Article
Cell Biology
Jinjing Jia, Ning Wang, Yan Zheng, Xiumei Mo, Yu Zhang, Siqi Ye, Junfeng Liu, Fenggen Yan, Hongyi Li, Dacan Chen
Summary: This study investigated the effect of RASSF1A on YAP in psoriasis and found that RASSF1A could influence the therapeutic effect of psoriasis by regulating the expression of YAP, indicating its potential role in treating psoriasis. Targeted drugs that can inhibit methylation or increase the expression of RASSF1A may be useful for psoriasis treatment.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Review
Oncology
Johanna Herbst, Klaus Pantel, Katharina Effenberger, Harriet Wikman
Summary: Human papilloma virus (HPV) is an infectious carcinogenic agent, and almost all cervical cancers are positive for high-risk HPV. Despite the introduction of HPV vaccines in many countries, most females worldwide are still not vaccinated. The use of blood-based liquid biopsy approaches, particularly cell-free DNA (cfDNA), has shown great potential in early detection and monitoring of cervical cancer.
BRITISH JOURNAL OF CANCER
(2022)
Article
Medicine, General & Internal
Boram Choi, Yoojin Na, Min Yeop Whang, Jung Yoon Ho, Mi-Ryung Han, Seong-Woo Park, Heekyoung Song, Soo Young Hur, Youn Jin Choi
Summary: In this study, the association between MGMT methylation and persistent HPV infection was examined using cervical cytology samples and a public database. The results showed that MGMT methylation was associated with HPV infection and downregulated MGMT mRNA expression correlated with poor overall survival. MGMT methylation level could potentially serve as a prognostic indicator for the transition from atypical squamous cells/low-grade squamous intraepithelial lesion to cervical cancer.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Katharine J. Bee, Ana Gradissimo, Zigui Chen, Ariana Harari, Mark Schiffman, Tina Raine-Bennett, Philip E. Castle, Megan Clarke, Nicolas Wentzensen, Robert D. Burk
Summary: This study aimed to identify genetic and epigenetic changes in HPV type 52 associated with high-grade cervical precancer and cancer. Increased methylation at CpG site 5615 in HPV52 L1 region was found to be significantly associated with CIN3, while specific SNPs present in sublineage C2 were linked to a higher risk of CIN3. These findings improve the potential for early diagnosis of cervical neoplasia caused by HPV52.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Matti Lehtinen, Ville N. Pimenoff, Belinda Nedjai, Karolina Louvanto, Lisanne Verhoef, Danielle A. M. Heideman, Mariam El-Zein, Martin Widschwendter, Joakim Dillner
Summary: This article is based on a recent scientific session that discussed the risk assessment of cervical cancer in the post-vaccination era. The study highlighted the impact of decreasing prevalence of vaccine-targeted high-risk HPV types on the triage methods for cervical intraepithelial neoplasia (CIN)/squamous intraepithelial lesion (SIL). The research emphasized the importance of evaluating new triage modalities in vaccinated women with CIN/SIL associated with nonvaccine HPV types.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Oncology
Qian Sun, Liangliang Wang, Cong Zhang, Zhenya Hong, Zhiqiang Han
Summary: Cervical cancer heterogeneity is crucial for effective prevention and treatment, involving aspects such as immune clearance of viruses, tumorigenesis, metastasis, and drug resistance. The combination of cervical cancer therapeutic vaccine and immune checkpoint inhibitors is an effective strategy to address treatment heterogeneity. Understanding global vaccination rates, screening rates, incidence, and mortality, as well as genomic factors, is important for cervical cancer prevention and control.
BIOMARKER RESEARCH
(2022)
Article
Oncology
Claire Bosire, Adriana C. Vidal, Jennifer S. Smith, Dereje Jima, Zhiqing Huang, David Skaar, Fidel Valea, Rex Bentley, Margaret Gradison, Kimberly S. H. Yarnall, Anne Ford, Francine Overcash, Susan K. Murphy, Cathrine Hoyo
Summary: There was a significant association found between altered DNA methylation at regulatory regions of the PEG3 and high-grade CIN in high-risk HPV positive cases, while no significant association was found between other DMRs and CIN risk. The number of high-grade CIN cases in the study was limited, which may affect the generalizability of the findings.
