KLF4 is regulated by RAS/RAF/MEK/ERK signaling through E2F1 and promotes melanoma cell growth

KLF4 is downregulated but not mutated during human esophageal squamous cell carcinogenesis and has tumor stage-specific functions

(2016) Yizeng Yang et al.   CANCER BIOLOGY & THERAPY

KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis

(2016) Daoyan Wei et al.   CANCER CELL

KLF4 regulates adult lung tumor-initiating cells and represses K-Ras-mediated lung cancer

(2015) T Yu et al.   CELL DEATH AND DIFFERENTIATION

HEDGEHOG/GLI-E2F1 axis modulates iASPP expression and function and regulates melanoma cell growth

(2015) S Pandolfi et al.   CELL DEATH AND DIFFERENTIATION

Phase 1 study of APTO-253 HCl, an inducer of KLF4, in patients with advanced or metastatic solid tumors

(2015) Andrea Cercek et al.   INVESTIGATIONAL NEW DRUGS

Regulation of anti-apoptotic signaling by Kruppel-like factors 4 and 5 mediates lapatinib resistance in breast cancer

(2015) M K Farrugia et al.   Cell Death & Disease

Krüppel-like Factor 4 Inhibits Tumorigenic Progression and Metastasis in a Mouse Model of Breast Cancer

(2015) Jennifer L Yori et al.   NEOPLASIA

SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells

(2014) R Santini et al.   ONCOGENE

The melanoma revolution: From UV carcinogenesis to a new era in therapeutics

(2014) J. A. Lo et al.   SCIENCE

HDAC1 and Klf4 interplay critically regulates human myeloid leukemia cell proliferation

(2014) Y Huang et al.   Cell Death & Disease

Epigenetic alterations of Krüppel-like factor 4 and its tumor suppressor function in renal cell carcinoma

(2013) Heng Li et al.   CARCINOGENESIS

The Hematopoietic Stem Cell Regulatory Gene Latexin Has Tumor-Suppressive Properties in Malignant Melanoma

(2013) Viswanathan Muthusamy et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts

(2013) Enas A El-Karim et al.   Molecular Cancer

Discovery of a Novel ERK Inhibitor with Activity in Models of Acquired Resistance to BRAF and MEK Inhibitors

(2013) E. J. Morris et al.   Cancer Discovery

Deficiency of the Kruppel-like factor KLF4 correlates with increased cell proliferation and enhanced skin tumorigenesis

(2012) Juan Li et al.   CARCINOGENESIS

Shaking the family tree: identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors

(2012) Olga Camacho-Vanegas et al.   FASEB JOURNAL

Melanoma: from mutations to medicine

(2012) H. Tsao et al.   GENES & DEVELOPMENT

Regulation of KLF4 Turnover Reveals an Unexpected Tissue-Specific Role of pVHL in Tumorigenesis

(2012) Armin M. Gamper et al.   MOLECULAR CELL

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4

(2012) Myoung Ok Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function

(2012) S Pandolfi et al.   ONCOGENE

HEDGEHOG-GLI Signaling Drives Self-Renewal and Tumorigenicity of Human Melanoma-Initiating Cells

(2012) Roberta Santini et al.   STEM CELLS

Deciphering the retinoblastoma protein phosphorylation code

(2012) Seth M. Rubin   TRENDS IN BIOCHEMICAL SCIENCES

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma

(2011) Sergey I Nikolaev et al.   NATURE GENETICS

Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion

(2011) F Yu et al.   ONCOGENE

Predicting and preventing melanoma invasiveness: advances in clarifying E2F1 function

(2010) Brigitte M Pützer et al.   Expert Review of Anticancer Therapy

KLF4α Up-regulation Promotes Cell Cycle Progression and Reduces Survival Time of Patients With Pancreatic Cancer

(2010) Daoyan Wei et al.   GASTROENTEROLOGY

A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers

(2009) Barbara Stecca et al.   EMBO JOURNAL

Noncatalytic Function of ERK1/2 Can Promote Raf/MEK/ERK-mediated Growth Arrest Signaling

(2009) Seung-Keun Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells

(2009) J. Utikal et al.   JOURNAL OF CELL SCIENCE

Final Version of 2009 AJCC Melanoma Staging and Classification

(2009) Charles M. Balch et al.   JOURNAL OF CLINICAL ONCOLOGY

Roles of Krüppel-like factor 4 in normal homeostasis, cancer and stem cells

(2008) Paul M Evans et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Kruppel-like Factor 4 Induces p27Kip1 Expression in and Suppresses the Growth and Metastasis of Human Pancreatic Cancer Cells

(2008) D. Wei et al.   CANCER RESEARCH

ERK activation is regulated by E2F1 and is essential for E2F1-induced S phase entry

(2008) Katya Korotayev et al.   CELLULAR SIGNALLING

E2F in vivo binding specificity: Comparison of consensus versus nonconsensus binding sites

(2008) A. Rabinovich et al.   GENOME RESEARCH

Krüppel-Like Factor 5 Mediates Cellular Transformation During Oncogenic KRAS-Induced Intestinal Tumorigenesis

(2007) Mandayam O. Nandan et al.   GASTROENTEROLOGY