Article
Cell Biology
Ying Wang, Chenming Yan, Junxia Qi, Chunyan Liu, Juan Yu, Huabin Wang
Summary: The study found that the downregulation of miR-874-3p in epithelial ovarian cancer cells is associated with cisplatin resistance, and reversing cisplatin resistance and enhancing sensitivity to cisplatin-induced apoptosis can be achieved by targeting XIAP.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Hongcheng Luo, Tingzhuang Yi, Deyou Huang, Xiaoping Chen, Xu Li, Qianquan Wan, Haineng Huang, Huadong Huang, Hongyu Wei, Ye Song, Tianshi Que, Rentong Hu, Huatuo Huang, Kunxiang Luo, Chuanyu Li, Chengjian Qin, Chuanhua Zheng, Chuanliu Lan, Wencheng Chen, Dan Zhou, Qisheng Luo
Summary: The study revealed that circ_PTN promotes DDP resistance in GBM cells through activating the PI3K/AKT pathway, with in vivo experiments demonstrating that circ_PTN silencing inhibits DDP resistance in GBM tumors.
MOLECULAR THERAPY NUCLEIC ACIDS
(2021)
Review
Pharmacology & Pharmacy
Sepideh Mirzaei, Aliasghar Tabatabaei Mohammadi, Mohammad Hossein Gholami, Farid Hashemi, Ali Zarrabi, Amirhossein Zabolian, Kiavash Hushmandi, Pooyan Makvandi, Marek Samec, Alena Liskova, Peter Kubatka, Noushin Nabavi, Amir Reza Aref, Milad Ashrafizadeh, Haroon Khan, Masoud Najafi
Summary: Nrf2 signaling plays a crucial role in protecting against oxidative damage, but its activation in cancer cells can lead to chemoresistance. Modulating Nrf2 signaling during cisplatin treatment can suppress the development of chemoresistance and alleviate drug toxicity. Activating Nrf2 signaling can help prevent the side effects of cisplatin.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Oncology
Hu Han, Yan Li, Wan Qin, Lu Wang, Han Yin, Beibei Su, Xianglin Yuan
Summary: The study found that miR-199b-3p is significantly up-regulated in CTx-resistant colorectal cancer cells. Inhibiting miR-199b-3p can improve the sensitivity of CTx-resistant cells to CTx by regulating the Wnt/β-catenin signaling pathway. Mouse models confirmed that down-regulating miR-199b-3p can restore the inhibitory effect of CTx on tumor growth.
CANCER CELL INTERNATIONAL
(2022)
Article
Biology
Chengjie Lin, Yan Wang, Yihong Dong, Shihui Lai, Liang Wang, Shangeng Weng, Xiang Zhang
Summary: SH3BP5-AS1 plays an important role in GEM-resistant PC by activating the Wnt signaling pathway and upregulating CTBP1 expression, thereby enhancing the sensitivity of PC cells to GEM.
Article
Oncology
Yang Zhou, Jiang Xu, Haichang Luo, Xiangjing Meng, Ming Chen, Di Zhu
Summary: Abnormal activation of the Wnt/beta-catenin signaling pathway is closely related to tumorigenesis and immune surveillance, leading to increased resistance to immunotherapy.
Article
Medicine, Research & Experimental
Adil Ali Sayyed, Piyush Gondaliya, Mukund Mali, Abhijeet Pawar, Palak Bhat, Amit Khairnar, Neha Arya, Kiran Kalia
Summary: The study demonstrates that miR-155 inhibitor-loaded exosomes show therapeutic potential in reversing cisplatin resistance in oral cancer by upregulating FOXO3a, inducing epithelial-to-mesenchymal transition, and inhibiting stem cell-like properties. This provides a novel alternative therapeutic strategy for refractory oral cancer patients.
MOLECULAR PHARMACEUTICS
(2021)
Article
Oncology
Yang Li, Lingling Zu, Heng Wu, Fang Zhang, Yaguang Fan, Hongli Pan, Xinxin Du, Fengjie Guo, Qinghua Zhou
Summary: MiR-192 plays a crucial role in cisplatin-resistance of lung cancer cells and may represent a therapeutic target for overcoming resistance to cisplatin-based chemotherapy in lung cancer.
Article
Oncology
Wenjie Xia, Wuzhen Chen, Chao Ni, Xuli Meng, Jun Wu, Qiong Yang, Hongchao Tang, Hongjun Yuan, Shan Fang
Summary: In this study, PTX-induced exosomal circBACH1 was found to promote stemness and migration of BC cells by sponging miR-217 to upregulate the expression of G3BP2. This provides a new therapeutic target for PTX-resistance and progression of BC via the circBACH1/miR-217/G3BP2 axis.
BREAST CANCER RESEARCH
(2023)
Article
Medicine, Research & Experimental
Di Zhang, Xiaofeng Liu, Yun Li, Li Sun, Shu-Shu Liu, Yue Ma, Huan Zhang, Xin Wang, Yue Yu
Summary: The study revealed that miR-586 functions as an oncogene promoting breast cancer proliferation and metastasis, while LINC01189 acts as a tumor suppressor inhibiting cancer progression. The interaction and feedback loop between the two are involved in the regulation of Wnt/β-catenin signaling and breast cancer development.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Review
Biochemistry & Molecular Biology
Sana Kouba, Frederic Hague, Ahmed Ahidouch, Halima Ouadid-Ahidouch
Summary: In the fight against cancer, the appearance of resistant cancer stem cells (CSCs) is a major obstacle for therapeutic strategies using cisplatin. Altered Ca2+ signaling, which is essential for various cellular processes, including proliferation and survival, has been linked to CSC functions and therapy resistance. Understanding the molecular mechanisms linking Ca2+ to cisplatin-induced resistance and CSC behaviors could lead to alternative therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Han Wu, Xibo Zhao, Jing Wang, Xinyan Jiang, Yan Cheng, Yanan He, Liyuan Sun, Guangmei Zhang
Summary: This study elucidates the role of CDR1as in cisplatin-resistant ovarian cancer and provides new insights for the clinical applications of cisplatin-resistant ovarian cancer.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Yuki Teramoto, Guiyang Jiang, Takuro Goto, Taichi Mizushima, Yujiro Nagata, George J. Netto, Hiroshi Miyamoto
Summary: In bladder cancer cells, GULP1 is regulated by AR signaling and influences sensitivity to cisplatin. Knockdown of GULP1 results in increased resistance to cisplatin treatment, reduced apoptosis, and increased G2/M phases. Additionally, GULP1 expression levels correlate with response to neoadjuvant chemotherapy in muscle-invasive bladder cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mengting Wu, Qiongzi Qiu, Qing Zhou, Jia Li, Juze Yang, Chengcai Zheng, Aoran Luo, Xufan Li, Honghe Zhang, Xiaodong Cheng, Weiguo Lu, Pengyuan Liu, Bingjian Lu, Yan Lu
Summary: This study identifies circFBXO7, a novel circRNA, as a tumor suppressor in ovarian cancer. The circFBXO7/miR-96-5p/MTSS1 axis is found to be an important regulator in the Wnt/beta-catenin signaling pathway.
Article
Biochemistry & Molecular Biology
Lipeng Pei, Feng Zhao, Yi Zhang
Summary: This study reveals that USP43 is highly expressed in epithelial ovarian cancer (EOC) and its overexpression promotes cancer cell proliferation, migration, invasion, and chemoresistance. USP43 achieves these effects by inhibiting HDAC2 degradation and activating the Wnt/beta-catenin signaling pathway. These findings suggest that USP43 may be a potential target for controlling ovarian cancer progression.