INFECTIOUS AGENTS AND CANCER
(2021)
Review
Biochemistry & Molecular Biology
Andraz Dovnik, Mario Poljak
Summary: CIN2 is an intermediate stage between CIN1 and CIN3. Traditional treatment involved conization or ablative methods, but recent years have seen a shift towards conservative management for younger patients due to the possibility of spontaneous regression and adverse effects on future pregnancies. Research has focused on the role of host and HPV gene methylation to identify patients at higher risk of progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Leabaneng Tawe, Surbhi Grover, Nicola Zetola, Erle S. Robertson, Simani Gaseitsiwe, Sikhulile Moyo, Ishmael Kasvosve, Giacomo M. Paganotti, Mohan Narasimhamurthy
Summary: The study revealed a high promoter methylation rate of multiple tumor suppressor genes in cervical cancer patients, which was associated with increased risk of cervical cancer. Methylation of the RARB gene showed the strongest association with cervical cancer, and both cervical cancer and promoter methylation of RARB and DAPK1 genes were associated with increasing age.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Chiara Herzog, Charlotte D. D. Vavourakis, James E. E. Barrett, Gerlinde Karbon, Andreas Villunger, Jiangrong Wang, Karin Sundstrom, Joakim Dillner, Martin Widschwendter
Summary: This study investigated the changes in the host epigenome induced by HPV infection and found that the WID-HPV can reflect the changes in the healthy host epigenome related to high-risk HPV infection. Interestingly, an increased WID-HPV index was observed in patients with minor cytological alterations, suggesting a successful viral clearance response. However, this response was not observed in patients with precancerous changes or invasive cervical cancer. Further analysis revealed that the WID-HPV is associated with apoptosis and the epigenetic replicative age.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Shizhi Wang, Bo Ding, Shiyuan Wang, Wenjing Yan, Qianqian Xia, Dan Meng, Shuqian Xie, Siyuan Shen, Bingjia Yu, Haohan Liu, Jing Hu, Xing Zhang
Summary: This study comprehensively analyzed the role of 33 m(6)A regulators in cervical cancer, and developed diagnostic and prognosis models. The results showed that the m(6)AScore can be used to predict the feasibility of immunotherapy in patients. This study provides a theoretical basis for the diagnosis, prognosis, and clinical treatment strategies of cervical cancer.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Liye Shi, Xue Yang, Ling He, Chunying Zheng, Zhen Ren, Juweria Abdisamad Warsame, Suye Suye, Lei Yan, Haiyi Cai, Xiao Xiao, Chun Fu
Summary: This study investigated the diagnostic value of methylation biomarkers of six tumor suppressor genes in cervical precancerous lesions and cervical cancer. The results showed a positive correlation between methylation score and lesion severity, and the GynTect (R) assay was found to be valuable in detecting CIN2 + and CIN3 +.
Article
Microbiology
Mingzhu Li, Chao Zhao, Yun Zhao, Jingran Li, Xiaobo Zhang, Wei Zhang, Qingqing Gao, Lihui Wei
Summary: This study aimed to evaluate the correlation between HPV viral load and PAX1 methylation and their effectiveness in predicting cervical lesions. The results showed that hypermethylation of PAX1 was associated with high HPV viral load, especially HPV16/18. PAX1 methylation had the highest specificity in diagnosing CIN2+, followed by HPV16/18 viral load, both of which were higher than cytology >= ASCUS.
Article
Biotechnology & Applied Microbiology
Zhenyu Xu, Junjie Sun, Yong Mao, Yang Chen, Ting Zhang, Yan Qin, Dong Hua
Summary: The study revealed that Higd-1a is underexpressed in colon adenocarcinoma (COAD) cells and its overexpression impairs the proliferation, migration, and invasiveness of COAD cells.
