Article
Cell Biology
Xiaohui Zhang, Fangyuan Li, Yidong Zhou, Feng Mao, Yan Lin, Songjie Shen, Yuntao Li, Sheng Zhang, Qiang Sun
Summary: The study demonstrated the crucial role of AFAP1-AS1 in triple-negative breast cancer (TNBC), showing that silencing AFAP1-AS1 and Sp1 or upregulating miR-2110 suppressed proliferation, migration, and invasion of TNBC cells. AFAP1-AS1 acted as a miR-2110 sponge to increase Sp1 expression, modulating breast cancer cell progression and tumorigenesis.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Jing Li, Yinmou Li, Hong Cheng
Summary: This study indicates that the silencing of circ-RPPH1 can suppress the malignant phenotypes and glycolysis of breast cancer cells through the miR-328-3p/HMGA2 axis, thereby impeding the progression of breast cancer.
CLINICAL BREAST CANCER
(2022)
Article
Reproductive Biology
Haixia Wu, Youliang Yan, Jialin Yuan, Mengze Luo, Yingjian Wang
Summary: Our study found that miR-4324 inhibited FEN1 expression, suppressed cell growth, and increased apoptosis in ovarian cancer cells. Therefore, we identified miR-4324 and FEN1 as potential therapeutic targets for ovarian cancer treatment.
JOURNAL OF OVARIAN RESEARCH
(2022)
Article
Medicine, Research & Experimental
Qi Li, Xiaoxia Liu, Weifang Liu, Yang Zhang, Mengying Wu, Zhirui Chen, Yin Zhao, Li Zou
Summary: In early-onset preeclampsia (EOPE), decreased expression of MALAT1 and PFKFB3 is associated with endothelial cell dysfunction. PFKFB3 modulates the proliferation, migration, and tube formation of ECs by regulating glycolysis, while MALAT1 regulates PFKFB3 expression by sponging miR-26a/26b. MALAT1 knockdown reduces EC angiogenesis by inhibiting PFKFB3-mediated glycolysis flux, suggesting that strategies targeting PFKFB3-driven glycolysis may be a promising approach for EOPE treatment.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Oncology
Zhongrui Wang, Xiqian Zhou, Xiaochong Deng, Danrong Ye, Diya Liu, Baian Zhou, Wenfang Zheng, Xuehui Wang, Yuying Wang, Oyungerel Borkhuu, Lin Fang
Summary: Breast cancer is the most common cancer type in women worldwide. This study demonstrates that miR-186-5p inhibits proliferation and induces apoptosis in breast cancer cells by targeting ANXA9. These findings provide a potential therapeutic target for breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Pathology
Dan Xie, Saiyang Li, Tianqi Wu, Xuehui Wang, Lin Fang
Summary: Breast cancer is the most common cancer in women worldwide, and triple negative breast cancer is a highly aggressive subtype of breast cancer. This study demonstrates that miR-181c inhibits the proliferation and migration of triple negative breast cancer cells, promotes apoptosis, and regulates the cell cycle. Importantly, miR-181c suppresses the tumor-promoting effect of MAP4K4 by targeting its expression.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Medicine, General & Internal
Zhuo Gao, Jannan Jiang, Lijian Hou, Bin Zhang
Summary: This study reveals the upregulation of RNF187 in colorectal cancer (CRC) and its association with poor prognosis. Inhibition of RNF187 expression suppresses the proliferation, migration, and invasion while promoting apoptosis of CRC cells. miR-144-5p is identified as a direct target of RNF187, and its downregulation in CRC tissues is negatively correlated with RNF187 expression. Restoration of miR-144-5p significantly inhibits CRC cell progression, which can be abolished by overexpression of RNF187.
JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Lei Wang, Yan Liu, Zhengtao Yu, Jianwu Gong, Zhiyong Deng, Nianjun Ren, Zhe Zhong, Hao Cai, Zhi Tang, Haofeng Cheng, Shuai Chen, Zhengwen He
Summary: The study investigates the pathogenesis and potential molecular markers of glioma by examining the differential expression of miRNA and mRNA. Several miRNAs and mRNAs were identified as having significant impact on glioma cell behavior, with miR-139-5p/GABRA1 axis suggested as a novel therapeutic target.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Chenlu Wu, Jiafei Ying, Mei Dai, Jing Peng, Danhua Zhang
Summary: The study found that DDR2 and IFITM1 are highly expressed in breast cancer and are associated with poor clinical outcomes and patient survival. Knockdown of DDR2 or IFITM1 can inhibit the viability and invasiveness of breast cancer cells and restrict tumor growth. Simultaneous knockdown of IFITM1 and DDR2 can more effectively suppress breast cancer development.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Oncology
Peng Bian, Chuan Liu, Wei Hu, Yu Ding, Shusheng Qiu, Liang Li
Summary: This study revealed that miR-4306 and miR-4508 were downregulated in breast cancer tissues and cells, and echinacoside inhibited cell proliferation, invasion, and migration while promoting apoptosis by downregulating the expression of miR-4306 and miR-4508. This is the first study to show the association between echinacoside and miRNAs in cancer, providing insights into the underlying molecular mechanism of its antitumor effect on breast cancer.
INTEGRATIVE CANCER THERAPIES
(2021)
Article
Medicine, Research & Experimental
Ri Chen, Chunfan Zhang, Yuanda Cheng, Shaoqiang Wang, Hang Lin, Heng Zhang
Summary: The long non-coding RNA UCC acts as a competing endogenous RNA of miR-143-3p and upregulates SOX5 by absorbing miR-143-3p, resulting in proliferation and migration of non-small-cell lung cancer (NSCLC) cells both in vitro and in vivo. UCC enhances carcinogenesis of NSCLC cells via the miR-143-3p/SOX5 axis, which may function as a novel target for NSCLC treatment.
LABORATORY INVESTIGATION
(2021)
Article
Pharmacology & Pharmacy
Serah Kimani, Suparna Chakraborty, Ikponmwosa Irene, Jo de la Mare, Adrienne Edkins, Andre du Toit, Ben Loos, Angelique Blanckenberg, Annick Van Niekerk, Leticia Costa-Lotufo, K. N. ArulJothi, Selwyn Mapolie, Sharon Prince
Summary: The study investigated the anti-cancer activity of a palladium complex, BTC2, in human breast cancer cells, demonstrating its selectivity, inhibition of cancer cell migration, and suppression of cancer stem cell activity. BTC2 also induced DNA double strand breaks, triggered cell cycle arrests, and activated multiple cell death pathways, showing promising anti-breast cancer activity both in vitro and in vivo.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Oncology
Xiurong Lu, Xiao Song, Xiaohui Hao, Xiaoyu Liu, Xianyu Zhang, Na Yuan, Huan Ma, Zhilin Zhang
Summary: The study revealed that miR-186-3p targets IGF1 and inhibits the proliferation and migration of CC cells while inducing apoptosis. IGF1 can reverse the effects of miR-186-3p on CC cell behaviors. This suggests that targeting IGF1 by miR-186-3p may play a crucial role in regulating CC progression.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Ramesh Chaudhari, Simran Nasra, Nikita Meghani, Ashutosh Kumar
Summary: MicroRNAs play important roles in various diseases, including cancer. They can act as tumor suppressors or oncogenes, and their expression levels vary depending on cancer subtypes and mutations. Modified metallic nanoparticles can be used for effective miRNA delivery.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Min Pang, Yongjie Jiang, Yuyan Huang, Bi Ren, Liping He, Li Jiang
Summary: Lung cancer is the leading cause of cancer-related death worldwide. The role of miR-654-3p in non-small cell lung cancer (NSCLC) is unclear. This study used various techniques to investigate the function of miR-654-3p in NSCLC. The results showed that miR-654-3p acted as an anti-cancer agent by regulating SRC, suggesting it as a potential therapeutic target for NSCLC.
CELLULAR AND MOLECULAR BIOLOGY
(2023)
