chen, Fanchen Wang, Pan Kang, Haoran Luo, Jianliang Li, Jiaxu Zeng, Shaocong Li, Junzheng Yang, Haibin Wang, Chi Zhou
Summary: In this study, arctiin (ARC) was found to have potential as a therapeutic agent for iron overload-induced osteoporosis (IOOP). ARC improved bone microarchitecture and biochemical parameters in a mouse model of iron overload by modulating the PI3K/Akt pathway and exhibiting anti-apoptotic, antioxidant, and osteogenic properties.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Christine Fischer, Chiara Volani, Timea Komlodi, Markus Seifert, Egon Demetz, Lara Valente de Souza, Kristina Auer, Verena Petzer, Laura von Raffay, Patrizia Moser, Erich Gnaiger, Guenter Weiss
Summary: This study investigates the effects of dietary and genetic iron overload on mitochondrial function, revealing that iron accumulation promotes ROS production and impairs mitochondrial respiratory capacity. Differences in response to iron overload were observed in wildtype and genetic hemochromatosis model mice, suggesting the potential for iron reduction therapy to improve mitochondrial function.
Article
Engineering, Environmental
Miao Yan, Zhiyuan Hu, Zhenhan Duan, Yongming Sun, Taili Dong, Xianfa Sun, Feng Zhen, Ying Li
Summary: This study reveals the stress exerted by accumulated VFAs on the microbiome in anaerobic digestion systems and explores the strategy of microbiome re-assembly to enhance methane production efficiency.
Article
Biochemistry & Molecular Biology
Hiromu Ito, Hiromi Kurokawa, Hirofumi Matsui
Summary: Mitochondria, essential organelles for energy production in eukaryotes, generate reactive oxygen species during the process which play pivotal roles in cell signaling and iron homeostasis regulation. The regulation of iron transportation, involving proteins like HCP1, DMT1, and mitoferrin, is increasingly understood in relation to mitochondrial reactive oxygen species and diseases.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Materials Science, Multidisciplinary
Sen Lin, Dahao Wang, Chang Xu, Peng Zhang, Kai Gao, Chang Liu, Xifan Mei
Summary: In this study, folic acid modified celastrol-loaded nanoparticles were developed, which can release RA symptoms and have validated anti-inflammatory effects. These nanoparticles modify the polarization of macrophages and significantly reduce inflammation levels in serum and joints.
MATERIALS & DESIGN
(2022)