Article
Multidisciplinary Sciences
Xiaoyue Yang, Ying Chen, Mei Li, Weipei Zhu
Summary: ERBB3 gene mutation and methylation modification have extensive regulatory mechanisms on the microenvironment of cervical squamous cell carcinoma and endocervical adenocarcinoma. ERBB3 is more likely to be a carcinogenic factor rather than a prognostic factor for cervical cancer, and its carcinogenic mechanism is related to immune system suppression and RNA methylation. Methylation of ERBB3 may serve as an immunotherapy target in cervical squamous cell carcinoma and endocervical adenocarcinoma.
SCIENTIFIC REPORTS
(2022)
Article
Obstetrics & Gynecology
Ling Liu, Yan Zhang, Yankui Wang, Wei Peng, Ning Zhang, Yuanhua Ye
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2018)
Article
Medicine, General & Internal
Ke-juan Song, Xiao-ni Yu, Teng Lv, Yu-long Chen, Yu-chao Diao, Su-li Liu, Yan-kui Wang, Qin Yao
Article
Oncology
Kejuan Song, Teng Lv, Yulong Chen, Yuchao Diao, Qin Yao, Yankui Wang
Article
Oncology
Xiaotian Luan, Yankui Wang
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2018)
Article
Oncology
Hongxia Zhang, Ruifeng Dong, Ping Zhang, Yankui Wang
Article
Medicine, General & Internal
Fu-Fen Yin, Li-Jun Zhao, Xiao-Yu Ji, Ning Duan, Yan-Kui Wang, Jing-Yi Zhou, Li-Hui Wei, Xiang-Jun He, Jian-Liu Wang, Xiao-Ping Li
CHINESE MEDICAL JOURNAL
(2019)
Article
Oncology
Chang Wang, Hao Zou, Hongjuan Yang, Lei Wang, Huijun Chu, Jinwen Jiao, Yankui Wang, Aiping Chen
MOLECULAR MEDICINE REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Chang Wang, Hao Zou, Aiping Chen, Hongjuan Yang, Xinping Yu, Xiao Yu, Yankui Wang
JOURNAL OF BIOCHEMISTRY
(2020)
Article
Oncology
Huihui Cai, Tingting Ma, Yanci Che, Yankui Wang, Chunlian Wang, Guangjie Yin
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2020)
Article
Cell Biology
Yijing Chu, Chengzhan Zhu, Qianqian Wang, Meixin Liu, Wei Wan, Jun Zhou, Rendong Han, Jing Yang, Wenqiang Luo, Chong Liu, Huansheng Zhou, Min Li, Fengsheng Yu, Yuanhua Ye
Summary: The study revealed that PAX8 is a key factor in promoting the proliferation of ovarian cancer cells induced by ADSCs, and inhibiting PAX8 can slow down tumor growth. Additionally, PAX8 can regulate cell proliferation by interacting with TAZ.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Oncology
Huihui Cai, Yanci Che, Xin Sun, Xiao Yu, Fengsheng Yu, Feng Hou, Yankui Wang, Tingting Ma
Summary: Five-aminolaevulinic acid photodynamic therapy (ALA-PDT) is an effective treatment for cervical intraepithelial neoplasia 2 (CIN 2), achieving a total response rate of 90.77%. Immune responses play a significant role in the prognosis of the disease.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Haixia Liu, Mei Song, Xiaoyan Sun, Xin Zhang, Huayan Miao, Yankui Wang
Summary: TBX1 acts as a tumor suppressor in cervical cancer by inhibiting cell proliferation, migration, and invasion, and may function through regulation of miR-6727-5p.
Article
Biotechnology & Applied Microbiology
Fengsheng Yu, Pingping Qiao, Guangjie Yin, Yewu Sun, Xiao Yu, Xin Sun, Yijing Chu, Yankui Wang
ONCOTARGETS AND THERAPY
(2020)