Mdm2 selectively suppresses DNA damage arising from inhibition of topoisomerase II independent of p53

p53 Maintains Genomic Stability by Preventing Interference between Transcription and Replication

(2016) Constance Qiao Xin Yeo et al.   Cell Reports

TDP2–Dependent Non-Homologous End-Joining Protects against Topoisomerase II–Induced DNA Breaks and Genome Instability in Cells and In Vivo

(2013) Fernando Gómez-Herreros et al.   PLoS Genetics

Epirubicin: Is it like doxorubicin in breast cancer? A clinical review

(2012) Mustafa Khasraw et al.   BREAST

Correlation ofTP53andMDM2genotypes with response to therapy in sarcoma

(2012) Hege O. Ohnstad et al.   CANCER

Mdm2 inhibitors synergize with topoisomerase II inhibitors to induce p53-independent pancreatic cancer cell death

(2012) Laura Conradt et al.   INTERNATIONAL JOURNAL OF CANCER

p53 Basic C Terminus Regulates p53 Functions through DNA Binding Modulation of Subset of Target Genes

(2012) Pierre-Jacques Hamard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Use of the γ-H2AX assay to monitor DNA damage and repair in translational cancer research

(2011) Alesia Ivashkevich et al.   CANCER LETTERS

The phenotype of MDM2 auto-degradation after DNA damage is due to epitope masking by phosphorylation

(2011) Qian Cheng et al.   CELL CYCLE

Current Management of Small Cell Lung Cancer

(2011) Joel W. Neal et al.   CLINICS IN CHEST MEDICINE

Systemic Management Strategies for Metastatic Soft Tissue Sarcoma

(2011) Sujana Movva et al.   DRUGS

Frequency of Mouse Double Minute 2 (MDM2) and Mouse Double Minute 4 (MDM4) amplification in parosteal and conventional osteosarcoma subtypes

(2011) Laure A E Duhamel et al.   HISTOPATHOLOGY

All tangled up: how cells direct, manage and exploit topoisomerase function

(2011) Seychelle M. Vos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

(2010) Yves Pommier et al.   CHEMISTRY & BIOLOGY

DNA Topoisomerase II Enzymes as Molecular Targets for Cancer Chemotherapy

(2010) K. Chikamori et al.   CURRENT CANCER DRUG TARGETS

The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor

(2010) J. J. Manfredi   GENES & DEVELOPMENT

TDP2/TTRAP Is the Major 5′-Tyrosyl DNA Phosphodiesterase Activity in Vertebrate Cells and Is Critical for Cellular Resistance to Topoisomerase II-induced DNA Damage

(2010) Zhihong Zeng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

γH2AX: a sensitive molecular marker of DNA damage and repair

(2010) L-J Mah et al.   LEUKEMIA

The p53 orchestra: Mdm2 and Mdmx set the tone

(2010) Mark Wade et al.   TRENDS IN CELL BIOLOGY

Reversal of P-glycoprotein-Mediated Multidrug Resistance by the Murine Double Minute 2 Antagonist Nutlin-3

(2009) M. Michaelis et al.   CANCER RESEARCH

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Mdm2-mediated ubiquitylation: p53 and beyond

(2009) J-C Marine et al.   CELL DEATH AND DIFFERENTIATION

Molecular characterization of commonly used cell lines for bone tumor research: A trans-European EuroBoNet effort

(2009) Laura Ottaviano et al.   GENES CHROMOSOMES & CANCER

A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

(2009) Felipe Cortes Ledesma et al.   NATURE

Murine double minute 2: p53-independent roads lead to genome instability or death

(2009) Alyssa Bouska et al.   TRENDS IN BIOCHEMICAL SCIENCES

p53-independent mechanisms regulate the P2-MDM2 promoter in adult astrocytic tumours

(2008) M Dimitriadi et al.   BRITISH JOURNAL OF CANCER

Mdm2 Promotes Genetic Instability and Transformation Independent of p53

(2008) A. Bouska et al.   MOLECULAR AND CELLULAR BIOLOGY

Casein kinase I  /  phosphorylates topoisomerase II  at serine-1106 and modulates DNA cleavage activity

(2008) A. G. Grozav et al.   NUCLEIC ACIDS RESEARCH